FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Opa1
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General Information
Symbol
Dmel\Opa1
Species
D. melanogaster
Name
Optic atrophy 1
Annotation Symbol
CG8479
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261276
Gene Model Status
Current
Stock Availability
13 publicly available
Gene Summary
Optic atrophy 1 (Opa1) encodes a dynamin-related GTPase that mediates fusion of the inner membrane of mitochondria. It usually works with the product of Marf to coordinately fuse both mitochondrial membranes. The product of Opa1 activity is regulated by proteolytic processing. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dOpa1, Opa1-like, optic atrophy 1-like, l(2)s3475

Key Links
Genomic Location
Cytogenetic map
50E4-50E4
Sequence location
Recombination map
2-69
RefSeq locus
NT_033778 REGION:14230611..14235449
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
enables cardiolipin binding
inferred from sequence or structural similarity with UniProtKB:O60313
(Gene Ontology Curators, 2002-)
enables GTP binding
inferred from electronic annotation with InterPro:IPR001401, InterPro:IPR030381
(InterPro Project Members, 2004-)
enables GTPase activity
inferred from sequence model
(Yarosh et al., 2008)
inferred from electronic annotation with InterPro:IPR001401
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(GO Reference Genome Project, 2011-)
enables GTPase-dependent fusogenic activity
inferred from sequence or structural similarity with UniProtKB:O60313
(Gene Ontology Curators, 2002-)
enables microtubule binding
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(GO Reference Genome Project, 2011-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in cristae formation
inferred from genetic interaction with FLYBASE:Adck1; FB:FBgn0035039
(Yoon et al., 2019)
involved_in mitochondrial fusion
inferred from mutant phenotype
(Deng et al., 2008, McQuibban et al., 2006)
involved_in mitochondrion organization
inferred from mutant phenotype
(Banerjee and Chinthapalli, 2014, Yarosh et al., 2008)
involved_in positive regulation of mitochondrial fusion
inferred from mutant phenotype
(Ziviani et al., 2010)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in cristae formation
inferred from sequence or structural similarity with UniProtKB:P58281
(Gene Ontology Curators, 2002-)
involved_in mitochondrial fusion
inferred from biological aspect of ancestor with PANTHER:PTN007514526
(GO Reference Genome Project, 2011-)
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
inferred from sequence or structural similarity with UniProtKB:O60313
(Gene Ontology Curators, 2002-)
involved_in peroxisome fission
inferred from biological aspect of ancestor with PANTHER:PTN008520527
(GO Reference Genome Project, 2011-)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Banerjee and Chinthapalli, 2014)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(GO Reference Genome Project, 2011-)
is_active_in microtubule
inferred from biological aspect of ancestor with PANTHER:PTN000170013
(GO Reference Genome Project, 2011-)
located_in mitochondrial crista
inferred from sequence or structural similarity with UniProtKB:O60313
(Gene Ontology Curators, 2002-)
is_active_in mitochondrial intermembrane space
inferred from biological aspect of ancestor with PANTHER:PTN007514526
(GO Reference Genome Project, 2011-)
is_active_in mitochondrial membrane
inferred from biological aspect of ancestor with PANTHER:PTN007514526
(GO Reference Genome Project, 2011-)
located_in mitochondrion
inferred from sequence or structural similarity with UniProtKB:O60313
(Yarosh et al., 2008)
inferred from sequence or structural similarity with UniProtKB:O60313
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
GTPase activity
RHEA 19669:
Summaries
Gene Snapshot
Optic atrophy 1 (Opa1) encodes a dynamin-related GTPase that mediates fusion of the inner membrane of mitochondria. It usually works with the product of Marf to coordinately fuse both mitochondrial membranes. The product of Opa1 activity is regulated by proteolytic processing. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
DYNAMIN-LIKE GTPASES -
The Dynamin-like GTPases are a family of GTPases that undergo nucleotide-dependent dimerization and dimer-dependent GTP hydrolysis. They are implicated in membrane remodelling and endocytic membrane fission events. (Adapted from PMID:22233676).
Summary (Interactive Fly)

mediates fusion of the inner mitochondrial membrane, suppression of Opa1 induces cardiac dysfunction associated with mitochondrial depolarization and ROS production

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Opa1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A1Z9N0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Opa1-RA
FBtr0087574
NM_166040
3217
972
Opa1-RB
FBtr0087573
NM_137097
3100
933
Opa1-RC
FBtr0339759
NM_001299482
3208
969
Opa1-RD
FBtr0339760
NM_001299483
3091
930
Opa1-RE
FBtr0339761
NM_001299484
3851
622
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Opa1-PA
FBpp0086700
111.8
972
8.99
A1Z9N0
NP_725369
AAF58275
Opa1-PB
FBpp0086699
107.2
933
9.37
Q95U20
NP_610941
AAM70993
Opa1-PC
FBpp0308806
111.5
969
8.90
A0A0B4LGF5
NP_001286411
AHN56209
Opa1-PD
FBpp0308807
106.9
930
9.31
A0A0B4LFB8
NP_001286412
AHN56210
Opa1-PE
FBpp0308808
70.4
622
9.75
A0A0B4LF33
NP_001286413
AHN56211
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Opa1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.02

Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
indirect flight muscle cell
(Katti et al., 2017)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in mitochondrion
inferred from direct assay
(Banerjee and Chinthapalli, 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Opa1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Opa1
Transgenic constructs containing regulatory region of Opa1
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene not disrupted in
Df(2R)trix
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Inferred from location ( 3 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of P-stage, with Scer\GAL4elav-C155
lethal - all die before end of P-stage, with Scer\GAL4insc.PU
lethal - all die before end of P-stage, with Scer\GAL4pros.PU
lethal - all die before end of P-stage, with Scer\GAL4sca.PU
lethal - all die before end of P-stage, with Scer\GAL4wor.PU
partially lethal - majority die
viable
viable, with Scer\GAL4Mef2.PU
Other Phenotypes
Allele
abnormal locomotor behavior | adult stage, with Scer\GAL4Mhc.PU
abnormal neuroanatomy | adult stage, with Scer\GAL4GMR.PF
abnormal neuroanatomy | adult stage, with Scer\GAL4ple.PF
abnormal neuroanatomy | adult stage, with Scer\GAL4VGlut1-OK371
abnormal neuroanatomy | adult stage | dominant
abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4GMR.PF
abnormal neuroanatomy | adult stage | somatic clone - tissue specific
abnormal neuroanatomy | larval stage, with Scer\GAL4pnt-14-94
abnormal neuroanatomy | larval stage, with Scer\GAL4wor.PU
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4109(2)80
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4smid-C161
abnormal neurophysiology | adult stage | somatic clone
abnormal size | third instar larval stage, with Scer\GAL4Cg.PA
chemical resistant | adult stage, with Scer\GAL4ple.PF
decreased cell number | larval stage, with Scer\GAL4pnt-14-94
decreased cell number | larval stage, with Scer\GAL4wor.PU
decreased efficacy of long-term memory | adult stage, with Scer\GAL4VT030559
decreased efficacy of medium-term memory | adult stage, with Scer\GAL4VT030559
decreased occurrence of cell division | larval stage, with Scer\GAL4pnt-14-94
decreased occurrence of cell division | larval stage, with Scer\GAL4wor.PU
decreased rate of movement | adult stage, with Scer\GAL4pnt-14-94
decreased rate of movement | adult stage, with Scer\GAL4wor.PU
decreased size | adult stage, with Scer\GAL4GMR.PF
increased cell death, with Scer\GAL4NP5130
increased cell death | somatic clone - Minute background
increased cell size | larval stage, with Scer\GAL4unspecified
increased size | larval stage, with Scer\GAL4ap.PU
short lived, with Scer\GAL4tin.CΔ4
some die during first instar larval stage
visible | adult stage, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
abdominal dorsal multidendritic neuron ddaA | third instar larval stage, with Scer\GAL4smid-C161
abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4109(2)80
adult heart, with Scer\GAL4HCH.Hand
adult heart, with Scer\GAL4tin.CΔ4
adult midgut progenitor cell, with Scer\GAL4NP5130
adult somatic muscle cell of thorax, with Scer\GAL4Mhc.PU
axon | adult stage
axon | adult stage, with Scer\GAL4GMR15B07
axon | adult stage, with Scer\GAL4VGlut1-OK371
axon | adult stage | decreased number, with Scer\GAL4GMR.PF
axon | adult stage | decreased number | somatic clone - tissue specific
cardial cell | adult stage, with Scer\GAL4tin.CΔ4
cone cell | somatic clone - Minute background
dendrite | third instar larval stage, with Scer\GAL4109(2)80
dendrite | third instar larval stage, with Scer\GAL4smid-C161
dopaminergic PPL1 neuron | adult stage, with Scer\GAL4ple.PF
embryonic/larval fat body | early third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Cg.PA
embryonic/larval hypodermal muscle cell | third instar larval stage, with Scer\GAL4Mef2.PU
embryonic/larval neuromuscular junction, with Scer\GAL4Feb36
epithelium, with Scer\GAL4Gug-AGiR
eye, with Scer\GAL4GMR.PF
eye | somatic clone
eye | somatic clone - Minute background
eye photoreceptor cell | adult stage, with Scer\GAL4GMR.PF
eye photoreceptor cell | adult stage | somatic clone - tissue specific
filamentous actin | adult stage, with Scer\GAL4HCH.Hand
ganglion mother cell | decreased number | larval stage, with Scer\GAL4pnt-14-94
gustatory receptor neuron of the wing, with Scer\GAL4GMR15B07
indirect flight muscle cell
indirect flight muscle cell, with Scer\GAL4Mef2.PR
intermediate neuronal progenitor | decreased number | larval stage, with Scer\GAL4pnt-14-94
intermediate neuronal progenitor | larval stage, with Scer\GAL4pnt-14-94
interommatidial cell | somatic clone - Minute background
interommatidial precursor cell | somatic clone - Minute background
larval brain | larval stage, with Scer\GAL4pnt-14-94
larval brain | larval stage, with Scer\GAL4wor.PU
larval neuroblast, with Scer\GAL4unspecified
larval neuron | decreased number | larval stage, with Scer\GAL4pnt-14-94
larval neuron | decreased number | larval stage, with Scer\GAL4wor.PU
mitochondrion
mitochondrion, with Scer\GAL4Cg.PA
mitochondrion, with Scer\GAL4Gug-AGiR
mitochondrion, with Scer\GAL4Mef2.PR
mitochondrion, with Scer\GAL4Tub.PU
mitochondrion & dopaminergic neuron, with Scer\GAL4ple.PF
mitochondrion | adult stage
mitochondrion | adult stage, with Scer\GAL4GMR15B07
mitochondrion | adult stage, with Scer\GAL4GMR.PF
mitochondrion | adult stage, with Scer\GAL4Mhc.PU
mitochondrion | adult stage, with Scer\GAL4ple.PF
mitochondrion | adult stage, with Scer\GAL4tin.CΔ4
mitochondrion | adult stage, with Scer\GAL4VGlut1-OK371
mitochondrion | adult stage | somatic clone - Minute background
mitochondrion | early third instar larval stage, with Scer\GAL4Cg.PA
mitochondrion | germline clone
mitochondrion | larval stage, with Scer\GAL4Mhc.PW
mitochondrion | larval stage, with Scer\GAL4pnt-14-94
mitochondrion | P-stage, with Scer\GAL4GMR.PF
mitochondrion | third instar larval stage, with Scer\GAL4109(2)80
mitochondrion | third instar larval stage, with Scer\GAL4Cg.PA
mitochondrion | third instar larval stage, with Scer\GAL4Mef2.PU
muscle cell of A1-7 ventral longitudinal muscle 3 | larval stage, with Scer\GAL4Mhc.PW
muscle cell of A1-7 ventral longitudinal muscle 4 | larval stage, with Scer\GAL4Mhc.PW
Nebenkern | germline clone
NMJ bouton, with Scer\GAL4Feb36
peripodial epithelium, with Scer\GAL4Gug-AGiR
retina | adult stage, with Scer\GAL4GMR.PF
retina | P-stage, with Scer\GAL4GMR.PF
retina | somatic clone
rhabdomere of eye photoreceptor cell | adult stage | decreased number, with Scer\GAL4GMR.PF
type II neuroblast | larval stage, with Scer\GAL4pnt-14-94
type II neuroblast | larval stage, with Scer\GAL4wor.PU
wing disc, with Scer\GAL4Gug-AGiR
wing disc | larval stage, with Scer\GAL4ap.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (9)
Hsap\OPA1
14 of 14
Yes
Yes
 
5  
Hsap\DNM1
2 of 14
No
No
Hsap\DNM1L
2 of 14
No
No
9  
Hsap\DNM2
2 of 14
No
No
6  
Hsap\DNM3
2 of 14
No
No
Hsap\MX1
2 of 14
No
No
Hsap\MX2
2 of 14
No
No
Hsap\MFN1
1 of 14
No
No
2  
Hsap\MFN2
1 of 14
No
No
5  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (8)
Rnor\Opa1
13 of 14
Yes
Yes
Rnor\Dnm3
2 of 14
No
No
Rnor\Dnm1
1 of 14
No
No
Rnor\Dnm2
1 of 14
No
No
Rnor\Mfn1
1 of 14
No
No
Rnor\Mfn2
1 of 14
No
No
Rnor\Mx1
1 of 14
No
No
Rnor\Mx2
1 of 14
No
No
Mus musculus (laboratory mouse) (7)
Mmus\Opa1
13 of 14
Yes
Yes
Mmus\Dnm1
2 of 14
No
No
Mmus\Dnm2
2 of 14
No
No
Mmus\Dnm3
2 of 14
No
No
Mmus\Dnm1l
1 of 14
No
No
Mmus\Mfn1
1 of 14
No
No
Mmus\Mfn2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\opa1
11 of 13
Yes
Yes
Xtro\dnm2
1 of 13
No
No
Xtro\drp2
1 of 13
No
No
Xtro\mx1
1 of 13
No
Yes
Xtro\shc3
1 of 13
No
No
Xtro\skp2
1 of 13
No
No
Danio rerio (Zebrafish) (14)
Drer\opa1
14 of 14
Yes
Yes
Drer\dnm2a
2 of 14
No
No
Drer\mxd
2 of 14
No
No
Drer\mxf
2 of 14
No
No
Drer\mxg
2 of 14
No
No
Drer\dnm1a
1 of 14
No
No
Drer\dnm1b
1 of 14
No
No
Drer\dnm1l
1 of 14
No
No
Drer\dnm3a
1 of 14
No
No
Drer\LOC100307079
1 of 14
No
Yes
Drer\mfn2
1 of 14
No
No
Drer\mxa
1 of 14
No
No
Drer\mxb
1 of 14
No
No
Drer\mxc
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\eat-3
14 of 14
Yes
Yes
Cele\drp-1
1 of 14
No
No
Cele\dyn-1
1 of 14
No
No
Cele\fzo-1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (3)
Agam\AgaP_AGAP011286
12 of 12
Yes
Yes
Agam\AgaP_AGAP008896
2 of 12
No
No
Agam\AgaP_AGAP003018
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\ADL6
3 of 13
Yes
Yes
Atha\DL1
3 of 13
Yes
No
Atha\DL1B
3 of 13
Yes
No
Atha\DL1C
3 of 13
Yes
No
Atha\DL1D
3 of 13
Yes
No
Atha\DL1E
3 of 13
Yes
No
Atha\DL3
3 of 13
Yes
Yes
Atha\DRP3A
3 of 13
Yes
No
Atha\DRP3B
3 of 13
Yes
No
Atha\DRP4C
3 of 13
Yes
Yes
Atha\ARC5
2 of 13
No
Yes
Atha\DRP4A
2 of 13
No
Yes
Atha\DRP5A
2 of 13
No
Yes
Atha\FZL
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\MGM1
5 of 13
Yes
Yes
Scer\DNM1
3 of 13
No
No
Scer\VPS1
3 of 13
No
No
Scer\FZO1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\msp1
3 of 12
Yes
Yes
Spom\dnm1
2 of 12
No
No
Spom\vps1
2 of 12
No
No
Spom\fzo1
1 of 12
No
No
Escherichia coli (enterobacterium) (1)
Ecol\rdcA
1 of 11
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Opa1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (3)
Drp1
4 of 13
shi
4 of 13
fzo
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 6 )
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
OPA1; OPA1 mitochondrial dynamin like GTPase
14 of 14
OPA1 MITOCHONDRIAL DYNAMIN-LIKE GTPase; OPA1
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Opa1
Hsap\OPA1
(Nitta et al., 2024)
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Opa1
enhanceable
Chchd2
(Liu et al., 2020)
Opa1
suppressible
Drp1
(Dubal et al., 2022)
Opa1
suppressible
gfzf
(Smith et al., 2019)
Opa1
enhanceable
Mtx2
(Zhang et al., 2025)
Opa1
suppressible
PPP1R15
(Tsuyama et al., 2017)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Adck1
suppressible
Opa1
(Yoon et al., 2019)
Chchd3
enhanceable
Opa1
(Birker et al., 2023)
Dhpr
enhanceable
Opa1
(Zhou et al., 2019)
Drp1
suppressible
Opa1
(Uttekar et al., 2024, Rival et al., 2011)
fwd
suppressible
Opa1
(Terriente-Felix et al., 2020)
gfzf
suppressible
Opa1
(Smith et al., 2019)
Hsc70-5
suppressible
Opa1
(Banerjee and Chinthapalli, 2014)
Marf
suppressible
Opa1
(El Fissi et al., 2018)
N
suppressible
Opa1
(Dubal et al., 2022)
park
suppressible
Opa1
(Park et al., 2009, Poole et al., 2008)
Pink1
enhanceable
Opa1
(Poole et al., 2008)
Pink1
suppressible
Opa1
(Vilain et al., 2012, Rival et al., 2011, Park et al., 2009, Deng et al., 2008, Poole et al., 2008, Yang et al., 2008)
Ssrp
suppressible
Opa1
(Lou et al., 2024)
trp
enhanceable
Opa1
(Huang et al., 2016)
yki
enhanceable
Opa1
(Sew et al., 2025)
yki|srl
suppressible
Opa1
(Sew et al., 2025)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-69
Cytogenetic map
50E4-50E4
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
50E4-50E4
Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338); Limits computationally determined from genome sequence between P{lacW}mamk05821 and P{lacW}l(2)s3475s3475&P{lacW}Hsc70-5k04907
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
50E4-50E5
(determined by in situ hybridisation)
(Spradling et al., 1999)
50E4-50E5
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location

2-69

(FlyBase, 2016)

2-74.9

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (13)
Genomic Clones (17)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (83)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Banerjee and Chinthapalli, 2014, Poole et al., 2010, Tsubouchi et al., 2009)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        400bp of dsRNA generated from primer-directed transcription from genomic DNA, corresponding to the gene opa1-like, when transfected into S2 cells results in a majority of cells exhibiting a highly fragmented mitochondrial network.

        (McQuibban et al., 2006)

        Mutants fail to pupariate but survive as third instar until 8-10 days after egg laying.

        (Alexander, 2005)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: opa1-like l(2)s3475

        (McQuibban et al., 2006)
        Additional comments

        One of the introns of opa1-like has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the opa1-like intron is mir-1016.

        (Ruby et al., 2007)
        Nomenclature History
        Source for database identify of

        Source for identity of: opa1-like CG8479

        (McQuibban et al., 2006)

        Source for identity of: Opa1 opa1-like

        (FlyBase, 2009-)
        Nomenclature comments

        Renamed from 'opa1-like' to 'Opa1' to reflect preferred usage in the published literature.

        (FlyBase, 2009-)
        Etymology

        Named "Opa1" after the human ortholog.

        (FlyBase, 2009-)
        Synonyms and Secondary IDs (17)
        Reported As
        Symbol Synonym
        CG8479
        (Kolkhof et al., 2017, Meadows, 2017.1.11, Çiçek et al., 2016, Banerjee and Chinthapalli, 2014, Fukuoh et al., 2014, Debattisti and Scorrano, 2013, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Tang et al., 2009, Poole et al., 2008, Yarosh et al., 2008, Bakal et al., 2007, Ruby et al., 2007)
        OPA1
        (Shaltouki et al., 2018, Khalil et al., 2017, Banerjee and Chinthapalli, 2014, Carelli et al., 2013, Tsubouchi et al., 2007, Uemura et al., 2007)
        OPA1-like
        (Duboff et al., 2012, Urban, 2006)
        Opa1
        (Matsuo et al., 2025, Murray-Cors et al., 2025, Richhariya et al., 2025, Tsakiri et al., 2025, Zhang et al., 2025, Au et al., 2024, Dark et al., 2024, Lou et al., 2024, Taylor et al., 2024, Vedelek et al., 2024, Cheon et al., 2023, Klucnika et al., 2023, Murakami et al., 2022, Petridi et al., 2022, Kim et al., 2021, Pant et al., 2021, Tapia et al., 2021, Tiwari and Mandal, 2021, Yamaguchi et al., 2021, Yamaguchi et al., 2021, Chen et al., 2020, Liu et al., 2020, Ponte et al., 2020, Bouska et al., 2019, Gilmore-Hall et al., 2019, Gumeni et al., 2019, Manola et al., 2019, Meltzer et al., 2019, Sênos Demarco et al., 2019, Smith et al., 2019, Tsakiri et al., 2019, Zhou et al., 2019, El Fissi et al., 2018, Levis, 2018.8.30, Sakakibara et al., 2018, Cao et al., 2017, Katti et al., 2017, Transgenic RNAi Project members, 2017-, Altanbyek et al., 2016, Deng et al., 2016, Bhandari et al., 2015, Foriel et al., 2015, Debattisti et al., 2014, Hwang et al., 2014, Sandoval et al., 2014, Dorn, 2013, Fabian and Brill, 2012, Dorn et al., 2011, Poole et al., 2010, Ziviani et al., 2010, Tang et al., 2009)
        Opa1-like
        (Hinton et al., 2023, Chan and McQuibban, 2013, Debattisti and Scorrano, 2013, Rahman and Kylsten, 2011, Yang et al., 2008, Yang et al., 2008, McQuibban et al., 2006)
        dOPA1
        (Yoon et al., 2019, Shaltouki et al., 2018, Alexander, 2005)
        dOpa
        (Gupta et al., 2022)
        dOpa1
        (Li et al., 2020, Tsuyama et al., 2017, Wagener, 2016, Yu et al., 2016, Kim et al., 2012, Shahrestani et al., 2009, Tang et al., 2009, Yarosh et al., 2008)
        l(2)s3475
        (Boyle et al., 2010)
        opa1
        (Liao et al., 2024, Uttekar et al., 2024, Li et al., 2023, Wong et al., 2020, Huang et al., 2016, Mulakkal et al., 2014, Fabian and Brill, 2012, Nagaraj et al., 2012, Vilain et al., 2012, Fernandes and Rao, 2011, Rival et al., 2011, Rival et al., 2011, Park et al., 2010, Tsubouchi et al., 2009, Deng et al., 2008, Poole et al., 2008)
        opa1-like
        (Cruz et al., 2018, Spinazzi and De Strooper, 2016)
        Name Synonyms
        Drosophila optic atrophy 1-like
        (McQuibban et al., 2006)
        Opa1-like
        (Banerjee and Chinthapalli, 2014)
        Optic atrophy 1
        (Tang et al., 2009)
        Optic atrophy 1 ortholog
        dOpa1
        (Yarosh et al., 2008)
        lethal (2) s3475
        opa1-like
        (Huang et al., 2015, Nagaraj et al., 2012)
        optic atrophy 1
        (Fabian and Brill, 2012, Dorn et al., 2011)
        optic atrophy 1-like
        (Chan and McQuibban, 2013, Cammarato et al., 2011)
        Secondary FlyBase IDs
        • FBgn0033914
        • FBgn0010687
        • FBgn0086250
        • FBgn0084864
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 60 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (169)