dOpa1, Opa1-like, optic atrophy 1-like, l(2)s3475
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Opa1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Opa1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: opa1-like l(2)s3475
Renamed from 'opa1-like' to 'Opa1' to reflect preferred usage in the published literature.
One of the introns of opa1-like has the sequence and structural characteristics of a "mirtron"- mirtrons are encoded as an intron of another gene which accumulate as a lariats after splicing and require debranching enzyme for conversion into a functional miRNA. The mirtron encoded by the opa1-like intron is mir-1016.
400bp of dsRNA generated from primer-directed transcription from genomic DNA, corresponding to the gene opa1-like, when transfected into S2 cells results in a majority of cells exhibiting a highly fragmented mitochondrial network.
Mutants fail to pupariate but survive as third instar until 8-10 days after egg laying.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Named "Opa1" after the human ortholog.