FlyBase Gene Report: Dmel\NimA

General Information

Symbol

Dmel\NimA

Species

D. melanogaster

Name

Nimrod A

Annotation Symbol

CG42282

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261514

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

DS00180.5, BG:DS00180.5 , j, jaunty

Key Links

Genomic Location

Cytogenetic map

34E5-34E5

Sequence location

2L:13,957,539..13,963,381 [+]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:13957539..13963381

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (0 terms)

There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2013-03-14 )

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in phagocytosis

inferred from sequence or structural similarity with FLYBASE:drpr; FB:FBgn0027594

(Kurucz et al., 2007)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in integral component of membrane

inferred from sequence model

(Kurucz et al., 2007)

is_active_in membrane

inferred from biological aspect of ancestor with PANTHER:PTN004653888

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS -: The Nimrod family of genes is characterised by the presence of NIM repeats, closely related to the EGF-repeat. They encode proteins which are secreted or integral to the plasma membrane. The Nimrod genes have been linked to the innate immune response and some members of this family have been shown to act as receptors for bacterial or apoptic cell phagocytosis. (Adapted from FBrf0212245).

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

j: jaunty

j: jaunty

From Bridges and Morgan, 1919, Carnegie Inst. Washington Publ. No. 278: 148.

Distal half of wing upturned but not twisted as in Cy. Curling is strong if wing unfolds at 25-30 but is weak or overlaps wild type if wing unfolds below 25. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\NimA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.42

Alternative translation stop created by use of multiphasic reading frames within coding region.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

NimA-RD

FBtr0304719

NM_001259097

2877

440

NimA-RE

FBtr0304720

NM_135847

2873

565

NimA-RF

FBtr0343642

NM_001298989

2185

565

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

NimA-PD

FBpp0293262

47.6

440

6.95

NP_001246026

AFH03700

NimA-PE

FBpp0293263

62.0

565

7.61

NP_609691

AAN10860

NimA-PF

FBpp0310235

62.0

565

7.61

NP_001285918

AHN54432

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

565 aa isoforms: NimA-PE, NimA-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NimA using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NimA_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\NimA in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\NimA

View exonic expression by tissue for Dmel\NimA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB

318930/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0261514

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 5 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of NimA

Transgenic constructs containing regulatory region of NimA

Aberrations (Deficiencies and Duplications) ( 86 )

Inferred from experimentation ( 86 )

Gene disrupted in

Df(2L)64j

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)A47

(Gubb et al., 1990, Ashburner et al., 1982)

Df(2L)b75

(Gubb et al., 1990, Woodruff and Ashburner, 1979)

Df(2L)b80e3

(Ashburner et al., 1981)

Df(2L)b-L

(Ashburner et al., 1981)

Df(2L)fn7

(Huen and Roote, 2009.11.6, Roote et al., 1996, Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn26

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn30

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn31

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)GT5

(Gubb et al., 1990)

Df(2L)rN149-rv3

(Roote, 2000.6.13)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Ts(YLt;2Lt)G74+Ts(YSt;2Rt)B210

(Woodruff and Ashburner, 1979)

Ts(YSt;2Lt)G74+Ts(YSt;2Rt)A80

(Woodruff and Ashburner, 1979)

Ts(YSt;2Lt)G74+Ts(YSt;2Rt)J165

(Woodruff and Ashburner, 1979)

Ts(YSt;2Lt)G74+Ts(YSt;2Rt)P58

(Woodruff and Ashburner, 1979)

Ts(YSt;2Lt)G74+Ts(YSt;2Rt)R15

(Woodruff and Ashburner, 1979)

Gene not disrupted in

Df(2L)A48

(Gubb et al., 1990, Ashburner et al., 1982)

Df(2L)A63

(Ashburner et al., 1982)

Df(2L)A72

(Ashburner et al., 1982)

Df(2L)A178

(Ashburner et al., 1982)

Df(2L)A215

(Ashburner et al., 1982)

Df(2L)A217

(Ashburner et al., 1982)

Df(2L)A220

(Ashburner et al., 1982)

Df(2L)A245

(Ashburner et al., 1982)

Df(2L)A246

(Ashburner et al., 1982)

Df(2L)A260

(Ashburner et al., 1982)

Df(2L)A263

(Ashburner et al., 1982)

Df(2L)A264

(Ashburner et al., 1982)

Df(2L)A266

(Ashburner et al., 1982)

Df(2L)A267

(Ashburner et al., 1982)

Df(2L)A376

(Ashburner et al., 1982)

Df(2L)A377

(Ashburner et al., 1982)

Df(2L)A379

(Ashburner et al., 1982)

Df(2L)A400

(Ashburner et al., 1982)

Df(2L)A445

(Ashburner et al., 1982)

Df(2L)b75

(Woodruff and Ashburner, 1979)

Df(2L)b80c1

(Ashburner et al., 1982)

Df(2L)el77

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

Df(2L)fn1

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn2

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn3

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn5

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn12

(Ashburner et al., 1982, Woodruff and Ashburner, 1979, O'Donnell et al., 1977)

Df(2L)fn15

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn27

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)fn36

(Ashburner et al., 1982, O'Donnell et al., 1977)

Df(2L)GT4

(Gubb et al., 1990)

Df(2L)noc11

(Roote, 1996.1.11, Roote, 1996.8)

Df(2L)Sco^rv4

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

Df(2L)Sco^rv10

(Woodruff and Ashburner, 1979)

Df(2L)Sco^rv14

(Woodruff and Ashburner, 1979)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35B-3

(Gubb et al., 1985)

Df(2L)TE35B-4

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35B-7

(Gubb et al., 1985)

Df(2L)TE35B-8

(Gubb et al., 1985)

Df(2L)TE35B-9

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-11

(Gubb et al., 1985)

Df(2L)TE35B-12

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35BC-1

(Gubb et al., 1984)

Df(2L)TE35BC-3

(Gubb et al., 1984)

Df(2L)TE35BC-4

(Gubb et al., 1984)

Df(2L)TE35BC-7

(Gubb et al., 1984)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Gubb et al., 1984)

Df(2L)TE35BC-28

(Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

Df(2L)W

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

In(2L)75c^LC158.1^R

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

In(2L)75c

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

In(2L)TE35B-13

(Gubb et al., 1985)

T(2;3)Sco^rv7

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

T(Y;2)A80^DR15^P

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

T(Y;2)J165^DP58^P

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

T(Y;2)R15^DJ165^P

(Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979)

Tp(2;2)A446

(Ashburner et al., 1982)

Tp(2;3)dp

(Ashburner et al., 1981)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

NimA^GD1134

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

NimA^GD13167

visible

visible | heat sensitive

Phenotype manifest in

Allele

anterior crossvein

NimA⁵⁸ⁱ

wing

wing | heat sensitive

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (26)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PEAR1

4 of 15

Yes

Hsap\DLK1

2 of 15

Yes

Hsap\MEGF10

2 of 15

Hsap\MEGF11

2 of 15

Hsap\CCBE1

1 of 15

Yes

Hsap\DKK1

1 of 15

Yes

Hsap\DKK2

1 of 15

Yes

Hsap\DKK3

1 of 15

Yes

Hsap\DKK4

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\SCARF2

1 of 15

Yes

Hsap\STAB1

1 of 15

Yes

Hsap\STAB2

1 of 15

Yes

Hsap\TIE1

1 of 15

Hsap\TNFAIP6

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (25)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Pear1

3 of 15

Yes

Mmus\Dlk1

2 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

Yes

Mmus\Dkk2

1 of 15

Yes

Mmus\Dkk3

1 of 15

Yes

Mmus\Dkk4

1 of 15

Yes

Mmus\Egfem1

1 of 15

Mmus\Esm1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Scarf2

1 of 15

Yes

Mmus\Stab1

1 of 15

Yes

Mmus\Stab2

1 of 15

Yes

Mmus\Tnfaip6

1 of 15

Yes

Rattus norvegicus (Norway rat) (26)

Rnor\Pear1

4 of 13

Yes

Rnor\Dlk1

2 of 13

Yes

Rnor\Megf10

2 of 13

Rnor\Megf11

2 of 13

Rnor\Dkk1

1 of 13

Yes

Rnor\Dkk2

1 of 13

Yes

Rnor\Dkk3

1 of 13

Yes

Rnor\Dkk4

1 of 13

Yes

Rnor\Esm1

1 of 13

Yes

Rnor\Lama1

1 of 13

Rnor\Lama2

1 of 13

Rnor\Lama3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\LOC103693812

1 of 13

Yes

Rnor\LOC108348049

1 of 13

Yes

Rnor\Megf6

1 of 13

Rnor\Ntn4

1 of 13

Rnor\Scarf2

1 of 13

Yes

Rnor\Stab1

1 of 13

Yes

Rnor\Stab2

1 of 13

Yes

Rnor\Tnfaip6

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (29)

Xtro\pear1

4 of 12

Yes

Xtro\megf11

2 of 12

Xtro\adgre2

1 of 12

Yes

Xtro\ccbe1

1 of 12

Yes

Xtro\dkk1

1 of 12

Yes

Xtro\dkk2

1 of 12

Yes

Xtro\dkk3

1 of 12

Yes

Xtro\esm1

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\LOC100494394

1 of 12

Yes

Xtro\LOC101731038

1 of 12

Yes

Xtro\LOC101732261

1 of 12

Yes

Xtro\LOC108645475

1 of 12

Yes

Xtro\megf10

1 of 12

Xtro\ntn1

1 of 12

Xtro\ntn1

1 of 12

Yes

Xtro\ntn4

1 of 12

Yes

Xtro\scarf2

1 of 12

Yes

Xtro\stab2

1 of 12

Yes

Xtro\tnfaip6

1 of 12

Yes

Danio rerio (Zebrafish) (38)

Drer\megf10

2 of 15

Yes

Drer\megf11

2 of 15

Yes

Drer\pear1

2 of 15

Yes

Drer\zgc:158328

2 of 15

Yes

Drer\ccbe1

1 of 15

Drer\dkk1a

1 of 15

Yes

Drer\dkk1b

1 of 15

Yes

Drer\dkk2

1 of 15

Yes

Drer\dkk3b

1 of 15

Yes

Drer\dlk1

1 of 15

Yes

Drer\esm1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\LOC110439061

1 of 15

Yes

Drer\LOC110439062

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\si:ch211-221n20.8

1 of 15

Drer\si:ch211-241e1.3

1 of 15

Drer\si:ch1073-15f12.3

1 of 15

Drer\si:dkey-202e22.2

1 of 15

Drer\si:dkey-220k22.1

1 of 15

Drer\slit1b

1 of 15

Drer\stab1

1 of 15

Yes

Drer\stab2

1 of 15

Yes

Drer\tnfaip6

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (31)

Cele\ced-1

2 of 15

Yes

Cele\D1044.7

2 of 15

Yes

Cele\C24A3.1

1 of 15

Yes

Cele\C53B7.2

1 of 15

Cele\dsl-1

1 of 15

Yes

Cele\dsl-2

1 of 15

Yes

Cele\dsl-3

1 of 15

Yes

Cele\dsl-4

1 of 15

Cele\dsl-5

1 of 15

Yes

Cele\dsl-6

1 of 15

Yes

Cele\dsl-7

1 of 15

Yes

Cele\epi-1

1 of 15

Cele\F07H5.8

1 of 15

Cele\F46B3.15

1 of 15

Yes

Cele\F48E3.8

1 of 15

Cele\F56B3.2

1 of 15

Yes

Cele\far-5

1 of 15

Yes

Cele\lag-2

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\pals-30

1 of 15

Yes

Cele\pqn-25

1 of 15

Cele\R05G6.9

1 of 15

Yes

Cele\sdz-23

1 of 15

Yes

Cele\spe-9

1 of 15

Yes

Cele\VC5.2

1 of 15

Yes

Cele\Y41D4B.26

1 of 15

Yes

Cele\Y64G10A.7

1 of 15

Arabidopsis thaliana (thale-cress) (1)

Atha\AT2G34123

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\IMH1

1 of 15

Yes

Scer\OM45

1 of 15

Yes

Scer\SLK19

1 of 15

Yes

Scer\SPC110

1 of 15

Yes

Scer\ZIP1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\alp7

1 of 12

Yes

Spom\mcp3

1 of 12

Yes

Spom\SPAC4H3.14c

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905GA )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA28782

Drosophila persimilis

Dper\GL21251

Drosophila willistoni

Dwil\GK15022

Drosophila virilis

Dvir\GJ18159

Drosophila mojavensis

Dmoj\GI12658

Drosophila grimshawi

Dgri\GH11128

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503QY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17007136

Glossina morsitans

Tsetse fly

Gmor\GMOY003154

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_00045

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03J3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Heliconius melpomene

Postman butterfly

Hmel\HMEL002534

Pediculus humanus

Human body louse

Phum\PHUM522270

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (21)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PEAR1; platelet endothelial aggregation receptor 1

4 of 15

610278

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261514

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

318930

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

34E5-34E5

Sequence location

2L:13,957,539..13,963,381 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34E5-34E5

Limits computationally determined from genome sequence between P{lacW}Sos^k05224&P{lacW}RpII33^k05605 and P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-45.3

(Comeron et al., 2012)

2-48.7

(Arvelighetsinstitutten, University)

Left of (cM)

Right of (cM)

(Woodruff and Ashburner, 1979)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

313

NimA¹

1025

cl¹ fy² NimA⁶⁷⁶

56414

y¹ w^*; Mi{MIC}NimA^MI11280

715

C(2L)RM-P3, NimA⁶³; C(2R)RM-P4, px¹

1064

T(2;3)ap^Xa, al¹ dpp^s1 cl¹ fy² NimA⁶⁷⁶ ap^Xa/al¹ dpp^s1 cl¹ fy² NimA⁶⁷⁶; rec¹ Ubx^bx-34e

Kyoto

106172

cl¹ fy² NimA⁶⁷⁶

105884

S¹/In(2L)Cy, In(2R)Cy, Duox^Cy E(S)¹ NimA¹; awd^K

VDRC

v104204

P{KK104348}VIE-260B

v105009

P{KK112811}VIE-260B

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (11)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP14095

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261514

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261514

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

318930

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: nimA CG42282

(Kurucz et al., 2007)

Source for identity of: NimA nimA

(FlyBase, 2009-)

Source for database merge of

Source for merge of: CG31765 CG31841

(FlyBase Genome Annotators, 2008)

Source for merge of: nimA j

(Huen and Roote, 2009.11.6)

Additional comments

FlyBase Curator comment: Following the merge of the "nimA" and "j" gene reports, "nimA/nimrod A" has been retained as the FlyBase symbol/name rather than "j/jaunty" in order to maintain consistency in the nomenclature of genes within the nimrod gene cluster.

(Huen and Roote, 2009.11.6)

Annotations CG31765 and CG31841 merged as CG42282 in release 5.8 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Annotation CG8855 split into CG33119 and CG31765 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

The sequence of gene prediction " BG:DS00180.5 " from FBrf0111326 overlaps three release 3.2 annotations; CG31765, CG31766 and CG31841.

(FlyBase, 1996-)

Other Comments

New annotation (CG31841) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Origin and Etymology

Discoverer

Bridges, 11th Dec. 1911.

Etymology

The "nimrod" gene cluster is dubbed after Nimrod, the biblical "mighty hunter before the Lord" (Genesis 10), who according to Gesta Hungarorum was also the ancestor of all Hungarians (Kezai Simon, Gesta Hunnorum et Hungarorum A.D. 1282).

(Kurucz et al., 2007)

Identification

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

318930

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AE003408

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261514

DRscDB

318930/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0261514

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NimA_1

FlyMine - An integrated database for Drosophila genomics

FBgn0261514

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

318930

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG42282

MARRVEL_MODEL

318930

modMine - A data warehouse for the modENCODE project

FBgn0261514

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261514

DRSC - Results frm RNAi screens

FBgn0261514

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

318930

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

BG:DS00180.5

(Ashburner et al., 1999, Ashburner et al., 1999)

CG31765

(Japanese National Institute of Genetics, 2012.5.21, Kim and Marqués, 2010, Huen and Roote, 2009.11.6, Keleman et al., 2009.8.5, Kurucz et al., 2007)

CG31841

(Keleman et al., 2009.8.5, Kurucz et al., 2007)

CG42282

(Okuda et al., 2016, FlyBase Genome Annotators, 2008)

CG8855

CT25428

(Hynes and Zhao, 2000)

DS00180.5

(Coates et al., 2000, Henikoff and Henikoff, 2000, Reese et al., 2000, Ashburner et al., 1999)

NimA

(Lu et al., 2020, Melcarne et al., 2019, Kurucz et al., 2007)

(Huen and Roote, 2009.11.6)

nimA

(Somogyi et al., 2010, Huen and Roote, 2009.11.6, Kurucz et al., 2007)

Name Synonyms

CG31765

CG31841

CG42282

(FlyBase Genome Annotators, 2008)

Nimrod A

jaunty

(Huen and Roote, 2009.11.6)

nimrod A

(Somogyi et al., 2008)

Secondary FlyBase IDs

FBgn0259177
FBgn0051765
FBgn0028937
FBgn0051841
FBgn0001277

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (68)

Report Sections

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