MKK3, DMEK3, D-MKK3, DMKK3, p38
a MAP kinase kinase targeting p38 MAP kinase - mutations provoke polarity defects in the eggshell and embryo, as a result of reduced activity of two localized determinants: Oskar and Gurken
Please see the JBrowse view of Dmel\lic for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
2.3 (northern blot)
1.906 (longest cDNA)
There is only one protein coding transcript and one polypeptide associated with this gene
335 (aa)
334 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lic using the Feature Mapper tool.
Comment: maternally deposited
lic transcripts are detected throughout embryonic development by in situ hybridization. There is a high level of maternal deposition. Later, expression is observed in most tissues with elevated levels in the anterior and posterior midguts.
GBrowse - Visual display of RNA-Seq signals
View Dmel\lic in GBrowse 21-41
1-41.4
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: lic l(1)G0252
May correspond to Mkk3.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells, a whole range of mitotic abnormalities and spindle abnormalities are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
lic is required in the germline during oogenesis, for proper asymmetric development of the egg.
lic functions as a p38 activator suggesting that it is involved in a p38 MAPK pathway.
A potential activator of Mpk2, cloned by making use of a yeast osmoregulation MAPK cascade.