DNT1, Spz2, spatzle 2, Spz-2
secreted ligand that maintains neuronal survival - expression rescues naturally occurring cell death and enables targeting by motor neurons
Please see the JBrowse view of Dmel\NT1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
Gene model reviewed during 5.46
Homodimer; disulfide-linked.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NT1 using the Feature Mapper tool.
Expression assayed at stages 9, 11, 13, and 17. Expression may be continuous between assayed stages in some tissues.
GBrowse - Visual display of RNA-Seq signals
View Dmel\NT1 in GBrowse 23-12
3-10.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG32242 CG32244
Source for merge of: spz2 CG42576
Source for merge of: NT1 spz2
Annotations CG32242 and CG32244 merged CG42576 in release 5.17 of the genome annotation.
Annotation CG18318 split into CG32242 and CG32244 in release 3 of the genome annotation.
Neurons die in excess in the absence of NT1.
NT1 promotes cell survival non-autonomously in the CNS.
NT1 produced by the muscle enables correct motor neuron targeting.
Identification: BLAST and other bioinformatic tools have identified a neurotrophin sequence homologue exhibiting sequence and structural conservation of functionally-important residues of the neurotrophin cystine-knot family.