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General Information
Symbol
Dmel\Thor
Species
D. melanogaster
Name
Thor
Annotation Symbol
CG8846
Feature Type
FlyBase ID
FBgn0261560
Gene Model Status
Stock Availability
Gene Summary
Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
Also Known As

4E-BP, 4EBP, d4E-BP, d4EBP, 4E-BP1

Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:3,478,434..3,479,612 [+]
Recombination map
2-10
RefSeq locus
NT_033779 REGION:3478434..3479612
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:eIF4E1; FB:FBgn0015218
inferred from physical interaction with FLYBASE:eIF4E4; FB:FBgn0035709
inferred from physical interaction with FLYBASE:eIF4E5; FB:FBgn0035823
inferred from physical interaction with FLYBASE:eIF4E7; FB:FBgn0040368
inferred from physical interaction with FLYBASE:eIF4E3; FB:FBgn0265089
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000292586
(assigned by GO_Central )
Biological Process (17 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from genetic interaction with FLYBASE:Chchd2; FB:FBgn0260747
inferred from direct assay
involved_in immune response
inferred from expression pattern
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Akt; FB:FBgn0010379
inferred from genetic interaction with FLYBASE:Pi3K92E; FB:FBgn0015279
inferred from direct assay
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000292586
(assigned by GO_Central )
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000292586
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the eIF4E-binding protein family. (Q9XZ56)
Summaries
Gene Snapshot
Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
Insulin-like Receptor Signaling Pathway Core Components -
The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
Pvr Signaling Pathway Core Components -
PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
Protein Function (UniProtKB)
Repressor of translation initiation that regulates eIF4E1 activity by preventing its assembly into the eIF4F complex (PubMed:11389445, PubMed:19804760, PubMed:25702871). Hypophosphorylated form competes with eIF4G1 and strongly binds to eIF4E1, leading to repress translation (PubMed:25702871). In contrast, hyperphosphorylated form dissociates from eIF4E1, allowing interaction between eIF4G1 and eIF4E1, leading to initiation of translation (PubMed:25702871). Acts as a regulator of various biological processes, such as innate immunity, cell growth or synaptic transmission (PubMed:10811906, PubMed:11389445, PubMed:27525480). Acts downstream of phosphoinositide-3-kinase (PI3K) to regulate cell growth (PubMed:11389445). Extends lifespan upon dietary restriction by regulating the mitochondrial translation (PubMed:19804760). Acts as a regulator of lifespan in response to cold by regulating the mitochondrial translation (PubMed:28827349). Acts as a negative regulator of presynaptic release of neurotransmitter in motor neurons: Thor expression is induced in response to insulin signaling, leading to prevent of translation of complexin (cpx), a protein known to regulate the exocytosis of synaptic vesicles (PubMed:27525480). Acts as a negative regulator of synaptic strength at the neuromuscular junction: Thor expression in response to acute fasting prevents translation, thereby suppressing retrograde synaptic enhancement (PubMed:27916456).
(UniProt, Q9XZ56)
Summary (Interactive Fly)

messenger RNA 5' cap binding protein - regulates translation during environmental stress - Ecdysone promotes growth of imaginal discs through the regulation of Thor Acute fasting regulates retrograde synaptic enhancement through a 4E-BP-dependent mechanism

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Thor for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0077524
755
117
FBtr0345289
667
117
Additional Transcript Data and Comments
Reported size (kB)

0.85 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0077213
12.9
117
10.19
FBpp0311456
12.9
117
10.19
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

117 aa isoforms: Thor-PA, Thor-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Hypophosphorylated Thor/4E-BP competes with eIF4G1 to interact with eIF4E1; insulin stimulated Akt1 or Tor phosphorylation of Thor/4E-BP causes dissociation of the complex allowing eIF4G1 to bind and consequent initiation of translation.

(UniProt, Q9XZ56)
Post Translational Modification

Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, impairs its ability to prevent the interaction between eIF4G1 and eIF4E1, without affecting its interaction with free eIF4E1 (PubMed:14645523, PubMed:25702871). Phosphorylated in rtesponse to insulin (PubMed:11389445). Phosphorylation at Thr-46 is regulated by Tor and constitutes the major phosphorylation event that regulates activity (PubMed:14645523).

(UniProt, Q9XZ56)
Domain

The YXXXXLphi motif mediates interaction with eIF4E1 (PubMed:11389445). Compared to other members of the family this YXXXXLphi is atypical and interaction with eIF4E1 is weaker (PubMed:11389445).

(UniProt, Q9XZ56)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Thor using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
posterior ectoderm anlage

Comment: anlage in statu nascendi

ventral ectoderm anlage

Comment: anlage in statu nascendi

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

antennal anlage

Comment: reported as procephalic ectoderm anlage

central brain anlage

Comment: reported as procephalic ectoderm anlage

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

visual anlage

Comment: reported as procephalic ectoderm anlage

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Thor transcripts are detected at all stages on northern blots and are strongly induced upon infection. They are observed by in situ hybridization in the embryonic central nervous system and in the reproductive systems of males and females. They are observed third instar male testis and in adult female ovaries.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Thor in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Thor
Transgenic constructs containing regulatory region of Thor
Aberrations (Deficiencies and Duplications) ( 7 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
1  
12 of 15
No
Yes
3  
11 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
12 of 15
No
Yes
11 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
12 of 13
Yes
Yes
9 of 13
No
Yes
6 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
6 of 12
Yes
Yes
Danio rerio (Zebrafish) (5)
12 of 15
Yes
Yes
12 of 15
Yes
Yes
11 of 15
No
Yes
6 of 15
No
Yes
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190IUR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila willistoni
Drosophila virilis
Drosophila virilis
Drosophila mojavensis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150CDP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0LF5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0KAS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ZHJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    RNA-protein
    Physical Interaction
    Assay
    References
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Hypophosphorylated Thor/4E-BP competes with eIF4G1 to interact with eIF4E1; insulin stimulated Akt1 or Tor phosphorylation of Thor/4E-BP causes dissociation of the complex allowing eIF4G1 to bind and consequent initiation of translation.
    (UniProt, Q9XZ56 )
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Insulin-like Receptor Signaling Pathway Core Components -
    The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
    Pvr Signaling Pathway Core Components -
    PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-10
    Cytogenetic map
    Sequence location
    2L:3,478,434..3,479,612 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    23F5-23F6
    Left limit from in situ hybridisation (FBrf0067338) Right limit from in situ hybridisation (FBrf0067338)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    23F5-23F6
    (determined by in situ hybridisation)
    23F-24A
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (18)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (74)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: Thor l(2)06270

    Source for merge of: Thor anon-WO0172774.158

    Additional comments

    "l(2)06270" probably corresponds to "Thor"; the P{PZ} insertion in the "l(2)0627006270" allele maps 20bp upstream of the 5' end of the CT9265 transcript of "Thor".

    Source for merge of Thor anon-WO0172774.158 was sequence comparison ( date:051113 ).

    Other Comments

    The Thor translational inhibitor is a relevant foxo target gene. Cellular stress may activate foxo and inhibit growth through the action of target genes such as Thor. Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.

    Thor participates in host immune defence and connects a translational regulator with innate immunity.

    The activity of eIF-4E is modulated by phosphorylation and by direct interaction with Thor.

    Identified in a screen to find interactors with eIF-4E from a cDNA expression library. When bound to eIF-4E, Thor prevents the integration of eIF-4E into the translationally active eIF-4F complex. Thor may be involved in the translational regulation of specific mRNAs throughout development and adult fly life.

    Cg25C is a member of the infection inducible enhancer detector strains.

    Origin and Etymology
    Discoverer
    Etymology

    Ecol\lacZ reporter gene expression from the Thor enhancer trap insertion P{lacW}Thork13517 increases upon infection, and so the gene is named "Thor" after the Nordic legendary character that was often called upon to use his hammer to protect mankind from harm.

    Identification
    External Crossreferences and Linkouts ( 56 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    FlyMine - An integrated database for Drosophila genomics
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
    Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (45)
    Reported As
    Symbol Synonym
    4E-BP
    (Han et al., 2021, Layalle et al., 2021, Ma et al., 2021, Yang et al., 2021, Yu and Hyun, 2021, Cheng et al., 2020, Chittoor-Vinod et al., 2020, Frank et al., 2020, Kim et al., 2020, Kim et al., 2020, Ma et al., 2020, Chatterjee et al., 2019, Harsh et al., 2019, Wei et al., 2019, Xi et al., 2019, Zheng et al., 2019, Inoue et al., 2018, Kang et al., 2018, Liu et al., 2018, Nowak et al., 2018, Rode et al., 2018, Staats et al., 2018, Tamirisa et al., 2018, Zeng et al., 2018, Hoedjes et al., 2017, Huang et al., 2017, Kang et al., 2017, Kim et al., 2017, Lee et al., 2017, Mathew et al., 2017, Meng et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Wu et al., 2017, Yun et al., 2017, Brill et al., 2016, David-Morrison et al., 2016, Donovan and Marr, 2016, Kakanj et al., 2016, Langston et al., 2016, Tio et al., 2016, Calap-Quintana et al., 2015, Das and Dobens, 2015, Figueroa-Clarevega and Bilder, 2015, Fischer et al., 2015, Frankel et al., 2015, Kohlmaier et al., 2015, Lin et al., 2015, Mensah et al., 2015, Nässel et al., 2015, Obata and Miura, 2015, Okada et al., 2015, Suh et al., 2015, Tiebe et al., 2015, Yan et al., 2015, Charroux and Royet, 2014, Huang et al., 2014, Igreja et al., 2014, Lanet and Maurange, 2014, Metaxakis et al., 2014, Mirth et al., 2014, Mulakkal et al., 2014, Obata et al., 2014, Owusu-Ansah and Perrimon, 2014, Ulgherait et al., 2014, Wang et al., 2014, Wang et al., 2014, Bai et al., 2013, Esslinger et al., 2013, Hernández et al., 2013, Hwang et al., 2013, Ibar et al., 2013, Karpac et al., 2013, Kayashima et al., 2013, Kwak et al., 2013, Lanet et al., 2013, Mason-Suares et al., 2013, Olson et al., 2013, Owusu-Ansah et al., 2013, Subramanian et al., 2013, Tixier et al., 2013, Tran et al., 2013, Wong et al., 2013, Bolukbasi et al., 2012, Hernandez et al., 2012, Homem and Knoblich, 2012, Iliadi et al., 2012, Lee et al., 2012, Pallares-Cartes et al., 2012, Poernbacher et al., 2012, Rera et al., 2012, Xu et al., 2012, Zitserman et al., 2012, Alic et al., 2011, Alic et al., 2011, Boyd et al., 2011, Liu et al., 2011, Muñoz-Soriano and Paricio, 2011, Oldham, 2011, Ottone et al., 2011, Partridge et al., 2011, Slack et al., 2011, Söderberg et al., 2011, Wang et al., 2011, Wang et al., 2011, Bauer et al., 2010, Bjedov et al., 2010, Bryk et al., 2010, Demontis and Perrimon, 2010, Gehrke et al., 2010, Grönke et al., 2010, Kim et al., 2010, Kühnlein, 2010, LaFever et al., 2010, Lam et al., 2010, Lee et al., 2010, Lee et al., 2010, Liu and Lu, 2010, Mahapatra et al., 2010, Mesquita et al., 2010, Stumpfe et al., 2010, Iwasaki et al., 2009, Tain et al., 2009, Duncan, 2008, Flatt et al., 2008, Harvey et al., 2008, Hernandez et al., 2008, Imai et al., 2008, Lee et al., 2008, Lee et al., 2008, Teleman et al., 2008, Wang et al., 2008, Yu et al., 2008, Ahrens et al., 2007, Hoshizaki and Gibbs, 2007, Tadros et al., 2007, Fuss et al., 2006, Hennig et al., 2006, Teleman and Cohen, 2006, Colombani et al., 2005, Hernandez et al., 2005, King-Jones and Thummel, 2005, Teleman et al., 2005, Teleman et al., 2005, Jenkins and Lasko, 2004, Jorgensen and Tyers, 2004, Pan et al., 2004, Nijhout, 2003, Oldham and Hafen, 2003, Saucedo and Edgar, 2002, Adams et al., 2000, Lehner, 1999, Won et al., 1999, Lachance and Lasko, 1997, Miron et al., 1997)
    BcDNA.HL08053
    BcDNA:HL08053
    Thor
    (Wang et al., 2021, Chattopadhyay and Thirumurugan, 2020, Feuillette et al., 2020, Hood et al., 2020, Khan et al., 2020, Kierdorf et al., 2020, Luo et al., 2020, Nakamura et al., 2020, Neamtu et al., 2020, Tang et al., 2020, Vandehoef et al., 2020, Banerjee et al., 2019, Blice-Baum et al., 2019, Brunet Avalos et al., 2019, Chandran et al., 2019, Erwin and Blumenstiel, 2019, Houtz et al., 2019, Huang et al., 2019, Kockel et al., 2019, Krittika and Yadav, 2019, Li et al., 2019, Melcarne et al., 2019, Scopelliti et al., 2019, Stobdan et al., 2019, Zirin et al., 2019, Buhler et al., 2018, Duncan et al., 2018, Kang et al., 2018, Levis, 2018.8.30, Lin et al., 2018, Lopez et al., 2018, Ugrankar et al., 2018, Liao et al., 2017, Tsuyama et al., 2017, Wang et al., 2017, Xu et al., 2017, Dobson et al., 2016, Gajan et al., 2016, Grüner et al., 2016, Kim et al., 2016, Kučerová et al., 2016, Strigini and Leulier, 2016, Vinayagam et al., 2016, Cagin et al., 2015, Calap-Quintana et al., 2015, Frankel et al., 2015, Hamilton et al., 2015, Katzenberger et al., 2015, Kopp et al., 2015, Kwon et al., 2015, Matsuda et al., 2015, Mensah et al., 2015, Peter et al., 2015, Sieber and Spradling, 2015, Wei et al., 2015, Bischof and FlyORF project members, 2014.6.20, Deivasigamani et al., 2014, Horiguchi et al., 2014, Igreja et al., 2014, Mirth et al., 2014, Mulakkal et al., 2014, Obata et al., 2014, Ruiz et al., 2014, Taylor et al., 2014, Ciurciu et al., 2013, Gendrin et al., 2013, Hernández et al., 2013, Kayashima et al., 2013, Nowak et al., 2013, Okamoto et al., 2013, Rallis et al., 2013, Soh et al., 2013, Subramanian et al., 2013, Taliaferro et al., 2013, Garelli et al., 2012, Koh et al., 2012, Paik et al., 2012, Pallares-Cartes et al., 2012, Papatheodorou et al., 2012, Pezzulo et al., 2012, Rera et al., 2012, Rynes et al., 2012, Tokusumi et al., 2012, Wong et al., 2012, Yampolsky et al., 2012, Ye et al., 2012, Zhang et al., 2012, Glatter et al., 2011, Marcu et al., 2011, Muñoz-Soriano and Paricio, 2011, Bauer et al., 2010, Becker et al., 2010, Blanco et al., 2010, De Luca et al., 2010, Demontis and Perrimon, 2010, Ellis and Carney, 2010, Fernández-Ayala et al., 2010, Kim et al., 2010, Kühnlein, 2010, LaFever et al., 2010, Lee et al., 2010, Mahapatra et al., 2010, Nagoshi et al., 2010, Sun et al., 2010, Alvarez-Ponce et al., 2009, Baker and Russell, 2009, Carpenter et al., 2009, Hong et al., 2009, Mendes et al., 2009, Owusu-Ansah and Banerjee, 2009, Tain et al., 2009, Walkiewicz and Stern, 2009, Kapelnikov et al., 2008, Libert et al., 2008, Pedersen et al., 2008, Curtis et al., 2007, Hall et al., 2007, Lasko and Sonenberg, 2007, Libert, 2007, Marygold et al., 2007, Zhang et al., 2007, Morozova et al., 2006, Greene et al., 2005, Terashima and Bownes, 2005, Bernal et al., 2004, Roxstrom-Lindquist et al., 2004)
    Thor/EIF4EBP
    anon-WO0172774.158
    l(2)k13517
    Name Synonyms
    Eif4e-binding protein
    eIF4E binding protein
    eif-4e binding protein
    eif4e-binding protein 4EBP
    eukaryotic initiation factor 4E binding protein
    eukaryotic initiation factor 4E- binding protein
    eukaryotic initiation factor 4E-binding protein
    eukaryotic translation initiation factor 4E binding protein
    eukaryotic translation initiation factor 4E-binding protein
    insulin-stimulated eIF-4E binding protein
    lethal (2) 06270
    translation initiation factor 4E binding protein
    Secondary FlyBase IDs
    • FBgn0022073
    • FBgn0017459
    • FBgn0020516
    • FBgn0027067
    • FBgn0046442
    • FBgn0010616
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (520)