eIF-2alpha, eIF-2α, eIF2a, eukaryotic translation Initiation Factor 2α, l(1)19-153
Gene model reviewed during 5.51
Heterotrimer composed of an alpha, a beta and a gamma chain.
Phosphorylation of eIF-2-alpha impairs the recycling of eIF-2 between successive rounds of initiation and thus leads to inhibition of translation.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF2α using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\eIF2α in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
eIF-2α protein from both control and heat shocked cells has been purified and characterised.
eIF-2α mRNA displays quasi-constitutive expression.
One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development.