CBP, dCBP, CREB-binding protein, CREB binding protein, CBP/p300
CBP, a transcriptional co-activator that interacts with a large number of developmentally important transcription factors - acetylates several nuclear proteins, including histone H3 on K18, K27, and H4 on K8. - roles in cell proliferation, cell signaling and differentiation, and in developmental patterning
Please see the JBrowse view of Dmel\nej for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.
Gene model reviewed during 5.43
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
3190 (aa); 332 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nej using the Feature Mapper tool.
Comment: extended 3' UTR isoform
Comment: extended 3' UTR isoform
Zygotic-specific isoforms of nej with long 3' UTR extensions were observed. The 3' UTR extension isoforms are highly enriched in nervous system tissues.
GBrowse - Visual display of RNA-Seq signals
View Dmel\nej in GBrowse 21-29
1-29
1-30.6
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: nej CG15319
Source for merge of: nej l(1)G0350 l(1)G0112 l(1)G0470 CG15321
Source for merge of: nej anon-WO03040301.89
Annotations CG15321 eliminated in release 5.25 of the genome annotation.
FlyBase curator comment: "EP950" overexpression phenotype stated to be due to its effect on nej but orientation of the P{EP} element suggests otherwise. FlyBase curator comment: "EP1410" overexpression phenotype stated to be due to its effect on nej but orientation of the P{EP} element suggests otherwise.
"l(1)G0464" may affect "nej".
"l(1)G0350" may affect "CG15321".
"l(1)G0112" may affect "CG15321".
"l(1)G0470" may affect "CG15321".
"l(1)G0350" may affect "CG15321". "l(1)G0286" may affect "CG15321". "l(1)G0137" may affect "CG15321". "l(1)G0112" may affect "CG15321". "l(1)G0270" may affect "CG15321". "l(1)G0470" may affect "CG15321". "l(1)G0236" may affect "CG15321".
Source for merge of nej anon-WO03040301.89 was sequence comparison ( date:051113 ).
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
Postsynaptic nej is necessary for normal presynaptic functional development.
Isolated from a genomic library using a fragment of the C.elegans CBP gene as a probe, under low stringency conditions.
nej has been cloned and characterised.