Gene: Dmel\Npc1b
R-9-28, 151, l(1)19Ec, l(1)R-9-28
Please see the JBrowse view of Dmel\Npc1b for information on other features
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Supported by strand-specific RNA-Seq data.
Gene model reviewed during 5.53
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Npc1b using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Npc1b in GBrowse 21-65
1-65.7
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: CG12092 NPC1b
Source for merge of: Npc1b l(1)19Ec
The "l(1)19Ec" complementation group was previously associated with the CG11233 annotation in FlyBase, based on information in FBrf0155430. However, data from FBrf0193836 suggests that the "l(1)19Ec" complementation group in fact corresponds to the "CG12092" annotation. Thus, the CG11233 annotation has been split out into a separate gene report in FlyBase and the l(1)19Ec complementation group has instead been merged with the gene corresponding to the "CG12092" annotation (Npc1b). The CG11233 annotation has also been renamed to CG42707 in release 5.26 of the genome annotation to avoid confusion.
FlyBase curator comment: The "l(1)19Ec" complementation group is stated to correspond to the "CG11233" annotation in FBrf0155430. However, data from FBrf0193836 suggests that the "l(1)19Ec" complementation group in fact corresponds to the "CG12092" annotation.
Mutant embryos from heterozygous females exhibit no defects in central or peripheral nervous systems; l(1)19Ec1 and l(1)19Ec18 are lethal in germ-line clones, whereas l(1)19Ec8 and l(1)19Ec25 germ-line clones exhibit a paternally rescuable maternal effect. Embryonic phenotype includes head and dorsal-closure defects and most embryos are twisted (Perrimon, Smouse, and Miklos, 1989).
