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FB2026_01
,
released March 12, 2026
Std, Pals1, BP1063
membrane-associated guanylate kinase (MAGUK) protein - codes for a regulatory component of the subapical complex of cellular junctions - crucial in the control of epithelial cell polarity and the organization of zonula adherens
Please see the JBrowse view of Dmel\sdt for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sdt using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as tracheal system anlage
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
Comment: reported as head epidermis primordium
In adult eyes, sdt is restricted to the photoreceptor cell stalk membrane, adjacent to the rhabdomere.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sdt in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
sdt is required for the regionalization of apical membrane into stalk membranes and rhabdomeres.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
sdt provides an essential component of the Subapical complex.
Loss of cell polarity in the epidermal primordium of sdt mutant embryos is associated with a failure to establish the zonulae adherentes. These junctions fail to develop when an altered polarity is induced by the overexpression of crb. crb and sdt have different functions during the formation of the zonula adherens.
crb and sdt encode critical components of a pathway that acts at the apical pole of epithelial cells to control their cytoarchitecture. Mosaic experiments suggest that sdt though not crb is required cell autonomously. Double mutant analysis suggests that sdt acts downstream of and is activated by crb.
Zygotically active locus involved in the terminal developmental program in the embryo.
A screen for X-linked genes that affect embryo morphology revealed sdt.
sdt mutants display almost total absence of hypoderm, small patches of cuticle remain.
Source for merge of: CG12658 sdt
Source for merge of: sdt CG12657
Source for merge of: sdt anon- EST:fe2E6
Source for merge of: sdt CG15340
Source for merge of: sdt BP1063
The release 5.2 annotation CG32717 (which corresponds to sdt) contains sequences corresponding to the release 2 annotation CG12657 (the transcript containing these sequences that was deleted in release 5.1 due to lack of evidence has been reinstated in release 5.2 due to new supporting evidence).
Annotations CG32717, CG15342, CG32716 and CG12657 merged as a single annotation (CG32717, which corresponds to sdt) in release 3.2 of the genome annotation.
Annotations CG12658, CG15340 and CG1617 merged as CG32717 in release 3 of the genome annotation.
"l(1)G0463" may affect "sdt".
Source for identity of sdt CG1617 CG15341 was sequence comparison ( date:011219 ).
Source for identity of: sdt CG1617 CG15341
