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General Information
Symbol
Dmel\east
Species
D. melanogaster
Name
enhanced adult sensory threshold
Annotation Symbol
CG4399
Feature Type
FlyBase ID
FBgn0261954
Gene Model Status
Stock Availability
Gene Summary
enhanced adult sensory threshold (east) encodes a ubiquitous protein localized to an extrachromosomal domain of the nucleus. It is involved in chemosensory behavior, chromosome segregation during cell division, cell survival and muscle development. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)
Also Known As

su(wsp), l(1)G0014, l(1)G0500, EG:133E12.4 , suppressor of white-spotted

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:2,010,860..2,024,647 [+]
Recombination map
1-0.5
RefSeq locus
NC_004354 REGION:2010860..2024647
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
involved_in metamorphosis
inferred from mutant phenotype
inferred from expression pattern
inferred from genetic interaction with FLYBASE:w; FB:FBgn0003996
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in nucleoplasm
inferred from direct assay
located_in nucleus
inferred from direct assay
inferred from direct assay
NOT located_in nuclear chromosome
inferred from direct assay
NOT located_in nucleolus
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Snapshot
    enhanced adult sensory threshold (east) encodes a ubiquitous protein localized to an extrachromosomal domain of the nucleus. It is involved in chemosensory behavior, chromosome segregation during cell division, cell survival and muscle development. [Date last reviewed: 2019-02-28]
    Phenotypic Description (Red Book; Lindsley and Zimm 1992)
    su(wsp): suppressor of white-spotted
    Results in nearly wild-type pigmentation of wsp1, wsp2, wsp3, and wsp4, but not wsp81d5. No phenotypic effect seen on eight other tested w alleles. The lesions of the spotted alleles map 500 to 1000 base pairs 5' to the w transcription unit and are postulated to affect an enhancer sequence. The normal allele of su(wsp) is postulated to encode a repressor of this enhancing function; the combination of the repressor and defective enhancer produces the spotted phenotype; the mutant allele of su(wsp), lacking repressor function, results in the derepression of the defective enhancers at the time of eye-pigment deposition, leading to increased pigmentation. wsp81d5, a molecular deletion extending more 3' that the other wsp alleles is postulated to be insensitive to the presence or absence of repression owing to loss of the site of interaction between the su(wsp) gene product and the w locus. Adult transcription of all w alleles, including w+, markedly increased by su(wsp), apparently after pigment deposition, since with the exception of wsp alleles, eye color does not respond to su(wsp). The latter observation implies a second site of repressor binding specific to adult transcription.
    Gene Model and Products
    Number of Transcripts
    6
    Number of Unique Polypeptides
    3

    Please see the JBrowse view of Dmel\east for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Low-frequency RNA-Seq exon junction(s) not annotated.

    Gene model reviewed during 5.52

    Gene model reviewed during 5.56

    Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

    Annotated transcripts do not represent all supported alternative splices within 5' UTR.

    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    FBtr0070326
    7368
    2301
    FBtr0303046
    7521
    2301
    FBtr0303047
    7579
    2301
    FBtr0307289
    7498
    2342
    FBtr0307290
    9407
    2342
    FBtr0343522
    7954
    2306
    Additional Transcript Data and Comments
    Reported size (kB)

    9.5, >9.5 (northern blot)

    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    FBpp0070312
    245.7
    2301
    5.91
    FBpp0292165
    245.7
    2301
    5.91
    FBpp0292166
    245.7
    2301
    5.91
    FBpp0298290
    250.2
    2342
    6.15
    FBpp0298291
    250.2
    2342
    6.15
    FBpp0310126
    246.2
    2306
    5.87
    Polypeptides with Identical Sequences

    The group(s) of polypeptides indicated below share identical sequence to each other.

    2342 aa isoforms: east-PE, east-PF
    2301 aa isoforms: east-PB, east-PC, east-PD
    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\east using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    Polypeptide Expression
    mass spectroscopy
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    located_in nucleoplasm
    inferred from direct assay
    located_in nucleus
    inferred from direct assay
    inferred from direct assay
    NOT located_in nuclear chromosome
    inferred from direct assay
    NOT located_in nucleolus
    inferred from direct assay
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\east in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    EMBL-EBI Single Cell Expression Atlas
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Images
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 24 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 9 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of east
    Transgenic constructs containing regulatory region of east
    Aberrations (Deficiencies and Duplications) ( 4 )
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Sterility
    Allele
    Other Phenotypes
    Allele
    Phenotype manifest in
    Allele
    larval salivary gland & nucleus, with Scer\GAL4hs.PB
    meiosis & nuclear chromosome | male
    meiotic metaphase I & primary spermatocyte
    meiotic prophase I & primary spermatocyte
    Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (0)
    No records found.
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (1)
    1 of 15
    Yes
    No
    Caenorhabditis elegans (Nematode, roundworm) (1)
    1 of 15
    Yes
    No
    Arabidopsis thaliana (thale-cress) (1)
    1 of 9
    Yes
    No
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900IR )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila willistoni
    Drosophila virilis
    Drosophila mojavensis
    Drosophila grimshawi
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150161 )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Glossina morsitans
    Tsetse fly
    Lucilia cuprina
    Australian sheep blowfly
    Mayetiola destructor
    Hessian fly
    Aedes aegypti
    Yellow fever mosquito
    Anopheles darlingi
    American malaria mosquito
    Anopheles gambiae
    Malaria mosquito
    Culex quinquefasciatus
    Southern house mosquito
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00EP )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Bombyx mori
    Silkmoth
    Danaus plexippus
    Monarch butterfly
    Heliconius melpomene
    Postman butterfly
    Apis florea
    Little honeybee
    Apis florea
    Little honeybee
    Apis mellifera
    Western honey bee
    Bombus impatiens
    Common eastern bumble bee
    Bombus terrestris
    Buff-tailed bumblebee
    Linepithema humile
    Argentine ant
    Megachile rotundata
    Alfalfa leafcutting bee
    Nasonia vitripennis
    Parasitic wasp
    Dendroctonus ponderosae
    Mountain pine beetle
    Tribolium castaneum
    Red flour beetle
    Pediculus humanus
    Human body louse
    Rhodnius prolixus
    Kissing bug
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Acyrthosiphon pisum
    Pea aphid
    Zootermopsis nevadensis
    Nevada dampwood termite
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00DQ )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Stegodyphus mimosarum
    African social velvet spider
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (2)
    1 of 10
    1 of 10
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement

      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-0.5
      Cytogenetic map
      Sequence location
      X:2,010,860..2,024,647 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      2C2-2B17
      Limits computationally determined from genome sequence between P{EP}EP427 and P{EP}ActnEP1193&P{EP}CG4322EP1631
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      2C1-2C2
      (determined by in situ hybridisation)
      2C1-2C8
      (determined by in situ hybridisation)
      2C1-2C1
      (determined by in situ hybridisation)
      Experimentally Determined Recombination Data
      Location

      1-0.16

      Left of (cM)
      Right of (cM)
      Notes

      Mapping based on 19 y-w recombinants.

      Stocks and Reagents
      Stocks (13)
      Genomic Clones (10)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (127)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      monoclonal

      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: east l(1)G0014 l(1)G0500

      Source for merge of: east su(w[sp])

      Source for merge of: east EG:133E12.4

      Source for merge of: east anon-WO03040301.224

      Additional comments

      Source for merge of east EG:133E12.4 was sequence comparison ( date:000423 ).

      Source for merge of east anon-WO03040301.224 was sequence comparison ( date:051113 ).

      Other Comments

      east inhibits muscle degradation during metamorphosis.

      When z and su(wsp) mutations are present the action of Ufo is blocked: no significant differences in eye colour detected.

      Identified by P element enhancer trap insertion causing semidominant effect on adult-specific chemosensory behaviour. No larval chemosensory defects noted. Phenotypes of mutant alleles suggest that both increases and decreases in levels of gene product cause a mutant phenotype.

      su(wsp) does not restore the ability of Inr-a mutants to interact with the w locus.

      su(wsp) strongly suppresses the mutant eye colour phenotype produced by all four of the spotted w mutations, but does not affect any other w mutation. The suppressor allele specificity is determined by the portion of the target locus mutationally affected, not by interaction with specific transposons.

      Origin and Etymology
      Discoverer

      Gelbart.

      Etymology
      Identification
      External Crossreferences and Linkouts ( 55 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      EMBL-EBI Single Cell Expression Atlas
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      FlyMine - An integrated database for Drosophila genomics
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (12)
      Reported As
      Name Synonyms
      enhanced adult salt tolerance
      suppressor of white-spotted
      Secondary FlyBase IDs
      • FBgn0010110
      • FBgn0023544
      • FBgn0027331
      • FBgn0040135
      • FBgn0066823
      • FBgn0003642
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (87)