dme-let-7
encodes an RNA species involved in translational silencing of target mRNAs - -to- miRNA switch regulates neuronal integrity and lifespan in Drosophila
Please see the JBrowse view of Dmel\mir-let7 for information on other features
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Locations and structures of miRNA models as mapped by miRBase (FBrf0220601).
Conserved: found throughout the Drosophila genus (FBrf0230987).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mir-let7 using the Feature Mapper tool.
Comment: 102h AEL - 36h APF
Comment: levels increase with age
Comment: levels increase with age
Comment: levels increase with age
Comment: levels increase with age
let-7-miRNA is detected in increasing quantities during larval to pupal transition.
GBrowse - Visual display of RNA-Seq signals
View Dmel\mir-let7 in GBrowse 22-53
2-53.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: mir-let7 let-7
The annotation for let-7 has been changed in release 5.31 of the genome annotation, so that instead of representing a mature miRNA it now represents the precursor stem loop pre-miRNA. The symbol of the annotation has been changed from CR32968 to CR42949 to reflect this change.
Added 'mir-' prefix to be consistent with miRNA naming conventions in FlyBase, and thereby indicate the gene encodes a miRNA in its symbol.
The three microRNAs let-7, mir-125 and mir-100 are co-transcribed as a single polycistronic transcription unit (the "let-7-Complex, let-7-C").
let-7 is required to ensure the appropriate remodeling of the abdominal neuromusculature during the larval-to-adult transition.
New annotation (CR32968) in release 3 of the genome annotation.
Hormone induced expression of let-7 may control developmental stage transitions.
A developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let-7 small temporal RNA (stRNA).