ZO-1, tamou, tam, Pyd/ZO-1
scaffolding protein, PDZ domain protein, MAGUK - involved in sensory organ development - mutations have a neurogenic effect - suppresses Deltex-regulated Notch activity to modulate germline stem cell niche formation
Gene model reviewed during 5.42
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Gene model reviewed during 6.31
10.5, 9.5, 8.1, 6.7, 5.6 (northern blot)
Cortactin protein SH3 domain binds to a PXXP motif in the pyd protein proline-rich domain. This binding is abolished when the central 2 P residues in a motif consisting of 3 overlapping PXXP motifs are mutated to A. Cortactin and pyd proteins coimmunoprecipitate from Drosophila embryo lysates.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pyd using the Feature Mapper tool.
The large form of pyd protein was assayed in embryos and wing discs and is present in both.
GBrowse - Visual display of RNA-Seq signalsView Dmel\pyd in GBrowse 2
Maps to 3R.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Most embryos lacking pyd die with striking defects in morphogenesis of embryonic epithelia including the epidermis, segmental grooves, and tracheal system.
?? need to add more comments and GO terms
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Candidate gene for quantitative trait (QTL) locus determining bristle number.
"3-48.1" was stated as revision.
In mutants of pyd inappropriate cell fate choices are made resulting in the presence of ectopic sensory organs. A decrease in pyd function results in defects in the process of cell to cell communication that normally restricts the sensory organ precursor to a single cell in each proneural cluster.
Recessive P-element insert alleles have extra macrochaetae on head and thorax. Acts as a dominant enhancer of emc.
Spencer, 31st Aug. 1939.
'tam' means 'hairy' in Japanese.