Cdh1, rap, retina aberrant in pattern, Rap/Fzr, redax
Trp-Asp repeat (WD-repeat) protein - negatively regulates the levels of cyclins A, B and B3 thus promoting mitosis - Notch-dependent Fizzy-related expression is required for the mitotic-to-endocycle transition in follicle cells
Gene model reviewed during 5.52
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fzr using the Feature Mapper tool.
fzr expression is detected in the testis in the subapical region containing primary spermatocyte clusters that have recently completed the last mitotic division.
Maternal fzr transcripts are detected during early syncytial stages but not in the late syncytial blastoderm. Zygotic expression initiates after the 13th embryonic mitosis and is detectable during gastrulation. Strong expression is observed at stage 11 in the salivary gland placodes and in the anterior and posterior midgut primordia. This is followed by expression at lower levels throughout the embryo. It appears that fzr is expressed in tissues during the stages when the cells become postmitotic.
fzr protein and loco protein are strongly co-localized along the ventral edge of the larval brain near the margin between the brain and ventral ganglion but not in deeper regions of the brain. Both proteins are expressed within glial cells and are also expressed early in neuroblasts in third instar larvae.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fzr in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The 'rap' locus was first phenotypically characterized and named by Karpilow et al., 1989 (FBrf0049809). Later Sigrist and Lehner, 1997 (FBrf0098351) molecularly & functionally characterized a gene and named it as 'fzr'. 4- 5 years later, the connection between the 'rap' locus and the 'fzr' gene was made (FBrf0134170, FBrf0151839), at which point FlyBase kept 'rap' as the 'merged' gene symbol. However, it's clear that 'fzr' is the preferred symbol in the published literature, and so the gene has now (FB2016_06) been renamed from 'rap' to 'fzr' to FlyBase to reflect this. This change is supported by Christian Lehner and Tadmiri Venkatesh.
Source for merge of rap anon-WO03040301.193 was sequence comparison ( date:051113 ).
In rap mutant embryos glial cells are not found at the normal positions but instead fail to migrate as far as in the wildtype embryonic nervous system.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Identification: screen for mutations affecting commissure formation in the CNS of the embryo.
rap negatively regulates the levels of CycA, CycB and CycB3 proteins. rap is required for cyclin removal during G1 when the embryonic epidermal cell proliferation stops and during G2 preceding salivary gland endoreduplication.
In rap mutants, although some of the R8-specific markers show normal expression patterns, other aspects of the R8 cell differentiation are abnormal. R1, R6 and R7 cells fail to differentiate properly. These results suggest rap gene encodes an R8-specific function that plays a role in the determination of the photoreceptor cells R1, R6 and R7.
Eyes grossly abnormal: rough surface texture and deep pseudopupil (DPP) has anomalous appearance; finer level observations show ommatidia to be aberrant in size, shape, and alignment; in sections, numbers of photoreceptor cells per ommatidium vary greatly and positions of such cells plus rhabdomere arrangements are altered. Developmentally, recruitment of presumptive photoreceptors behind morphogenetic furrow in third larval instar eye disc is abnormal: e.g., arrangement of five-cell preclusters is very disorganized and the normal increase in numbers of cells within clusters does not occur, so that, in regions where eight-cell clusters are found in wild-type, there are small clusters in rap, intermingled with others than can have >8 cells; cell bodies of developing photoreceptor cells do not become apically positioned in the disc, as in wild-type.