FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\AGO1
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General Information
Symbol
Dmel\AGO1
Species
D. melanogaster
Name
Argonaute-1
Annotation Symbol
CG6671
Feature Type
FlyBase ID
FBgn0262739
Gene Model Status
Stock Availability
Gene Summary
Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
Also Known As

Ago-1, dAGO1, Argonaute, MRE20, Ago

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
2-68
RefSeq locus
NT_033778 REGION:13943387..13958089
Sequence
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
Gene Ontology (GO) Annotations (31 terms)
Molecular Function (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001113179
enables RNA binding
inferred from electronic annotation with InterPro:IPR003100
inferred from biological aspect of ancestor with PANTHER:PTN008584027
inferred from biological aspect of ancestor with PANTHER:PTN000527276
Biological Process (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
involved_in habituation
inferred from mutant phenotype
inferred from mutant phenotype
involved_in miRNA processing
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:gw; FB:FBgn0051992
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from genetic interaction with FLYBASE:Dcr-1; FB:FBgn0039016
inferred from genetic interaction with FLYBASE:AGO2; FB:FBgn0087035
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Cellular Component (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
located_in P-body
inferred from direct assay
inferred from direct assay
part_of RISC complex
inferred from physical interaction with FLYBASE:gw; FB:FBgn0051992
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001113179
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000527275
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001875625
part_of RISC complex
inferred from biological aspect of ancestor with PANTHER:PTN001113179
Protein Family (UniProt)
-
Summaries
Gene Snapshot
Argonaute-1 (AGO1) encodes an Argonaute/Piwi family protein, which interacts with microRNAs to form miRNA-induced silencing complexes (miRISCs). miRISCs are guided to target and repress mRNAs either by transcript destabilisation, translational inhibition, or both. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
miRNA-INDUCED SILENCING COMPLEX -
The miRNA RNA-induced silencing complex (miRISC) mediates post-transcriptional repression of gene expression by incorporating mature miRNA and down-regulating the expression of the target mRNA via repression of translation or mRNA degradation. (Adapted from FBrf0247552 and FBrf0194513.)
miRNA RISC LOADING COMPLEX -
The miRNA-RISC loading complex binds microRNA (miRNA) and loads it onto AGO1 to form an RNA-induced silencing complex (RISC). (Adapted from FBrf0215456.)
ARGONAUTE ENDORIBONUCLEASES -
Argonaute (AGO) proteins play an important role in small-RNA-mediated (miRNA, siRNA and piRNA) gene-silencing events and form the core constituent of the RNA-induced silencing complex (RISC). The PIWI domain of AGO proteins resembles RNase-H and accounts for their endonuclease activity that cleaves target mRNA complementary to the bound small RNA. (Adapted from PMID: 29447113).
Summary (Interactive Fly)

PAZ domain protein involved in post-transcriptional gene silencing - interacts with microRNAs to form miRNA-induced silencing complexes - repress mRNAs either by transcript destabilisation, translational inhibition, or both - mutants exhibit defects in the embryonic nervous system

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\AGO1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q32KD4)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Multiple (sequential) stage-specific extensions of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0087613
3481
984
FBtr0087614
5738
950
FBtr0087612
7528
984
FBtr0305592
7888
984
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FBpp0086739
109.8
984
9.36
FBpp0086740
106.2
950
9.46
FBpp0086738
109.8
984
9.36
FBpp0294043
109.8
984
9.36
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

984 aa isoforms: AGO1-PA, AGO1-PC, AGO1-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AGO1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.44

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

AGO1 transcripts are detected early and late in embryogenesis but transcripts containing the 3' UTR extension (~8.5 kb) are only detected at later stages and appear after the maternal-to-zygotic transition. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis). AGO1 transcripts are expressed nearly ubiquitously in the embryo but the extended 3' UTR isoforms are expressed primarily in neural tissues.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

AGO1 is distributed in the cytoplasm and enriched in the developing oocyte in stage 7 egg chambers. AGO1 colocalizes with osk on the posterior cortex of the oocyte of a stage 10 egg chamber.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
located_in P-body
inferred from direct assay
inferred from direct assay
part_of RISC complex
inferred from physical interaction with FLYBASE:gw; FB:FBgn0051992
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\AGO1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 61 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AGO1
Transgenic constructs containing regulatory region of AGO1
Aberrations (Deficiencies and Duplications) ( 26 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
chordotonal organ & neuron | germ-line clone
Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (8)
14 of 14
Yes
Yes
12 of 14
No
Yes
12 of 14
No
Yes
1  
12 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
13 of 14
Yes
Yes
12 of 14
No
Yes
11 of 14
No
Yes
8 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Mus musculus (laboratory mouse) (7)
14 of 14
Yes
Yes
12 of 14
No
Yes
12 of 14
No
Yes
11 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (8)
11 of 13
Yes
Yes
10 of 13
No
Yes
6 of 13
No
Yes
6 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Danio rerio (Zebrafish) (8)
14 of 14
Yes
Yes
12 of 14
No
Yes
12 of 14
No
Yes
11 of 14
No
Yes
9 of 14
No
Yes
3 of 14
No
Yes
1 of 14
No
No
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (25)
13 of 14
Yes
Yes
13 of 14
Yes
Yes
6 of 14
No
Yes
4 of 14
No
Yes
4 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
3 of 14
No
Yes
2 of 14
No
Yes
2 of 14
No
Yes
2 of 14
No
Yes
2 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
No
1 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
Yes
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (5)
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (10)
13 of 13
Yes
Yes
12 of 13
No
Yes
12 of 13
No
Yes
5 of 13
No
Yes
4 of 13
No
Yes
4 of 13
No
Yes
4 of 13
No
Yes
4 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (1)
10 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:AGO1. Refer to their site for version information.
Paralogs
Paralogs (via DIOPT v9.1)
Drosophila melanogaster (Fruit fly) (5)
5 of 13
1 of 13
1 of 13
1 of 13
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    RNA-RNA
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    Interaction Browsers

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-68
    Cytogenetic map
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    50C9-50C17
    Limits computationally determined from genome sequence between P{lacW}shotk04204 and P{lacW}AGO1k00208&P{lacW}Cp1k15606
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    50C14-50C15
    (determined by in situ hybridisation) 50C17--19 (determined by in situ hybridisation) 50C12--21 (determined by in situ hybridisation)
    50C-50C
    (determined by in situ hybridisation)
    50C12-50C21
    (determined by in situ hybridisation)
    50C14-50C15
    50C17--19 50C12--21
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (17)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (196)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
        Other Comments

        smg protein interacts with AGO1 protein, and AGO1 protein interacts with and is required for the translational repression of the smg target, nos mRNA. The AGO1 protein/nos mRNA interaction does not require a miRNA, but does require msg protein.

        The miRNA strand selection of AGO1 is influenced by the presence of a 5' uridine residue in a strand of the miRNA duplex as well as thermodynamic asymmetry of the miRNA strands.

        Double-stranded miRNAs and siRNAs participate in a common sorting step that partitions them into AGO1- or AGO2-containing effector complexes.

        The Dcr-2-r2d2 heterodimer acts as a gatekeeper for the assembly of AGO2 complexes, promoting the incorporation of siRNAs and disfavoring miRNAs as loading substrates for AGO2. A separate mechanism acts in parallel to favor miRNA/miRNA* duplexes and exclude siRNAs from assembly into AGO1 complexes.

        dsRNA made from templates generated with primers directed against this gene are used to infer a role for this gene in the miRNA pathway.

        AGO1 is required for maintenance of long-distance chromosomal interactions between endogenous PcG target loci.

        AGO1 protein associates with miRNA and cleaves target RNA completely complementary to the miRNA.

        dsRNA has been made from templates generated with primers directed against this gene.

        AGO1 and AGO2 are not redundant.

        Local overexpression of AGO1 can alter wing vein patterns or cause transformation of posterior cell identity.

        Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology.

        Relationship to Other Genes
        Source for database merge of

        Source for merge of: AGO1 l(2)04845 l(2)k08121 l(2)k00208

        Source for merge of: AGO1 anon-WO0257455.29

        Source for merge of: AGO1 MRE20

        Additional comments

        MRE20 is part of the 3' UTR of AGO1.

        MRE20 corresponds to a portion of the 3' UTR of AGO1.

        Not allelic to shot.

        Source for merge of AGO1 anon-WO0257455.29 was sequence comparison ( date:051113 ).

        Nomenclature History
        Source for database identify of
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (32)
        Reported As
        Symbol Synonym
        AGO1
        (Jones et al., 2025, Li et al., 2025, Liang et al., 2024, Candia et al., 2023, Sheng et al., 2023, Shi et al., 2023, Pegoraro et al., 2022, Evans et al., 2021, Huang et al., 2021, Malik, 2021, Proshkina et al., 2021, Schneider and Imler, 2021, Takemura et al., 2021, Bertolazzi et al., 2020, Gamez et al., 2020, Kakumani et al., 2020, Kinser and Pincus, 2020, Liu et al., 2020, Soleimani et al., 2020, Ahlers et al., 2019, Casier et al., 2019, Dou et al., 2019, Fingerhut et al., 2019, Hanyu-Nakamura et al., 2019, Kolliopoulou et al., 2019, Liu et al., 2019, Luhur et al., 2019, Martin Anduaga et al., 2019, Tiwari et al., 2019, Daniel et al., 2018, Ghosh and Liu, 2018, Kennerdell et al., 2018, Lee et al., 2018, Lin et al., 2018, Lou et al., 2017, Marygold et al., 2017, Vallejos Baier et al., 2017, Azlan et al., 2016, Brewer-Jensen et al., 2016, Kockel et al., 2016, Luo et al., 2016, Na et al., 2016, Bozzetti et al., 2015, Chak et al., 2015, Kavi et al., 2015, Lee et al., 2015, Mugat et al., 2015, Wen et al., 2015, Xiong et al., 2015, Chen et al., 2014, Gonzalez et al., 2014, Majzoub et al., 2014, Wen et al., 2014, Yang et al., 2014, Gomes et al., 2013, Huntzinger et al., 2013, Laneve et al., 2013, Lim and Allada, 2013, Nishihara et al., 2013, Ohtani et al., 2013, Okamura et al., 2013, Sentmanat et al., 2013, Smibert et al., 2013, Wei et al., 2013, Zekri et al., 2013, Zhang et al., 2013, Kibanov et al., 2012, Rodriguez et al., 2012, Spasic et al., 2012, Westholm et al., 2012, Berezikov et al., 2011, Chekulaeva et al., 2011, Chung et al., 2011, FlyBase Genome Annotators, 2011, Khong and Jan, 2011, Kolaczkowski et al., 2011, Lindquist et al., 2011, Liu et al., 2011, Ni et al., 2011, Okamura et al., 2011, Shen et al., 2011, Chekulaeva et al., 2010, Flynt et al., 2010, Haas et al., 2010, Herranz et al., 2010, Huntzinger et al., 2010, Jäger and Dorner, 2010, Miyoshi et al., 2010, Swami, 2010, Wasbrough et al., 2010, Czech et al., 2009, Eulalio et al., 2009, Eulalio et al., 2009, Eulalio et al., 2009, Kadener et al., 2009, Miyoshi et al., 2009, Okamura et al., 2009, Reich et al., 2009, Taft et al., 2009, Zekri et al., 2009, Aliyari et al., 2008, Berdnik et al., 2008, Berdnik et al., 2008, Bolduc et al., 2008, Chung et al., 2008, Czech et al., 2008, Eulalio et al., 2008, Haley et al., 2008, Kawamura et al., 2008, Neumuller et al., 2008, Okamura et al., 2008, Okamura et al., 2008, Okamura et al., 2008, Brower-Toland et al., 2007, Buszczak et al., 2007, Dietzl et al., 2007, Eulalio et al., 2007, Eulalio et al., 2007, Grewal and Elgin, 2007, Grieder et al., 2007, Gunawardane et al., 2007, Gunawardane et al., 2007, Marygold et al., 2007, Minidorff et al., 2007, Nishida et al., 2007, Saito et al., 2007, Behm-Ansmant et al., 2006, Dorner et al., 2006, Friedman and Perrimon, 2006, Molnar et al., 2006, Rehwinkel et al., 2006, Saito et al., 2006, Gesellchen et al., 2005, Miyoshi et al., 2005, Rehwinkel et al., 2005, Siomi et al., 2005, Jin et al., 2004)
        Ago1
        (Luan, 2025, Jang et al., 2024, Kim et al., 2023, Örkenby et al., 2023, Gartland et al., 2022, He et al., 2022, Wu et al., 2022, Zatsepina et al., 2022, Kingston and Bartel, 2021, Paturi and Deshmukh, 2021, Vidaurre and Chen, 2021, Galagali and Kim, 2020, Guan and Grigoriev, 2020, Iki et al., 2020, Lim et al., 2020, Malik et al., 2020, Nitschko et al., 2020, Song and Zhou, 2020, Tchurikov et al., 2020, Xia et al., 2020, Xie et al., 2020, Reichholf et al., 2019, Saha and Mishra, 2019, Specchia et al., 2019, Lim et al., 2018, Yamashiro and Siomi, 2018, Busto et al., 2017, Niinuma and Tomari, 2017, Golovin and Broadie, 2016, Lewis et al., 2016, Schmidts et al., 2016, Gehrke et al., 2015, Hauptmann et al., 2015, Karaiskos et al., 2015, Lin et al., 2015, Singh and Mishra, 2015, Spellberg and Marr, 2015, Abe et al., 2014, Lee et al., 2014, McElroy et al., 2014, Temme et al., 2014, Weidmann et al., 2014, Barckmann and Simonelig, 2013, Gomes et al., 2013, Li et al., 2013, Nishida et al., 2013, Pinder and Smibert, 2013, Sabin et al., 2013, Wu et al., 2013, Yamanaka et al., 2013, Aumiller et al., 2012, Djuranovic et al., 2012, Hodgetts et al., 2012, Li et al., 2012, Popkova et al., 2012, Pressman et al., 2012, Ameres et al., 2011, Kawamata et al., 2011, Lindquist et al., 2011, Liu et al., 2011, Pek and Kai, 2011, Seitz et al., 2011, Ameres et al., 2010, Dekanty et al., 2010, Djuranovic et al., 2010, Ghildiyal et al., 2010, Iwasaki et al., 2010, Nayak et al., 2010, Chekulaeva et al., 2009, Hong et al., 2009, Iwasaki et al., 2009, Kawamata et al., 2009, Lee et al., 2009, Li et al., 2009, Sabin et al., 2009, Jacquier et al., 2008, Shah and Förstemann, 2008, Sweeney et al., 2008, Zhou et al., 2008, Brennecke et al., 2007, Easow et al., 2007, Liu et al., 2007, Okamura et al., 2007, Tomari et al., 2007, Yang et al., 2007, Yang et al., 2007, Zamore, 2007, Zaratiegui, 2007, Bhadra et al., 2006, Du et al., 2006, Obbard et al., 2006, Vagin et al., 2006, Valencia-Sanchez et al., 2006, Filipowicz, 2005, Hammond, 2005, Preall and Sontheimer, 2005, Mason et al., 2004, Murchison and Hannon, 2004, Perrini et al., 2004, Skipper, 2004, Tomari et al., 2004)
        anon-WO0257455.29
        Secondary FlyBase IDs
        • FBgn0026611
        • FBgn0010586
        • FBgn0022056
        • FBgn0022275
        • FBgn0063793
        • FBgn0086551
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 89 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        PDB - An information portal to biological macromolecular structures
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (420)