Nrf2, CncC, Cap 'n' collar, cap and collar, l(3)03921
Please see the JBrowse view of Dmel\cnc for information on other features
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gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
6.6, 5.4, 3.3 (northern blot)
2.722 (longest cDNA)
1296, 805, 533 (aa)
533 (aa)
cnc protein shows the strongest resemblance to the jun subclass of bZIP proteins in the basic binding domain but is very divergent from this class in the leucine-repeat region.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cnc using the Feature Mapper tool.
Comment: maternally deposited
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reference states 12-24 hr AEL
Comment: reference states 0-2 hr AEL
Comment: reference states >2 hr AEL
cnc is first seen in an anterior domain and a more posterior band anterior to the cephalic furrow at embryonic stage 7. By stage 9, expression extends from the posterior of the early "cap" of expression to form a ring around the stomodeum. In the germband extended embryo, there is a continuous expression domain from the mandibular lobes extending through the hypopharyngeal primordium and expression in the labrum.
cnc protein is expressed only in non-dorsal/ventral boundary cells of the wing pouch. No expression is observed in the haltere disc.
Strong cnc staining is observed in the mandibular and labral segments from stage 6 on. This is presumed to be isoform B since only the mRNA for isoform B is expressed in these cells.
cnc antiserum detects a low level ubiquitous staining in syncytial embryos. From stage 6-14, staining is localized to the mandibular and labral segments. After stage 14 a low level ubiquitous staining is observed in addition to the strong staining in the mandibular and labral cells. The antibody recognizes all cnc isoforms.
GBrowse - Visual display of RNA-Seq signals
View Dmel\cnc in GBrowse 23-78
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: cnc anon-WO0153538.6 anon-WO0153538.7
Source for merge of: cnc CG17894
Source for merge of: CG13826 BcDNA:RE05559
Source for merge of: cnc CG13826
Annotations CG17894 and CG13826 merged as CG43286 in release 5.35 of the genome annotation.
Annotations CG4566, CG4578 and CG17894 merged as CG17894 (which corresponds to cnc) in release 3 of the genome annotation.
Source for merge of cnc anon-WO0153538.6 anon-WO0153538.7 was sequence comparison ( date:051113 ).
Source for merge of cnc CG17894 was a shared cDNA ( date:010720 ).
Source for merge of CG13826 BcDNA:RE05559 was a shared cDNA ( date:030728 ).
DNA-protein interactions: genome-wide binding profile assayed for cnc protein in 0-12 hr embryos; see mE1_TFBS_cnc collection report.
cnc has diverse functions in anterior-posterior patterning in the embryonic head.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. cnc is required for germ cell viability or early oogenesis.
cnc functions in combination with Dfd to specify mandibular development and is also required for labral segment identity. fkh and cnc homeotic genes are required for the maintenance of segment polarity gene expression in the foregut. cnc is required for the continued expression of the dorsal pharyngeal domains of wg and hh expression past stage 10 and the labral domain of wg expression past the middle stage 11.
Expression pattern and DNA sequence data suggest a role of cnc in cephalic patterning during embryogenesis.