FlyBase Gene Report: Dmel\scrib

General Information

Symbol

Dmel\scrib

Species

D. melanogaster

Name

scribble

Annotation Symbol

CG43398

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263289

Gene Model Status

Stock Availability

32 publicly available

Gene Summary

scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

scribbled, smi97B, scrb, ird15, l(3)j7B3

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:26,536,350..26,604,051 [+]

Recombination map

3-91

RefSeq locus

NT_033777 REGION:26536350..26604051

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (53 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:gukh; FB:FBgn0026239

(Mathew et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (40 terms)

Terms Based on Experimental Evidence (31 terms)

CV Term

Evidence

References

involved_in anterior/posterior axis specification, follicular epithelium

inferred from mutant phenotype

(assigned by BHF-UCL )

(Li et al., 2009)

involved_in basal protein localization

inferred from mutant phenotype

(Albertson and Doe, 2003)

involved_in cell fate commitment involved in pattern specification

inferred from mutant phenotype

(assigned by BHF-UCL )

(Li et al., 2009)

involved_in cell fate specification

inferred from mutant phenotype

(assigned by BHF-UCL )

(Li et al., 2009)

involved_in cell morphogenesis

inferred from mutant phenotype

(Zeitler et al., 2004)

involved_in compound eye development

inferred from mutant phenotype

(Zeitler et al., 2004)

involved_in dorsal closure

inferred from mutant phenotype

(Zeitler et al., 2004)

involved_in establishment of epithelial cell apical/basal polarity

inferred from mutant phenotype

(Dow et al., 2003)

involved_in establishment of imaginal disc-derived wing hair orientation

inferred from mutant phenotype

(Courbard et al., 2009)

involved_in establishment of ommatidial planar polarity

inferred from mutant phenotype

(Courbard et al., 2009)

involved_in establishment or maintenance of apical/basal cell polarity

inferred from mutant phenotype

(Zeitler et al., 2004)

involved_in establishment or maintenance of polarity of follicular epithelium

inferred from mutant phenotype

(Bilder et al., 2000)

involved_in establishment or maintenance of polarity of larval imaginal disc epithelium

inferred from mutant phenotype

(Bilder et al., 2000)

involved_in Malpighian tubule development

inferred from mutant phenotype

(Zeng et al., 2010, Campbell et al., 2009)

involved_in memory

inferred from mutant phenotype

(Cervantes-Sandoval et al., 2016)

involved_in morphogenesis of follicular epithelium

inferred from mutant phenotype

(Bilder et al., 2000)

involved_in morphogenesis of larval imaginal disc epithelium

inferred from mutant phenotype

(Bilder et al., 2000)

involved_in negative regulation of cell population proliferation

inferred from mutant phenotype

(Dow et al., 2003)

involved_in negative regulation of epithelial cell proliferation

inferred from mutant phenotype

(Zeitler et al., 2004)

involved_in negative regulation of imaginal disc growth

inferred from mutant phenotype

(Gerlach et al., 2018, Zeitler et al., 2004)

involved_in olfactory behavior

inferred from mutant phenotype

(Ganguly et al., 2003, Anholt et al., 1996)

involved_in ovarian follicle cell development

inferred from mutant phenotype

(assigned by BHF-UCL )

(Li et al., 2009)

involved_in pole plasm protein localization

inferred from mutant phenotype

(assigned by BHF-UCL )

(Li et al., 2009)

involved_in R3/R4 cell fate commitment

inferred from mutant phenotype

(Courbard et al., 2009)

involved_in regulation of endocytosis

inferred from mutant phenotype

(Igaki et al., 2009)

involved_in regulation of synapse structure or activity

inferred from mutant phenotype

(Roche et al., 2002)

involved_in septate junction assembly

inferred from mutant phenotype

(Zeitler et al., 2004)

involved_in stem cell differentiation

inferred from mutant phenotype

(Zeng et al., 2010)

involved_in stem cell proliferation

inferred from mutant phenotype

(Zeng et al., 2010)

involved_in wing disc morphogenesis

inferred from mutant phenotype

(Zeitler et al., 2004)

involved_in zonula adherens assembly

inferred from mutant phenotype

(Zeitler et al., 2004)

Terms Based on Predictions or Assertions (10 terms)

CV Term

Evidence

References

involved_in cell-cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN001501163

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in dorsal closure

traceable author statement

(Harden, 2002)

involved_in establishment or maintenance of epithelial cell apical/basal polarity

inferred from biological aspect of ancestor with PANTHER:PTN001501163

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in establishment or maintenance of polarity of embryonic epithelium

traceable author statement

(Bilder et al., 2000)

involved_in morphogenesis of a polarized epithelium

traceable author statement

(Gibson and Perrimon, 2003)

involved_in morphogenesis of embryonic epithelium

traceable author statement

(Bilder et al., 2000)

involved_in neurotransmitter receptor transport postsynaptic membrane to endosome

inferred from biological aspect of ancestor with PANTHER:PTN001900149

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane

inferred from biological aspect of ancestor with PANTHER:PTN001900149

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in receptor clustering

inferred from biological aspect of ancestor with PANTHER:PTN001501163

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in receptor localization to synapse

inferred from biological aspect of ancestor with PANTHER:PTN001501163

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (12 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

located_in apicolateral plasma membrane

inferred from direct assay

(Bilder et al., 2000)

located_in basolateral part of cell

inferred from direct assay

(Bunker et al., 2015)

located_in basolateral plasma membrane

inferred from direct assay

(Sotillos et al., 2004, Dow et al., 2003)

located_in cell cortex

inferred from direct assay

(Albertson and Doe, 2003)

located_in fusome

inferred from direct assay

(Lighthouse et al., 2008)

located_in lateral plasma membrane

inferred from direct assay

(Bilder et al., 2000)

located_in neuromuscular junction

inferred from direct assay

(Kohsaka et al., 2007)

located_in septate junction

inferred from direct assay

(Bilder and Perrimon, 2000)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

is_active_in adherens junction

inferred from biological aspect of ancestor with PANTHER:PTN002508426

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in basolateral plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001501163

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in basolateral plasma membrane

traceable author statement

(Gibson and Perrimon, 2003)

is_active_in cell junction

inferred from biological aspect of ancestor with PANTHER:PTN001501163

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in postsynaptic density

inferred from biological aspect of ancestor with PANTHER:PTN001900149

(assigned by GO_Central )

(Gaudet et al., 2011)

colocalizes_with postsynaptic membrane

inferred from biological aspect of ancestor with PANTHER:PTN001900149

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in septate junction

non-traceable author statement

(Tepass et al., 2001)

traceable author statement

(Cereijido et al., 2003, Caruana, 2002)

Gene Group (FlyBase)

SCRIBBLE COMPLEX

Protein Family (UniProt)

Belongs to the LAP (LRR and PDZ) protein family. (Q7KRY7)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

scribble (scrib) encodes a scaffolding protein that is part of the conserved machinery regulating apicobasal polarity. It acts with the products of dlg1 and l(2)gl to distinguish the basolateral domain of epithelial cells and neuroblasts, via reciprocally antagonistic interactions with the aPKC/par-6 complex that impacts vesicle trafficking. The product of scrib also organizes synaptic architecture and is implicated in learning and memory. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

SCRIBBLE COMPLEX -: The scribble complex is the basolateral polarity complex that localizes to the adherens junction and regulate cell polarity. Scribble complex works with the PAR and Crumbs polarity complexes to regulate apicobasal polarity and asymmetry in cells. (Adapted from FBrf0246382 and FBrf0220779).

Protein Function (UniProtKB)

Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior.

(UniProt, Q7KRY7)

Summary (Interactive Fly)

scaffolding protein with multiple PDZ and LLR regions - functions to localize junctional components in the determination of epithelial cell apicobasal polarity - acts with and to distinguish the basolateral domain of epithelial cells and neuroblasts - exhibits antagonistic interactions with the aPKC/Par-6 complex that impacts vesicle trafficking - organizes synaptic architecture and is implicated in learning and memory

Interactive Fly

Gene Model and Products

Number of Transcripts

18

Number of Unique Polypeptides

17

Please see the JBrowse view of Dmel\scrib for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KRY7)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.39

Gene model reviewed during 5.49

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.40

Two sites of polyadenylation reported in FBrf0139743.

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0308620

7048

1756

FBtr0308621

7148

1756

FBtr0308624

4752

1247

FBtr0308625

7433

1851

FBtr0308622

6323

1939

FBtr0308623

6087

1711

FBtr0308626

8891

2426

FBtr0308627

8667

2331

FBtr0308628

9438

2585

FBtr0308629

9153

2490

FBtr0308630

9372

2554

FBtr0308631

8538

2515

FBtr0308632

6219

1729

FBtr0308633

9414

2577

FBtr0308634

6636

1951

FBtr0335520

6905

1859

FBtr0335521

9224

2444

FBtr0335522

7178

1766

Additional Transcript Data and Comments

Reported size (kB)

7.1, 5.9, 4.6 (northern blot)

(Ganguly et al., 2003)

7.2, 6.0, 4.6 (northern blot)

(Li et al., 2001)

6.2 (northern blot)

(Bilder and Perrimon, 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0300844

190.2

1756

4.80

FBpp0300845

190.2

1756

4.80

FBpp0300848

136.4

1247

4.78

FBpp0300849

200.4

1851

4.81

FBpp0300846

210.2

1939

5.03

FBpp0300847

184.7

1711

4.90

FBpp0300850

263.3

2426

4.46

FBpp0300851

253.1

2331

4.45

FBpp0300852

280.9

2585

4.54

FBpp0300853

270.6

2490

4.53

FBpp0300854

277.3

2554

5.11

FBpp0300855

273.7

2515

4.53

FBpp0300856

187.0

1729

4.87

FBpp0300857

280.8

2577

4.56

FBpp0300858

211.8

1951

5.13

FBpp0307488

199.9

1859

4.64

FBpp0307489

265.2

2444

5.11

FBpp0307490

191.3

1766

4.79

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1756 aa isoforms: scrib-PA, scrib-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

1756, 1247 (aa); 250, 180 (kD)

(Li et al., 2001)

1756 (aa); 210 (kD observed); 195 (kD predicted)

(Bilder and Perrimon, 2000)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scrib using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

foregut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

(Organista et al., 2015)

maxillary palpus

(Ganguly et al., 2003)

(Ganguly et al., 2003)

third segment of antenna

(Ganguly et al., 2003)

second segment of antenna

(Ganguly et al., 2003)

adult brain | restricted

(Ganguly et al., 2003)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 11

Comment: reference states 0-6 hr AEL

(Li et al., 2001)

embryonic stage 1 -- 17

Comment: reference states 0-24 hr AEL

(Li et al., 2001)

embryonic stage 12 -- 17

Comment: reference states 9-22 hr AEL

(Li et al., 2001)

(Li et al., 2001)

(Ganguly et al., 2003)

larval stage | male

(Ganguly et al., 2003)

larval stage | female

(Ganguly et al., 2003)

(Li et al., 2001)

(Ganguly et al., 2003, Li et al., 2001)

adult stage | male

(Li et al., 2001)

(Ganguly et al., 2003, Li et al., 2001)

adult stage | female

(Li et al., 2001)

(Ganguly et al., 2003, Li et al., 2001)

Additional Descriptive Data

scrib transcripts are detected in antennae, maxillary palps, Johnston's organ and in restricted cortical regions of the brain.

(Ganguly et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

blastoderm stage

organism | ubiquitous

(Li et al., 2001)

embryonic stage 13 -- 15

(Li et al., 2001)

embryonic stage 13 -- 17

presumptive embryonic/larval central nervous system

(Li et al., 2001)

embryonic stage 15 -- 16

larval ventral nerve cord

(Li et al., 2001)

presumptive embryonic/larval peripheral nervous system

(Li et al., 2001)

(Li et al., 2001)

presumptive embryonic/larval central nervous system

(Li et al., 2001)

embryonic sensory system

(Li et al., 2001)

third instar larval stage

optic lobe forming neuroblast

(Southall et al., 2013)

adult stage | female

• fusome

(Lighthouse et al., 2008)

• spectrosome

(Lighthouse et al., 2008)

adult stage | female & oogenesis

follicle stem cell

(Kronen et al., 2014)

(Kronen et al., 2014)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 15

Comment: reference states 0-12 hr AEL

(Li et al., 2001)

(Li et al., 2001)

embryonic stage 15 -- 16

primordial germ cell

(Li et al., 2001)

(Li et al., 2001)

embryonic stage 15 -- 17

Comment: reference states 12-24 hr AEL

(Li et al., 2001)

embryonic stage 16 -- 17

• axon

(Li et al., 2001)

larval longitudinal connective

(Li et al., 2001)

ventral midline of embryo

(Li et al., 2001)

larval ventral nerve cord commissure

(Li et al., 2001)

Additional Descriptive Data

scrib protein is localized to the epithelial septate junction at the boundary of the apical and basolateral cell surfaces.

(Lighthouse et al., 2008, Bilder and Perrimon, 2000)

scrib protein is detected in the brain, especially in the antennal nerves and the ventrolateral and superior medial protocerebrum. It is also widely deposited in the antennae and maxillary palps.

(Ganguly et al., 2003)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apicolateral plasma membrane

inferred from direct assay

(Bilder et al., 2000)

located_in basolateral part of cell

inferred from direct assay

(Bunker et al., 2015)

located_in basolateral plasma membrane

inferred from direct assay

(Sotillos et al., 2004, Dow et al., 2003)

located_in cell cortex

inferred from direct assay

(Albertson and Doe, 2003)

located_in fusome

inferred from direct assay

(Lighthouse et al., 2008)

located_in lateral plasma membrane

inferred from direct assay

(Bilder et al., 2000)

located_in neuromuscular junction

inferred from direct assay

(Kohsaka et al., 2007)

located_in septate junction

inferred from direct assay

(Bilder and Perrimon, 2000)

Expression Deduced from Reporters

Reporter: P{PTT-GA}scrib^CA07683

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | female

• fusome

(Lighthouse et al., 2008)

• spectrosome

(Lighthouse et al., 2008)

adult stage | male

male germline cyst

• fusome

(Lighthouse et al., 2008)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\scrib in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\scrib

View exonic expression by tissue for Dmel\scrib

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263289

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44448/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263289

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263289

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 45 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 41 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of scrib

Transgenic constructs containing regulatory region of scrib

Aberrations (Deficiencies and Duplications) ( 25 )

Inferred from experimentation ( 25 )

Gene disrupted in

(Christensen et al., 2009.2.28)

(Ryder and Roote, 2004.11.10)

(Spradling et al., 1999)

(Cook and Carpenter, 2002)

(Wu et al., 2001)

Df(3R)Tl^84cRPA

(Howe et al., 1995)

(Brumby et al., 2004, Cook and Carpenter, 2002)

(Brumby et al., 2004, Thibault et al., 2004, Cook and Carpenter, 2002, Spradling et al., 1999, Szeged Stock Center, 1998-, BDGP Project Members, 1994-1999)

(Brumby et al., 2004, Zeitler et al., 2004, Ganguly et al., 2003, Cook and Carpenter, 2002, Roche et al., 2002, Wu et al., 2001, Bilder and Perrimon, 2000, Kidd et al., 1999)

(Brumby et al., 2004)

T(2;3)lt-x13p20

(Howe et al., 1995)

T(2;3)lt-x13p89

(Howe et al., 1995)

(Howe et al., 1995)

(Howe et al., 1995)

(Howe et al., 1995)

(Howe et al., 1995)

(Howe et al., 1995)

(Howe et al., 1995)

(Howe et al., 1995)

T(2;3)tx-x13p100

(Howe et al., 1995)

Gene not disrupted in

(Brumby et al., 2004)

(Cook and Carpenter, 2002)

(Cook and Carpenter, 2002, Kidd et al., 1999)

(Brumby et al., 2004)

(Bilder and Perrimon, 2000)

(Howe et al., 1995)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone

scrib¹

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone, with Scer\GAL4^{Act5C.CoinFLP-FRT}

scrib^GD11663

FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone, with Scer\GAL4^Act5C.PP

scrib^GD11666

lethal | recessive

lethal - all die before end of larval stage (with Df(3R)Tl-X)

lethal - all die before end of larval stage (with scrib¹)

lethal - all die before end of larval stage (with scrib⁶⁷³)

lethal - all die before end of larval stage (with scrib^ird15)

lethal - all die before end of larval stage (with scrib^j7B3)

scrib¹

lethal - all die before end of larval stage | recessive

scrib^63S15

lethal - all die before end of P-stage (with scrib¹)

scrib⁸⁸²

lethal - all die before end of P-stage (with scrib⁸⁸²)

scrib¹

lethal - all die before end of P-stage | recessive

scrib^dt14

lethal - all die before end of P-stage | somatic clone

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

lethal - all die before end of pupal stage (with Df(3R)Tl-X)

lethal - all die before end of pupal stage (with scrib¹)

lethal - all die before end of pupal stage (with scrib⁶⁷³)

lethal - all die before end of pupal stage (with scrib⁸⁸²)

lethal - all die before end of pupal stage (with scrib^dt6)

lethal - all die before end of pupal stage (with scrib^dt12)

lethal - all die before end of pupal stage (with scrib^dt14)

lethal - all die before end of pupal stage (with scrib^ird15)

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

scrib^GD11663

lethal - all die during pupal stage | somatic clone, with Scer\GAL4^Act5C.PI

scrib^GD11663

partially lethal - majority die | recessive

scrib^S042405b

partially lethal - majority die | somatic clone

scrib¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

scrib^GD11666

viable (with scrib¹)

scrib⁵

viable (with scrib⁵)

viable (with scrib⁸⁸²)

scrib^dt14

viable (with scrib^dt14)

scrib⁸⁸²

viable (with scrib^jB709)

scrib⁵

Sterility

Allele

female fertile | germline clone

Other Phenotypes

Allele

abnormal behavior | recessive

scrib^smi97B

abnormal cell growth | somatic clone

scrib¹

abnormal cell migration | third instar larval stage, with Scer\GAL4^ptc-559.1

scrib^GD11666

abnormal cell migration | third instar larval stage, with Scer\GAL4^ptc.PU

scrib^GD11666

abnormal cell polarity | larval stage

scrib¹

abnormal cell polarity | larval stage (with scrib⁶⁷³)

scrib^ird15

abnormal cell polarity | larval stage (with scrib^ird15)

scrib⁶⁷³

abnormal cell polarity | larval stage | recessive

scrib⁶⁷³

abnormal cell polarity | somatic clone

abnormal cell shape | larval stage (with scrib⁶⁷³)

abnormal cell shape | larval stage (with scrib^dt6)

scrib⁶⁷³

abnormal cell shape | larval stage (with scrib^dt12)

scrib⁶⁷³

abnormal cell shape | larval stage (with scrib^ird15)

scrib⁶⁷³

abnormal cell shape | larval stage | recessive

scrib⁶⁷³

abnormal developmental rate | third instar larval stage (with Df(3R)Tl-X)

abnormal developmental rate | third instar larval stage (with scrib⁶⁷³)

scrib^ird15

abnormal developmental rate | third instar larval stage (with scrib^ird15)

scrib⁶⁷³

abnormal immune response | recessive

scrib^ird15

abnormal memory, with Scer\GAL4^238Y

scrib^KK106065

abnormal memory, with Scer\GAL4¹⁴⁷¹

scrib^KK106065

abnormal memory, with Scer\GAL4^c739

scrib^KK106065

abnormal memory, with Scer\GAL4^c747

scrib^KK106065

abnormal memory, with Scer\GAL4^GMR13F02

abnormal memory, with Scer\GAL4^Mef2.247

scrib^KK106065

abnormal memory, with Scer\GAL4^nSyb.PU

scrib^KK106065

abnormal memory, with Scer\GAL4^ple.PF

abnormal memory | dominant

scrib¹

abnormal mitotic cell cycle | somatic clone

scrib⁶⁷³

abnormal neuroanatomy

scrib¹

abnormal neuroanatomy | larval stage

scrib⁶⁷³

abnormal neuroanatomy | larval stage (with Df(3R)Tl-X)

scrib⁶⁷³

abnormal neuroanatomy | somatic clone

scrib^unspecified

abnormal neuroanatomy | somatic clone | third instar larval stage

scrib¹

abnormal neurophysiology, with Scer\GAL4^GMR13F02

scrib^KK106065

abnormal neurophysiology, with Scer\GAL4^ple.PF

scrib^KK106065

abnormal neurophysiology | larval stage

scrib⁶⁷³

abnormal neurophysiology | larval stage (with Df(3R)Tl-X)

scrib⁶⁷³

abnormal planar polarity | larval stage (with scrib¹)

scrib^j7B3

abnormal planar polarity | larval stage (with scrib^j7B3)

scrib¹

abnormal planar polarity | somatic clone

abnormal size | larval stage (with scrib¹)

scrib⁶⁷³

abnormal size | larval stage (with scrib⁶⁷³)

abnormal size | larval stage (with scrib⁸⁸²)

scrib⁶⁷³

abnormal size | larval stage (with scrib^dt6)

scrib⁶⁷³

abnormal size | larval stage (with scrib^dt12)

scrib⁶⁷³

abnormal size | larval stage (with scrib^dt14)

scrib⁶⁷³

abnormal size | larval stage (with scrib^ird15)

scrib⁶⁷³

abnormal size | larval stage | recessive

scrib⁶⁷³

abnormal size | recessive

scrib^j7B3

abnormal size | somatic clone | third instar larval stage

scrib¹

abnormal size | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

scrib¹

abnormal smell perception

scrib^smi97B

abnormal smell perception | adult stage (with scrib¹)

scrib^smi97B

abnormal smell perception | adult stage (with scrib⁶⁷³)

scrib^smi97B

abnormal smell perception | adult stage (with scrib^smi97B)

abnormal smell perception | adult stage | female (with Df(3R)Tl-X)

scrib^smi97B

abnormal smell perception | adult stage | female | recessive

scrib^smi97B

abnormal smell perception | adult stage | female limited (with scrib^S042405b)

scrib^smi97B

abnormal smell perception | adult stage | female limited (with scrib^smi97B)

scrib^S042405b

abnormal smell perception | adult stage | female limited | recessive

scrib^smi97B-2A

abnormal smell perception | adult stage | male (with Df(3R)Tl-X)

scrib^smi97B

abnormal smell perception | adult stage | male | recessive

scrib^smi97B

abnormal smell perception | adult stage | male limited | recessive

scrib^smi97B-15A

abnormal smell perception | larval stage

scrib^smi97B

decreased cell number | larval stage | somatic clone

scrib¹

decreased cell number | somatic clone | third instar larval stage

scrib¹

decreased occurrence of cell division | somatic clone

scrib¹

decreased size | larval stage | somatic clone - tissue specific

scrib¹

scrib¹

hyperplasia | recessive

scrib¹

increased body size | larval stage | somatic clone

scrib⁶⁷³

increased body size | third instar larval stage (with Df(3R)Tl-X)

increased body size | third instar larval stage (with scrib¹)

increased body size | third instar larval stage (with scrib⁶⁷³)

increased body size | third instar larval stage (with scrib^ird15)

increased cell death | larval stage

scrib¹

increased cell death | larval stage, with Scer\GAL4^ptc-559.1

scrib^HMS01490

increased cell death | larval stage | somatic clone

increased cell death | somatic clone

scrib¹

increased cell death | somatic clone | third instar larval stage

scrib¹

increased cell death | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

scrib^KK101128

increased cell number | larval stage

scrib¹

increased cell number | larval stage (with scrib⁶⁷³)

increased cell number | larval stage (with scrib^dt6)

scrib⁶⁷³

increased cell number | larval stage (with scrib^ird15)

scrib⁶⁷³

increased cell number | larval stage | somatic clone

scrib^A128

increased cell number | somatic clone

scrib¹

increased occurrence of cell division | adult stage | somatic clone

scrib¹

increased occurrence of cell division | larval stage | somatic clone

scrib¹

increased size | larval stage, with Scer\GAL4^ptc-559.1

scrib^HMS01490

neoplasia | adult stage | somatic clone

scrib¹

neoplasia | larval stage

scrib¹

neoplasia | larval stage | somatic clone

neoplasia | somatic clone

neoplasia | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

scrib^KK101128

neoplasia | third instar larval stage

scrib¹

neoplasia | third instar larval stage, with Scer\GAL4^Bx-MS1096

scrib^HMS01490

neoplasia | third instar larval stage, with Scer\GAL4^sd-SG29.1

scrib^KK101128

some die during larval stage (with scrib¹)

scrib^j7B3

some die during larval stage (with scrib^j7B3)

scrib¹

some die during larval stage | recessive

scrib^63S15

some die during pharate adult stage (with scrib¹)

scrib⁸⁸²

some die during pharate adult stage (with scrib⁸⁸²)

scrib¹

some die during pharate adult stage | recessive

scrib^dt14

some die during pharate adult stage | somatic clone

some die during P-stage | somatic clone

scrib⁶⁷³

some die during pupal stage, with Scer\GAL4^pnr-MD237

some die during pupal stage (with Df(3R)Tl-X)

some die during pupal stage (with scrib¹)

some die during pupal stage (with scrib⁶⁷³)

some die during pupal stage (with scrib⁸⁸²)

some die during pupal stage (with scrib^dt6)

some die during pupal stage (with scrib^dt12)

some die during pupal stage (with scrib^dt14)

some die during pupal stage (with scrib^ird15)

some die during pupal stage | somatic clone

scrib¹

some die during third instar larval stage (with Df(3R)Tl-X)

some die during third instar larval stage (with scrib¹)

some die during third instar larval stage (with scrib⁶⁷³)

some die during third instar larval stage (with scrib^ird15)

visible, with Scer\GAL4^pnr-MD237

scrib^GD11663

visible (with scrib¹)

scrib⁵

visible (with scrib⁵)

visible (with scrib^jB709)

scrib⁵

visible | recessive | somatic clone

scrib^dt6

scrib^hs.PB

Phenotype manifest in

Allele

adherens junction

scrib⁶⁷³

adherens junction (with scrib¹)

scrib⁶⁷³

adherens junction (with scrib⁶⁷³)

scrib¹

adult head | somatic clone

adult Malpighian tubule | somatic clone

scrib¹

adult thorax (with scrib¹)

scrib⁵

adult thorax (with scrib⁵)

adult thorax (with scrib^jB709)

scrib⁵

antennal disc | somatic clone | third instar larval stage

scrib¹

anterior-posterior compartment boundary of the wing disc, with Scer\GAL4^ptc.PU

scrib^GD11666

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc-559.1

scrib^GD11666

anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4^ptc.PU

scrib^GD11666

chaeta (with scrib¹)

scrib⁵

chaeta (with scrib⁵)

chaeta (with scrib^jB709)

scrib⁵

dopaminergic neuron, with Scer\GAL4^GMR13F02

scrib^KK106065

dopaminergic neuron, with Scer\GAL4^ple.PF

scrib^KK106065

egg | maternal effect (with T(Y;3)G75)

scrib^j7B3

embryonic/first instar larval cuticle

scrib^unspecified

embryonic/larval brain

embryonic/larval brain | somatic clone | third instar larval stage

scrib¹

embryonic/larval cuticle | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

scrib^HMS01490

embryonic/larval fat body

scrib^unspecified

embryonic/larval hemocyte | larval stage

scrib¹

embryonic dorsal epidermis | germline clone

scrib^dt6

embryonic epidermis | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

scrib^HMS01490

epithelial cell

epithelial cell, with Scer\GAL4^ptc-559.1

scrib^GD11666

epithelial cell (with scrib⁶⁷³)

epithelial cell (with scrib^dt6)

scrib⁶⁷³

epithelial cell (with scrib^dt12)

scrib⁶⁷³

epithelial cell (with scrib^ird15)

scrib⁶⁷³

epithelial cell | embryonic stage

scrib^unspecified

scrib¹

eye (with scrib¹)

scrib⁵

eye (with scrib⁵)

eye (with scrib^jB709)

scrib⁵

eye | somatic clone

eye-antennal disc | somatic clone

eye-antennal disc | somatic clone | third instar larval stage

scrib¹

eye-antennal disc | somatic clone | third instar larval stage, with Scer\GAL4^FRT.Act5C

scrib¹

eye disc | somatic clone

eye disc | somatic clone - tissue specific

scrib¹

eye photoreceptor cell | somatic clone

scrib⁵

follicle cell | cell autonomous | somatic clone

scrib^unspecified

garland cell, with Scer\GAL4^sns.PK

scrib^HMS01993

scrib¹

scrib^L97C

scrib¹

mesothoracic tergum, with Scer\GAL4^pnr-MD237

scrib^GD11663

neuroblast | embryonic stage

scrib¹

ommatidial precursor cluster

scrib⁶⁷³

ommatidium | cell non-autonomous | somatic clone

scrib¹

ommatidium | somatic clone

organism | third instar larval stage (with scrib¹)

scrib^j7B3

organism | third instar larval stage (with scrib^j7B3)

scrib¹

photoreceptor neuron | somatic clone

rhabdomere | somatic clone

scrib⁵

septate junction

scrib⁶⁷³

septate junction (with scrib¹)

scrib⁶⁷³

septate junction (with scrib⁶⁷³)

septate junction (with scrib^dt6)

scrib⁶⁷³

slit diaphragm | decreased number, with Scer\GAL4^sns.PK

scrib^HMS01993

synaptic vesicle | larval stage

scrib⁶⁷³

synaptic vesicle | larval stage (with Df(3R)Tl-X)

scrib⁶⁷³

type I bouton | larval stage

scrib⁶⁷³

type I bouton | larval stage (with Df(3R)Tl-X)

scrib⁶⁷³

type II neuroblast | somatic clone | third instar larval stage

scrib¹

wing disc (with scrib¹)

scrib⁶⁷³

wing disc (with scrib⁶⁷³)

wing disc (with scrib⁸⁸²)

scrib⁶⁷³

wing disc (with scrib^dt6)

scrib⁶⁷³

wing disc (with scrib^dt12)

scrib⁶⁷³

wing disc (with scrib^dt14)

scrib⁶⁷³

wing disc (with scrib^ird15)

scrib⁶⁷³

wing disc | larval stage, with Scer\GAL4^ptc-559.1

scrib^HMS01490

wing disc | somatic clone | third instar larval stage

scrib¹

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

scrib^KK101128

wing disc | third instar larval stage

scrib¹

wing disc | third instar larval stage, with Scer\GAL4^Bx-MS1096

scrib^HMS01490

wing disc | third instar larval stage (with scrib¹)

scrib^j7B3

wing disc | third instar larval stage (with scrib^j7B3)

scrib¹

wing hair | somatic clone

scrib⁵

wing hinge primordium | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

scrib^KK101128

wing hinge primordium | somatic clone | third instar larval stage, with Scer\GAL4^sd-SG29.1

scrib^KK101128

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (5)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

7 of 15

Yes

Yes

1

6 of 15

No

Yes

3 of 15

No

No

2 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

7 of 15

Yes

Yes

6 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

Rattus norvegicus (Norway rat) (7)

5 of 13

Yes

Yes

5 of 13

Yes

Yes

3 of 13

No

No

2 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (4)

3 of 12

Yes

Yes

3 of 12

Yes

No

3 of 12

Yes

Yes

2 of 12

No

No

Danio rerio (Zebrafish) (4)

8 of 15

Yes

Yes

4 of 15

No

Yes

3 of 15

No

No

2 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (4)

8 of 15

Yes

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (9)

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

1 of 9

Yes

No

Saccharomyces cerevisiae (Brewer's yeast) (1)

1 of 15

Yes

No

Schizosaccharomyces pombe (Fission yeast) (1)

1 of 12

Yes

No

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (3)

Gene Symbol

Score

Source

Alignment

2 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 8 )

Allele

Disease

Evidence

References

model of cancer

CEA

(Tamori et al., 2016)

CEA with Stat92E^{ΔNΔC.UASp.Tag:HA}, RhoGEF2^HMS01118

(Tamori et al., 2016)

CEA with Ras85D^V12.UAS

(Muzzopappa et al., 2017)

model of leukemia

CEA with Ras85D^V12.UAS

(Arefin et al., 2017)

model of carcinoma

CEA with Ras85D^V12.UAS

(Murcia et al., 2019)

model of cancer

CEA with Hsap\SCRIB^UAS.EGFP

(Dow et al., 2003)

CEA with Ras85D^V12.UAS

(Pagliarini and Xu, 2003)

model of carcinoma

CEA

(Wu et al., 2021)

model of carcinoma

CEA

(Brumby and Richardson, 2003, Bilder et al., 2000)

CEA with Ras85D^V12.UAS

(Amcheslavsky et al., 2018)

model of carcinoma

CEA

(Ding et al., 2022, Sun et al., 2019, Zhang et al., 2019)

model of cancer

CEA with Ras85D^V12.UAS

(Hodgson et al., 2021, Külshammer et al., 2015, Külshammer and Uhlirova, 2013, Willoughby et al., 2013, Wu et al., 2010, Pagliarini and Xu, 2003)

CEA with cno^R2

(Rives-Quinto et al., 2017)

CEA

(Bunker et al., 2015, Ohsawa et al., 2011)

CEA with rl^R80S.UAS

(Kushnir et al., 2020)

CEA with rl^{D334N.UAS.cKa}

(Kushnir et al., 2020)

CEA with rl^{R80S.D334N.UAS}

(Kushnir et al., 2020)

CEA with Ras85D^V12.QUAS.cHa

(Hodgson et al., 2021)

CEA with Ras85D^V12.cUa.UAS

(Khezri et al., 2021)

model of benign neoplasm

CEA

(de Vreede et al., 2018)

model of carcinoma

CEA

(Kong et al., 2021, Parvy et al., 2019, Katsukawa et al., 2018, O'Keefe et al., 2015, Igaki et al., 2009, Uhlirova et al., 2005, Brumby and Richardson, 2003, Bilder et al., 2000)

CEA with Ras85D^V12.UAS

(Kong et al., 2021, Mishra-Gorur et al., 2019, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

CEA with Raf^UAS.F179

(Wei et al., 2021, Uhlirova et al., 2005)

CEA with egr¹

(Igaki et al., 2009)

CEA with Rab5^S43N.UAS

(Igaki et al., 2009)

model of kidney cancer

CEA

(Zeng et al., 2010)

model of cancer

CEA

(Bunker et al., 2015)

model of carcinoma

CEA

(Yadav and Srikrishna, 2019)

scrib^{dsRNA.UAS.cUa}

model of cancer

CEA with Ras85D^V12.UAS

(Hodgson et al., 2021)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 8 )

Allele

Disease

Interaction

References

model of cancer

is exacerbated by Stat92E^{ΔNΔC.UASp.Tag:HA}

(Tamori et al., 2016)

ameliorates viral infectious disease

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates infectious mononucleosis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

ameliorates Epstein-Barr virus hepatitis

modeled by EBV\BRLF1^GMR.PA

(Adamson and Lajeunesse, 2012)

model of carcinoma

is ameliorated by puc^UAS.cMa

(Wu et al., 2021)

is ameliorated by CtBP^HMS00677

(Wu et al., 2021)

is ameliorated by CtBP^JF01291

(Wu et al., 2021)

model of carcinoma

is ameliorated by lic^GD7546

(Sun et al., 2019)

is ameliorated by lic^JF01433

(Sun et al., 2019)

is ameliorated by pan^JF02306

(Zhang et al., 2019)

is ameliorated by wg^GD5007

(Zhang et al., 2019)

is exacerbated by Toll-7^{C993Y.UAS.Tag:FLAG}

(Ding et al., 2022)

is ameliorated by Toll-7^GD14417

(Ding et al., 2022)

is ameliorated by Toll-7^HM05230

(Ding et al., 2022)

model of cancer

is ameliorated by hep^r75

(Bunker et al., 2015)

is ameliorated by yki^B5

(Bunker et al., 2015)

is ameliorated by egr¹

(Ohsawa et al., 2011)

model of carcinoma

is exacerbated by BacA\p35^UAS.cHa

(Brumby and Richardson, 2003)

is ameliorated by Dad^UAS.cTa

(Brumby and Richardson, 2003)

is ameliorated by Egfr^DN.UAS

(Brumby and Richardson, 2003)

is exacerbated by N^ICN.UAS

(Brumby and Richardson, 2003)

is exacerbated by Ras85D^V12.UAS

(Brumby and Richardson, 2003)

is exacerbated by bsk^K53R.UAS

(Uhlirova et al., 2005, Brumby and Richardson, 2003)

is ameliorated by pan^ΔN.UAS

(Brumby and Richardson, 2003)

is ameliorated by Wwox^KK108459

(O'Keefe et al., 2015)

is exacerbated by Dif^LA00958

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^GD12724

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^HMS01371

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^c01214

(Katsukawa et al., 2018)

is ameliorated by Spn88Ea^eld5

(Katsukawa et al., 2018)

is exacerbated by Tl^10b.UAS

(Katsukawa et al., 2018)

is exacerbated by dl^UAS.cHa

(Katsukawa et al., 2018)

is ameliorated by hep^Act.UAS

(Uhlirova et al., 2005)

is ameliorated by kay^dsRNA.UAS

(Uhlirova and Bohmann, 2006)

is ameliorated by puc^UAS.cMa

(Uhlirova and Bohmann, 2006)

is exacerbated by Def^SK3

(Parvy et al., 2019)

is exacerbated by egr³

(Parvy et al., 2019)

is exacerbated by bsk^DN.UAS.cUa

(Kong et al., 2021)

is ameliorated by msn^UAS.cSa

(Kong et al., 2021)

is ameliorated by HAdV-C\E4orf4^UAS.cPa

(Rosen et al., 2019)

is ameliorated by HAdV-C\E4orf4^UAS.cPb

(Rosen et al., 2019)

model of cancer

is ameliorated by dome^ΔCYT.UAS

(Bunker et al., 2015)

is ameliorated by Socs36E^UASp.cCa

(Bunker et al., 2015)

model of carcinoma

is exacerbated by park^JF01200

(Yadav and Srikrishna, 2019)

is ameliorated by park^{UAS.Tag:FLAG,Tag:Mito(hCOX4I1)}

(Yadav and Srikrishna, 2019)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

ameliorates autism spectrum disorder

modeled by Nrx-1²⁷³

(Rui et al., 2017)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SCRIB; scribble planar cell polarity protein

7 of 15

LRRC1; leucine rich repeat containing 1

6 of 15

LRRC7; leucine rich repeat containing 7

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

(Dow et al., 2003)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

proximity ligation assay, fluorescence microscopy

(Sharifkhodaei et al., 2019)

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

pull down, western blot, anti tag coimmunoprecipitation

(Rui et al., 2017)

anti tag coimmunoprecipitation, western blot

(Bahri et al., 2010)

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016, Bahri et al., 2010)

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016)

pull down, autoradiography

(Mathew et al., 2011)

pull down, autoradiography, two hybrid

(Courbard et al., 2009)

proximity ligation assay, fluorescence microscopy

(Sharifkhodaei et al., 2019)

colocalization, fluorescence microscopy, inferred by author, proximity ligation assay, anti tag coimmunoprecipitation, western blot, proximity-dependent biotin identification, anti bait coimmunoprecipitation

(Sharp et al., 2021, Ventura et al., 2020, Nakajima et al., 2019, Sharifkhodaei et al., 2019, Rui et al., 2017, Mathew et al., 2002)

anti bait coimmunoprecipitation, western blot, isothermal titration calorimetry, predetermined participant, x-ray crystallography

(Caria et al., 2018, Mathew et al., 2002)

anti tag coimmunoprecipitation, anti tag western blot

(Gui et al., 2016)

anti tag coimmunoprecipitation, western blot

(Cervantes-Sandoval et al., 2016)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Rives-Quinto et al., 2017)

suppressible

(Igaki et al., 2006)

Atg13|Ras85D|scrib

suppressible

(Katheder et al., 2017)

suppressible

(Katheder et al., 2017)

suppressible

(Katheder et al., 2017)

suppressible

(Katheder et al., 2017)

Atg13|Ras85D|scrib

suppressible

(Katheder et al., 2017)

suppressible

(Ma et al., 2014)

suppressible

(Katheder et al., 2017, Wu et al., 2010, Srivastava et al., 2007, Igaki et al., 2006, Uhlirova and Bohmann, 2006)

suppressible

(Zhang et al., 2019, Rives-Quinto et al., 2017, Uhlirova et al., 2005, Brumby and Richardson, 2003)

suppressible

(Wei et al., 2021)

enhanceable

(Uhlirova et al., 2005)

suppressible

(Willoughby et al., 2013)

suppressible

(Willoughby et al., 2013)

suppressible

(Külshammer and Uhlirova, 2013)

enhanceable

(Rives-Quinto et al., 2017)

suppressible

(Willoughby et al., 2013)

suppressible

(Brumby and Richardson, 2003)

suppressible

(Brumby and Richardson, 2003)

suppressible

(Hwangbo et al., 2016)

enhanceable

(Hwangbo et al., 2016)

enhanceable

(Parvy et al., 2019)

suppressible

(Parvy et al., 2019)

enhanceable

(Bilder et al., 2000)

suppressible

(Bunker et al., 2015)

suppressible

(Katheder et al., 2017, Wu et al., 2010)

suppressible

(Brumby and Richardson, 2003)

enhanceable

(Ohsawa et al., 2011)

suppressible

(Parisi et al., 2014, Khoo et al., 2013, Igaki et al., 2009)

suppressible

(Katheder et al., 2017, Andersen et al., 2015)

Ras85D|kay|scrib

suppressible

(Külshammer et al., 2015)

suppressible

(Külshammer et al., 2015)

Ras85D|ftz-f1|scrib

suppressible

(Külshammer et al., 2015)

suppressible

(Katheder et al., 2017)

suppressible

(Ma et al., 2017)

Ets21C|Ras85D|scrib

suppressible

(Külshammer et al., 2015)

suppressible

(Külshammer et al., 2015)

suppressible

(Willoughby et al., 2013)

suppressible

(Andersen et al., 2015)

suppressible

(Andersen et al., 2015)

suppressible

(Uhlirova et al., 2005)

suppressible

(Bunker et al., 2015, Wu et al., 2010, Uhlirova et al., 2005)

suppressible

(Brumby and Richardson, 2003)

suppressible

(Khan et al., 2013)

suppressible

(Katheder et al., 2017, Külshammer et al., 2015)

Ets21C|Ras85D|scrib

suppressible

(Külshammer et al., 2015)

enhanceable

(Uhlirova and Bohmann, 2006)

enhanceable

(Bilder et al., 2000)

suppressible

(Brumby and Richardson, 2003)

suppressible

(Sun et al., 2019)

suppressible

(Srivastava et al., 2007, Uhlirova and Bohmann, 2006)

suppressible

(Uhlirova and Bohmann, 2006)

suppressible

(Uhlirova and Bohmann, 2006)

suppressible

(Kong et al., 2021)

enhanceable

(Kong et al., 2021)

suppressible

(Kong et al., 2021)

suppressible

(Willoughby et al., 2013)

suppressible

(Zhang et al., 2019)

suppressible

(Willoughby et al., 2013)

suppressible

(Fedorowicz et al., 1998)

suppressible

(Willoughby et al., 2013)

suppressible

(Willoughby et al., 2013)

suppressible

(Sheng and Du, 2020)

suppressible

(Ding et al., 2022, Sun et al., 2019, Zhang et al., 2019)

suppressible

(Uhlirova and Bohmann, 2006)

suppressible

(Willoughby et al., 2013)

suppressible

(Igaki et al., 2009)

suppressible

(Rives-Quinto et al., 2017)

enhanceable

(Rives-Quinto et al., 2017, Uhlirova and Bohmann, 2006)

suppressible

(Srivastava et al., 2007)

suppressible

(Muzzopappa et al., 2017)

suppressible

(Jiang et al., 2011)

suppressible

(Jiang et al., 2011)

suppressible

(Chabu and Xu, 2014)

suppressible

(Pagliarini and Xu, 2003)

enhanceable

(Fedorowicz et al., 1998)

suppressible

(Bunker et al., 2015)

suppressible

(Wu et al., 2010)

enhanceable

(Tamori et al., 2016)

enhanceable

(Uhlirova and Bohmann, 2006)

suppressible

(Uhlirova and Bohmann, 2006)

suppressible

(Ding et al., 2022)

suppressible

(Ma et al., 2013)

suppressible

(Zhang et al., 2019)

suppressible

(Bunker et al., 2015)

suppressible

(Külshammer and Uhlirova, 2013)

enhanceable

(Wei et al., 2021)

suppressible

(Wei et al., 2021)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Krahn et al., 2010)

enhanceable

(Rives-Quinto et al., 2017)

suppressible

(Bilder et al., 2003, Tanentzapf and Tepass, 2003)

enhanceable

(Tanentzapf and Tepass, 2003)

suppressible

(Brumby et al., 2004)

suppressible

(Silver et al., 2019)

enhanceable

(Read et al., 2005)

suppressible

(Fedorowicz et al., 1998)

enhanceable

(Uhlirova et al., 2005)

enhanceable

(Ito and Igaki, 2021, Kong et al., 2021, Arefin et al., 2017, Uhlirova and Bohmann, 2006, Pagliarini and Xu, 2003)

suppressible

(Uhlirova and Bohmann, 2006)

enhanceable

(Read et al., 2005)

suppressible

(Read et al., 2005)

suppressible

(Tanentzapf and Tepass, 2003)

enhanceable

(Fedorowicz et al., 1998)

enhanceable

(Courbard et al., 2009)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263289

MIST (genetic) - An integrated Molecular Interaction Database

scrib

MIST (protein-protein) - An integrated Molecular Interaction Database

scrib

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Hippo signaling pathway - fly

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-91

Cytogenetic map

Sequence location

3R:26,536,350..26,604,051 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

97C1-97C1

Limits computationally determined from genome sequence between P{lacW}scrib^j7B3 and P{lacW}His2Av^L1602

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

97B-97B

(Bilder, 1999.9.29, Choe et al., 1999)

97B8-97B9

(determined by in situ hybridisation)

(Spradling et al., 1999)

97C-97C

(determined by in situ hybridisation)

(Szeged Stock Center, 1998-, Deak et al., 1997)

97B-97B

(determined by in situ hybridisation)

(Anholt et al., 1996)

97B8-97B9

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

3-91

(FlyBase, 2016)

3-88.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (32)

Aberrations including deletions of this gene Aberrations including duplications of this gene

59079

w^*; P{UAS-scrib.R}B2

59078

w^*; P{UASp-scrib.R}B10

59080

w^*; P{UAS-scrib.RNAi}7L

59081

w^*; P{UAS-scrib.ΔPDZ}B1

59083

w^*; P{UAS-scrib.ΔPDZ.GFP}M5

17791

w¹¹¹⁸; PBac{PB}scrib^c06968

v100363

P{KK106065}VIE-260B

v102821

P{KK103936}VIE-260B

v105412

P{KK101128}VIE-260B

v27430

w¹¹¹⁸ P{GD11666}v27430

v45555

w¹¹¹⁸; P{GD11666}v45555/CyO

v45556

w¹¹¹⁸; P{GD11666}v45556/TM3

More stocks available...

Genomic Clones (61)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (126)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263289

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44448

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Cervantes-Sandoval et al., 2016, Li et al., 2001, Bilder and Perrimon, 2000)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: scrib l(3)c00119

(FlyBase, 1996-)

Source for merge of: scrib l(3)j7B3 l(3)673

(Bilder, 1999.9.28)

Source for merge of: scrib l(3)S042405

(Bilder and Perrimon, 2000)

Source for merge of: scrib CG5462

(Bilder, 2000.3.24)

Source for merge of: scrib vart CG5462

(Bryant, 2000.5.26, Mechler, 2000.4.12)

Source for merge of: scrib smi97B

(Ganguly et al., 2001)

Source for merge of: scrib CG5467

(FlyBase Genome Annotators, 2009)

Source for merge of: scrib CG31082

(FlyBase Genome Annotators, 2011)

Additional comments

Annotations CG42614 and CG31082 merged as CG43398 in release 5.39 of the genome annotation.

(FlyBase Genome Annotators, 2011)

Annotations CG5462 and CG5467 merged as CG42614 in release 5.20 of the genome annotation.

(FlyBase Genome Annotators, 2009)

Other Comments

scrib is required for proper forgetting of olfactory memories.

(Cervantes-Sandoval et al., 2016)

The LRR region of the scrib product is necessary and sufficient to form a polarized epithelial monolayer, provides significant control of cell proliferation, and also regulates its subcellular localization.

(Zeitler et al., 2004)

The PDZ domains of the scrib product are not essential for the development of monolayered epithelia but are involved in providing full control over cell proliferation.

(Zeitler et al., 2004)

scrib is essential for odour guided behaviour.

(Ganguly et al., 2003)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

New annotation (CG31082) in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

scrib specifically restricts apical membrane determinants to the apical cell surface.

(Bilder and Perrimon, 2000)

scrib is required for polarisation of the embryonic, imaginal disc and follicular epithelia. scrib acts as a tumour suppressor.

(Bilder et al., 2000)

Mutations in scrib disrupt cell adhesion, polarity and shape in the ovarian follicular epithelium, the imaginal disc and the embryonic epidermis.

(Bilder and Perrimon, 1999)

Identification: Isolated in a screen for mutants that failure to induce a Dpt-Ecol\lacZ reporter after E.coli injection.

(Choe et al., 1999)

Identified during a screen for olfactory mutants.

(Anholt et al., 1996)

Origin and Etymology

Discoverer

L. and Y. Jan.

Etymology

Named 'scribble' because embryos that are maternally and zygotically mutant for the gene produce a corrugated cuticular surface that is riddled with holes.

(Bilder and Perrimon, 2000)

Identification

External Crossreferences and Linkouts ( 161 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44448

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KRY7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KRY7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KRY7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263289

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263289

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44448/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263289

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263289

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44448

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011397

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG43398

MARRVEL_MODEL - MARRVEL (model organism gene)

44448

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q7KRY7

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

12159-scrib[j7B3]

DroID - A comprehensive database of gene and protein interactions.

FBgn0263289

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Hippo signaling pathway - fly

MIST (genetic) - An integrated Molecular Interaction Database

scrib

MIST (protein-protein) - An integrated Molecular Interaction Database

scrib

Synonyms and Secondary IDs (33)

Reported As

Symbol Synonym

0424/05

(Deak et al., 1997)

CG31082

(Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Yano et al., 2012, Keleman et al., 2009.8.5)

CG42614

(Hosono et al., 2015, Azad et al., 2012, Ni et al., 2011.7.19, FlyBase Genome Annotators, 2009)

CG43398

(FlyBase Genome Annotators, 2011, Ni et al., 2010.12.1)

CG5462

(Rosa-Ferreira et al., 2015, Yoshigi et al., 2013, Christis and Munro, 2012, Klement et al., 2010, Hazelett et al., 2009, Keleman et al., 2009.8.5, Mummery-Widmer et al., 2009, Perkins et al., 2009, Norga et al., 2003, Bryant, 2000.5.26, Mechler, 2000.4.12)

CG5467

(Ashwal-Fluss et al., 2014, Keleman et al., 2009.8.5, Doheny et al., 2008)

CT17324

(Hynes and Zhao, 2000)

MENE (3R)-F

(Menut et al., 2007)

SCR

(Kramer, 2000)

SCRIB

(Jouette et al., 2017, Gonzalez, 2013, Grifoni et al., 2013, Harvey and Hariharan, 2012)

Scb

(Lecuit, 2004)

Scrb

(Heiden et al., 2021, Somorjai and Martinez-Arias, 2008, Kolsch et al., 2007)

Scrib

(van de Leemput et al., 2022, Costa-Rodrigues et al., 2021, Finger et al., 2021, Gogia et al., 2021, Harnish et al., 2021, Lam Wong and Verheyen, 2021, Lu et al., 2021, Mishra et al., 2021, Mysh and Poulton, 2021, Nakajima, 2021, Paraskevopoulos and McGuigan, 2021, Carmena, 2020, Jossin, 2020, Liang et al., 2020, Sun et al., 2020, van Soldt and Cardoso, 2020, Ventura et al., 2020, Bonello and Peifer, 2019, Khadilkar and Tanentzapf, 2019, Ma et al., 2019, Nakajima et al., 2019, Yadav and Srikrishna, 2019, Caria et al., 2018, Carmena, 2018, Stephens et al., 2018, Brüser and Bogdan, 2017, Golub et al., 2017, Lang and Munro, 2017, Richardson and Portela, 2017, Tamori and Deng, 2017, Clavería and Torres, 2016, Flores-Benitez and Knust, 2016, Padash Barmchi et al., 2016, Roman-Fernandez and Bryant, 2016, Schimizzi et al., 2016, Yadav et al., 2016, Bell et al., 2015, Cao et al., 2015, Carvalho et al., 2015, Felix et al., 2015, Irvine and Harvey, 2015, O'Keefe et al., 2015, Peterson and Krasnow, 2015, Turkel et al., 2015, Amoyel and Bach, 2014, Bätz et al., 2014, Wang et al., 2014, Chen and Zhang, 2013, Chintapalli et al., 2013, Khan et al., 2013, Pastor-Pareja and Xu, 2013, Yu and Guan, 2013, Andersen et al., 2012, Azad et al., 2012, Hafezi et al., 2012, Kelsom and Lu, 2012, Liu et al., 2012, Muñoz-Soriano et al., 2012, Tepass, 2012, Cho et al., 2011, Djiane et al., 2011, Genevet and Tapon, 2011, Laprise, 2011, Laprise and Tepass, 2011, Mathew et al., 2011, Miles et al., 2011, Zhao et al., 2011, Laprise et al., 2010, Warner et al., 2010, Zeng et al., 2010, Ramachandran et al., 2009, Romani et al., 2009, Warner and Longmore, 2009, Harris and Tepass, 2008, Mendoza-Topaz et al., 2008, Somorjai and Martinez-Arias, 2008, Zhu et al., 2008, Egger et al., 2007, Gorczyca et al., 2007, Gorfinkiel and Arias, 2007, Kohsaka et al., 2007, Rolls et al., 2007, Guan et al., 2006, Lee et al., 2006, Suzuki and Ohno, 2006, Le Bivic, 2005, Wei et al., 2005, Wu and Beitel, 2004, Caruana, 2002, Santoni et al., 2002)

Scribble

(Noyes et al., 2021)

ird

(Wasserman, 2000)

ird15

(Anholt and Mackay, 2001, Dean et al., 2001, Choe et al., 1999, Choe et al., 1999)

l(3)673

(Kidd et al., 1999, Howe et al., 1995)

l(3)S042405

(Szeged Stock Center, 1998-)

l(3)c00119

l(3)j7B3

(Spradling et al., 1999, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999)

scrb

(Schmidt et al., 2018, Cervantes-Sandoval et al., 2016, Hwangbo et al., 2016, Weber et al., 2012, Thomson and Johnson, 2010)

scrib

(Ding et al., 2022, Ecovoiu et al., 2022, Logeay et al., 2022, Akai et al., 2021, Alvarez-Ochoa et al., 2021, Bilder et al., 2021, Cong et al., 2021, Dillard et al., 2021, Ding et al., 2021, Ferguson et al., 2021, Fic et al., 2021, Gong et al., 2021, Hodgson et al., 2021, Hounsell and Fan, 2021, Ito and Igaki, 2021, Khezri et al., 2021, Kong et al., 2021, Lodge et al., 2021, Manzanero-Ortiz et al., 2021, Mishra et al., 2021, Pang et al., 2021, Parra-Peralbo et al., 2021, Rouka et al., 2021, Sharp et al., 2021, Snigdha et al., 2021, Wei et al., 2021, Wei et al., 2021, Wu et al., 2021, Yamamura et al., 2021, Baker, 2020, Banreti and Meier, 2020, Canales Coutiño et al., 2020, Denton et al., 2020, Feuillette et al., 2020, Jacqueline et al., 2020, Kanda and Igaki, 2020, Khoury and Bilder, 2020, Kushnir et al., 2020, La Marca and Richardson, 2020, Lee et al., 2020, Morata and Calleja, 2020, Sanaki et al., 2020, Sheng and Du, 2020, Baker et al., 2019, Banerjee et al., 2019, Bhattacharjee et al., 2019, Chatterjee and Deng, 2019, Coelho and Moreno, 2019, Fahey-Lozano et al., 2019, Franco and Carmena, 2019, Gui et al., 2019, Khezri and Rusten, 2019, Lahvic and Hariharan, 2019, Li et al., 2019, Luhur et al., 2019, Mirzoyan et al., 2019, Mishra-Gorur et al., 2019, Murcia et al., 2019, Ohsawa, 2019, Parvy et al., 2019, Pinal et al., 2019, Richardson, 2019.11.11, Saavedra and Perrimon, 2019, Silver et al., 2019, Snigdha et al., 2019, Strassburger et al., 2019, Su, 2019, Sun et al., 2019, Sun et al., 2019, Xu et al., 2019, Zhang et al., 2019, Cong et al., 2018, Courgeon et al., 2018, de Vreede et al., 2018, Donohoe et al., 2018, Enomoto et al., 2018, Katsukawa et al., 2018, La Fortezza et al., 2018, Parvy et al., 2018, Richardson and Portela, 2018, Sotillos et al., 2018, Zoranovic et al., 2018, Aw et al., 2017, Baker, 2017, Banerjee and Roy, 2017, Jacqueline et al., 2017, Katheder et al., 2017, Ma et al., 2017, Ma et al., 2017, Muzzopappa et al., 2017, Pérez et al., 2017, Resnik-Docampo et al., 2017, Yamamoto et al., 2017, Aigouy and Le Bivic, 2016, Atkins et al., 2016, Carbone et al., 2016, Cheng et al., 2016, Cloud-Richardson et al., 2016, Gene Disruption Project members, 2016-, Ma et al., 2016, Moreira and Morais-de-Sá, 2016, Tamori et al., 2016, Andersen et al., 2015, Aradska et al., 2015, Bosch et al., 2015, Doggett et al., 2015, Enomoto et al., 2015, Enomoto et al., 2015, Feng and Martin, 2015, Figueroa-Clarevega and Bilder, 2015, Gailite et al., 2015, Grifoni and Bellosta, 2015, Keder et al., 2015, Külshammer et al., 2015, Matthews et al., 2015, Organista et al., 2015, Richardson, 2015.3.11, Ashwal-Fluss et al., 2014, Chabu and Xu, 2014, de Vreede et al., 2014, Johnston, 2014, Kim and Choe, 2014, Liang et al., 2014, Ma et al., 2014, Skwarek et al., 2014, Stickel and Su, 2014, Tipping and Perrimon, 2014, Wang et al., 2014, Westholm et al., 2014, Bangi, 2013, Brown et al., 2013, Harbison et al., 2013, Hirabayashi et al., 2013, Hombría and Serras, 2013, Khan et al., 2013, Khoo et al., 2013, Külshammer and Uhlirova, 2013, Levayer and Moreno, 2013, Ma et al., 2013, Ma et al., 2013, Nakajima et al., 2013, Tamori and Deng, 2013, Willoughby et al., 2013, Yoshigi et al., 2013, Zoranovic et al., 2013, Adamson and Lajeunesse, 2012, Andersen et al., 2012, Aranjuez et al., 2012, Chen et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Justiniano et al., 2012, Nelson et al., 2012, Tan et al., 2012, Weber et al., 2012, Brumby et al., 2011, Goossens et al., 2011, Grusche et al., 2011, Jiang et al., 2011, Kanda et al., 2011, Li et al., 2011, Miles et al., 2011, Ohsawa et al., 2011, Bahri et al., 2010, Cordero et al., 2010, Fichelson et al., 2010, Froldi et al., 2010, Grzeschik et al., 2010, Krahn et al., 2010, Menéndez et al., 2010, Rhiner et al., 2010, Siegrist et al., 2010, Wu et al., 2010, Campbell et al., 2009, Christensen et al., 2009.2.28, Courbard et al., 2009, Igaki et al., 2009, Laprise et al., 2009, Leong et al., 2009, Li et al., 2009, Mao and Freeman, 2009, Rhiner et al., 2009, Chia et al., 2008, Hauenschild et al., 2008, Li et al., 2008, Lighthouse et al., 2008, Pastor-Pareja et al., 2008, Zhao et al., 2008, Buszczak et al., 2007, Firth and Baker, 2007, Grzeschik et al., 2007, Guthridge et al., 2007, Junion et al., 2007, Menut et al., 2007, Mishra and Nigam, 2007, Srivastava et al., 2007, Tountas and Fortini, 2007, Tyler et al., 2007, Igaki et al., 2006, Igaki et al., 2006, Uhlirova and Bohmann, 2006, Wirtz-Peitz and Knoblich, 2006, Wodarz and Gonzalez, 2006, Djiane et al., 2005, Lu and Bilder, 2005, Uhlirova et al., 2005, Albertson et al., 2004, Grifoni et al., 2004, Zeitler et al., 2004, Dow et al., 2003, Mathew et al., 2002)

scribble

(Marques-Reis and Moreno, 2021)

smi97B

(Anholt, 2004, Mackay, 2004, Anholt et al., 2003, Anholt and Mackay, 2001, Dean et al., 2001, Ganguly et al., 2001, Anholt et al., 1996)

vart

(Bryant, 2000.5.26, Mechler, 2000.4.12, Mechler, 1999.12.23)

Name Synonyms

CG5467

Scribble

(Csordás et al., 2021, Gillard et al., 2021, Rice et al., 2021, Kon, 2018, Brüser and Bogdan, 2017, Davis and Zhong, 2017, Lang and Munro, 2017, Ajduk and Zernicka-Goetz, 2016, Bergstralh et al., 2016, Di Gregorio et al., 2016, Padash Barmchi et al., 2016, Bell et al., 2015, Keder et al., 2015, Turkel et al., 2015, Amoyel and Bach, 2014, Bergstralh et al., 2013, Chen and Zhang, 2013, Khan et al., 2013, Levayer and Moreno, 2013, Sotillos et al., 2013, Yu and Guan, 2013, Andersen et al., 2012, Bier and Guichard, 2012, Kelsom and Lu, 2012, Cho et al., 2011, Djiane et al., 2011, Hatan et al., 2011, Hogan et al., 2011, Laprise, 2011, Mateus and Martinez Arias, 2011, Rodrigues et al., 2011, Bahri et al., 2010, Grzeschik et al., 2010, Siegrist et al., 2010, Thomson and Johnson, 2010, Warner et al., 2010, Campbell et al., 2009, Swanson et al., 2009, Warner and Longmore, 2009, Das et al., 2008, Harris and Tepass, 2008, Li et al., 2008, Garcia-Mata and Burridge, 2007, Gorczyca et al., 2007, Khoo et al., 2007, Kohsaka et al., 2007, Ataman et al., 2006, Das et al., 2006, Muschalik et al., 2006, Suzuki and Ohno, 2006, Swanson and Beitel, 2006, Zhao et al., 2006, Margolis and Borg, 2005, Albertson et al., 2004, Rodriguez-Boulan et al., 2004, Wu and Beitel, 2004, Caruana, 2002)

Scribbled

(Khadilkar and Tanentzapf, 2019, Saito et al., 2018, Schmidt and Grosshans, 2018, Nakajima et al., 2013, Tan et al., 2012, Zhu et al., 2008, Kolsch et al., 2007)

Scribbles

(Lecuit, 2004)

gp150-like

(Hynes and Zhao, 2000)

immune response deficient 15

(Choe et al., 1999)

lethal (3) c00119

scribble

(Kim and Jain, 2020, Santoni et al., 2020, Shohayeb et al., 2020, Rosen et al., 2019, Strassburger et al., 2019, Medina, 2018, Rui et al., 2017, Atkins et al., 2016, Hwangbo et al., 2016, Morata and Ballesteros-Arias, 2015, Bergstralh et al., 2013, Harvey et al., 2013, Tamori and Deng, 2013, Zoranovic et al., 2013, Chen et al., 2012, Justiniano et al., 2012, Li et al., 2011, Miles et al., 2011, Cordero et al., 2010, Fichelson et al., 2010, Froldi et al., 2010, Laprise et al., 2010, Rhiner et al., 2010, Tamori et al., 2010, Leong et al., 2009, Li et al., 2009, Newman and Prehoda, 2009, Rhiner et al., 2009, Chia et al., 2008, Lighthouse et al., 2008, Pastor-Pareja et al., 2008, Sambandan et al., 2008, Zhao et al., 2008, Firth and Baker, 2007, Sahota et al., 2007, Tountas and Fortini, 2007, Vidal et al., 2007, Guan et al., 2006, Humbert et al., 2006, Uhlirova and Bohmann, 2006, Uhlirova and Bohmann, 2006, Lu and Bilder, 2005, Wiggin et al., 2005, Zhao et al., 2005, Anholt, 2004, Baas et al., 2004, Brumby et al., 2004, Coffman, 2004, Grifoni et al., 2004, Levine, 2004, Polesello and Payre, 2004, Torban et al., 2004, Zeitler et al., 2004, Brumby and Richardson, 2003, Dow et al., 2003, Humbert et al., 2003, Muller, 2003, Veeman et al., 2003, Roche et al., 2002, Santoni et al., 2002, Schober et al., 2002, Ganguly et al., 2001, Li et al., 2001, Mathew et al., 2001, Bilder, 2000.3.24, Bilder et al., 2000, Bryant and Huwe, 2000, Jan and Jan, 2000, Knust, 2000, Kramer, 2000, Bilder and Perrimon, 1999)

scribbled

(Harbison et al., 2013, Hirabayashi et al., 2013, Willoughby et al., 2013, Yoshigi et al., 2013, Weber et al., 2012, Grusche et al., 2011, Klement et al., 2010, Menéndez et al., 2010, Wu et al., 2010, Hazelett et al., 2009, Hauenschild et al., 2008, Srivastava et al., 2007, Bilder and Perrimon, 1999)

smell impaired 97B

(Anholt et al., 1996)

vartul

(Mechler, 1999.12.23)

Secondary FlyBase IDs

FBgn0261263
FBgn0026178
FBgn0011401
FBgn0016016
FBgn0016937
FBgn0026234
FBgn0028155
FBgn0028975
FBgn0039432
FBgn0069188
FBgn0039433
FBgn0051082

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References (597)