scribbled, smi97B, scrb, ird15, vart
scaffolding protein with multiple PDZ and LLR regions - functions to localize junctional components in the determination of epithelial cell apicobasal polarity - acts with and to distinguish the basolateral domain of epithelial cells and neuroblasts - exhibits antagonistic interactions with the aPKC/Par-6 complex that impacts vesicle trafficking - organizes synaptic architecture and is implicated in learning and memory
Gene model reviewed during 5.47
Gene model reviewed during 5.39
Gene model reviewed during 5.49
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.40
Two sites of polyadenylation reported in FBrf0139743.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scrib using the Feature Mapper tool.
scrib protein is localized to the epithelial septate junction at the boundary of the apical and basolateral cell surfaces.
GBrowse - Visual display of RNA-Seq signalsView Dmel\scrib in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: scrib l(3)c00119
Source for merge of: scrib l(3)j7B3 l(3)673
Source for merge of: scrib l(3)S042405
Source for merge of: scrib CG5462
Source for merge of: scrib smi97B
Source for merge of: scrib CG5467
Source for merge of: scrib CG31082
The LRR region of the scrib product is necessary and sufficient to form a polarized epithelial monolayer, provides significant control of cell proliferation, and also regulates its subcellular localization.
The PDZ domains of the scrib product are not essential for the development of monolayered epithelia but are involved in providing full control over cell proliferation.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
New annotation (CG31082) in release 3 of the genome annotation.
scrib specifically restricts apical membrane determinants to the apical cell surface.
Mutations in scrib disrupt cell adhesion, polarity and shape in the ovarian follicular epithelium, the imaginal disc and the embryonic epidermis.
Identified during a screen for olfactory mutants.
L. and Y. Jan.
Named 'scribble' because embryos that are maternally and zygotically mutant for the gene produce a corrugated cuticular surface that is riddled with holes.