FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Tet
Open Close
General Information
Symbol
Dmel\Tet
Species
D. melanogaster
Name
Ten-Eleven Translocation (TET) family protein
Annotation Symbol
CG43444
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263392
Gene Model Status
Current
Stock Availability
23 publicly available
Enzyme Name (EC)
DNA N(6)-methyladenine demethylase (1.14.11.51)
Gene Summary
Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936838, PubMed:30078725). N(6)-methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression (PubMed:25936838). Promotes differentiation of early germ cells in ovary (PubMed:25936838). Contributes to neuronal morphology, development, and function in the brain (PubMed:30078725). By interacting with histone modifier wds, binds to a specific set of genes, modulates intragenic (N(6)-methyladenosine) DNA levels and thereby maintains transcriptional activation (PubMed:30078725). Also able to catalyze the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:25936838). (UniProt, M9NEY8)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

DMAD, dTet

Key Links
Genomic Location
Cytogenetic map
62F4-63A1
Sequence location
Recombination map
3-4
RefSeq locus
NT_037436 REGION:2786207..2879158
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables DNA N6-methyladenine demethylase activity
inferred from direct assay
(Zhang et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables 2-oxoglutarate-dependent dioxygenase activity
inferred from electronic annotation with InterPro:IPR040175
(InterPro Project Members, 2004-)
enables DNA binding
inferred from electronic annotation with InterPro:IPR002857
(InterPro Project Members, 2004-)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR002857
(InterPro Project Members, 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in DNA modification
inferred from mutant phenotype
(Zhang et al., 2015)
involved_in germ cell development
inferred from mutant phenotype
(Zhang et al., 2015)
involved_in RNA modification
inferred from mutant phenotype
(Delatte et al., 2016)
involved_in transposable element silencing
inferred from mutant phenotype
(Zhang et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in epigenetic regulation of gene expression
inferred from electronic annotation with InterPro:IPR040175
(InterPro Project Members, 2004-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004634693
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from mutant phenotype
(Zhang et al., 2015)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN004634693
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TET family. (M9NEY8)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
DNA N6-methyladenine demethylase activity
an N(6)-methyl-2'-deoxyadenosine in DNA + 2-oxoglutarate + O2 = a 2'-deoxyadenosine in DNA + formaldehyde + succinate + CO2 (1.14.11.51)
RHEA 49524:
Summaries
Gene Group (FlyBase)
UNCLASSIFIED 2-OXOGLUTARATE-DEPENDENT DIOXYGENASES -
This group comprises 2-oxoglutarate-dependent dioxygenases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936838, PubMed:30078725). N(6)-methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression (PubMed:25936838). Promotes differentiation of early germ cells in ovary (PubMed:25936838). Contributes to neuronal morphology, development, and function in the brain (PubMed:30078725). By interacting with histone modifier wds, binds to a specific set of genes, modulates intragenic (N(6)-methyladenosine) DNA levels and thereby maintains transcriptional activation (PubMed:30078725). Also able to catalyze the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:25936838).
(UniProt, M9NEY8)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Tet for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9NEY8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.40

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tet-RA
FBtr0309117
NM_001259652
12592
2860
Tet-RB
FBtr0309118
NM_001259653
12477
2915
Tet-RC
FBtr0309119
NM_139493
9642
2056
Tet-RD
FBtr0309120
NM_001259654
9919
2056
Tet-RE
FBtr0333880
NM_001274414
12610
2866
Tet-RF
FBtr0333881
NM_001274415
12495
2921
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Tet-PA
FBpp0301125
306.7
2860
7.76
M9NEY8
NP_001246581
AFH04252
Tet-PB
FBpp0301126
312.9
2915
7.77
NP_001246582
AFH04253
Tet-PC
FBpp0301127
221.3
2056
7.19
NP_647750
AAF47691
Tet-PD
FBpp0301128
221.3
2056
7.19
NP_001246583
AFH04254
Tet-PE
FBpp0306012
307.4
2866
7.80
NP_001261343
AGB94038
Tet-PF
FBpp0306013
313.6
2921
7.81
NP_001261344
AGB94039
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2056 aa isoforms: Tet-PC, Tet-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts (via C-terminus) with wds (via WD repeats).

(UniProt, M9NEY8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tet using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.63

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval imaginal tissue | restricted
(Grubbs et al., 2013)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
hindgut anlage
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
third instar larval stage
leg disc | ubiquitous
(Grubbs et al., 2013)
antennal disc | ubiquitous
(Grubbs et al., 2013)
eye disc | restricted
(Grubbs et al., 2013)
wing disc | ubiquitous
(Grubbs et al., 2013)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
larval brain
(Delatte et al., 2016)
Additional Descriptive Data

Tet levels are much higher in larval brain than salivary gland or ovary.

(Delatte et al., 2016)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis
nurse cell
(Zhang et al., 2015)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood | male -- day 7 of adulthood | male
spermatozoon
(Wasbrough et al., 2010)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Zhang et al., 2015)
adult stage | female
ovary
(Zhang et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from mutant phenotype
(Zhang et al., 2015)
Expression Deduced from Reporters
Reporter: Mi{PT-GFSTF.0}MI05009-GFSTF.0
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
larval brain
(Delatte et al., 2016)
embryonic/larval optic lobe
(Delatte et al., 2016)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Tet in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tet
Transgenic constructs containing regulatory region of Tet
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation ( 3 )
Gene disrupted in
Df(3L)Exel6091
(Ryder, 2004.4.26)
Df(3L)Exel6092
(Ryder, 2004.4.26)
Gene partially disrupted in
Df(3L)spz5AW18
(Ward et al., 2015)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal - all die before end of larval stage
lethal - all die during P-stage
partially lethal
partially lethal, with Scer\GAL4Tet-MI05009-GAL4
partially lethal (with Df(3L)Exel6091)
partially lethal (with TetMI03920)
partially lethal (with TetMI04973-TG4.0)
partially lethal (with Tetnull)
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority live, with Scer\GAL4GMR25A01
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal flight, with Scer\GAL4Mef2.PR
abnormal locomotor behavior | adult stage
abnormal locomotor behavior | larval stage, with Scer\GAL4Tet-MI04973-TG4.0
abnormal locomotor behavior | larval stage (with Df(3L)Exel6091)
abnormal locomotor behavior | larval stage (with TetMI03920)
abnormal locomotor behavior | larval stage (with Tetnull)
abnormal neuroanatomy | adult stage (with TetMI03920)
abnormal neuroanatomy | adult stage (with Tetnull)
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage (with Df(3L)Exel6091)
abnormal neuroanatomy | larval stage (with TetMI03920)
abnormal neuroanatomy | larval stage (with Tetnull)
increased cell death | larval stage (with TetMI03920)
increased cell death | larval stage (with Tetnull)
increased cell number | adult stage (with TetMI03920)
increased cell number | adult stage (with Tetnull)
increased cell number | larval stage (with TetMI03920)
increased cell number | larval stage (with Tetnull)
increased occurrence of cell division | larval stage (with Df(3L)Exel6091)
increased occurrence of cell division | larval stage (with TetMI03920)
increased occurrence of cell division | larval stage (with Tetnull)
majority die during P-stage (with Tet1)
majority die during P-stage (with Tet2)
majority die during P-stage (with Tetdel-CD)
majority die during P-stage | heat sensitive, with Scer\GAL4αTub84B.PL
short lived, with Scer\GAL4Tet-MI05009-GAL4
short lived (with Df(3L)Exel6091)
short lived (with Tet1)
short lived (with Tet2)
short lived (with Tetdel-CD)
short lived (with TetMI03920)
short lived (with TetMI04973-TG4.0)
short lived (with Tetnull)
some die during embryonic stage
some die during P-stage (with Df(3L)Exel6091)
some die during P-stage (with TetMI03920)
some die during P-stage (with Tetnull)
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult CNS glial cell | increased number (with TetMI03920)
adult CNS glial cell | increased number (with Tetnull)
adult inner optic chiasma giant glial cell (with TetMI03920)
adult inner optic chiasma giant glial cell (with Tetnull)
adult mushroom body (with TetMI03920)
adult mushroom body (with Tetnull)
adult mushroom body beta-lobe (with TetMI03920)
adult mushroom body beta-lobe (with Tetnull)
commissure | larval stage (with Df(3L)Exel6091)
commissure | larval stage (with TetMI03920)
commissure | larval stage (with Tetnull)
female germline cell, with Scer\GAL4VP16.nanos.UTR
female germline stem cell, with Scer\GAL4VP16.nanos.UTR
larval brain | larval stage
larval brain | larval stage (with Df(3L)Exel6091)
larval brain | larval stage (with TetMI03920)
larval brain | larval stage (with Tetnull)
larval glial cell | increased number | larval stage (with TetMI03920)
larval glial cell | increased number | larval stage (with Tetnull)
larval ventral nerve cord | larval stage (with Df(3L)Exel6091)
larval ventral nerve cord | larval stage (with TetMI03920)
larval ventral nerve cord | larval stage (with Tetnull)
medulla | larval stage
mesonotum, with Scer\GAL4pnr-MD237
midline glial cell | larval stage (with Df(3L)Exel6091)
midline glial cell | larval stage (with TetMI03920)
midline glial cell | larval stage (with Tetnull)
mushroom body vertical lobe (with TetMI03920)
mushroom body vertical lobe (with Tetnull)
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (3)
Hsap\TET3
8 of 14
Yes
Yes
1  
Hsap\TET2
6 of 14
No
Yes
Hsap\TET1
5 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (3)
Rnor\Tet3
7 of 14
Yes
Yes
Rnor\Tet2
6 of 14
No
Yes
Rnor\Tet1
3 of 14
No
Yes
Mus musculus (laboratory mouse) (3)
Mmus\Tet2
7 of 14
Yes
Yes
Mmus\Tet3
7 of 14
Yes
Yes
Mmus\Tet1
4 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
Xtro\tet3
6 of 13
Yes
Yes
Xtro\LOC100487424
5 of 13
No
Yes
Xtro\tet2
4 of 13
No
Yes
Xtro\washc5
1 of 13
No
No
Danio rerio (Zebrafish) (3)
Drer\tet3
7 of 14
Yes
Yes
Drer\tet1
6 of 14
No
Yes
Drer\tet2
6 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP007180
9 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Tet. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    TET2; tet methylcytosine dioxygenase 2
    model of  myelodysplastic syndrome
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 3 )
    Allele
    Disease
    Interaction
    References
    TetGD9718
    ameliorates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    TetGD14834
    ameliorates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    TetGD14330
    ameliorates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TET3; tet methylcytosine dioxygenase 3
    8 of 14
    613555
       
      TET2; tet methylcytosine dioxygenase 2
      6 of 14
      612839
      TET1; tet methylcytosine dioxygenase 1
      5 of 14
      607790
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          Interaction Browsers
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Subunit Structure (UniProtKB)
          Interacts (via C-terminus) with wds (via WD repeats).
          (UniProt, M9NEY8 )
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyBase
          External Links
          External Data
          Linkouts
          Class of Gene
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          3L
          Recombination map
          3-4
          Cytogenetic map
          62F4-63A1
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          62F4-63A1
          Limits computationally determined from genome sequence between P{PZ}Spn06911 and P{PZ}l(3)0680306803;
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-4

          (FlyBase, 2016)

          3-5.9

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (23)
          Genomic Clones (64)
          cDNA Clones (114)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Zhang et al., 2015)
          Commercially Available Antibodies
           
          Cell Line Information
          Publicly Available Cell Lines
           
            Other Stable Cell Lines
             
              Other Comments

              Tet mutants show a decrease in RNA hydroxymethylation levels compared to controls (the level of hydroxymethylcytosine in RNA is reduced).

              (Delatte et al., 2016)
              Relationship to Other Genes
              Source for database merge of

              Source for merge of: CG2083 CG9973

              (FlyBase Genome Annotators, 2011)
              Additional comments

              Annotations CG2083 and CG9973 merged as CG43444 in release 5.40 of the genome annotation.

              (FlyBase Genome Annotators, 2011)

              Merge supported by RNA-seq junction and RNA-seq expression data.

              (FlyBase Genome Annotators, 2011)
              Nomenclature History
              Source for database identify of

              Source for identity of: Tet CG43444

              (Dunwell et al., 2013)
              Nomenclature comments
              Etymology
              Synonyms and Secondary IDs (14)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              Study result (0)
              Result
              Result Type
              Title
              External Crossreferences and Linkouts ( 56 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              Linkouts
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              MIST (protein-protein) - An integrated Molecular Interaction Database
              References (96)