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FB2021_04, released August 17, 2021

Gene: Dmel\BubR1

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General Information
Symbol
Dmel\BubR1
Species
D. melanogaster
Name
Bub1-related kinase
Annotation Symbol
CG7838
Feature Type
protein_coding_gene
FlyBase ID
FBgn0263855
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Summary
Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

bub1, l(2)k03113

Key Links
Genomic Location
Cytogenetic map
42A5-42A6
Sequence location
2R:5,969,099..5,974,385 [-]
Recombination map
2-55
RefSeq locus
NT_033778 REGION:5969099..5974385
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000361607
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in female meiosis sister chromatid cohesion
inferred from mutant phenotype
(Malmanche et al., 2007)
involved_in male meiosis sister chromatid cohesion
inferred from mutant phenotype
(Malmanche et al., 2007)
involved_in meiotic sister chromatid cohesion, centromeric
inferred from mutant phenotype
(Malmanche et al., 2007)
involved_in mitotic spindle assembly checkpoint signaling
inferred from mutant phenotype
(Rahmani et al., 2009, Perez-Mongiovi et al., 2005, Basu et al., 1999)
inferred from direct assay
(Logarinho et al., 2004)
involved_in positive regulation of chromatin silencing
inferred from mutant phenotype
(Torras-Llort et al., 2010)
involved_in regulation of exit from mitosis
inferred from mutant phenotype
(Garner et al., 2001)
inferred from genetic interaction with FLYBASE:dup; FB:FBgn0000996
(Garner et al., 2001)
involved_in regulation of mitotic sister chromatid separation
inferred from mutant phenotype
(Rahmani et al., 2009)
involved_in synaptonemal complex organization
inferred from mutant phenotype
(Malmanche et al., 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in meiotic sister chromatid cohesion, centromeric
inferred from biological aspect of ancestor with PANTHER:PTN000361607
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in mitotic spindle assembly checkpoint signaling
inferred from biological aspect of ancestor with PANTHER:PTN000361607
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Buffin et al., 2005)
located_in kinetochore
inferred from direct assay
(Delcros et al., 2006, Buffin et al., 2005, Dzhindzhev et al., 2005, Logarinho et al., 2004)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Bub1-related kinase (BubR1) encodes a motif-rich protein with a C-terminal serine-threonine kinase domain. During prometaphase and metaphase, it plays important roles in spindle assembly checkpoint signalling, stabilization of kinetochore-microtuble attachments and chromosome alignment. It is also essential to maintain sister-chromatid cohesion during meiotic progression and for normal maintenance of Synaptonemal Complex in females. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
OTHER CONVENTIONAL PROTEIN KINASE DOMAIN KINASES -
The group of 'other conventional protein kinase domain kinases' consists of kinases with a conventional eukaryotic protein kinase domain that do not fit into any of the other major groups. This grouping is described in FBrf0201870.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\BubR1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
BubR1-RA
FBtr0086032
NM_058034
4626
1460
Additional Transcript Data and Comments
Reported size (kB)

4.601 (longest cDNA)

(Basu et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
BubR1-PA
FBpp0085368
165.1
1460
6.27
NP_477382
AAF57298
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

1461 (aa); 165 (kD observed); 165 (kD predicted)

(Basu et al., 1999)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\BubR1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data

Bub1 protein is detected at the kinetochore in chromosomes from colchicine treated S2 cells and larval neuroblasts. Bub1 protein shows cell-cycle dependent localization. Diffuse nucleoplasmic staining is detected at interphase. Strong kinetochore localization is found in prophase. This staining is weaker at prometaphase. At metaphase, no Bub1 protein is detected at chromosomes at the metaphase plate. Weak kintetochore staining may be seen in early anaphase, but not in late anaphase or telophase. Localization of Bub1 protein shows a similar dynamic distribution pattern in the first and second meiotic divisions during spermatogenesis.

(Basu et al., 1999)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Buffin et al., 2005)
located_in kinetochore
inferred from direct assay
(Delcros et al., 2006, Buffin et al., 2005, Dzhindzhev et al., 2005, Logarinho et al., 2004)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\BubR1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of BubR1
Transgenic constructs containing regulatory region of BubR1
Aberrations (Deficiencies and Duplications) ( 30 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
partially lethal - majority live
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with BubR1D1326N)
viable (with BubR1k06109)
viable (with BubR1Rev1)
viable (with Df(2R)nap9)
Sterility
Allele
female sterile
female sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
fertile
male fertile
Other Phenotypes
Allele
abnormal cell cycle
abnormal meiotic cell cycle (with BubR1D1326N)
abnormal meiotic cell cycle (with BubR1k06109)
abnormal meiotic cell cycle (with BubR1Rev1)
abnormal meiotic cell cycle (with Df(2R)nap9)
abnormal meiotic cell cycle | recessive
abnormal mitotic cell cycle
abnormal mitotic cell cycle (with BubR1k06109)
abnormal mitotic cell cycle (with BubR1Rev1)
abnormal mitotic cell cycle | embryonic stage 2
abnormal mitotic cell cycle | embryonic stage 3
abnormal mitotic cell cycle | embryonic stage 4
abnormal mitotic cell cycle | recessive
abnormal mitotic cell cycle | third instar larval stage, with BubR1k06109
abnormal mitotic cell cycle | third instar larval stage, with BubR1KEN.mRFP1
abnormal neuroanatomy | larval stage
increased cell death | larval stage
increased cell death | third instar larval stage, with Scer\GAL4en-e16E
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
chromosome
condensed chromosome
condensed chromosome (with BubR1k06109)
condensed chromosome (with BubR1Rev1)
embryonic/larval brain | larval stage
ganglion mother cell | larval stage
imaginal disc
larval neuroblast | larval stage
meiotic cell cycle | male
mitosis & nuclear chromosome
mitotic anaphase
mitotic anaphase & nuclear chromosome
mitotic cell cycle
neuroblast
neuroblast (with BubR1k06109)
neuroblast (with BubR1Rev1)
nucleus
onion stage spermatid
onion stage spermatid & nucleus
spindle
spindle microtubule
trichogen cell, with Scer\GAL4pnr-MD237
wing disc posterior compartment | third instar larval stage, with Scer\GAL4en-e16E
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BUB1
10 of 15
Yes
Yes
Hsap\BUB1B
6 of 15
No
Yes
1  
Hsap\HR
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Bub1
10 of 15
Yes
Yes
Mmus\Bub1b
6 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Bub1
9 of 13
Yes
No
Rnor\Bub1b
5 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\bub1
9 of 12
Yes
Yes
Xtro\bub1b
5 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\bub1
10 of 15
Yes
Yes
Drer\bub1bb
5 of 15
No
Yes
Drer\bub1ba
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\bub-1
6 of 15
Yes
No
Cele\san-1
2 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\AT2G20635
5 of 9
Yes
Yes
Atha\AT5G05510
2 of 9
No
Yes
Atha\BUBR1
2 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\BUB1
8 of 15
Yes
Yes
Scer\MAD3
5 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\bub1
6 of 12
Yes
Yes
Spom\mad3
2 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901AJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012966
Drosophila simulans
Dsim\GD10345
Drosophila sechellia
Dsec\GM16494
Drosophila erecta
Dere\GG10842
Drosophila ananassae
Dana\GF13829
Drosophila pseudoobscura pseudoobscura
Dpse\GA20621
Drosophila persimilis
Dper\GL17789
Drosophila willistoni
Dwil\GK21755
Drosophila virilis
Dvir\GJ18402
Drosophila mojavensis
Dmoj\GI19597
Drosophila grimshawi
Dgri\GH20410
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501KH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17009134
Glossina morsitans
Tsetse fly
Gmor\GMOY008574
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08920
Mayetiola destructor
Hessian fly
Mdes\Mdes006172
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011596
Anopheles darlingi
American malaria mosquito
Adar\ADAC004835
Anopheles darlingi
American malaria mosquito
Adar\ADAC004840
Anopheles gambiae
Malaria mosquito
Agam\AGAP011124
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009759
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01D2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Rhodnius prolixus
Kissing bug
Rpro\RPRC013297
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Bub1
7 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
BubR1DN.UAS
ameliorates  autosomal dominant cerebellar ataxia
modeled by Hsap\ATXN182Q.UAS
(Park et al., 2013)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
BUB1; BUB1 mitotic checkpoint serine/threonine kinase
10 of 15
602452
BUB1B; BUB1 mitotic checkpoint serine/threonine kinase B
6 of 15
602860
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
BubR1|bsk
suppressible
dap
(Wong et al., 2014)
BubR1
enhanceable
Pepck1
(Hussain et al., 2017)
BubR1
enhanceable
Sas-4
(Caous et al., 2015)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
asp
suppressible
BubR1
(Rahmani et al., 2009, Basto et al., 2000)
cid
suppressible
BubR1
(Blower et al., 2006)
dup
suppressible
BubR1
(Garner et al., 2001)
polo
suppressible
BubR1
(Donaldson et al., 2001)
Sas-4
suppressible
BubR1
(Caous et al., 2015)
Sas-4
enhanceable
BubR1
(Caous et al., 2015)
sub
suppressible
BubR1
(Cesario et al., 2006)
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-55
Cytogenetic map
42A5-42A6
Sequence location
2R:5,969,099..5,974,385 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
42A5-42A6
Limits computationally determined from genome sequence between P{PZ}l(2)0985109851&P{lacW}Src42Ak10108 and P{lacW}l(2)k09848k09848&P{EP}EP407
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
42A1-42A2
(determined by in situ hybridisation)
(Spradling et al., 1999)
42A1-42A3
(determined by in situ hybridisation)
(Basu et al., 1999)
42A1-42A2
(BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location

2-55

(FlyBase, 2016)

2-55.7

(Comeron et al., 2012)

2-

(Wakimoto et al., 2004)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (19)
Genomic Clones (13)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (43)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Maia et al., 2007, Logarinho et al., 2004, Basu et al., 1999)
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: BubR1 CG7838

(Logarinho et al., 2004)
Source for database merge of

Source for merge of: BubR1 mcl(2)Z1525

(Malmanche et al., 2007)
Additional comments

Previous molecular and genetic analysis (FBrf0109303) identified the CG7838 annotation as having significant homology to "Bub1" proteins from other organisms (FlyBase curator comment: this resulted in the "CG7838" gene being renamed to "Bub1" in FlyBase). However, the completion of the Drosophila genome revealed the existence of a second annotation, CG14030, that is also closely related to "Bub1" proteins. Higher eukaryotes also have two genes encoding proteins closely related to "Bub1", one of which retains the symbol "Bub1", while the other is called "BubR1". From phylogenetic analysis including both CG7838 and CG14030 it is difficult to determine unequivocally which gene codes for "Bub1" and which gene codes for "BubR1". However, functional analysis of these proteins in FBrf0174806 suggests that CG14030 encodes the homolog of Bub1 (FlyBase curator comment: as a consequence of this, the gene corresponding to the CG7838 annotation has been renamed "BubR1" and the gene corresponding to the CG14030 annotation has been renamed "Bub1" in FlyBase).

(Logarinho et al., 2004)
Other Comments

RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

(Goshima et al., 2007)

dsRNA against this gene has been used to treat SL2 cells to study the effect of depletion of BubR1 on the spindle checkpoint.

(Muller et al., 2006)

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, aneuploidy, an increase in mitotic index, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells, a whole range of mitotic abnormalities, central spindle defects, chromosome abnormalities, and lagging chromatids are seen.

(Bettencourt-Dias et al., 2004)

BubR1 has a role in blocking exit from mitosis.

(Garner et al., 2001)

Loss of function mutations in BubR1 cause severe mitotic abnormalities consistent with accelerated transit through metaphase.

(Basu et al., 1999)

Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

(Roch et al., 1998)
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 43 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DRscDB
EMBL-EBI Single Cell Expression Atlas
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
DroID - A comprehensive database of gene and protein interactions.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (20)
Reported As
Symbol Synonym
31/13
(Roch et al., 1998)
BUB1
(Williams et al., 2003)
BUBR1
(Heun et al., 2006)
BcDNA:LD23835
Bub1
(De Lucia et al., 2005)
BubR1
(Khan et al., 2021, Cunha-Silva et al., 2020, Tang et al., 2020, Huang et al., 2019, Levis, 2018.8.30, Resende et al., 2018, Tsui et al., 2018, Das et al., 2016, Derive et al., 2015, Liang et al., 2014, Rowshanravan et al., 2014, Rubin et al., 2014, Sopko et al., 2014, Wong et al., 2014, Cane et al., 2013, Cipressa and Cenci, 2013, Conde et al., 2013, Feijão et al., 2013, Morais da Silva et al., 2013, Park et al., 2013, Schertel et al., 2013, Althoff et al., 2012, Delgehyr et al., 2012, Di Stefano et al., 2011, Neumüller et al., 2011, Przewloka et al., 2011, Shieh and Bonini, 2011, Toku et al., 2011, Venkei et al., 2011, Li et al., 2010, Nishiyama et al., 2010, Oliveira et al., 2010, Podhraski et al., 2010, Royou et al., 2010, Schittenhelm et al., 2010, Torras-Llort et al., 2010, Bucciarelli et al., 2009, Graham et al., 2009, Lince-Faria et al., 2009, Martins et al., 2009, Matos et al., 2009, Rahmani et al., 2009, Schittenhelm et al., 2009, Kwon et al., 2008, Pauli et al., 2008, Wen et al., 2008, Buffin et al., 2007, Garcia et al., 2007, Gilliland et al., 2007, Lehner et al., 2007, Li et al., 2007, Maia et al., 2007, Orr et al., 2007, Pandey et al., 2007, Blower et al., 2006, Cesario et al., 2006, Delcros et al., 2006, Laycock et al., 2006, Muller et al., 2006, Buffin, 2005, Buffin et al., 2005, Buffin et al., 2005, Dzhindzhev et al., 2005, Goshima and Vale, 2005, Heeger et al., 2005, Karess, 2005, Maia and Sunkel, 2005, Malmanche and Sunkel, 2005, Page et al., 2005, Perez-Mongiovi et al., 2005, Royou et al., 2005, Royou et al., 2005, Abad et al., 2004, Bettencourt-Dias et al., 2004, Fischer et al., 2004, Fisk and Winey, 2004, Logarinho et al., 2004, Parks, 2004.5.12, Parry et al., 2003, Maiato et al., 2002)
CG 7838
(Buffin, 2005)
CG7838
(Meadows, 2017.1.11, Hosono et al., 2015, Moutinho-Pereira et al., 2013, Schertel et al., 2013, Ni et al., 2011.7.19, Goshima et al., 2007, Buffin et al., 2005, Logarinho et al., 2004, Jin et al., 2001, Morrison et al., 2000)
DmBUB1
(Tyler-Smith and Floridia, 2000)
DmBubRI
(Oliveira et al., 2010)
Dmbub1
(Lopes et al., 2000)
bub1
(Myster et al., 2004, Deak et al., 2003, Lee and Orr-Weaver, 2003, Champion et al., 2002, Donaldson et al., 2001, Basto et al., 2000, Basu et al., 1999, Basu et al., 1998)
bubR1
(Vicars et al., 2021, Wang et al., 2019, Silva et al., 2018, Duranteau et al., 2016, Caous et al., 2015, Gogendeau et al., 2015, Royou et al., 2010, Torras-Llort et al., 2010, Rahmani et al., 2009, Wainman et al., 2009, Castellanos et al., 2008, Cenci et al., 2008, Musarò et al., 2008, Malmanche et al., 2007, Williams et al., 2007, Cullen et al., 2005, Purdy et al., 2005)
bubr1
(Blower et al., 2006)
dBUB1
(Dobie et al., 1999)
l(2)k03113
(BDGP Project Members, 1994-1999)
l(2)k06109
(Beaton, 2000.1.31)
mcl(2)Z1525
Name Synonyms
Bub1-related kinase
bub related one
(Castellanos et al., 2008)
Secondary FlyBase IDs
  • FBgn0025458
  • FBgn0022226
  • FBgn0069180
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (189)