FlyBase Gene Report: Dmel\CG43736

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG43736 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

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Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG43736 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG43736

View exonic expression by tissue for Dmel\CG43736

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263993

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3771905/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263993

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263993

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG43736

Transgenic constructs containing regulatory region of CG43736

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\F30F8.5

3 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP010890

4 of 12

Yes

Agam\AgaP_AGAP010889

3 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG43736. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

CG43736 - stau

anti tag coimmunoprecipitation, partial DNA sequence identification by hybridization

(Laver et al., 2013)

protein-protein

Physical Interaction

Assay

References

CG43736 - Su(var)205

anti tag coimmunoprecipitation, peptide massfingerprinting

(Alekseyenko et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263993

MIST (protein-protein) - An integrated Molecular Interaction Database

3771905

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis, 2011.11.18)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-18

Cytogenetic map

6E1-6E2

Sequence location

X:6,863,888..6,881,580 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

6E1-6E2

; Limits computationally determined from genome sequence between P{EP}EP1338 and P{EP}inx7^EP1641

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-18

(FlyBase, 2016)

1-19.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

64707

w¹¹¹⁸ PBac{IT.GAL4}CG43736^0313-G4

15098

y¹ P{SUPor-P}CG43736^KG02072/FM7c, sn⁺

62772

w¹¹¹⁸ PBac{IT.GAL4}CG14434^0310-G4 CG43736^0310-G4/FM7a

91562

y^* w¹¹¹⁸ CG43736⁷⁰² P{ey-FLP.N}2 P{neoFRT}19A/FM0; P{PRE.Scr-PS1}Q1

Kyoto

105395

y^* w^* P{GawB}CG43736^NP7207 / FM7c

NIG-Fly

4571R-1

P{NIG.4571R}1

Genomic Clones (25)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (70)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0263993

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Pilot et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG4564 CG4571

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: CG33691 CG33692

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG33691 and CG33692 merged as CG43736 in release 5.44 of the genome annotation. Merge supported by stop codon read-through analysis (FBrf0216884).

(FlyBase Genome Annotators, 2012)

Dicistronic annotation CG32737 split out into separate annotations for each open reading frame, CG33691 and CG33692, in release 4.2 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG14433

CG32737

(Quinones-Coello, 2007, Müller et al., 2005, Harbison et al., 2004, Giot et al., 2003)

CG32737 ORF A

(Pilot et al., 2006)

CG32737-ORFA

CG32737-ORFB

CG33691

(Nil et al., 2019, Hosono et al., 2015, Antao et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Carreira et al., 2011, Jungreis, 2011.11.18, Quinones-Coello, 2007, FlyBase Genome Annotators, 2002-2003)

CG33692

(FlyBase Genome Annotators, 2002-2003)

CG43736

(Kennison, 2020.10.22, Meyer-Nava et al., 2020, Clandinin and Owens, 2016-, Alekseyenko et al., 2014, Laver et al., 2013, FlyBase Genome Annotators, 2012)

CG4564

(Pilot et al., 2006)

CG4571

Name Synonyms

Secondary FlyBase IDs

FBgn0064122
FBgn0029916
FBgn0029917
FBgn0052737
FBgn0053691
FBtr0070996
FBpp0070956
FBtr0070997
FBtr0070998
FBpp0070958
FBtr0070999
FBgn0064121
FBgn0029918
FBgn0053692
FBpp0070957
FBpp0070959

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 80 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3771905

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PGK3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PGK3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0263993

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3771905/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263993

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263993

InterPro - A database of protein families, domains and functional sites

Zinc finger CCHC domain-containing protein 10

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43736

MARRVEL_MODEL - MARRVEL (model organism gene)

3771905

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0263993

DroID - A comprehensive database of gene and protein interactions.

FBgn0263993

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263993

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004778

MIST (protein-protein) - An integrated Molecular Interaction Database

3771905

References (29)

The following external sites may use different assemblies or annotations than FlyBase.

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Report Sections