FlyBase Gene Report: Dmel\Hmx

General Information

Symbol

Dmel\Hmx

Species

D. melanogaster

Name

H6-like-homeobox

Annotation Symbol

CG43748

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264005

Gene Model Status

Current

Stock Availability

22 publicly available

Gene Summary

Transcription factor involved in specification of neuronal cell types. (UniProt, Q9VEI9)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

90B4-90B5

Sequence location

3R:17,558,930..17,569,097 [+]

Recombination map

3-61

RefSeq locus

NT_033777 REGION:17558930..17569097

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

inferred from sequence or structural similarity with UniProtKB:Q9NP08

(Gene Ontology Curators, 2002-)

inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR020479

(InterPro Project Members, 2004-)

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002518681

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR017970

(InterPro Project Members, 2004-)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002518681

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in negative regulation of DNA-templated transcription

inferred from sequence or structural similarity with UniProtKB:Q9NP08

(Gene Ontology Curators, 2002-)

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR017970

(InterPro Project Members, 2004-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN002518681

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002518681

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Belongs to the HMX homeobox family. (Q9VEI9)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS -: NK-like (NKL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. NKL transcription factors are homeobox genes closely related to Hox-like genes, a number of which are found in the NK cluster. Many of the NKL members contain an Engrailed Homology 1 (EH1) motif. (Adapted from FBrf0232555 and PMID:22094586).

Protein Function (UniProtKB)

Transcription factor involved in specification of neuronal cell types.

(UniProt, Q9VEI9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Hmx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VEI9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216885.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Hmx-RC

FBtr0330385

NM_169763

2691

592

Hmx-RD

FBtr0330386

NM_001275745

2691

718

Hmx-RE

FBtr0346339

NM_001300447

3384

592

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Hmx-PC

FBpp0303411

62.6

592

8.74

FBpp0303412

75.9

718

7.03

FBpp0312056

62.6

592

8.74

Q9VEI9

NP_001287376

AHN57375

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

592 aa isoforms: Hmx-PC, Hmx-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hmx using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hmx_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.57

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5 -- 12

procephalic neurogenic region | restricted

(Wang et al., 2000)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

central brain primordium

(Fisher et al., 2012)

embryonic stage 10 -- 12

procephalic neuroblast

(Wang et al., 2000)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

embryonic stage 11 -- 14

ventral nerve cord primordium | restricted | segmentally repeated

Comment: single cluster of neuronal precursors per hemisegment

(Wang et al., 2000)

embryonic stage 13

germ band | dorsal | segmentally repeated

(Wang et al., 2000)

embryonic stage 13 -- 15

protocerebrum primordium | restricted

(Wang et al., 2000)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic optic lobe primordium | restricted

(Wang et al., 2000)

embryonic stage 15 -- 16

larval ventral nerve cord | restricted | segmentally repeated

Comment: two clusters of neuronal precursors per hemisegment

(Wang et al., 2000)

Additional Descriptive Data

Hmx transcript is first expressed at cellular blastoderm, in bilateral dorsolateral patches in the procephalic neurogenic region, located at about 75% egg length. At embryonic stage 8, a second pair of patches of expression appear 3-4 cell lengths posterior to the first pair, just anterior to the cephalic furrow. At embryonic stage 9, a third pair of patches of expression, anterior to the first pair, appears as the central and posterior patches become fragmented. At embryonic stage 10, Hmx-expressing neuroblasts develop in the Hmx-expressing areas of the procephalic neurogenic region. At stages 13-14, expression is localized to three regions of the protocerebrum primordium. At late stages Hmx is expressed in the embryonic optic lobes. Expression is also observed from stage 11 in a single cluster of neurogenic precursors in each hemisegment of the ventral neurogenic region. By stage 15, Hmx is expressed in two clusters per hemisegment of the ventral nerve cord.

(Wang et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Hmx in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hmx

View exonic expression by tissue for Dmel\Hmx

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264005

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42110/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264005

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264005

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hmx

Transgenic constructs containing regulatory region of Hmx

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Hmx^MI02025

lethal, with Scer\GAL4^pnr-MD237

Hmx^GD4361

lethal | male limited, with Scer\GAL4^Bx-MS1096

Hmx^{UAS.ORF.GW.Tag:HA}

viable

Hmx^{MI02025-GFSTF.2}

viable, with Scer\GAL4^Mef2.PR

Hmx^GD9519

viable, with Scer\GAL4^tin.CΔ4

Hmx^GD9519

Other Phenotypes

Allele

abnormal flight, with Scer\GAL4^Mef2.PR

Hmx^GD9519

visible | female limited, with Scer\GAL4^Bx-MS1096

Hmx^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

wing | female limited, with Scer\GAL4^Bx-MS1096

Hmx^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (113)

Hsap\HMX1

7 of 14

Yes

Hsap\HMX3

7 of 14

Yes

Hsap\HMX2

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DUX4L7

1 of 14

Yes

Hsap\DUX4L9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (69)

Rnor\Hmx3

7 of 14

Yes

Rnor\Hmx1

6 of 14

Yes

Rnor\Hmx2

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (74)

Mmus\Hmx1

7 of 14

Yes

Mmus\Hmx3

7 of 14

Yes

Mmus\Hmx2

4 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rhox3f

1 of 14

Yes

Mmus\Rhox3h

1 of 14

Yes

Mmus\Tlx1

1 of 14

Mmus\Tlx2

1 of 14

Mmus\Tlx3

1 of 14

Xenopus tropicalis (Western clawed frog) (93)

Xtro\hmx1

6 of 13

Yes

Xtro\hmx3

5 of 13

Yes

Xtro\hmx2

4 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (100)

Drer\hmx3a

8 of 14

Yes

Drer\hmx1

7 of 14

Yes

Drer\hmx3b

5 of 14

Yes

Drer\hmx2

4 of 14

Yes

Drer\hmx4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (34)

Cele\mls-2

5 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (41)

Agam\AgaP_AGAP000488

8 of 12

Yes

4 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (31)

Atha\HB-1

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\HMRA1

1 of 13

Yes

Scer\YOX1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\phx1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Hmx. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (74)

NK7.1

5 of 13

slou

4 of 13

bap

3 of 13

B-H2

3 of 13

bsh

3 of 13

btn

3 of 13

CG18599

3 of 13

Dbx

3 of 13

Dfd

3 of 13

Dll

3 of 13

ems

3 of 13

exex

3 of 13

ftz

3 of 13

H2.0

3 of 13

HGTX

3 of 13

inv

3 of 13

lms

3 of 13

tin

3 of 13

unpg

3 of 13

zen2

3 of 13

zen

3 of 13

abd-A

2 of 13

Abd-B

2 of 13

Antp

2 of 13

bcd

2 of 13

B-H1

2 of 13

C15

2 of 13

cad

2 of 13

CG11085

2 of 13

CG34031

2 of 13

eve

2 of 13

hbn

2 of 13

HHEX

2 of 13

ind

2 of 13

lab

2 of 13

lbe

2 of 13

lbl

2 of 13

Lim1

2 of 13

otp

2 of 13

Pph13

2 of 13

scro

2 of 13

Scr

2 of 13

Ubx

2 of 13

vnd

2 of 13

Awh

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

eyg

1 of 13

Gsc

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

prd

1 of 13

Ptx1

1 of 13

toy

1 of 13

tup

1 of 13

unc-4

1 of 13

Vsx1

1 of 13

Vsx2

1 of 13

vvl

1 of 13

zfh1

1 of 13

zfh2

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

HMX1; H6 family homeobox 1

model of oculoauricular syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HMX1; H6 family homeobox 1

7 of 14

142992

OCULOAURICULAR SYNDROME; OCACS

oculoauricular syndrome

HMX3; H6 family homeobox 3

7 of 14

613380

HMX2; H6 family homeobox 2

4 of 14

600647

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hmx - CG46385

two hybrid

(Hu et al., 2017.6.13)

Hmx - hale

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264005

MIST (protein-protein) - An integrated Molecular Interaction Database

42110

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis, 2011.11.18)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-61

Cytogenetic map

90B4-90B5

Sequence location

3R:17,558,930..17,569,097 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

90B4-90B5

Limits computationally determined from genome sequence between P{PZ}l(3)07882⁰⁷⁸⁸² and P{EP}cpo^EP3679

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-61

(FlyBase, 2016)

3-59.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (22)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40074

w¹¹¹⁸; P{GMR80C07-GAL4}attP2

40075

w¹¹¹⁸; P{GMR80C08-GAL4}attP2

54276

w¹¹¹⁸; P{GMR80C08-lexA}attP40

54372

w¹¹¹⁸; P{GMR80C09-lexA}attP40

600855

w¹¹¹⁸; P{R80C09-p65.AD}attP40

25233

w¹¹¹⁸; Mi{ET1}Hmx^MB05774

54333

w¹¹¹⁸; P{GMR80C07-lexA}attP40/CyO

60419

y¹ v¹; P{TRiP.HMJ22710}attP40

FlyORF

F004980

M{UAS-Hmx.ORF.3xHA.GW}ZH-86Fb

VDRC

v40128

w¹¹¹⁸; P{GD9519}v40128

v52505

w¹¹¹⁸; P{GD11781}v52505

v318004

PBac{fTRG00011.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264005

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

IP08947

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identified as a PCR fragment amplified using primers for the mammalian H6 homeobox gene family.

Relationship to Other Genes

Source for database merge of

Source for merge of: Hmx CG5832

(Misra, 2000.7.28)

Source for merge of: Hmx CG5829

(FlyBase Genome Annotators, 2007)

Source for merge of: CG18139 Hmx

(FlyBase Genome Annotators, 2012)

Additional comments

Annotations CG18139 and CG34419 merged as CG43748 in release 5.44 of the genome annotation.

(FlyBase Genome Annotators, 2012)

Annotations CG5832 and CG5829 merged as CG34419 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

An Hmx knock in to the Mmus\Hmx3 locus (producing a gene with Hmx expression controlled by Mmus\Hmx3 regulatory sequences) rescues the neuroendocrine and inner ear phenotypes of Mmus\Hmx2^-, Mmus\Hmx3^- double homozygous mice.

(Wang et al., 2004)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG18139

(Yi et al., 2007)

CG34419

(FlyBase Genome Annotators, 2007)

CG43748

(Meadows, 2014.12.12, FlyBase Genome Annotators, 2012, Ni et al., 2010.12.1, Perkins et al., 2009)

CG5829

CG5832

(Popovici et al., 2001, Coulier et al., 2000)

DHmx

(Wang et al., 2004)

Hmx

(Soffers et al., 2025, Pegoraro et al., 2022, Velten et al., 2022, Michki et al., 2021, Quiquand et al., 2021, Lau et al., 2020, Hu et al., 2017.6.13, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Bürglin and Affolter, 2016, Sarov et al., 2016, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Schertel et al., 2015, Iyer et al., 2013, Jungreis, 2011.11.18, Hoskins et al., 2005)

hmx

(DeLuca et al., 2020)

Name Synonyms

CG5829

H6-like-homeobox

(Nagarkar-Jaiswal et al., 2015)

Secondary FlyBase IDs

FBgn0038522
FBgn0085448
FBgn0038521
FBgn0014858
FBgn0038520

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 38 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42110

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

U17647

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VEI9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VEI9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VEI9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264005

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42110/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264005

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264005

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG43748

MARRVEL_MODEL - MARRVEL (model organism gene)

42110

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264005

DroID - A comprehensive database of gene and protein interactions.

FBgn0264005

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hmx_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264005

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012136

MIST (protein-protein) - An integrated Molecular Interaction Database

42110

References (59)

The following external sites may use different assemblies or annotations than FlyBase.

-0.57

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