FlyBase Gene Report: Dmel\Meltrin

General Information

Symbol

Dmel\Meltrin

Species

D. melanogaster

Name

Meltrin

Annotation Symbol

CG7649

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265140

Gene Model Status

Current

Stock Availability

47 publicly available

Enzyme Name (EC)

Gene Summary

Meltrin (Meltrin) encodes an ADAM protein that belongs to the metzincin superfamily of metalloproteases. It is regulated by the homeobox protein encoded by vnd during embryonic development. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Neu3, CT23341, DMeltrin

Key Links

Genomic Location

Cytogenetic map

88C10-88D1

Sequence location

3R:14,664,907..14,697,292 [-]

Recombination map

3-56

RefSeq locus

NT_033777 REGION:14664907..14697292

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables identical protein binding

inferred from physical interaction with FLYBASE:Meltrin; FB:FBgn0265140

(Meyer et al., 2010)

enables metalloendopeptidase activity

inferred from direct assay

(Sapir et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000224844

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR001590

(InterPro Project Members, 2004-)

enables metallopeptidase activity

inferred from electronic annotation with InterPro:IPR024079

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in membrane protein ectodomain proteolysis

inferred from direct assay

(Sapir et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in membrane protein ectodomain proteolysis

inferred from biological aspect of ancestor with PANTHER:PTN002628656

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:P78536

(Gene Ontology Curators, 2002-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001590

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity with UniProtKB:P78536

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

ADAM METALLOPROTEASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

metalloendopeptidase activity

Summaries

Gene Snapshot

Gene Group (FlyBase)

ADAM METALLOPROTEASES -: A Disintegrin And Metalloprotease (ADAM) proteins belong to the metzincin superfamily of metalloproteases. ADAM proteins are characterized by a highly conserved domain organization that generally includes a prodomain, metalloprotease domain, disintegrin-like domain, cysteine rich domain, EGF-like domain, transmembrane domain and a cytoplasmic domain. The metalloprotease domain is attributed to a process known as ectodomain shedding in which it cleaves at cell surfaces to release the ectodomains of membrane proteins. ADAM proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506 and FBrf0211961).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Meltrin for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q6QU65)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Meltrin-RC

FBtr0301498

NM_001032403

5841

1407

Meltrin-RD

FBtr0301499

NM_001032404

4105

975

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Meltrin-PC

FBpp0290713

151.7

1407

7.98

FBpp0290714

107.3

975

7.01

Q400M8

NP_001027576

AAZ83996

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Meltrin using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Meltrin_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.63

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

blastoderm stage

ventral ectoderm anlage

(Stathopoulos et al., 2002)

embryonic stage 4 -- 6

clypeo-labral anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

(Fisher et al., 2012)

organism | gap expression pattern

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 6

ventral neurectoderm lateral zone

(Meyer et al., 2010)

embryonic stage 7 -- 8

clypeo-labral anlage

(Fisher et al., 2012)

hypopharynx anlage

(Fisher et al., 2012)

lateral head epidermis

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 8 -- 11

ventral neurectoderm intermediate zone

(Meyer et al., 2010)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

clypeo-labral primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as head epidermis primordium

(Fisher et al., 2012)

epipharynx primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

embryonic stage 11 -- 14

larval neuroblast

Comment: intermediate colums

(Meyer et al., 2010)

embryonic stage 13 -- 16

embryonic epipharynx

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic stage 14

embryonic/larval tracheal section

(Meyer et al., 2010)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Meyer et al., 2010)

adult stage | male

organism

(Meyer et al., 2010)

adult stage | female

organism

(Meyer et al., 2010)

Additional Descriptive Data

Meltrin is expressed in the neurectoderm at embryonic stage 6. From stages 8-10, expression becomes increasingly segmental and restricted. By stage 11, expression is almost exclusively in two rows of cells along the dorsoventral axis. Based on its co-expressed with ind, it is expressed in intermediate neurectoderm and neuroblasts.

(Meyer et al., 2010)

Meltrin is expressed in lateral stripes in the presumptive neurogenic ectoderm.

(Stathopoulos et al., 2002)

Meltrin is expressed in broad lateral stripes in the presumptive neurogenic ectoderm.

(Stathopoulos et al., 2002)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter or direct label

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic cycle 14

organism | lateral

(Reeves et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in perivitelline space

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: P{ST.lexA::HG}DRH-2

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

wing disc

(Bloomington Drosophila Stock Center, 2019)

larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

ring gland

(Bloomington Drosophila Stock Center, 2019)

corpus cardiacum

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval salivary gland

(Bloomington Drosophila Stock Center, 2019)

Reporter: P{ST.lexA::HG}Meltrin^JPC-10

Stage

Tissue/Position (including subcellular localization)

Reference

Reporter: PBac{602.P.SVS-1}Meltrin^CPTI000218

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

Reporter: PBac{681.P.FSVS-1}Meltrin^CPTI001259

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Meltrin in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Meltrin

View exonic expression by tissue for Dmel\Meltrin

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265140

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772109/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265140

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051314

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265140

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31314

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 28 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Meltrin

Transgenic constructs containing regulatory region of Meltrin

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel8160

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

viable

Meltrin^{MI09878-GFSTF.0}

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

wild-type, with Scer\GAL4^Bx-MS1096

Meltrin^RNAi.UAS.cSa

Phenotype manifest in

Allele

embryo

Meltrin^MB01428

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (44)

Hsap\ADAM19

12 of 14

Yes

Hsap\ADAM12

11 of 14

Yes

Hsap\ADAM33

11 of 14

Yes

Hsap\ADAM8

10 of 14

Yes

Hsap\ADAM15

9 of 14

Yes

Hsap\ADAM9

8 of 14

Yes

Hsap\ADAM28

8 of 14

Yes

Hsap\ADAM7

6 of 14

Yes

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

6 of 14

5 of 14

5 of 14

4 of 14

4 of 14

4 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (34)

Rnor\Adam19

12 of 14

Yes

Rnor\Adam12

10 of 14

Yes

Rnor\Adam33

10 of 14

Yes

Rnor\Adam8

9 of 14

Yes

Rnor\Adam15

8 of 14

Yes

Rnor\Adam28

8 of 14

Yes

Rnor\Adam9

7 of 14

Yes

Rnor\Adam7

6 of 14

Yes

6 of 14

6 of 14

6 of 14

6 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Rnor\Adam26a

1 of 14

Yes

Rnor\Adamts1

1 of 14

Rnor\LOC102550654

1 of 14

Yes

Rnor\LOC103690152

1 of 14

Yes

Mus musculus (laboratory mouse) (40)

Mmus\Adam19

12 of 14

Yes

Mmus\Adam12

11 of 14

Yes

Mmus\Adam33

11 of 14

Yes

Mmus\Adam8

9 of 14

Yes

Mmus\Adam15

9 of 14

Yes

Mmus\Adam28

9 of 14

Yes

Mmus\Adam7

6 of 14

Yes

Mmus\Adam9

6 of 14

Yes

Mmus\Adam20

6 of 14

Yes

Mmus\Adam21

6 of 14

Yes

Mmus\Adam24

6 of 14

Yes

Mmus\Adam25

6 of 14

Yes

Mmus\Adam26a

6 of 14

Yes

Mmus\Adam26b

6 of 14

Yes

Mmus\Adam29

6 of 14

Yes

Mmus\Adam34l

6 of 14

Yes

Mmus\Adam34

6 of 14

Yes

Mmus\Adam39

6 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

5 of 14

Yes

5 of 14

5 of 14

5 of 14

5 of 14

4 of 14

Yes

Mmus\Adam6a

4 of 14

Mmus\Adam6b

4 of 14

Mmus\Adam18

4 of 14

Yes

Mmus\Adam23

4 of 14

Mmus\Adam32

4 of 14

Yes

4 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gm33242

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (34)

Xtro\adam12

9 of 13

Yes

Xtro\adam28.2

8 of 13

Yes

Xtro\adam19

7 of 13

Yes

Xtro\adam28.1

7 of 13

Yes

Xtro\adam9

6 of 13

Yes

Xtro\adam33

6 of 13

Yes

Xtro\adam11

5 of 13

Xtro\LOC100493925

5 of 13

Yes

Xtro\slc16a6

5 of 13

Yes

Xtro\XB990656

5 of 13

Yes

Xtro\adam15

4 of 13

Yes

Xtro\adam22

4 of 13

Xtro\adam23

3 of 13

Xtro\XB5838589

3 of 13

Yes

Xtro\adam28.4

2 of 13

Yes

Xtro\adam10

1 of 13

Xtro\adam17

1 of 13

Xtro\adam28.3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\thsd4

1 of 13

Danio rerio (Zebrafish) (22)

Drer\adam19b

12 of 14

Yes

Drer\adam15

11 of 14

Yes

Drer\adam12b

10 of 14

Yes

Drer\adam8a

9 of 14

Yes

Drer\adam8b

9 of 14

Yes

Drer\adam9

7 of 14

Yes

Drer\adam19a

7 of 14

Yes

Drer\zgc:174164

7 of 14

Yes

6 of 14

6 of 14

6 of 14

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch1073-396h14.1

2 of 14

Yes

Drer\adam12

1 of 14

Yes

Drer\adamts9

1 of 14

Drer\LOC568792

1 of 14

Drer\LOC101882358

1 of 14

Yes

Drer\LOC101884782

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\adm-2

11 of 14

Yes

Cele\unc-71

6 of 14

Cele\F27D9.7

4 of 14

Yes

Cele\tag-275

4 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (11)

Agam\AgaP_AGAP003498

12 of 12

Yes

Agam\AgaP_AGAP013468

6 of 12

Yes

Agam\AgaP_AGAP000974

5 of 12

Agam\AgaP_AGAP003496

4 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\mde10

6 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Meltrin. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (10)

mmd

6 of 13

Kul

2 of 13

kuz

2 of 13

Tace

2 of 13

AdamTS-A

1 of 13

AdamTS-B

1 of 13

loh

1 of 13

Ppn

1 of 13

sona

1 of 13

stl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

ADAM9; ADAM metallopeptidase domain 9

model of cone-rod dystrophy 9

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Meltrin^EY03366

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Feuillette et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADAM19; ADAM metallopeptidase domain 19

12 of 14

603640

ADAM12; ADAM metallopeptidase domain 12

11 of 14

602714

ADAM33; ADAM metallopeptidase domain 33

11 of 14

607114

ADAM8; ADAM metallopeptidase domain 8

10 of 14

602267

ADAM15; ADAM metallopeptidase domain 15

9 of 14

605548

ADAM9; ADAM metallopeptidase domain 9

8 of 14

602713

CONE-ROD DYSTROPHY 9; CORD9

cone-rod dystrophy 9

ADAM28; ADAM metallopeptidase domain 28

8 of 14

606188

ADAM7; ADAM metallopeptidase domain 7

6 of 14

607310

ADAM11; ADAM metallopeptidase domain 11

6 of 14

155120

ADAM20; ADAM metallopeptidase domain 20

6 of 14

603712

ADAM21; ADAM metallopeptidase domain 21

6 of 14

603713

ADAM22; ADAM metallopeptidase domain 22

6 of 14

603709

DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 61; DEE61

developmental and epileptic encephalopathy 61

ADAM23; ADAM metallopeptidase domain 23

6 of 14

603710

ADAM29; ADAM metallopeptidase domain 29

6 of 14

604778

ADAM2; ADAM metallopeptidase domain 2

5 of 14

601533

ADAM30; ADAM metallopeptidase domain 30

5 of 14

604779

ADAM18; ADAM metallopeptidase domain 18

4 of 14

619495

ADAM32; ADAM metallopeptidase domain 32

4 of 14

618602

ADAMDEC1; ADAM like decysin 1

4 of 14

606393

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Meltrin

comigration in non denaturing gel electrophoresis, molecular weight estimation by staining, western blot

(Meyer et al., 2010)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265140

MIST (protein-protein) - An integrated Molecular Interaction Database

3772109

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-56

Cytogenetic map

88C10-88D1

Sequence location

3R:14,664,907..14,697,292 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

88C10-88D1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-56

(FlyBase, 2016)

3-54.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (47)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

12962

P{VT041685-GAL4}attP2

12963

P{VT041694-GAL4}attP2

13804

P{VT041688-GAL4}attP2

13805

P{VT041692-GAL4}attP2

14879

P{VT041689-GAL4}attP2

15222

P{VT041687-GAL4}attP2

14470

P{VT041692-lexA}attP2

15818

P{VT041688-lexA::GADfl}attP2

17280

P{VT041694-lexA::GADfl}attP2

16526

P{VT041694-lexA::GADfl}attP40

VDRC

v102041

P{KK110487}VIE-260B

v3702

w¹¹¹⁸; P{GD124}v3702

More stocks available...

Genomic Clones (33)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (37)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD03917

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265140

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : S2 cell lines expressing circCG32369, circMCPH1, circeIF5B, circrl, circPde11, circCG17715, circzfh2, circTao, circcrol, circdrn, circMeltrin, circpxb, circfru, circdati, circstw, circSarm, circStim, circCG2991, circPvr, circHil, circmub, circsxc, circbnl, and circCG9743 were created. The author reports new stable cell lines S2-circMCPH1, S2-circCG32369, S2-Flag-Ddx56 , and S2-Flag-gw.
(Su et al., 2024)

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: CG31314 CG31385

(Sapir, 2004.1.14)

Source for merge of: Neu3 Meltrin-α

(Sapir et al., 2005)

Additional comments

Annotations CG31314 and CG31385 merged as CG7649 (which corresponds to Neu3) in release 4.2 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Annotation CG7649 split into CG31314 and CG31385 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Meltrin Neu3

(Sapir et al., 2005)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG31314

(Sapir et al., 2005)

CG31385

(Sapir et al., 2005)

CG7649

(Christis and Munro, 2012, Meyer et al., 2010, Ni et al., 2010.12.1, Yu et al., 2010, Keleman et al., 2009.8.5, Asha et al., 2003, Stathopoulos et al., 2002)

CT23341

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

DMeltrin

(Sapir et al., 2005)

FBgn0051314

(Tikhonov et al., 2013)

Meltrin

(Bar et al., 2025, Hunt et al., 2024, Bossen et al., 2023, Olivares et al., 2023, Zhao et al., 2023, Scholl et al., 2021, Feuillette et al., 2020, Meltzer et al., 2019, Everman and Morgan, 2018, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Kockel et al., 2016, Gene Disruption Project members, 2015-)

Neu3

(Titlow et al., 2023, Sandler and Stathopoulos, 2016, Duff et al., 2015, Ashwal-Fluss et al., 2014, Saunders et al., 2013, Korenjak et al., 2012, Reeves et al., 2012, Desalvo et al., 2011, Lott et al., 2011, Campos et al., 2010, Meyer et al., 2010, Skora and Spradling, 2010, Boettiger and Levine, 2009, Liberman and Stathopoulos, 2009, Roeder et al., 2009, Buszczak et al., 2007, Firth and Baker, 2007)

meltrin

(Baassiri et al., 2024, Meyer et al., 2011)

Name Synonyms

DMeltrin

(Sapir et al., 2005)

Meltrin

(Albright et al., 2022, Adebambo et al., 2020, Wu et al., 2018)

Meltrin-like

(Hynes and Zhao, 2000)

Neu3

(Kong et al., 2010)

Neuroectoderm-expressed 3

dMeltrin-alpha

(Sapir and Shilo, 2002)

meltrin

(Meyer et al., 2010)

Secondary FlyBase IDs

FBgn0051314
FBgn0038253
FBgn0051385
FBtr0082972
FBpp0082431
FBtr0082973
FBpp0082432
FBgn0062267

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3772109

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q6QU65

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q6QU65

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0265140

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772109/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265140

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265140

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7649

MARRVEL_MODEL - MARRVEL (model organism gene)

3772109

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265140

DroID - A comprehensive database of gene and protein interactions.

FBgn0265140

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Meltrin_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051314

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265140

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31314

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0265140

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010657

MIST (protein-protein) - An integrated Molecular Interaction Database

3772109

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (101)

The following external sites may use different assemblies or annotations than FlyBase.

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