FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\l(3)neo38
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General Information
Symbol
Dmel\l(3)neo38
Species
D. melanogaster
Name
lethal (3) neo38
Annotation Symbol
CG6930
Feature Type
protein_coding_gene
FlyBase ID
FBgn0265276
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Summary
lethal (3) neo38 (l(3)neo38) encodes an essential regulator of neuromuscular junction and brain development, required at post-embryonic stages. [Date last reviewed: 2021-01-21] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
86E18-86E18
Sequence location
Recombination map
3-51
RefSeq locus
NT_033777 REGION:11765038..11779128
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in brain development
inferred from mutant phenotype
(Reddington et al., 2020)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Reddington et al., 2020)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN004619861
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in heterochromatin
inferred from direct assay
(Swenson et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN009066117
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
lethal (3) neo38 (l(3)neo38) encodes an essential regulator of neuromuscular junction and brain development, required at post-embryonic stages. [Date last reviewed: 2021-01-21]
Gene Group (FlyBase)
C2H2 ZINC FINGER TRANSCRIPTION FACTORS -
Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys2His2 zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).
Gene Model and Products
Number of Transcripts
10
Number of Unique Polypeptides
6

Please see the JBrowse view of Dmel\l(3)neo38 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A0B4KGA3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
l(3)neo38-RA
FBtr0082533
NM_141856
1522
380
l(3)neo38-RB
FBtr0110876
NM_001043243
6236
447
l(3)neo38-RC
FBtr0110877
NM_001043244
2247
447
l(3)neo38-RD
FBtr0305186
NM_001260136
4963
434
l(3)neo38-RF
FBtr0307082
NM_001260130
1417
373
l(3)neo38-RG
FBtr0307083
NM_001260131
3815
360
l(3)neo38-RI
FBtr0307085
NM_001260133
1414
373
l(3)neo38-RJ
FBtr0307086
NM_001260134
3691
360
l(3)neo38-RK
FBtr0307087
NM_001260135
1611
447
l(3)neo38-RL
FBtr0330170
NM_001275556
2247
455
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
l(3)neo38-PA
FBpp0082007
40.4
380
10.08
Q8SZN9
NP_650113
AAF54696
l(3)neo38-PB
FBpp0110176
47.1
447
10.03
Q7KSP5
NP_001036708
AAN13528
l(3)neo38-PC
FBpp0110177
47.1
447
10.03
Q7KSP5
NP_001036709
ABI31165
l(3)neo38-PD
FBpp0293716
45.5
434
10.06
E0R905
NP_001247065
AFH06383
l(3)neo38-PF
FBpp0297925
39.6
373
10.08
A0A0B4K6F4
NP_001247059
AFH06377
l(3)neo38-PG
FBpp0297926
38.1
360
10.10
A0A0B4K6S1
NP_001247060
AFH06378
l(3)neo38-PI
FBpp0297928
39.6
373
10.08
A0A0B4K6F4
NP_001247062
AFH06380
l(3)neo38-PJ
FBpp0297929
38.1
360
10.10
A0A0B4K6S1
NP_001247063
AFH06381
l(3)neo38-PK
FBpp0297930
47.1
447
10.03
Q7KSP5
NP_001247064
AFH06382
l(3)neo38-PL
FBpp0303203
48.1
455
9.99
A0A0B4KGA3
NP_001262485
AGB95867
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

447 aa isoforms: l(3)neo38-PB, l(3)neo38-PC, l(3)neo38-PK
373 aa isoforms: l(3)neo38-PF, l(3)neo38-PI
360 aa isoforms: l(3)neo38-PG, l(3)neo38-PJ
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(3)neo38 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.54

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
organism | subset
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 5
organism | ubiquitous
(Reddington et al., 2020)
embryonic stage 7 -- 8
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
anterior endoderm anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 9 -- 10
ventral nerve cord primordium
(Fisher et al., 2012)
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
larval lateral VNC glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
embryonic stage 14
larval central nervous system
(Reddington et al., 2020)
larval peripheral nervous system
(Reddington et al., 2020)
embryonic stage 15
ventral nerve cord
(Magalhaes et al., 2007)
embryonic brain | restricted
(Magalhaes et al., 2007)
Additional Descriptive Data

l(3)neo38 mRNA is expressed broadly from stage 5 until stage 12 before becoming restricted to a smaller number of tissues, including the central and peripheral

(Reddington et al., 2020)

nervous systems by stage 14.

(Reddington et al., 2020)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in heterochromatin
inferred from direct assay
(Swenson et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\l(3)neo38 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of l(3)neo38
Transgenic constructs containing regulatory region of l(3)neo38
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3R)Exel7310
(Ryder, 2004.4.26)
Df(3R)M-Kx1
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (98)
Hsap\ZNF367
2 of 14
Yes
Yes
Hsap\BCL11B
1 of 14
No
No
Hsap\GLI3
1 of 14
No
No
4  
Hsap\MTF1
1 of 14
No
No
1  
Hsap\OSR1
1 of 14
No
No
Hsap\PRDM1
1 of 14
No
No
Hsap\SP5
1 of 14
No
No
Hsap\SP8
1 of 14
No
No
Hsap\ZBTB7C
1 of 14
No
Yes
Hsap\ZBTB37
1 of 14
No
No
Hsap\ZBTB47
1 of 14
No
No
Hsap\ZFP30
1 of 14
No
Yes
Hsap\ZFP41
1 of 14
No
Yes
Hsap\ZFP62
1 of 14
No
No
Hsap\ZFX
1 of 14
No
Yes
Hsap\ZIC2
1 of 14
No
No
Hsap\ZKSCAN2
1 of 14
No
No
1  
Hsap\ZKSCAN3
1 of 14
No
No
Hsap\ZNF2
1 of 14
No
No
Hsap\ZNF25
1 of 14
No
No
Hsap\ZNF32
1 of 14
No
Yes
Hsap\ZNF48
1 of 14
No
No
Hsap\ZNF75A
1 of 14
No
No
Hsap\ZNF75CP
1 of 14
No
Yes
Hsap\ZNF84
1 of 14
No
No
Hsap\ZNF100
1 of 14
No
No
Hsap\ZNF101
1 of 14
No
Yes
Hsap\ZNF107
1 of 14
No
No
Hsap\ZNF131
1 of 14
No
No
Hsap\ZNF134
1 of 14
No
Yes
Hsap\ZNF148
1 of 14
No
Yes
Hsap\ZNF175
1 of 14
No
No
Hsap\ZNF184
1 of 14
No
No
Hsap\ZNF197
1 of 14
No
No
Hsap\ZNF205
1 of 14
No
No
Hsap\ZNF232
1 of 14
No
Yes
Hsap\ZNF236
1 of 14
No
Yes
Hsap\ZNF286B
1 of 14
No
Yes
Hsap\ZNF287
1 of 14
No
No
Hsap\ZNF302
1 of 14
No
Yes
Hsap\ZNF304
1 of 14
No
No
Hsap\ZNF335
1 of 14
No
No
Hsap\ZNF343
1 of 14
No
No
Hsap\ZNF345
1 of 14
No
No
Hsap\ZNF384
1 of 14
No
No
1  
Hsap\ZNF391
1 of 14
No
Yes
Hsap\ZNF397
1 of 14
No
No
Hsap\ZNF398
1 of 14
No
No
Hsap\ZNF404
1 of 14
No
No
Hsap\ZNF415
1 of 14
No
No
Hsap\ZNF425
1 of 14
No
No
Hsap\ZNF426
1 of 14
No
Yes
Hsap\ZNF431
1 of 14
No
No
Hsap\ZNF439
1 of 14
No
No
Hsap\ZNF444
1 of 14
No
Yes
Hsap\ZNF449
1 of 14
No
No
1  
Hsap\ZNF470
1 of 14
No
No
Hsap\ZNF471
1 of 14
No
No
Hsap\ZNF473
1 of 14
No
No
Hsap\ZNF496
1 of 14
No
Yes
Hsap\ZNF519
1 of 14
No
No
Hsap\ZNF530
1 of 14
No
No
Hsap\ZNF534
1 of 14
No
No
Hsap\ZNF543
1 of 14
No
No
Hsap\ZNF544
1 of 14
No
No
Hsap\ZNF548
1 of 14
No
Yes
Hsap\ZNF559
1 of 14
No
No
Hsap\ZNF560
1 of 14
No
No
Hsap\ZNF570
1 of 14
No
No
Hsap\ZNF583
1 of 14
No
No
Hsap\ZNF586
1 of 14
No
No
Hsap\ZNF605
1 of 14
No
No
Hsap\ZNF611
1 of 14
No
No
Hsap\ZNF613
1 of 14
No
No
Hsap\ZNF660-ZNF197
1 of 14
No
No
Hsap\ZNF680
1 of 14
No
No
Hsap\ZNF683
1 of 14
No
No
Hsap\ZNF692
1 of 14
No
No
Hsap\ZNF700
1 of 14
No
No
Hsap\ZNF710
1 of 14
No
No
Hsap\ZNF711
1 of 14
No
Yes
Hsap\ZNF714
1 of 14
No
No
Hsap\ZNF732
1 of 14
No
No
Hsap\ZNF749
1 of 14
No
No
Hsap\ZNF761
1 of 14
No
No
Hsap\ZNF765-ZNF761
1 of 14
No
No
Hsap\ZNF780B
1 of 14
No
No
Hsap\ZNF786
1 of 14
No
No
Hsap\ZNF791
1 of 14
No
No
Hsap\ZNF808
1 of 14
No
No
Hsap\ZNF835
1 of 14
No
No
Hsap\ZNF860
1 of 14
No
No
Hsap\ZSCAN16
1 of 14
No
No
Hsap\ZSCAN21
1 of 14
No
No
Hsap\ZSCAN22
1 of 14
No
No
Hsap\ZSCAN25
1 of 14
No
No
Hsap\ZSCAN26
1 of 14
No
Yes
Hsap\ZXDC
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (45)
Rnor\Egr4
1 of 14
Yes
No
Rnor\Klf6
1 of 14
Yes
No
Rnor\Klf15
1 of 14
Yes
No
Rnor\LOC682225
1 of 14
Yes
No
Rnor\LOC691254
1 of 14
Yes
No
Rnor\LOC102546572
1 of 14
Yes
Yes
Rnor\LOC102556967
1 of 14
Yes
No
Rnor\Patz1
1 of 14
Yes
Yes
Rnor\Prdm1
1 of 14
Yes
No
Rnor\Prdm10
1 of 14
Yes
Yes
Rnor\Sp4
1 of 14
Yes
No
Rnor\Sp5
1 of 14
Yes
No
Rnor\Sp8
1 of 14
Yes
No
Rnor\Vezf1
1 of 14
Yes
Yes
Rnor\Zbtb7c
1 of 14
Yes
Yes
Rnor\Zbtb47
1 of 14
Yes
No
Rnor\Zfp1
1 of 14
Yes
No
Rnor\Zfp3
1 of 14
Yes
No
Rnor\Zfp7
1 of 14
Yes
No
Rnor\Zfp26
1 of 14
Yes
No
Rnor\Zfp46
1 of 14
Yes
No
Rnor\Zfp62
1 of 14
Yes
No
Rnor\Zfp69
1 of 14
Yes
Yes
Rnor\Zfp78
1 of 14
Yes
No
Rnor\Zfp84
1 of 14
Yes
Yes
Rnor\Zfp90
1 of 14
Yes
No
Rnor\Zfp92
1 of 14
Yes
Yes
Rnor\Zfp136
1 of 14
Yes
Yes
Rnor\Zfp260
1 of 14
Yes
No
Rnor\Zfp287
1 of 14
Yes
No
Rnor\Zfp300
1 of 14
Yes
Yes
Rnor\Zfp317
1 of 14
Yes
No
Rnor\Zfp329
1 of 14
Yes
No
Rnor\Zfp367
1 of 14
Yes
Yes
Rnor\Zfp397
1 of 14
Yes
No
Rnor\Zfp458
1 of 14
Yes
No
Rnor\Zfp583
1 of 14
Yes
No
Rnor\Zfp623
1 of 14
Yes
Yes
Rnor\Zfp637
1 of 14
Yes
Yes
Rnor\Zfp648
1 of 14
Yes
No
Rnor\Zfp707
1 of 14
Yes
No
Rnor\Zfp846
1 of 14
Yes
Yes
Rnor\Zscan2
1 of 14
Yes
No
Rnor\Zscan5b
1 of 14
Yes
Yes
Rnor\Zscan10
1 of 14
Yes
Yes
Mus musculus (laboratory mouse) (59)
Mmus\9130019O22Rik
1 of 14
Yes
Yes
Mmus\Gm4924
1 of 14
Yes
No
Mmus\Gm14443
1 of 14
Yes
No
Mmus\Klf6
1 of 14
Yes
No
Mmus\Klf11
1 of 14
Yes
No
Mmus\Plag1
1 of 14
Yes
Yes
Mmus\Prdm1
1 of 14
Yes
No
Mmus\Sp4
1 of 14
Yes
No
Mmus\Sp5
1 of 14
Yes
No
Mmus\Sp8
1 of 14
Yes
No
1  
Mmus\Zbtb7c
1 of 14
Yes
Yes
Mmus\Zfp3
1 of 14
Yes
Yes
Mmus\Zfp46
1 of 14
Yes
Yes
Mmus\Zfp61
1 of 14
Yes
No
Mmus\Zfp62
1 of 14
Yes
No
Mmus\Zfp69
1 of 14
Yes
Yes
Mmus\Zfp78
1 of 14
Yes
No
Mmus\Zfp92
1 of 14
Yes
Yes
Mmus\Zfp110
1 of 14
Yes
Yes
Mmus\Zfp112
1 of 14
Yes
No
Mmus\Zfp120
1 of 14
Yes
No
Mmus\Zfp128
1 of 14
Yes
No
Mmus\Zfp180
1 of 14
Yes
No
Mmus\Zfp182
1 of 14
Yes
No
Mmus\Zfp184
1 of 14
Yes
No
Mmus\Zfp236
1 of 14
Yes
Yes
Mmus\Zfp260
1 of 14
Yes
No
Mmus\Zfp287
1 of 14
Yes
Yes
Mmus\Zfp300
1 of 14
Yes
No
Mmus\Zfp317
1 of 14
Yes
No
Mmus\Zfp367
1 of 14
Yes
Yes
Mmus\Zfp369
1 of 14
Yes
Yes
Mmus\Zfp383
1 of 14
Yes
Yes
Mmus\Zfp467
1 of 14
Yes
Yes
Mmus\Zfp473
1 of 14
Yes
No
Mmus\Zfp599
1 of 14
Yes
Yes
Mmus\Zfp612
1 of 14
Yes
No
Mmus\Zfp616
1 of 14
Yes
No
Mmus\Zfp629
1 of 14
Yes
No
Mmus\Zfp658
1 of 14
Yes
No
Mmus\Zfp707
1 of 14
Yes
Yes
Mmus\Zfp719
1 of 14
Yes
No
Mmus\Zfp747
1 of 14
Yes
Yes
Mmus\Zfp760
1 of 14
Yes
No
Mmus\Zfp819
1 of 14
Yes
No
Mmus\Zfp846
1 of 14
Yes
No
Mmus\Zfp868
1 of 14
Yes
Yes
Mmus\Zfp869
1 of 14
Yes
Yes
Mmus\Zfp870
1 of 14
Yes
Yes
Mmus\Zfp871
1 of 14
Yes
Yes
Mmus\Zfp950
1 of 14
Yes
No
Mmus\Zfp965
1 of 14
Yes
Yes
Mmus\Zfp973
1 of 14
Yes
Yes
Mmus\Zfp974
1 of 14
Yes
No
Mmus\Zim1
1 of 14
Yes
Yes
Mmus\Zkscan5
1 of 14
Yes
Yes
Mmus\Zkscan14
1 of 14
Yes
No
Mmus\Zscan2
1 of 14
Yes
No
Mmus\Zscan21
1 of 14
Yes
No
Xenopus tropicalis (Western clawed frog) (43)
Xtro\gli1
1 of 13
Yes
No
Xtro\gli3
1 of 13
Yes
No
Xtro\klf5
1 of 13
Yes
No
Xtro\klf10
1 of 13
Yes
No
Xtro\klf12
1 of 13
Yes
No
Xtro\klf15.2
1 of 13
Yes
No
Xtro\klf15
1 of 13
Yes
No
Xtro\LOC100485218
1 of 13
Yes
No
Xtro\LOC100489897
1 of 13
Yes
No
Xtro\LOC100492687
1 of 13
Yes
Yes
Xtro\LOC100493522
1 of 13
Yes
No
Xtro\LOC100493797
1 of 13
Yes
No
Xtro\LOC100495617
1 of 13
Yes
No
Xtro\LOC101731232
1 of 13
Yes
No
Xtro\LOC101734390
1 of 13
Yes
Yes
Xtro\LOC105947706
1 of 13
Yes
No
Xtro\LOC108645295
1 of 13
Yes
No
Xtro\LOC116406487
1 of 13
Yes
No
Xtro\mtf1
1 of 13
Yes
No
Xtro\ovol2
1 of 13
Yes
No
Xtro\plag1
1 of 13
Yes
No
Xtro\prdm1
1 of 13
Yes
No
Xtro\prdm10
1 of 13
Yes
Yes
Xtro\sp3
1 of 13
Yes
No
Xtro\sp5
1 of 13
Yes
No
Xtro\sp8
1 of 13
Yes
No
Xtro\sp9
1 of 13
Yes
No
Xtro\XB5795368
1 of 13
Yes
No
Xtro\zbtb12
1 of 13
Yes
Yes
Xtro\zbtb45
1 of 13
Yes
Yes
Xtro\znf91
1 of 13
Yes
No
Xtro\znf143
1 of 13
Yes
Yes
Xtro\znf276
1 of 13
Yes
Yes
Xtro\znf319
1 of 13
Yes
Yes
Xtro\znf329
1 of 13
Yes
No
Xtro\znf335
1 of 13
Yes
No
Xtro\znf526
1 of 13
Yes
No
Xtro\znf574
1 of 13
Yes
No
Xtro\znf585a
1 of 13
Yes
No
Xtro\znf605
1 of 13
Yes
No
Xtro\znf850
1 of 13
Yes
No
Xtro\znf853
1 of 13
Yes
No
Xtro\znf883l
1 of 13
Yes
No
Danio rerio (Zebrafish) (70)
Drer\drll.3
1 of 14
Yes
No
Drer\e4f1
1 of 14
Yes
Yes
Drer\im:7141269
1 of 14
Yes
No
Drer\klf11a
1 of 14
Yes
No
Drer\LOC557537
1 of 14
Yes
Yes
Drer\LOC100329258
1 of 14
Yes
No
Drer\LOC100329790
1 of 14
Yes
No
Drer\LOC100331219
1 of 14
Yes
No
Drer\LOC100537361
1 of 14
Yes
No
Drer\LOC101884367
1 of 14
Yes
No
Drer\LOC103910897
1 of 14
Yes
No
Drer\LOC108183709
1 of 14
Yes
No
Drer\LOC108183847
1 of 14
Yes
Yes
Drer\LOC108183935
1 of 14
Yes
Yes
Drer\LOC108184006
1 of 14
Yes
No
Drer\LOC110437786
1 of 14
Yes
Yes
Drer\LOC110439557
1 of 14
Yes
No
Drer\plag1
1 of 14
Yes
Yes
Drer\si:ch73-109d9.2
1 of 14
Yes
No
Drer\si:ch73-144d13.4
1 of 14
Yes
Yes
Drer\si:ch73-266f23.4
1 of 14
Yes
Yes
Drer\si:ch73-367f21.6
1 of 14
Yes
No
Drer\si:ch211-202h22.10
1 of 14
Yes
Yes
Drer\si:ch211-216l23.1
1 of 14
Yes
No
Drer\si:ch1073-127d16.1
1 of 14
Yes
No
Drer\si:dkey-77f5.4
1 of 14
Yes
Yes
Drer\si:dkey-122c11.8
1 of 14
Yes
No
Drer\si:dkey-237m9.1
1 of 14
Yes
No
Drer\si:dkey-253d23.5
1 of 14
Yes
No
Drer\si:zfos-932h1.3
1 of 14
Yes
No
Drer\sp1
1 of 14
Yes
No
Drer\sp3a
1 of 14
Yes
No
Drer\sp3b
1 of 14
Yes
No
Drer\sp5a
1 of 14
Yes
No
Drer\sp5b
1 of 14
Yes
No
Drer\sp5l
1 of 14
Yes
No
Drer\sp6
1 of 14
Yes
No
Drer\sp7
1 of 14
Yes
No
Drer\sp8a
1 of 14
Yes
No
Drer\sp9
1 of 14
Yes
No
Drer\wu:fc30c06
1 of 14
Yes
No
Drer\zbtb12.2
1 of 14
Yes
Yes
Drer\zbtb24
1 of 14
Yes
Yes
Drer\zeb2b
1 of 14
Yes
No
Drer\zgc:113135
1 of 14
Yes
Yes
Drer\zgc:113294
1 of 14
Yes
Yes
Drer\zgc:171673
1 of 14
Yes
No
Drer\zgc:174314
1 of 14
Yes
No
Drer\zgc:174624
1 of 14
Yes
No
Drer\znf76
1 of 14
Yes
Yes
Drer\znf143a
1 of 14
Yes
Yes
Drer\znf143b
1 of 14
Yes
Yes
Drer\znf271
1 of 14
Yes
No
Drer\znf281a
1 of 14
Yes
No
Drer\znf281b
1 of 14
Yes
No
Drer\znf319b
1 of 14
Yes
Yes
Drer\znf423
1 of 14
Yes
No
Drer\znf652
1 of 14
Yes
Yes
Drer\znf740a
1 of 14
Yes
Yes
Drer\znf865
1 of 14
Yes
No
Drer\znf970
1 of 14
Yes
No
Drer\znf1007
1 of 14
Yes
No
Drer\znf1040
1 of 14
Yes
No
Drer\znf1068
1 of 14
Yes
No
Drer\znf1072
1 of 14
Yes
No
Drer\znf1078
1 of 14
Yes
Yes
Drer\znf1102
1 of 14
Yes
No
Drer\znf1136
1 of 14
Yes
No
Drer\znf1141
1 of 14
Yes
No
Drer\znf1174
1 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\che-1
1 of 14
Yes
No
Cele\F47E1.20
1 of 14
Yes
Yes
Cele\sptf-3
1 of 14
Yes
No
Cele\znf-782
1 of 14
Yes
No
Anopheles gambiae (African malaria mosquito) (28)
Agam\AgaP_AGAP004178
10 of 12
Yes
Yes
Agam\AgaP_AGAP011548
6 of 12
No
No
Agam\AgaP_AGAP000164
1 of 12
No
No
Agam\AgaP_AGAP001555
1 of 12
No
No
Agam\AgaP_AGAP002705
1 of 12
No
No
Agam\AgaP_AGAP003885
1 of 12
No
No
Agam\AgaP_AGAP004060
1 of 12
No
No
Agam\AgaP_AGAP004081
1 of 12
No
Yes
Agam\AgaP_AGAP004269
1 of 12
No
No
Agam\AgaP_AGAP004285
1 of 12
No
No
Agam\AgaP_AGAP004637
1 of 12
No
No
Agam\AgaP_AGAP004764
1 of 12
No
Yes
Agam\AgaP_AGAP005348
1 of 12
No
No
Agam\AgaP_AGAP005568
1 of 12
No
No
Agam\AgaP_AGAP005573
1 of 12
No
No
Agam\AgaP_AGAP006592
1 of 12
No
No
Agam\AgaP_AGAP006794
1 of 12
No
No
Agam\AgaP_AGAP007915
1 of 12
No
No
Agam\AgaP_AGAP008845
1 of 12
No
No
Agam\AgaP_AGAP008901
1 of 12
No
No
Agam\AgaP_AGAP009010
1 of 12
No
No
Agam\AgaP_AGAP009130
1 of 12
No
No
Agam\AgaP_AGAP009566
1 of 12
No
No
Agam\AgaP_AGAP010926
1 of 12
No
No
Agam\AgaP_AGAP010979
1 of 12
No
Yes
Agam\AgaP_AGAP011566
1 of 12
No
No
Agam\AgaP_AGAP011963
1 of 12
No
Yes
Agam\AgaP_AGAP012834
1 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (16)
Atha\AT1G14580
1 of 13
Yes
No
Atha\AT3G45260
1 of 13
Yes
No
Atha\AT5G22890
1 of 13
Yes
No
Atha\AT5G60470
1 of 13
Yes
No
Atha\DOT5
1 of 13
Yes
Yes
Atha\IDD1
1 of 13
Yes
No
Atha\IDD2
1 of 13
Yes
Yes
Atha\IDD4
1 of 13
Yes
No
Atha\IDD5
1 of 13
Yes
No
Atha\IDD7
1 of 13
Yes
No
Atha\IDD11
1 of 13
Yes
No
Atha\JKD
1 of 13
Yes
No
Atha\MGP
1 of 13
Yes
No
Atha\NTT
1 of 13
Yes
Yes
Atha\NUC
1 of 13
Yes
No
Atha\TT1
1 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:l(3)neo38. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (50)
CG7368
4 of 13
Clamp
2 of 13
Spps
2 of 13
Blimp-1
1 of 13
btd
1 of 13
cbt
1 of 13
Cf2
1 of 13
CG1233
1 of 13
CG1529
1 of 13
CG3065
1 of 13
CG3281
1 of 13
CG4282
1 of 13
CG7691
1 of 13
CG8159
1 of 13
CG10959
1 of 13
CG11902
1 of 13
CG12071
1 of 13
CG12299
1 of 13
CG12391
1 of 13
CG17328
1 of 13
CG17385
1 of 13
CG30431
1 of 13
CG32767
1 of 13
CG32772
1 of 13
CG42741
1 of 13
dar1
1 of 13
erm
1 of 13
esg
1 of 13
gl
1 of 13
hkb
1 of 13
Imzf
1 of 13
jim
1 of 13
Klf15
1 of 13
Kr-h1
1 of 13
luna
1 of 13
MTF-1
1 of 13
Neu2
1 of 13
odd
1 of 13
Opbp
1 of 13
pad
1 of 13
Paris
1 of 13
pita
1 of 13
prg
1 of 13
rgr
1 of 13
scrt
1 of 13
sens
1 of 13
Sp1
1 of 13
spdt
1 of 13
sr
1 of 13
Zif
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    l(3)neo38GD12076
    exacerbates  Machado-Joseph disease
    modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
    (Voßfeldt et al., 2012)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    bw
    suppressible
    l(3)neo38
    (Schneiderman et al., 2010)
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map
    3-51
    Cytogenetic map
    86E18-86E18
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    86E18-86E18
    Limits computationally determined from genome sequence between P{EP}Lk6EP886 and P{PZ}svp07842
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    86F1-86F11
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    86F1-86F11
    (BDGP Project Members, 1994-1999)
    86F-86F
    (determined by in situ hybridisation)
    (Cooley et al., 1988)
    Experimentally Determined Recombination Data
    Location

    3-51

    (FlyBase, 2016)

    3-48.8

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (20)
    cDNA Clones (235)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          New annotation (CG31364) in release 3 of the genome annotation. Annotation CG14725 was eliminated in release 3 of the genome annotation, October 2002.

          (FlyBase Genome Annotators, 2002-2003)

          Not created in release 3 of the genome annotation, April 2002. anon-EST:fe2F4 corresponds to no genome annotation - existence reported in FBrf0098343 and FBrf0120351 based on cDNAs primed from genomic runs of As in intronic or intergenic regions.

          (FlyBase Genome Annotators, 2002-2003)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: l(3)neo38 CG31364

          (Levis, 2003.3.6)

          Source for merge of: l(3)neo38 BcDNA:SD16005

          (FlyBase Genome Annotators, 2006, FlyBase, 1996-)

          Source for merge of: l(3)neo38 anon- EST:fe2F4

          (FlyBase, 1992-)
          Additional comments

          Source for merge of l(3)neo38 BcDNA:SD16005 was a shared cDNA ( date:030728 ).

          (FlyBase Genome Annotators, 2006, FlyBase, 1996-)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (11)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 74 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          References (93)