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General Information
Symbol
Dmel\Bx
Species
D. melanogaster
Name
Beadex
Annotation Symbol
CG44425
Feature Type
FlyBase ID
FBgn0265598
Gene Model Status
Stock Availability
Gene Summary
Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
Also Known As

dLMO, hdp, dttg, fliH, LIM-only

Key Links
Genomic Location
Cytogenetic map
Sequence location
X:18,515,428..18,572,809 [+]
Recombination map
1-60
RefSeq locus
NC_004354 REGION:18515428..18572809
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:pnr; FB:FBgn0003117
inferred from physical interaction with FLYBASE:chianti; FB:FBgn0020863
Terms Based on Predictions or Assertions (0 terms)
Biological Process (11 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
involved_in chaeta development
inferred from mutant phenotype
involved_in gastric emptying
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:ap; FB:FBgn0267978
inferred from mutant phenotype
involved_in locomotor rhythm
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
non-traceable author statement
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Beadex (Bx) encodes a LIM-only protein that regulates activity of LIM-homeodomain proteins such as the product of ap by binding to form hetero-tetramers. It regulates the activity of the product of ap in the wing disc, and presumably other tissues. [Date last reviewed: 2019-03-07]
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Bx: Beadex
Male and homozygous female with Beaded-like wings; long, narrow, and excised along both margins; fully viable. Heterozygous female less extreme and overlaps wild type. Some venation abnormality. Development studied by Goldschmidt [1935, Biol. Zentralbl. 55: 535-54 (fig.)]. According to Waddington (1940), embryological effect is same as that of vg. RK2 (RK3 as Bx/+).
Bx2
thumb
Bx2: Beadex-2
Edith M. Wallace, unpublished.
Wings of males and homozygous females narrowed by marginal excision. Wings often bubbly and ragged. Homozygous female fully viable. Bx2/+ less extreme; overlaps wild type. Classifiable in a single dose in triploids (Schultz, 1934, DIS 1: 55). RK1 (RK3 as Bx2/+).
Bx3
Extreme allele usually without the bubbles in the wing. Shortened L5 a constant character (few Bx2 show this). Wings more pointed than Bx2 and hairs at tip of wing clumped. Third-instar larvae show 20-40 degenerating cells in area of wing disk corresponding to future wing margin (D. Fristrom, 1969, Mol. Gen. Genet. 103: 363-79). Scalloping visible in prepupal wing bud [Waddington, 1940, J. Genet. 41: 75-139 (fig.)]. Bx3 in heterozygous combination with a Bx deficiency or hdp-a has normal wing phenotype (Lifschytz and Green, 1979, Mol. Gen. Genet. 171: 153-59). Bx3/+ fully separable. RK1.
BxJ: Beadex of Jollos
Wings reduced to slender strip; only posterior cell present at tip. BxJ/+ have half and BxJ/BxJ one third the normal number of cells in membrane of wing. Femur shortened or legs otherwise abnormal, especially third pair. Halteres abnormal. Homozygous female viable. Interacts with bi to give more nearly normal wings. The only dominant Bx allele not suppressed by a Bx deficiency [e.g., In(1)ClLy4R] or hdp (Lifschytz and Green, 1979, Mol. Gen. Genet. 171: 153-59). Embryology like Bx [Goldschmidt, 1935, Biol. Zentralbl. 55: 535-54; Waddington, 1940, J. Genet. 41: 75-139 (fig.)]. Clonal analysis of wing disk development indicates massive cell loss during third larval instar. Clones of Bx+ cells in BxJ/+ wings that reach the margin but are confined to the dorsal or ventral surface often cause reconstitution of both surfaces and appearance of marginal elements derived from both surfaces (Santamaria and Garcia-Bellido). RK1. 1975, Wilhelm Roux' Arch. Entwicklungsmech. Organ. 178: 233-45.
Bxr: Beadex-recessive
Bxr/+ is normal. Male and homozygous female show less extreme narrowing of wings than Bx. Anterior crossvein short and thickened and that region blistered. May overlap wild type in old crowded cultures at 25, more extreme at 19. RK3A.
Bxr49k
thumb
Bxr49k: Beadex-recessive 49k
From Green, 1953, Z. Indukt. Abstamm. Vererbungsl. 85: 435-49.
Slight scalloping of posterior wing margin only; overlaps wild type. RK3A.
hdp-a
Wings held up to various degrees; may overlap wild type. hdp-a alleles act as dominant suppressors of Bx in either cis or trans (Lifschytz and Green, 1979, Mol. Gen. Genet. 171: 153-59). Lifschytz and Green consider hdp-a mutants to be hypomorphic or amorphic alleles of a gene that is under cis control of Bx+; Bx mutants cause overproduction hdp-a+ product.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\Bx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Supported by strand-specific RNA-Seq data.

Shares 5' UTR with upstream gene.

Gene model reviewed during 5.50

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 5.44

Stop-codon suppression (UAA) postulated; FBrf0216885.

Gene model reviewed during 5.40

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0340364
2494
313
FBtr0340365
2051
384
FBtr0340366
3413
313
FBtr0340367
2494
424
FBtr0340363
2309
383
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0309322
32.7
313
7.88
FBpp0309323
41.2
384
6.98
FBpp0309324
32.7
313
7.88
FBpp0309325
43.1
424
8.49
FBpp0309321
40.0
383
7.08
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

313 aa isoforms: Bx-PA, Bx-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Bx using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data

There are two major transcript classes and two promoters for Bx and they show differential expression. Transcripts initiating from the upstream promoter show expression in the wing disc which is restricted to the dorsal compartment and is observed in the wing pouch and notum. Transcripts initiating from the downstream promoter are detected in the wing dics only near the hinge on both the dorsal and ventral sides and are not detected in the notum.

There are two major transcript classes and two promoters for Bx and they show differential expression. Transcripts initiating from the upstream promoter are observed in the wing disc in the dorsal compartment and are also observed in the wing pouch and notum. Transcripts initiating from the downstream promoter are detected in the wing dics only near the hinge on both the dorsal and ventral sides and are not detected in the notum.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
wing disc

Comment: expression level is higher than in second instar discs

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}BxMS1096
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}Bxpdrm
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Bx in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 101 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Bx
Transgenic constructs containing regulatory region of Bx
Aberrations (Deficiencies and Duplications) ( 19 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
1  
7 of 15
No
Yes
1  
2 of 15
No
Yes
1  
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1  
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
8 of 15
Yes
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
7 of 13
Yes
Yes
4 of 13
No
Yes
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (7)
2 of 12
Yes
Yes
2 of 12
Yes
No
2 of 12
Yes
No
1 of 12
No
No
1 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (12)
8 of 15
Yes
Yes
8 of 15
Yes
Yes
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190GXR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150EKR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0H90 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HAV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0LKW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (7)
3 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-60
    Cytogenetic map
    Sequence location
    X:18,515,428..18,572,809 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    17C1-17C1
    Limits computationally determined from genome sequence between P{EP}CG32549EP1317 and P{EP}EP443EP443&P{EP}BxEP1383
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    17C1-17C2
    Limits computationally determined from genome sequence between P{EP}CG32549EP1317 and P{EP}EP443EP443&P{EP}BxEP1383; (determined by in situ hybridisation)
    17C-17C
    (determined by in situ hybridisation)
    17C2-17C3
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes

    hdp-a maps to the left of Bx3: 0.0045

    Stocks and Reagents
    Stocks (31)
    Genomic Clones (29)
    cDNA Clones (72)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    RNAi and Array Information
    Linkouts
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Bx CG6500

    Source for database merge of

    Source for merge of: Bx Lmo

    Source for merge of: Bx hdp-a Lmo

    Source for merge of: Source for merge of: Bx CG15048

    Additional comments

    Annotations CG6500 and CG15048 merged as CG44425 in release 5.50 of the genome annotation. Merge supported by RNA-seq junction data.

    The "mgg, maggot" complementation group does not correspond to Bx ("hdp" loss of function alleles of "Bx" complement the lethal "mgg" alleles), but rather to one of the two distal neighbouring genes, CG15042 or CG15047.

    FlyBase curator comment: "EP443" overexpression phenotype stated to be due to its effect on Bx but orientation of the P{EP} element suggests otherwise.

    FlyBase curator comment: FBrf0104769 suggests that the "mgg, maggot" complementation group may be allelic to Bx (based on non-complementation of mgg[3E] with mutations generated by excision of insertions in the Bx region). However, FBrf0205286 shows that mgg mutants are not allelic to Bx, but rather mgg corresponds to one of the two distal neighbouring genes, CG15042 or CG15047.

    At least three different genetic entities appear to have been designated "hdp" on the basis of similarity of phenotype and map position to the now-lost "hdp" of Fahmy and Fahmy (FBrf0063418). Deak (FBrf0030355) so designated "wup-A" of Hotta and Benzer (FBrf0024284). Lifschytz and Green (FBrf0033647) selected reversions and suppressors of "Bx", both of which had a "held-up" phenotype and were so designated. Engels and Preston (FBrf0035947) selected P-element induced sex-linked mutants with held-up wings; 93% are associated with chromosome rearrangements with one breakpoint in 17C2-3; the other 7% are not associated with rearrangements and act as suppressors of Bx1; the latter group of mutants complement both the other 93% of mutants recovered by Engels and Preston and those described by Deak. Lindsley and Zimm (FBrf0066905) resurrected the name "wupA: wingsupA" for the mutants studied by Deak anddesignated the Bx suppressors "hdp-a" and the mutants associated with 17C2-3 breakpoints "hdp-b". In addition Fahmy (FBrf0063418) describes "rwg": reduced wings, a mutant with the same map position and a slightly different phenotype from other held-up-like mutants; Lindsley and Zimm (FBrf0066905) arbitrarily designated it an "hdp-a" allele. Relation between "hdp-a" and "hdp-b" unclear, they are in the same polytene bands but complement each other completely. They are separated by Bx (Mattox).

    Other Comments

    Bx is required in motor neurons for normal fecundity and fertility.

    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

    Over expression 'Beadex' mutations and loss of function 'heldup-a' mutations affect the 3' regulatory and coding components, respectively, of the Bx gene.

    In analogy to their vertebrate counterparts, the gene products of Bx, ap and Chi form a DNA-binding complex, that regulates wing development.

    A wing margin mutation that interacts additively with ct.

    Isolated from a genomic library using a human rhombotin cDNA fragment as a probe, under low stringency conditions.

    Suppression used to select null alleles or deficiencies from treated wild type or Bx3 chromosomes; seven derivatives of Bx3 and those of Bx+ all have "hdp-a" effects as well.

    Bx1 interpreted as mutation in cis-acting control element causing overproduction of hdp-a gene product. Tandem duplication of Bx+(e.g. Bxr) has recessive effect; tandem triplication and quadruplication have dominant Bx effects in combination with a normal X, but not in combination with "hdp-a" alleles or a Bx deficiency. Amorphic or extreme hypomorphic Bx mutations and deficiencies for Bx act as trans-suppressors of Bx1.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 94 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    Linkouts
    DroID - A comprehensive database of gene and protein interactions.
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (32)
    Reported As
    Symbol Synonym
    Ptd
    Rho
    beadex/dLMO
    hdp-a
    Secondary FlyBase IDs
    • FBgn0001183
    • FBgn0000242
    • FBgn0004958
    • FBgn0015251
    • FBgn0030935
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (209)