FlyBase Gene Report: Dmel\Su(z)2

General Information

Symbol

Dmel\Su(z)2

Species

D. melanogaster

Name

Suppressor of zeste 2

Annotation Symbol

CG3905

Feature Type

protein_coding_gene

FlyBase ID

FBgn0265623

Gene Model Status

Current

Stock Availability

29 publicly available

Gene Summary

Suppressor of zeste 2 (Su(z)2) encodes a protein that regulates gene expression by modifying epigenetic marks. The gene is related to Psc and was orginally identified due to its ability to suppress transvection at z. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

Suppressor 2 of zeste, Su(z)2D, Arp, l(2)k06344, Suppressor of zeste two

Key Links

Genomic Location

Cytogenetic map

49E7-49E7

Sequence location

2R:12,996,501..13,007,911 [+]

Recombination map

2-67

RefSeq locus

NT_033778 REGION:12996501..13007911

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables DNA binding

inferred from direct assay

(Lo et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables metal ion binding

inferred from electronic annotation with InterPro:IPR018957

(InterPro Project Members, 2004-)

enables promoter-specific chromatin binding

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in heterochromatin formation

inferred from direct assay

(Lo et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in negative regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Lo et al., 2009)

part_of PRC1 complex

inferred from direct assay

(Lo et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of PRC1 complex

inferred from biological aspect of ancestor with PANTHER:PTN000850589

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

POLYCOMB REPRESSIVE COMPLEX 1, SU(Z)2 VARIANT -: The Polycomb repressive complex 1 (PRC1) is a Polycomb group complex. It binds to histone H3K27me3 (histone H3 K27 methylation is catalyzed by PRC2) and monoubiquitinates H2A on K119. This leads to chromatin compaction, RNA polymerase II stalling and gene silencing. (Adapted from FBrf0179742 and FBrf0228921).

Protein Function (UniProtKB)

Regulates expression of the homeotic selector genes by influencing higher-order chromatin structure through interaction with other proteins.

(UniProt, P25172)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Arp: Aristapedioid (P. Adler)

Homozygous lethal. Two dramatic dominant phenotypes: One is a partial transformation of arista to tarsus, the other is the loss or reduction in size of medially located macrochaetae on the dorsal thorax. Both phenotypes show high penetrance but variable expressivity.

Su(z)2: Suppressor 2 of zeste

Dominant suppressor of the yellow eye color associated with the z1 mutation. Can be detected in homozygous z1 females and in males. Lethal in homozygous or hemizygous condition and in trans-allelic heterozygotes. Viability reduced in trans heterozygotes in some Psc/Su(z)2 combinations, lethal in others. Psc and Su(z)2 are both members of the Su(z)2 complex.

Summary (Interactive Fly)

transcription factor - zinc finger - ring motif - chromatin associated protein - Su(Z)2 and Psc proteins co-localize to and silence many of the same chromosomal loci acted upon by other Pc-G proteins, suggesting that Pc-G proteins function in a multi-protein complex to maintain gene silencing

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Su(z)2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P25172)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Stop-codon suppression (UAG) postulated; FBrf0216884

Gene model reviewed during 5.44

Gene model reviewed during 5.49

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Su(z)2-RA

FBtr0087793

NM_079002

6301

1368

Su(z)2-RB

FBtr0300387

NM_001169663

6631

1368

Su(z)2-RC

FBtr0330613

NM_001274004

6522

1396

Additional Transcript Data and Comments

Reported size (kB)

6.3 (longest cDNA)

(Brunk et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Su(z)2-PA

FBpp0086906

146.4

1368

9.87

FBpp0289616

146.4

1368

9.87

FBpp0303463

149.5

1396

9.80

A0A0B4KEM5

NP_001260933

AGB93466

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1368 aa isoforms: Su(z)2-PA, Su(z)2-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

1365 (aa)

(Brunk et al., 1991)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(z)2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.57

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Lo et al., 2009)

part_of PRC1 complex

inferred from direct assay

(Lo et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Su(z)2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Su(z)2

View exonic expression by tissue for Dmel\Su(z)2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36432/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265623

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0008654

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265623

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 71 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Su(z)2

Transgenic constructs containing regulatory region of Su(z)2

Aberrations (Deficiencies and Duplications) ( 39 )

Inferred from experimentation ( 39 )

Gene disrupted in

Df(2R)CX1

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)Exel6062

(Ryder, 2004.4.26)

Df(2R)P3C

(Classen et al., 2009)

Df(2R)Su(z)2-1.a2

(Wu and Howe, 1995)

Df(2R)Su(z)2-1.a3

(Wu and Howe, 1995)

Df(2R)Su(z)2-1.a4

(Wu and Howe, 1995)

Df(2R)Su(z)2-1.a6

(Wu and Howe, 1995)

Df(2R)Su(z)2-1.b8

(Emmons et al., 2009, Soto et al., 1995, Wu and Howe, 1995, Cheng et al., 1994, Brunk et al., 1991, Adler et al., 1989)

Df(2R)Su(z)2-1.b10

(Wu and Howe, 1995)

Df(2R)Su(z)2-1.b11

(Wu and Howe, 1995)

Df(2R)Su(z)2⁵

(Muller et al., 1999, Wu and Howe, 1995)

Df(2R)Su(z)2^D.c13

(Wu and Howe, 1995)

Df(2R)Su(z)2^D.c14

(Wu and Howe, 1995)

Df(2R)Su(z)2^D.c16

(Wu and Howe, 1995)

Df(2R)Su(z)2^D.c17

(Wu and Howe, 1995)

Df(2R)Su(z)3-1.i31

(Wu and Howe, 1995)

Df(2R)Su(z)3-1.iy

(Wu and Howe, 1995)

Df(2R)Su(z)3-1.j32

(Wu and Howe, 1995)

Df(2R)Su(z)3-1.jtg

(Wu and Howe, 1995)

Df(2R)Su(z)3^1.y

(Brunk et al., 1991)

Df(2R)vg-B

(Spradling et al., 1999, Wu and Howe, 1995, BDGP Project Members, 1994-1999, Cheng et al., 1994)

Df(2R)XL26

(Li et al., 2010)

In(2R)Arp1

(Brunk et al., 1991, Adler, 1984)

In(2R)Arp2

(Adler, 1984)

In(2R)Su(z)2-1.b9

(Wu and Howe, 1995)

In(2R)Su(z)2^D.c12

(Wu and Howe, 1995)

In(2R)Su(z)2^D.c15

(Wu and Howe, 1995)

In(2R)Su(z)2^D.c18

(Wu and Howe, 1995)

T(2;3)Su(z)2^1.a1

(Wu and Howe, 1995)

Gene duplicated in

Ts(2Lt;3Rt)BTD20+Ts(3Lt;2Rt)BTD14

(Wu and Howe, 1995)

Ts(2Lt;3Rt)BTD20+Ts(3Lt;2Rt)BTD71

(Wu and Howe, 1995)

Ts(2Lt;3Rt)BTD24+Ts(3Lt;2Rt)BTD14

(Wu and Howe, 1995)

Ts(2Lt;3Rt)BTD24+Ts(3Lt;2Rt)BTD71

(Wu and Howe, 1995)

Gene not disrupted in

Df(2R)Arp1.Fbf1a

(Brunk et al., 1991, Adler et al., 1989)

Df(2R)Su(z)2-1.b8

(Emmons et al., 2009)

Df(2R)vg62

(Wu and Howe, 1995)

Df(2R)vg135

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2R)vg-C

(Wu and Howe, 1995)

Df(2R)vg-D

(Wu and Howe, 1995)

In(2R)Arp1

(Adler, 1995.3.28)

T(2;3)Su(z)2^1.a1

(Wu and Howe, 1995)

Gene partially disrupted in

Df(2R)Psc-Su(z)2-0

(Bonnet et al., 2026)

Df(2R)Su(z)2-1.b8

(Emmons et al., 2009)

Df(2R)Su(z)2⁵

(Wu and Howe, 1995)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal (with Df(2R)Su(z)2-1.b8)

lethal (with Su(z)2^1.b7)

Su(z)2^s84

lethal (with Su(z)2¹)

lethal (with Su(z)2^4-31)

lethal (with Su(z)2^4-34)

lethal (with Su(z)2^e26)

lethal (with Su(z)2^h29)

lethal (with Su(z)2^s20)

Su(z)2¹

lethal (with Su(z)2^s36)

lethal (with Su(z)2^s84)

lethal (with Su(z)2^s95)

lethal | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Su(z)2^GD4494

lethal - all die during embryonic stage

Su(z)2¹

lethal - all die during embryonic stage | recessive

partially lethal - majority die

Su(z)2^e26

partially lethal - majority die (with Df(2R)Su(z)2-1.b8)

partially lethal - majority die (with Su(z)2^1.b7)

partially lethal - majority die (with Su(z)2¹)

partially lethal - majority die (with Su(z)2^3-1)

partially lethal - majority die (with Su(z)2^4-31)

Su(z)2^s15

partially lethal - majority die (with Su(z)2^4-34)

partially lethal - majority die (with Su(z)2^e26)

partially lethal - majority die (with Su(z)2^eos)

partially lethal - majority die (with Su(z)2^h29)

Su(z)2^s15

partially lethal - majority die (with Su(z)2^s15)

partially lethal - majority die (with Su(z)2^s20)

partially lethal - majority die (with Su(z)2^s21)

partially lethal - majority die (with Su(z)2^s36)

partially lethal - majority die (with Su(z)2^s84)

partially lethal - majority die (with Su(z)2^s95)

partially lethal - majority die (with Su(z)2^sM)

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Su(z)2^GD16388

viable (with Df(2R)Su(z)2-1.b8)

viable (with Su(z)2^1.b7)

viable (with Su(z)2^3-1)

viable (with Su(z)2^4-31)

viable (with Su(z)2^4-34)

viable (with Su(z)2^5-SZ-3055)

Su(z)2^handC-GFP1.1

viable (with Su(z)2^d01221)

Su(z)2^handC-GFP1.1

viable (with Su(z)2^e26)

viable (with Su(z)2^eos)

viable (with Su(z)2^h29)

viable (with Su(z)2^handC-GFP1.1)

viable (with Su(z)2^k06344)

Su(z)2^handC-GFP1.1

viable (with Su(z)2^KG07068)

Su(z)2^handC-GFP1.1

viable (with Su(z)2^s15)

Su(z)2^1.b7

viable (with Su(z)2^s20)

viable (with Su(z)2^s21)

viable (with Su(z)2^s36)

viable (with Su(z)2^s84)

Su(z)2^sM

viable (with Su(z)2^s95)

Su(z)2^sM

viable (with Su(z)2^sM)

Sterility

Allele

fertile

Su(z)2^EY09805

Other Phenotypes

Allele

abnormal eye color | dominant

abnormal locomotor behavior | adult stage (with Su(z)2^5-SZ-3055)

Su(z)2^handC-GFP1.1

abnormal locomotor behavior | adult stage (with Su(z)2^d01221)

Su(z)2^handC-GFP1.1

abnormal locomotor behavior | adult stage (with Su(z)2^handC-GFP1.1)

abnormal locomotor behavior | adult stage (with Su(z)2^k06344)

Su(z)2^handC-GFP1.1

abnormal locomotor behavior | adult stage (with Su(z)2^KG07068)

Su(z)2^handC-GFP1.1

abnormal locomotor behavior | adult stage | recessive

Su(z)2^handC-GFP1.1

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Su(z)2^GD16388

chemical sensitive

Su(z)2⁵

decreased size | adult stage

Su(z)2^handC-GFP1.1

increased cell number | adult stage | female, with Scer\GAL4^C587

Su(z)2^{N1.UAS.Tag:MYC}

long lived | dominant

Su(z)2^c433

long lived | female

Su(z)2^c433

long lived | male

Su(z)2^c433

neoplasia | adult stage | female, with Scer\GAL4^C587

Su(z)2^{N1.UAS.Tag:MYC}

non-suppressor of variegation | dominant, with In(1)w^m4

non-suppressor of variegation | dominant, with P{hsp26-pt-T}8-M76

Su(z)2^1.a1

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

Su(z)2¹

non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-66

Su(z)2^1.a1

some die during embryonic stage

Su(z)2¹

some die during embryonic stage | recessive

some die during pupal stage, with Scer\GAL4^pnr-MD237

Su(z)2^GD4494

suppressor of variegation, with P{hsp26-pt-T}39C-5

suppressor of variegation, with P{hsp26-pt-T}39C-27

suppressor of variegation, with P{hsp26-pt-T}39C-27, T(2;4)X-12

Su(z)2⁵

suppressor of variegation, with P{hsp26-pt-T}39C-31

suppressor of variegation, with P{hsp26-pt-T}39C-50

suppressor of variegation, with P{hsp26-pt-T}39C-51

suppressor of variegation, with P{hsp26-pt-T}39C-58

suppressor of variegation, with P{hsp26-pt-T}39C-62

suppressor of variegation, with P{hsp26-pt-T}118E-16

suppressor of variegation, with P{hsp26-pt-T}118E-21

Su(z)2⁵

suppressor of variegation, with P{hsp26-pt-T}118E-26

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-27

Su(z)2⁵

suppressor of variegation | dominant, with P{hsp26-pt-T}39C-31

Su(z)2⁵

suppressor of variegation | dominant, with P{wA}4-4

Su(z)2⁵

suppressor of variegation | partially, with P{hsp26-pt-T}39C-5

Su(z)2⁵

visible

visible, with Scer\GAL4^Bx-MS1096

Su(z)2^{UAS.ORF.GW.Tag:HA}

visible | dominant

wild-type

Su(z)2^Tag:MYC

Phenotype manifest in

Allele

abdomen & macrochaeta

Su(z)2^hs.PS

arista

costal vein & macrochaeta

Su(z)2^hs.PS

cuticle & abdomen

dorsal double row & macrochaeta

Su(z)2^hs.PS

dorsal triple row & macrochaeta

Su(z)2^hs.PS

germarium, with Scer\GAL4^C587

Su(z)2^{N1.UAS.Tag:MYC}

head & macrochaeta

Su(z)2^hs.PS

leg & macrochaeta

Su(z)2^hs.PS

macrochaeta

macrochaeta | decreased number

Su(z)2^handC-GFP1.1

pigment cell

pulvillus

Su(z)2^handC-GFP1.1

scutellum & macrochaeta

Su(z)2^hs.PS

scutum & macrochaeta

Su(z)2^hs.PS

thorax & macrochaeta

ventral double row & macrochaeta

Su(z)2^hs.PS

ventral triple row & macrochaeta

Su(z)2^hs.PS

wing, with Scer\GAL4^Bx-MS1096

Su(z)2^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (28)

Hsap\BMI1

5 of 14

Yes

Hsap\COMMD3-BMI1

5 of 14

Yes

Hsap\PCGF1

5 of 14

Yes

Hsap\PCGF2

5 of 14

Yes

Hsap\PCGF5

5 of 14

Yes

Hsap\PCGF6

5 of 14

Yes

4 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DTX3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RNF8

1 of 14

Yes

Hsap\TRIM10

1 of 14

Yes

Hsap\TRIM26

1 of 14

Yes

Hsap\TRIM35

1 of 14

Yes

Hsap\TRIM50

1 of 14

Yes

Hsap\TRIM60

1 of 14

Yes

Hsap\TRIM69

1 of 14

Yes

Hsap\TRIM73

1 of 14

Yes

Hsap\TRIM74

1 of 14

Yes

Hsap\TRIM75P

1 of 14

Yes

Hsap\TRIML1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Bmi1

5 of 14

Yes

Rnor\Pcgf1

5 of 14

Yes

Rnor\Pcgf2

5 of 14

Yes

Rnor\Pcgf5

5 of 14

Yes

Rnor\Pcgf6

5 of 14

Yes

4 of 14

4 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Dtx3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rnf8

1 of 14

Yes

Rnor\Rnf10

1 of 14

Rnor\Traip

1 of 14

Rnor\Trim65

1 of 14

Yes

Rnor\Triml1

1 of 14

Yes

Mus musculus (laboratory mouse) (25)

Mmus\Bmi1

5 of 14

Yes

Mmus\Pcgf2

5 of 14

Yes

Mmus\Pcgf5

5 of 14

Yes

Mmus\Pcgf6

5 of 14

Yes

Mmus\Pcgf1

4 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Mmus\Dtx3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rnf8

1 of 14

Yes

Mmus\Rnf10

1 of 14

Mmus\Traip

1 of 14

Mmus\Trim5

1 of 14

Yes

Mmus\Trim12c

1 of 14

Yes

Mmus\Trim17

1 of 14

Yes

Mmus\Trim30b

1 of 14

Yes

Mmus\Trim38

1 of 14

Yes

Mmus\Trim69

1 of 14

Yes

Mmus\Trim75

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (19)

Xtro\bmi1

3 of 13

Yes

Xtro\pcgf3

3 of 13

Yes

Xtro\pcgf6

3 of 13

Yes

Xtro\pcgf1

2 of 13

Xtro\pcgf5

2 of 13

Xtro\chfr

1 of 13

Yes

Xtro\dtx3

1 of 13

Yes

Xtro\LOC100485658

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (22)

Drer\bmi1a

5 of 14

Yes

Drer\bmi1b

5 of 14

Yes

Drer\pcgf1

5 of 14

Yes

Drer\pcgf5a

5 of 14

Yes

Drer\pcgf5b

5 of 14

Yes

Drer\pcgf6

5 of 14

Yes

Drer\rnf2

2 of 14

Drer\btr20

1 of 14

Yes

Drer\btr31

1 of 14

Yes

Drer\btr32

1 of 14

Yes

Drer\chfr

1 of 14

Drer\cop1

1 of 14

Yes

Drer\dtx3

1 of 14

Yes

Drer\ftr55

1 of 14

Yes

Drer\pcgf3

1 of 14

Yes

Drer\rnf8

1 of 14

Yes

Drer\rnf24

1 of 14

Yes

Drer\rnf151

1 of 14

Drer\si:dkey-46i9.6

1 of 14

Yes

Drer\traip

1 of 14

Drer\trim69

1 of 14

Yes

Drer\trim109

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\mig-32

3 of 14

Yes

Cele\spat-3

1 of 14

Cele\T02C1.1

1 of 14

Cele\T02C1.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (5)

Agam\AgaP_AGAP006402

9 of 12

Yes

Agam\AgaP_AGAP006403

5 of 12

Agam\AgaP_AGAP002533

4 of 12

Agam\AgaP_AGAP001292

1 of 12

Yes

Agam\AgaP_AGAP002073

1 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\AT3G23060

4 of 13

Yes

Atha\DRIP1

4 of 13

Yes

Atha\DRIP2

4 of 13

Yes

Atha\AT1G35183

2 of 13

Yes

Atha\AT1G18660

1 of 13

Atha\AT1G19310

1 of 13

Atha\AT1G28080

1 of 13

Yes

Atha\AT3G27330

1 of 13

Atha\AT3G54360

1 of 13

Yes

Atha\AT5G13250

1 of 13

Yes

Atha\BRCA1

1 of 13

Yes

Atha\COP1

1 of 13

Atha\RING1A

1 of 13

Atha\RING1B

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\IRC20

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\rhp18

1 of 12

Yes

Spom\SPAC144.05

1 of 12

Yes

Spom\SPCC548.05c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Su(z)2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (3)

Psc

7 of 13

l(3)73Ah

6 of 13

Sce

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

cancer, multiple, epigenetic mechanisms

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Su(z)2^GD16388

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

Su(z)2^GD4494

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

Su(z)2^KK103634

exacerbates cancer

modeled by dlg1², dlg1^A40.2

(Bunker et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

BMI1; BMI1 proto-oncogene, polycomb ring finger

5 of 14

164831

COMMD3-BMI1; COMMD3-BMI1 readthrough

5 of 14

PCGF1; polycomb group ring finger 1

5 of 14

610231

PCGF2; polycomb group ring finger 2

5 of 14

600346

TURNPENNY-FRY SYNDROME; TPFS

PCGF5; polycomb group ring finger 5

5 of 14

617407

PCGF6; polycomb group ring finger 6

5 of 14

607816

PCGF3; polycomb group ring finger 3

4 of 14

617543

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Su(z)2 - Br140

cross-linking study, tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2017)

Su(z)2 - Pc

affinity chromatography technology, molecular weight estimation by staining, western blot, anti bait coimmunoprecipitation, pull down, peptide massfingerprinting, tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2015, Strübbe et al., 2011, Lo et al., 2009)

Su(z)2 - RYBP

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Su(z)2 - Sce

affinity chromatography technology, molecular weight estimation by staining, western blot, anti bait coimmunoprecipitation

(Lo et al., 2009)

Su(z)2 - Scm

tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2015)

Su(z)2 - fs(1)h

cross-linking study, tandem affinity purification, Identification by mass spectrometry

(Kang et al., 2017)

Su(z)2 - ph-d

anti tag coimmunoprecipitation, peptide massfingerprinting

(Frey et al., 2016)

Su(z)2 - ph-p

anti bait coimmunoprecipitation, western blot, affinity chromatography technology, molecular weight estimation by staining

(Lo et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Li et al., 2016)

suppressible

(Li et al., 2016)

enhanceable

(Brunk and Adler, 1990)

suppressible

(Li et al., 2016)

enhanceable

(Li et al., 2016)

enhanceable

(Yang et al., 2019)

Su(z)2

suppressible

Sce

(Sharp et al., 1994)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

ash1|trx

enhanceable

Su(z)2

(Gildea et al., 2000)

chb

suppressible

Su(z)2

(Lowery et al., 2010)

enhanceable

Su(z)2

(Melnikova et al., 1996)

dlg1

enhanceable

Su(z)2

(Bunker et al., 2015)

enhanceable

(Ji et al., 2012)

enhanceable

(Ji et al., 2012)

suppressible

(Ji et al., 2012)

suppressible

(Morimoto et al., 2016)

Myc

suppressible

Su(z)2

(Secombe et al., 2007)

enhanceable

(Li et al., 2016)

enhanceable

(Harris et al., 2020)

Sce

enhanceable

Su(z)2

(Yang et al., 2019)

trx|brm

enhanceable

Su(z)2

(Gildea et al., 2000)

suppressible

Su(z)2

(Emmons et al., 2009, Wu and Howe, 1995, Brunk et al., 1991, Brunk and Adler, 1990, Wu et al., 1989, Kalisch and Rasmuson, 1974)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0265623

MIST (genetic) - An integrated Molecular Interaction Database

36432

MIST (protein-protein) - An integrated Molecular Interaction Database

36432

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-67

Cytogenetic map

49E7-49E7

Sequence location

2R:12,996,501..13,007,911 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49E7-49E7

Left limit from non-inclusion within Df(2R)vg-C (FBrf0082794) Right limit from inclusion within Df(2R)Su(z)3-1.jtg (FBrf0082794)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

49E6-49E7

(determined by in situ hybridisation)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

49A12-49B3

(determined by in situ hybridisation)

(Brunk and Adler, 1990)

Experimentally Determined Recombination Data

Location

2-67

(FlyBase, 2016)

2-71.3

(Comeron et al., 2012)

2-66.8 or 2-67.3

(Wu and Howe, 1995)

2-70.7

(Kalisch and Rasmuson, 1974)

Left of (cM)

(Wu and Howe, 1995)

Right of (cM)

(Wu and Howe, 1995)

Notes

2-67.3 or 2-68.7 or 2-66.0 Mapping based on Su(z)2¹. Mapping based on Su(z)2⁵.

(Wu and Howe, 1995)

Mapping based on Su(z)3¹. Mapping based on Su(z)3^eos.

(Wu and Howe, 1995)

Su(z)2 maps very close to vg.

(Adler, 1984)

Stocks and Reagents

Stocks (29)

Aberrations including deletions of this gene Aberrations including duplications of this gene

5548

5550

5549

5572

43505

w^*; P{GSV1}Su(z)2^s-338

31335

y¹ v¹; P{TRiP.JF01293}attP2

68224

y¹ w^*; P{UAS-Su(z)2.N1.Myc}2

FlyORF

F004816

M{UAS-Su(z)2.ORF-VN}ZH-86Fb

108292

108293

v100096

v50368

w¹¹¹⁸; P{GD16388}v50368/CyO

More stocks available...

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (25)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP01427

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0265623

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hodgson et al., 2001)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Mutations in Su(z)2 suppress telomeric Position Effect Variegation (PEV) on the second and third chromosomes, but not on the fourth chromosome.

(Cryderman et al., 1999)

Deletion analysis of the protein reveals the homology region (HR) is necessary and sufficient for Su(z)2 locus specific polytene chromosome binding.

(Sharp et al., 1997)

l(3)73Ah amino acid sequence comparison reveals homology to the zinc-finger containing N-terminal domain of Psc and Su(z)2.

(Irminger-Finger and Nothiger, 1995)

Mosaic and expression pattern analysis reveals that the Pc-group genes do not act only in a common complex or pathway: they must have some independent functions.

(Soto et al., 1995)

The mutant phenotypes of Psc, Su(z)2 and Su(z)3, the similarities of the phenotypes and the mutational interactions between them suggest that the products are functionally similar and act at the level of chromatin, possibly as a multimeric complex.

(Wu and Howe, 1995)

Members of the Pc group function as potent repressors in mammalian cells.

(Bunker and Kingston, 1994)

Su(z)2 is one of several Pc-G genes required for the repression of gap genes by maternally supplied hb product.

(Pelegri and Lehmann, 1994)

Psc and Su(z)2 gene products are nuclear proteins and are associated with more than 80 sites in the salivary gland polytene chromosomes. There is considerable overlap with the sites that are bound by antibodies to z, Pc and the polyhomeotic proteins. This association of the Psc and Su(z)2 proteins with the chromosomes is dependent on the presence of active E(z) protein.

(Rastelli et al., 1993)

Su(z)2 alleles are dominant suppressors of the yellow eye color associated with the z¹ mutation. Can be detected in homozygous z¹ females and in males. Lethal in homozygous or hemizygous condition and in trans-allelic heterozygotes. Viability reduced in transheterozygotes in some Psc¹/Su(z)2 combinations, lethal in others.

(Lindsley and Zimm, 1992)

The "Aristapedioid" mutant phenotype results from the juxtaposition of unrelated DNA with Su(z)2, causing a gain of function mutation.

(Brunk and Adler, 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: Su(z)2 l(2)k06344

(Spradling et al., 1999)

Source for merge of: Su(z)2 Su(z)3

(Emmons et al., 2009)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

Arp

(Rogat and Miller, 2002, Lindsley and Zimm, 1992, Adler, 1984)

CG3905

(National Institute of Genetics Fly Stocks, 2022-, Butzlaff et al., 2015, Ying et al., 2011, Lowery et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Klebes et al., 2005)

SU(Z)2

(Schwartz and Pirrotta, 2007, Hodgson et al., 2001)

SUZ2

(Zhimulev and Belyaeva, 2003)

Su(Z)2

(Wani et al., 2016, Bai et al., 2013)

Su(z)2

(Bonnet et al., 2026, Gemeinhardt et al., 2025, Martinez, 2025, Liang and Luan, 2024, Mitchell et al., 2024, Parreno et al., 2024, Aromolaran et al., 2023, Candia et al., 2023, Erokhin et al., 2023, Kang et al., 2022, Lam Wong and Verheyen, 2021, Lucas et al., 2021, Ponrathnam et al., 2021, Vidaurre and Chen, 2021, Yazar et al., 2021, Damschroder et al., 2020, Kuroda et al., 2020, Parkhitko et al., 2020, Watanabe et al., 2020, Berlandi et al., 2019, Cheutin and Cavalli, 2019, Dorafshan et al., 2019, Hall et al., 2019, Leatham-Jensen et al., 2019, Luhur et al., 2019, Tudrej et al., 2019, Yang et al., 2019, Bischof et al., 2018, Dasari et al., 2018, Ma et al., 2018, Erceg et al., 2017, Huang et al., 2017, Kang et al., 2017, Nguyen et al., 2017, Sharma et al., 2017, Transgenic RNAi Project members, 2017-, Bielmeier et al., 2016, Frey et al., 2016, Kahn et al., 2016, Morimoto et al., 2016, Peng et al., 2016, Piunti and Shilatifard, 2016, Butzlaff et al., 2015, Dorn and Dorn, 2015, Ghasemi et al., 2015, Hüsken et al., 2015, Kang et al., 2015, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Herz et al., 2014, McElroy et al., 2014, Wang et al., 2014, Debruhl et al., 2013, de Celis et al., 2013.9.11, Kwon et al., 2013, Silva-Sousa and Casacuberta, 2013, Follmer et al., 2012, Gutiérrez et al., 2012, Ji et al., 2012, Morillo Prado et al., 2012, Park et al., 2012, Di Stefano et al., 2011, Du et al., 2011, Jungreis et al., 2011, Kharchenko et al., 2011, Klusza and Deng, 2011, Pérez et al., 2011, Strübbe et al., 2011, Baig et al., 2010, Gandille et al., 2010, Li et al., 2010, Lowery et al., 2010, Potter et al., 2010, Schwartz et al., 2010, Classen et al., 2009, Emmons et al., 2009, Khan et al., 2009, Doheny et al., 2008, Bai et al., 2007, Bello et al., 2007, Minidorff et al., 2007, Secombe et al., 2007, Holmes et al., 2006, Barmina et al., 2005, Hoskins et al., 2005, King et al., 2005, Ali and Bender, 2004, Breiling et al., 2004, Balasov, 2002, Lindsley and Zimm, 1992)

Su(z)2D

(Emmons et al., 2009, Cryderman et al., 1999, Roche and Rio, 1998, Wu and Howe, 1995)

Su(z)3

(Doheny et al., 2008)

Su(z)₂

(Atchison et al., 2003)

Suz2

(Vasanthi et al., 2013)

l(2)k06344

(BDGP Project Members, 1994-1999)

su(z)2

(Harris et al., 2020, Hirose et al., 2001, Spradling et al., 1999)

su(z)3

(Doheny et al., 2008)

Name Synonyms

Aristapedioid

(Lindsley and Zimm, 1992)

Aristopedoid

(Adler, 1984)

Suppressor 2 of zeste

(Emmons et al., 2009, Lo et al., 2009, Ali and Bender, 2004, Balasov, 2002, Lindsley and Zimm, 1992)

Suppressor of Zeste 3

(Marin et al., 2004)

Suppressor of zeste (2)

(Doheny et al., 2008)

Suppressor of zeste (3)

(Doheny et al., 2008)

Suppressor of zeste 2

(Bielmeier et al., 2016, Piunti and Shilatifard, 2016, Herz et al., 2014, McElroy et al., 2014, Baig et al., 2010, Classen et al., 2009, Bello et al., 2007)

Suppressor of zeste 3

Suppressor of zeste two

(Morillo Prado et al., 2012, Li et al., 2010)

Suppressor two of Zeste

(Wani et al., 2016)

Supressor of zeste 2

(Breiling et al., 2004)

suppressor of zeste two

(Dorn and Dorn, 2015)

Secondary FlyBase IDs

FBgn0008654
FBgn0000118
FBgn0022134
FBgn0003645

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 43 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36432

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P25172

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P25172

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P25172

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36432/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0265623

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0265623

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3905

MARRVEL_MODEL - MARRVEL (model organism gene)

36432

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0265623

DroID - A comprehensive database of gene and protein interactions.

FBgn0265623

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0008654

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0265623

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0265623

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

36432

MIST (protein-protein) - An integrated Molecular Interaction Database

36432

References (259)

The following external sites may use different assemblies or annotations than FlyBase.

-1.57

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