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FB2026_01
,
released March 12, 2026
Please see the JBrowse view of Dmel\rdgC for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
Gene model reviewed during 6.23
661 (aa); 95 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rdgC using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
rdgC protein is observed in extracts from adult heads but not bodies. In sections of adult heads, staining is observed in the retina, occelli, and mushroom bodies.
JBrowse - Visual display of RNA-Seq signals
View Dmel\rdgC in JBrowse3-47
3-43.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
The calmodulin/rdgC interaction is required to potentiate dephosphorylation of rhodopsin in vivo and for rapid termination of the photoresponse.
rdgC is a calmodulin-dependant protein phosphatase.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
In disrupted photoreceptor cells metarhodopsin is not stabilised until arrestin is present. In intact photoreceptor cels significant metarhodopsin stabilisation occurs even in the absence of bound arrestin.
Phototransduction, a phospholipase C-mediated, calcium-regulated G protein-coupled pathway, is studied for genetic dissection of G protein-coupled receptor (GPCR) function and regulation.
The calcium content of light and dark raised flies demonstrates that calcium accumulation is a secondary effect, rather than primary effect, in the degeneration process.
Analysis of rdgC mutants reveals that retinal degeneration is a consequence of light stimulation of rhodopsin. rdgC+ function is required in a metabolic process that results from rhodopsin stimulation but is not needed in the phospholipase C activated transduction pathway.
Source for merge of: rdgC CG13814
Annotations CG6571 and CG13814 merged as CG44746 in release 5.51 of the genome annotation. Merge supported by second tier modENCODE RNA-seq junction data (FBrf0217580) and RNA-seq expression data.
