DopR2, DAMB, DopR99B, dopamine receptor in mushroom bodies, Dopamine receptor 2
Gene model reviewed during 5.50
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Transposon inserted in intron 2
5.2 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop1R2 using the Feature Mapper tool.
Dop1R2 protein is moderately expressed in the mushroom body alpha' and beta' lobes and weakly in mushroom body alpha, beta and gamma lobes and spur.
Dop1R2 protein is detected in the neuropil that houses the mushroom body axons, including the pedunculi and the α, β, and γ lobes. Higher intensity staining is observed in the α and β lobes than in the pedunculi and γ lobes. This suggests that the receptor functions primarily in the axons of mushroom body cells. The distribution is similar to that of rut protein.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Dop1R2 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Dop1R2 DopR2
Source for merge of: DopR2 K13sc
FlyBase curator comment: The nomenclature of the three genes encoding D. melanogaster dopamine receptors ('Dop1R1', 'Dop1R2' and 'Dop2R') has been revised to improve consistency and clarity, and to reduce confusion between them.
DopR2 when expressed in Xenopus oocytes couples to two second messenger systems: initiation of an intracellular calcium signal and stimulation of adenylyl cyclase activity.
A candidate molecule for mediating signal transduction processes leading to learning and memory.