FlyBase Gene Report: Dmel\Dop1R2

General Information

Symbol

Dmel\Dop1R2

Species

D. melanogaster

Name

Dopamine 1-like receptor 2

Annotation Symbol

CG18741

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266137

Gene Model Status

Current

Stock Availability

85 publicly available

Gene Summary

Dopamine 1-like receptor 2 (Dop1R2) encodes one of four different dopamine receptors. It is a G-protein coupled receptor that can activate two different G-proteins (Gαs and Gαq), leading to the activation of the cAMP or Ca[2+] second messenger pathway, respectively. It is mainly expressed in the mushroom body where it is involved in long term memory formation. [Date last reviewed: 2025-11-06] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DopR2, DAMB, DopR99B, dopamine receptor in mushroom bodies, Dopamine receptor 2

Key Links

Genomic Location

Cytogenetic map

99B5-99B6

Sequence location

3R:29,630,304..29,659,984 [-]

Recombination map

3-99

RefSeq locus

NT_033777 REGION:29630304..29659984

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables dopamine neurotransmitter receptor activity, coupled via Gs

inferred from direct assay

(Feng et al., 1996, Han et al., 1996)

enables tyramine receptor activity

inferred from direct assay

(Feng et al., 1996)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables adrenergic receptor activity

inferred from electronic annotation with InterPro:IPR002233

(InterPro Project Members, 2004-)

enables dopamine neurotransmitter receptor activity, coupled via Gs

inferred from sequence or structural similarity with FLYBASE:Dop1R1; FB:FBgn0011582

(Han et al., 1996)

inferred from sequence or structural similarity with UniProtKB:P21728

(Han et al., 1996)

enables dopamine neurotransmitter receptor activity

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables G protein-coupled amine receptor activity

inferred from sequence or structural similarity

(Radford et al., 2002)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(GO Reference Genome Project, 2011-)

Biological Process (9 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating dopamine receptor signaling pathway

inferred from direct assay

(Feng et al., 1996)

involved_in cellular response to dopamine

inferred from mutant phenotype

(Pimentel et al., 2016)

involved_in negative regulation of circadian sleep/wake cycle, sleep

inferred from mutant phenotype

(Pimentel et al., 2016)

involved_in regulation of presynaptic cytosolic calcium ion concentration

inferred from mutant phenotype

(Cohn et al., 2015)

involved_in response to odorant

inferred from mutant phenotype

(Cohn et al., 2015)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating adrenergic receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN001205212

(GO Reference Genome Project, 2011-)

involved_in G protein-coupled dopamine receptor signaling pathway

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

involved_in G protein-coupled receptor signaling pathway

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR002233

(InterPro Project Members, 2004-)

traceable author statement

(Han et al., 1996)

involved_in positive regulation of MAPK cascade

inferred from biological aspect of ancestor with PANTHER:PTN001205212

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR002233, InterPro:IPR017452

(InterPro Project Members, 2004-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002798190

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from sequence or structural similarity with UniProtKB:P14416

(Han et al., 1996)

inferred from sequence or structural similarity with UniProtKB:P25100

(Han et al., 1996)

inferred from sequence model

(Feng et al., 1996)

located_in synaptic vesicle membrane

inferred by curator from GO:0001588

(Han et al., 1996)

Gene Group (FlyBase)

DOPAMINE RECEPTORS

Protein Family (UniProt)

Belongs to the G-protein coupled receptor 1 family. (Q24563)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

DOPAMINE RECEPTORS -: Dopamine GPCRs are Class A GPCRs. Dopamine is a neurotransmitter involved in a variety of behavioural and physiological functions such as memory, arousal and mating behaviour. (Adapted from PMID:17088868 and FBrf0219823).

Protein Function (UniProtKB)

Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Also capable of generating a calcium signal. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group. This receptor is an attractive candidate for initiating biochemical cascades underlying olfactory learning.

(UniProt, Q24563)

Summary (Interactive Fly)

G-protein coupled receptor - Dopamine receptor - locomotor activity - presynaptic autoreceptor - appetitive and aversive learning

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dop1R2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q24563)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Transposon inserted in intron 2

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dop1R2-RA

FBtr0085467

NM_170420

4990

537

Dop1R2-RB

FBtr0085468

NM_079824

5164

539

Dop1R2-RC

FBtr0330293

NM_001276143

4990

807

Additional Transcript Data and Comments

Reported size (kB)

5.2 (northern blot)

(Han et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dop1R2-PA

FBpp0084833

58.9

537

7.95

NP_733299

AAF56908

Dop1R2-PB

FBpp0084834

59.5

539

8.22

FBpp0303325

86.5

807

7.96

A0A0B4KI18

NP_001263072

AGB96452

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

537 (aa)

(Han et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dop1R2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dop1R2_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.76

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

(Han et al., 1996)

(Han et al., 1996)

Additional Descriptive Data

Dop1R2 is detected by northern blots in heads but not bodies of adults. Dop1R2 transcripts are detected predominantly in the perikarya of the mushroom body cells by in situ hybridization. They are expressed specifically in mushroom body neurons.

(Han et al., 1996)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

lobe system of mushroom body

(Han et al., 1996)

Additional Descriptive Data

Dop1R2 protein is moderately expressed in the mushroom body alpha' and beta' lobes and weakly in mushroom body alpha, beta and gamma lobes and spur.

(Crittenden et al., 1998)

Dop1R2 protein is detected in the neuropil that houses the mushroom body axons, including the pedunculi and the α, β, and γ lobes. Higher intensity staining is observed in the α and β lobes than in the pedunculi and γ lobes. This suggests that the receptor functions primarily in the axons of mushroom body cells. The distribution is similar to that of Adcy1 protein.

(Han et al., 1996)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dop1R2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dop1R2

View exonic expression by tissue for Dmel\Dop1R2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43484/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266137

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015129

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266137

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18741

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 20 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dop1R2

Transgenic constructs containing regulatory region of Dop1R2

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)DAMB¹

(Selcho et al., 2009)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage, with Scer\GAL4^ChAT.7.4

Dop1R2^UAS.cHa

lethal - all die before end of pupal stage, with Scer\GAL4^elav-C155

Dop1R2^UAS.cHa

lethal - all die before end of pupal stage, with Scer\GAL4^ple.PF

Dop1R2^UAS.cHa

viable

Dop1R2^attP

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dop1R2^GD703

viable, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Dop1R2^WKO.1-C1

viable, with Scer\GAL4^Mef2.PR

Dop1R2^GD703

viable, with Scer\GAL4^pnr-MD237

Dop1R2^GD703

viable, with Scer\GAL4^repo

Dop1R2^UAS.cHa

viable, with Scer\GAL4^tin.CΔ4

Dop1R2^GD703

viable, with Scer\GAL4^Trhn.PB

Dop1R2^UAS.cHa

viable, with Scer\GAL4^VGlut1.PC

Dop1R2^UAS.cHa

Sterility

Allele

fertile

Dop1R2^attP

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^Clk.-856

Dop1R2^JF02043

abnormal locomotor behavior | adult stage, with Scer\GAL4^Pdf.PU

Dop1R2^JF02043

abnormal locomotor behavior | RU486 conditional, with Scer\GAL4^Pdf.Switch1a

Dop1R2^JF02043

abnormal memory, with Scer\GAL4^GMR13F02

Dop1R2^UAS.cCSa

abnormal neuroanatomy | pupal stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Dop1R2^WKO.1-C1

abnormal neurophysiology

Dop1R2^attP

abnormal neurophysiology, with Scer\GAL4^GMR16A06

Dop1R2^HMC02893

abnormal neurophysiology | adult stage, with Scer\GAL4^GMR23E10

Dop1R2^KK110947

abnormal sleep

Dop1R2^MI08664

abnormal sleep, with Scer\GAL4^GMR23E10

Dop1R2^KK110947

abnormal sleep | adult stage

abnormal smell perception

Dop1R2^attP

abnormal smell perception, with Scer\GAL4^GMR16A06

Dop1R2^HMC02893

chemical resistant, with Scer\GAL4^ple.PF

Dop1R2^UAS.cHa

chemical resistant, with Scer\GAL4^VGlut1.PC

Dop1R2^GD703

chemical sensitive, with Scer\GAL4^VGlut1.PC

Dop1R2^UAS.cHa

decreased efficacy of long-term memory | adult stage | somatic clone - tissue specific, with Scer\GAL4^c305a

Dop1R2^FRT.HA

decreased efficacy of long-term memory | adult stage | somatic clone - tissue specific, with Scer\GAL4^c739

Dop1R2^FRT.HA

decreased efficacy of long-term memory | adult stage | somatic clone - tissue specific, with Scer\GAL4^ey-OK107

Dop1R2^FRT.HA

decreased efficacy of medium-term memory | adult stage | somatic clone - tissue specific, with Scer\GAL4^c305a

Dop1R2^FRT.HA

decreased efficacy of medium-term memory | adult stage | somatic clone - tissue specific, with Scer\GAL4^c739

Dop1R2^FRT.HA

decreased efficacy of medium-term memory | adult stage | somatic clone - tissue specific, with Scer\GAL4^ey-OK107

Dop1R2^FRT.HA

decreased efficacy of memory | adult stage | somatic clone - tissue specific, with Scer\GAL4^elav.PU

Dop1R2^FRT.HA

decreased sleep, with Scer\GAL4^Pdf.PU

Dop1R2^JF02043

decreased sleep | RU486 conditional, with Scer\GAL4^Pdf.Switch1a

Dop1R2^JF02043

Phenotype manifest in

Allele

axon | pupal stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Dop1R2^WKO.1-C1

fan-shaped body, with Scer\GAL4^GMR23E10

Dop1R2^KK110947

gamma Kenyon cell | pupal stage, with Scer\GAL4^GMR71G10, Spyo\Cas9^{UAS.Tag:NLS(Unk)}

Dop1R2^WKO.1-C1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (124)

Hsap\ADRA1B

6 of 14

Yes

Hsap\ADRA1D

6 of 14

Yes

Hsap\ADRA1A

5 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CCKAR

1 of 14

Hsap\CCKBR

1 of 14

Hsap\CCR2

1 of 14

Yes

Hsap\CCR8

1 of 14

Yes

Hsap\CCRL2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\EDNRB

1 of 14

Yes

Hsap\GALR1

1 of 14

Hsap\GHSR

1 of 14

Hsap\GPER1

1 of 14

Yes

Hsap\GPR27

1 of 14

Yes

Hsap\GPR50

1 of 14

Hsap\GPR85

1 of 14

Yes

Hsap\GPR161

1 of 14

Yes

Hsap\GPR173

1 of 14

Yes

Hsap\GPR182

1 of 14

Yes

Hsap\GPR183

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\OR4K5

1 of 14

Yes

Hsap\OR4L1

1 of 14

Yes

Hsap\OR5T1

1 of 14

Yes

Hsap\OR13F1

1 of 14

Yes

Hsap\OR56A1

1 of 14

Yes

Hsap\OR56A4

1 of 14

Yes

Hsap\OR56A5

1 of 14

Yes

Hsap\P2RY1

1 of 14

Yes

Hsap\P2RY8

1 of 14

Yes

Hsap\PROKR1

1 of 14

Yes

Hsap\PROKR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (49)

Rnor\Adra1d

6 of 14

Yes

Rnor\Adra1a

5 of 14

Yes

Rnor\Adra1b

5 of 14

Yes

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Gpr101

1 of 14

Yes

Rnor\Gpr182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Npffr1

1 of 14

Rnor\Olr193

1 of 14

Yes

Rnor\Olr533

1 of 14

Yes

Rnor\Olr841

1 of 14

Yes

Rnor\Olr1257

1 of 14

Yes

Rnor\Olr1320

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (51)

Mmus\Adra1b

6 of 14

Yes

Mmus\Adra1d

6 of 14

Yes

Mmus\Adra1a

5 of 14

Yes

4 of 14

3 of 14

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Ccr8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Drd5

1 of 14

Mmus\Gpr15

1 of 14

Yes

Mmus\Gpr101

1 of 14

Yes

Mmus\Gpr182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Olfr275

1 of 14

Yes

Mmus\Olfr683

1 of 14

Yes

Mmus\Olfr684

1 of 14

Yes

Mmus\Olfr919

1 of 14

Yes

Mmus\Olfr1101

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (102)

Xtro\adra1d

6 of 13

Yes

Xtro\adra1a

5 of 13

Yes

Xtro\adra1b

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ei24

1 of 13

Xtro\f2rl3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\gpr83

1 of 13

Xtro\gpr85

1 of 13

Yes

Xtro\gpr161

1 of 13

Yes

Xtro\gpr173

1 of 13

Yes

Xtro\gpr174

1 of 13

Yes

Xtro\gpr176

1 of 13

Yes

Xtro\hrh4.b2

1 of 13

Xtro\hrh4.d1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100494508

1 of 13

Xtro\LOC100498398

1 of 13

Yes

Xtro\LOC101732366

1 of 13

Xtro\LOC101733830

1 of 13

Yes

Xtro\LOC105946838

1 of 13

Xtro\LOC116411706

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\opn5

1 of 13

Xtro\opn8

1 of 13

Xtro\opnpl [provisonal]

1 of 13

Xtro\oprk1

1 of 13

Xtro\p2ry4

1 of 13

Yes

Xtro\qrfprl2.2

1 of 13

Yes

Xtro\qrfpr

1 of 13

Yes

Xtro\rho

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\tmtops

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (79)

Drer\adra1ba

8 of 14

Yes

Drer\adra1aa

7 of 14

Yes

Drer\adra1bb

7 of 14

Yes

Drer\adra1d

7 of 14

Yes

Drer\adra1ab

5 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\hrh2a

1 of 14

Drer\hrh3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100330650

1 of 14

Drer\LOC100331077

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-247m21.3

1 of 14

Drer\tacr3a

1 of 14

Drer\tshr

1 of 14

Drer\zgc:162592

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (44)

Cele\dop-4

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (56)

Agam\GPRDOP2

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dop1R2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (59)

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Lkr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Rh2

1 of 13

Rh3

1 of 13

Rh4

1 of 13

Rh5

1 of 13

Rh6

1 of 13

Rh7

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Dop1R2^JF02043

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^fl.SCA3.UAS

(Ashraf et al., 2020)

Dop1R2^HMC02893

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^fl.SCA3.UAS

(Ashraf et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADRA1B; adrenoceptor alpha 1B

6 of 14

104220

ADRA1D; adrenoceptor alpha 1D

6 of 14

104219

ADRA1A; adrenoceptor alpha 1A

5 of 14

104221

ADRB1; adrenoceptor beta 1

3 of 14

109630

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

Dop1R2 - mir-276a

luminiscence technology

(Zhang et al., 2021)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dop1R2

enhanceable

Dop1R1

(Fernandez-Chiappe et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dop1R1

enhanceable

Dop1R2

(Fernandez-Chiappe et al., 2020)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266137

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

Class of Gene

gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-99

Cytogenetic map

99B5-99B6

Sequence location

3R:29,630,304..29,659,984 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99B5-99B6

Limits computationally determined from genome sequence between P{PZ}l(3)06743⁰⁶⁷⁴³ and P{PZ}ncd⁰⁵⁸⁸⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

99B3-99B5

(determined by in situ hybridisation)

(Feng et al., 1996)

99A10-99B1

(Hannan et al., 1995)

Experimentally Determined Recombination Data

Location

3-99

(FlyBase, 2016)

3-96.6

(Comeron et al., 2012)

(Hannan et al., 1995)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (85)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Korea

11977

P{VT049489-GAL4}attP2

12230

P{VT049485-GAL4}attP2

12523

P{VT049497-GAL4}attP2

12787

P{VT049492-GAL4}attP2

13555

P{VT049494-GAL4}attP2

13851

P{VT049488-GAL4}attP2

13852

P{VT049493-GAL4}attP2

15292

P{VT049486-GAL4}attP2

14473

P{VT049486-lexA}attP2

18741R-3

18741R-4

v105324

More stocks available...

Genomic Clones (30)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RH55627

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266137

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Han et al., 1996)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

DopR2 when expressed in Xenopus oocytes couples to two second messenger systems: initiation of an intracellular calcium signal and stimulation of adenylyl cyclase activity.

(Reale et al., 1997)

Cloning and characterisation of DopR2.

(Feng et al., 1996)

A candidate molecule for mediating signal transduction processes leading to learning and memory.

(Han et al., 1996)

DopR2 was identified as a dopamine D1 receptor by sequence analysis and pharmacological characterization. The spatial expression of DopR2 coincides with that of rut, and possibly initiates biochemical cascades underlying learning.

(Han et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: DopR2 K13sc

(FlyBase, 2009-)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Dop1R2 DopR2

(FlyBase, 2009-)

Nomenclature comments

The nomenclature of the three genes encoding D. melanogaster dopamine receptors ('Dop1R1', 'Dop1R2' and 'Dop2R') has been revised to improve consistency and clarity, and to reduce confusion between them.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (30)

Reported As

Symbol Synonym

CG18741

(Mao et al., 2024, Ashraf et al., 2020, Kondo et al., 2020, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.1.15, Selcho et al., 2009, Camporeale et al., 2007, Hauser et al., 2006, Srivastava et al., 2005)

CG7569

(Stapleton et al., 2006, Whitfield, 2000.10.24)

D1R2

(Akiba et al., 2020)

D2R

(Stern et al., 2019)

DDR2

(Vickrey and Venton, 2011)

DOPR2

(Danchin and Pontarotti, 2004)

DOPR99B

(Feng et al., 2003)

DR2

(Yang et al., 2015)

Damb

(Sun et al., 2018, Himmelreich et al., 2017, Cassar et al., 2015)

Dar2

(Hannan et al., 1995)

DmDOP2

(Qi et al., 2017)

Dop1R2

(Avishai and Parnas, 2025, Gao et al., 2025, Hakim et al., 2025, Jones et al., 2025, Kajtor et al., 2025, Shi et al., 2025, Song et al., 2025, Larnerd et al., 2024, Qu et al., 2024, Bossen et al., 2023, Corthals et al., 2023, Godfrey et al., 2023, Wang et al., 2023, Corrales et al., 2022, Deshpande et al., 2022, Kapoor et al., 2022, Philyaw et al., 2022, Raouf Issa et al., 2022, Schlichting et al., 2022, Ceder et al., 2021, El Kholy et al., 2021, Felsenberg, 2021, Klose and Shaw, 2021, Liu et al., 2021, Sareen et al., 2021, Scaplen and Petruccelli, 2021, Siju et al., 2021, Xie et al., 2021, Ashraf et al., 2020, Chakravarti Dilley et al., 2020, Chvilicek et al., 2020, Jakšić et al., 2020, Karam et al., 2020, Kondo et al., 2020, Petruccelli et al., 2020, Scaplen et al., 2020, Brunet Avalos et al., 2019, Deng et al., 2019, Engel et al., 2019, Harbison et al., 2019, Meltzer et al., 2019, Rao and Deng, 2019.10.23, Shih et al., 2019, Croset et al., 2018, Gene Disruption Project members, 2018-, Peiris et al., 2018, Sun et al., 2018, Branco et al., 2017, Ferguson et al., 2017, Liu et al., 2017, Tomita et al., 2017, Transgenic RNAi Project members, 2017-, Carbone et al., 2016, Clandinin and Owens, 2016-, Pimentel et al., 2016, Regna et al., 2016, Shankar et al., 2015)

Dop1r2

(Li et al., 2023)

DopD1

DopR

(Zajitschek et al., 2017, Zhang et al., 2014)

DopR2

(Tawa and Notterman, 2025, Wang et al., 2025, Mao et al., 2024, Bobrovskikh and Gruntenko, 2023, Sidisky et al., 2023, Yamazaki et al., 2023, Driscoll et al., 2021, Raun et al., 2021, Zhang et al., 2021, Kondo et al., 2020, Mazzotta et al., 2020, Handler et al., 2019, Zhang et al., 2019, Ugrankar et al., 2018, Xie et al., 2018, Lark et al., 2017, Liu et al., 2017, Crocker et al., 2016, Koenig et al., 2016, Wang et al., 2016, Zhang et al., 2016, Cohn et al., 2015, Krüttner et al., 2015, Landayan and Wolf, 2015, Tomita et al., 2015, Ashwal-Fluss et al., 2014, Faisal et al., 2014, Argue and Neckameyer, 2013, Argue and Neckameyer, 2013, Crickmore and Vosshall, 2013, Inagaki et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Keleman et al., 2012, Liu et al., 2012, Neckameyer and Bhatt, 2012, Bang et al., 2011, Jungreis et al., 2011, Pospisilik et al., 2010, Hoopfer et al., 2008, Draper et al., 2007)

DopR99B

(Yuan and Lee, 2007, Blenau and Baumann, 2001, Evans et al., 1997, Reale et al., 1997, Feng et al., 1996, Hall, 1995.8.21)

DopRII

(Gerber et al., 2005)

K13sc

damb

(Sabandal et al., 2021, Srivastav et al., 2018, Cervantes-Sandoval et al., 2016)

dop1R2

(Metaxakis et al., 2023)

dopr2

(Naganos et al., 2016)

Name Synonyms

D2-like receptor

(Srivastava et al., 2005)

DAMB DA receptor

(Musso et al., 2015)

Dopamine 1-like receptor 2

(Shafer, 2025)

Dopamine receptor 2

(Camporeale et al., 2007)

K13sc

(Han et al., 1996)

damb

(Zhang et al., 2016)

dopamine receptor in mushroom bodies

(Seugnet et al., 2011, Selcho et al., 2009, Seugnet et al., 2008, Towers and Sattelle, 2002)

dopamine receptor in mushroom body

(Medina, 2018)

dopamine-2 receptor

(Vickrey and Venton, 2011)

Secondary FlyBase IDs

FBgn0015129
FBgn0042212
FBgn0015741

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43484

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q24563

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q24563

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KI18

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q24563

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43484/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266137

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266137

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG18741

MARRVEL_MODEL - MARRVEL (model organism gene)

43484

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266137

DroID - A comprehensive database of gene and protein interactions.

FBgn0266137

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dop1R2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015129

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266137

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG18741

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0266137

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000574

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Neuroactive ligand-receptor interaction

References (236)

The following external sites may use different assemblies or annotations than FlyBase.

-0.76

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