HIF-1α, HIF-1a, HIF1α, HIF-1, HIFα
bHLH-PAS domain transcription factor - a key regulator of responses to hypoxia - mediates mitochondrial retrograde signaling - regulates lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis
Please see the JBrowse view of Dmel\sima for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.53
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
6.1 (northern blot)
None of the polypeptides share 100% sequence identity.
1505 (aa); 150 (kD observed)
Efficient DNA binding requires dimerization with another bHLH protein. Interacts with Vhl.
The oxygen-dependent degradation (ODD) domain is required for cytoplasmic localization in normoxia.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sima using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
sima is expressed in most or all cells in the embryo from the blastoderm stage to the end of embryogenesis.
JBrowse - Visual display of RNA-Seq signals
View Dmel\sima in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: sima l(3)j11B7
Source for merge of: sima CG31031
Annotations CG7951 and CG31031 merged as CG45051 in release 5.53 of the genome annotation; merge based primarily on RNA-Seq junction and coverage data.
