HIF-1α, HIF-1a, l(3)j11B7, HIF-1, HIF1A
bHLH-PAS domain transcription factor - a key regulator of responses to hypoxia - mediates mitochondrial retrograde signaling - regulates lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.53
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
6.1 (northern blot)
None of the polypeptides share 100% sequence identity.
1505 (aa); 150 (kD observed)
Efficient DNA binding requires dimerization with another bHLH protein. Interacts with Vhl.
The oxygen-dependent degradation (ODD) domain is required for cytoplasmic localization in normoxia.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sima using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\sima in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG7951 and CG31031 merged as CG45051 in release 5.53 of the genome annotation; merge based primarily on RNA-Seq junction and coverage data.
New annotation (CG31031) in release 3 of the genome annotation.
Isolated from a genomic library using a fragment containing the sim basic helix-loop-helix region as a probe, under reduced stringency conditions.