FlyBase Gene Report: Dmel\wake

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\wake

General Information

Symbol

Dmel\wake

Species

D. melanogaster

Name

wide awake

Annotation Symbol

CG45058

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266418

Gene Model Status

Stock Availability

18 publicly available

Gene Summary

wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:22,639,808..22,683,827 [+]

Recombination map

3-75

RefSeq locus

NT_033777 REGION:22639808..22683827

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables GABA receptor binding

inferred from physical interaction with FLYBASE:Rdl; FB:FBgn0004244

(Liu et al., 2014)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in asymmetric neuroblast division

inferred from mutant phenotype

(Mauri et al., 2014)

involved_in asymmetric stem cell division

inferred from mutant phenotype

(Mauri et al., 2014)

involved_in establishment of mitotic spindle orientation

inferred from mutant phenotype

(Mauri et al., 2014)

involved_in positive regulation of circadian sleep/wake cycle, sleep

inferred from mutant phenotype

(Li et al., 2017, Liu et al., 2014)

involved_in regulation of establishment of bipolar cell polarity

inferred from mutant phenotype

(Mauri et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in establishment of mitotic spindle orientation

inferred from biological aspect of ancestor with PANTHER:PTN000484755

(GO Reference Genome Project, 2011-)

involved_in regulation of establishment of bipolar cell polarity

inferred from biological aspect of ancestor with PANTHER:PTN000484755

(GO Reference Genome Project, 2011-)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000159

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Mauri et al., 2014)

located_in spindle

inferred from direct assay

(Mauri et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in spindle

inferred from biological aspect of ancestor with PANTHER:PTN000484755

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

wide awake (wake) encodes a clock output molecule that regulates the timing of sleep onset. It upregulates the GABA receptor encoded by Rdl in the arousal-promoting large ventrolateral neurons, thus suppressing activity of the these cells at dusk and facilitating sleep onset at that time. [Date last reviewed: 2019-03-21]

Summary (Interactive Fly)

a multi-domain signaling protein that regulates asymmetric cell division, cell polarization, spindle orientation, and asymmetric protein localization, regulation of circadian timing of sleep onset

Interactive Fly

Gene Model and Products

Number of Transcripts

7

Number of Unique Polypeptides

5

Please see the JBrowse view of Dmel\wake for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry X4YX01)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.47

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0344404

4933

1255

FBtr0344405

7092

1553

FBtr0344406

5188

1417

FBtr0344407

5224

1417

FBtr0344403

4973

1255

FBtr0344408

5917

1648

FBtr0344409

6723

1403

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0310772

137.8

1255

8.32

FBpp0310773

171.1

1553

9.11

FBpp0310774

156.0

1417

8.63

FBpp0310775

156.0

1417

8.63

FBpp0310771

137.8

1255

8.32

FBpp0310776

178.5

1648

9.55

FBpp0310777

154.4

1403

8.61

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1255 aa isoforms: wake-PB, wake-PF

1417 aa isoforms: wake-PD, wake-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

WAKE-Ab1 was raised against CG42686 and WAKE-Ab2 against CG6954. The amount of wake-protein detected varies throughout the day and is strongest at zeitgeber time 14. Both antibodies recognize a 180 kDa peptide in a western blot assay but do not work in immunohistochemistry.

(Liu et al., 2014)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wake using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.11

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

dorsal ectoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 9 -- 10

inclusive hindgut primordium

(Fisher et al., 2012)

tracheal primordium

Comment: reported as tracheal system anlage

(Fisher et al., 2012)

embryonic stage 11 -- 12

tracheal primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood | male -- day 7 of adulthood | male

(Wasbrough et al., 2010)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

Comment: expression dependent on circadian time

(Liu et al., 2014)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in centrosome

inferred from direct assay

(Mauri et al., 2014)

located_in spindle

inferred from direct assay

(Mauri et al., 2014)

Expression Deduced from Reporters

Reporter: P{wake-GAL4.4.5}

Stage

Tissue/Position (including subcellular localization)

Reference

(Liu et al., 2014)

LNd neuron | subset

(Liu et al., 2014)

(Liu et al., 2014)

(Liu et al., 2014)

(Liu et al., 2014)

adult brain | restricted

(Liu et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\wake in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\wake

View exonic expression by tissue for Dmel\wake

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266418

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42676/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266418

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266418

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6954

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 28 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of wake

Transgenic constructs containing regulatory region of wake

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene partially disrupted in

(Mauri et al., 2014)

Gene disrupted in

(Zhang et al., 2015)

(Zhang et al., 2015)

(Zhang et al., 2015)

(Zhang et al., 2015, Ryder, 2004.4.26)

(Ryder, 2004.4.26)

Gene not disrupted in

(Zhang et al., 2015)

(Zhang et al., 2015)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of P-stage

wake^Δ

partially lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

wake^GD9428

partially lethal - majority die | recessive

wake^29-3

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

wake^GD12087

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

wake^GD12087

Other Phenotypes

Allele

abnormal cell polarity

wake^Δ

abnormal cell polarity, with Scer\GAL4^insc-Mz1407

wake^GD12087

abnormal cell polarity, with Scer\GAL4^pnr-MD237

wake^GD12087

abnormal courtship behavior

abnormal courtship behavior, with Ecol\lexA^VP16.Ilp2.PL

wake^RNAi.lexAop

abnormal courtship behavior, with Scer\GAL4^elav.PU

abnormal courtship behavior, with Scer\GAL4^NP1350

wake^GD12087

abnormal courtship behavior, with Scer\GAL4^NP3168

wake^GD12087

abnormal courtship behavior, with Scer\GAL4^NP3624

wake^GD12087

abnormal courtship behavior, with Scer\GAL4^wake-15185

wake^GD12087

abnormal courtship behavior (with wake³²⁰⁹⁹)

abnormal courtship behavior (with wake^GS17103)

wake³²⁰⁹⁹

abnormal courtship behavior (with wake^NP3168)

wake³²⁰⁹⁹

abnormal courtship behavior | recessive

wake³²⁰⁹⁹

abnormal courtship behavior | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

abnormal courtship behavior | RU486 conditional, with Scer\GAL4^GS.Ilp2.PU

abnormal locomotor behavior | adult stage

abnormal neuroanatomy | adult stage, with Ecol\lexA^VP16.Ilp2.PL

wake^RNAi.lexAop

abnormal sleep, with Scer\GAL4^cry.PZ

wake^RNAi.UAS.1

abnormal sleep, with Scer\GAL4^nSyb.PS

wake^RNAi.UAS.1

abnormal sleep, with Scer\GAL4^P2.4.Pdf

abnormal sleep, with Scer\GAL4^per.PK

wake^RNAi.UAS.1

abnormal sleep, with Scer\GAL4^wake.4.5

abnormal sleep, with Scer\GAL4^wake.4.5, Scer\GAL80^Pdf.PS

wake^RNAi.UAS.1

abnormal sleep (with wake^EY02219)

wake^GS17103

abnormal sleep (with wake^GS17103)

wake^EY02219

abnormal sleep | adult stage

abnormal sleep | adult stage, with Scer\GAL4^dimm-929

wake^RNAi.UAS.2

abnormal sleep | adult stage, with Scer\GAL4^P2.4.Pdf

wake^RNAi.UAS.2

abnormal sleep | dominant

wake^3-10

abnormal sleep | recessive

wake^EY02219

abnormal sleep | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

wake^UAS.cLa

abnormal starvation stress response | adult stage

wake³²⁰⁹⁹

decreased sleep | adult stage

wake^D2

decreased sleep | adult stage, with Scer\GAL4^dimm-929

wake^RNAi.UAS.2

decreased sleep | adult stage, with Scer\GAL4^P2.4.Pdf

wake^RNAi.UAS.2

some die during pupal stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

wake^GD9428

visible, with Scer\GAL4^pnr-MD237

wake^GD12087

Phenotype manifest in

Allele

adult olfactory receptor neuron Or67d, with Ecol\lexA^VP16.Ilp2.PL

wake^RNAi.lexAop

external sensory organ precursor cell IIa, with Scer\GAL4^pnr-MD237

wake^GD12087

external sensory organ precursor cell IIb | ectopic, with Scer\GAL4^pnr-MD237

wake^GD12087

wake^Δ

mitotic spindle

wake^Δ

wake^Δ

sensory mother cell

wake^Δ

tormogen cell, with Scer\GAL4^pnr-MD237

wake^GD12087

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

9 of 14

Yes

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

5 of 14

Yes

Yes

Mus musculus (laboratory mouse) (1)

10 of 14

Yes

Yes

Xenopus tropicalis (Western clawed frog) (2)

7 of 13

Yes

Yes

7 of 13

Yes

Yes

Danio rerio (Zebrafish) (2)

7 of 14

Yes

Yes

Drer\LOC100535772

1 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

10 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP001726

11 of 12

Yes

Yes

Agam\AgaP_AGAP013340

1 of 12

No

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:wake. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANKFN1; ankyrin repeat and fibronectin type III domain containing 1

9 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, western blot

(Liu et al., 2014)

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Mauri et al., 2014)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Huang et al., 2022)

suppressible

(Chen et al., 2022)

suppressible

(Chen et al., 2022)

suppressible

(Li et al., 2017)

suppressible

(Chen et al., 2022)

suppressible

(Chen et al., 2022)

suppressible

(Chen et al., 2022)

suppressible

(Liu et al., 2014)

suppressible

(Liu et al., 2014)

suppressible

(Chen et al., 2022)

suppressible

(Chen et al., 2022)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Liu et al., 2014)

suppressible

(Li et al., 2017)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266418

MIST (protein-protein) - An integrated Molecular Interaction Database

42676

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-75

Cytogenetic map

Sequence location

3R:22,639,808..22,683,827 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94B8-94C1

; Limits computationally determined from genome sequence between P{lacW}Dph5^L4910 and P{lacW}Gclm^L0580

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-75

(FlyBase, 2016)

3-78.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (18)

Aberrations including deletions of this gene Aberrations including duplications of this gene

26376

w¹¹¹⁸; Mi{ET1}wake^MB08442

27847

w¹¹¹⁸; Mi{ET1}wake^MB10828

32099

w^*; P{UAS-Mob2.ECFP}wake³²⁰⁹⁹

61232

y¹ v¹; P{TRiP.HMJ23011}attP40

36032

y¹ w^*; Mi{MIC}wake^MI02709

42125

y¹ w^*; Mi{MIC}wake^MI05961

15858

y¹ w^67c23; P{EPgy2}wake^EY02219

104560

w^*; P{GawB}wake^NP3624

113136

w^*; P{GawB}wake^NP3168

HMJ23101

y¹ v¹; P{TRiP.HMJ23101}attP40/CyO

v102564

P{KK112014}VIE-260B

v108215

P{KK102108}VIE-260B

More stocks available...

Genomic Clones (30)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (28)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD15640

Other clones

MIP14060

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266418

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Liu et al., 2014)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

wake promotes sleep and is required for circadian timing of sleep onset. It appears to act as a clock output molecule, inhibiting the large ventrolateral neurons (l-LNvs) at dusk to promote the transition from wake to sleep.

(Liu et al., 2014)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG17622 CG17623

(FlyBase Genome Annotators, 2010)

Source for merge of: CG6954 CG42686

(FlyBase Genome Annotators, 2013)

Additional comments

Annotations CG6954 and CG42686 merged as CG45058 in release 5.53 of the genome annotation. Merge based on RNA-Seq junction and expression data.

(FlyBase Genome Annotators, 2013)

Annotations CG17622 and CG17623 merged as CG42686 in release 5.25 of the genome annotation.

(FlyBase Genome Annotators, 2010)

Nomenclature History

Source for database identify of

Source for identity of: wake CG45058

(Liu et al., 2014)

Nomenclature comments

Etymology

Gene is named "wide awake" after the mutant phenotype of significantly reduced sleep amount and markedly increased sleep latency.

(Liu et al., 2014)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG17622

(Ashwal-Fluss et al., 2014, Bantignies et al., 2011, Keleman et al., 2009.8.5)

CG17623

(Keleman et al., 2009.8.5)

CG42686

(Liu et al., 2014, FlyBase Genome Annotators, 2010)

CG45058

(National Institute of Genetics Fly Stocks, 2023-, Zhang et al., 2015, FlyBase Genome Annotators, 2013)

CG6954

(Liu et al., 2014, Kwon et al., 2013, Tian et al., 2013, Anholt and Williams, 2010, Wasbrough et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009)

WAKE

(Chaturvedi and Emery, 2024, Tabuchi et al., 2021)

Wide awake

(Patke et al., 2020)

ban

(Mauri et al., 2014)

wake

(Axelrod et al., 2023, Chen et al., 2022, Belfer et al., 2021, Shafer and Keene, 2021, Huang et al., 2020, King and Sehgal, 2020, Tabuchi et al., 2018, Li et al., 2017, Sanfilippo et al., 2017, Tomita et al., 2017, Zhang et al., 2015, Liu et al., 2014)

Name Synonyms

banderuola

(Mauri et al., 2014)

wide awake

(Shafer, 2025, Belfer et al., 2021, Hill et al., 2020, Tomita et al., 2017, Liu et al., 2014)

Secondary FlyBase IDs

FBgn0039000
FBgn0038998
FBgn0038999
FBgn0261572

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 62 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42676

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

X4YX01

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

X4YX01

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0266418

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42676/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0266418

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0266418

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG45058

MARRVEL_MODEL - MARRVEL (model organism gene)

42676

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266418

DroID - A comprehensive database of gene and protein interactions.

FBgn0266418

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0266418

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6954

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034180

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

42676

References (67)