a multi-domain signaling protein that regulates asymmetric cell division, cell polarization, spindle orientation, and asymmetric protein localization, regulation of circadian timing of sleep onset
Gene model reviewed during 5.52
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.47
Gene model reviewed during 5.53
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wake using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\wake in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: wake CG45058
Annotations CG6954 and CG42686 merged as CG45058 in release 5.53 of the genome annotation. Merge based on RNA-Seq junction and expression data.
Annotations CG17622 and CG17623 merged as CG42686 in release 5.25 of the genome annotation.
wake promotes sleep and is required for circadian timing of sleep onset. It appears to act as a clock output molecule, inhibiting the large ventrolateral neurons (l-LNvs) at dusk to promote the transition from wake to sleep.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Gene is named "wide awake" after the mutant phenotype of significantly reduced sleep amount and markedly increased sleep latency.