FlyBase Gene Report: Dmel\stai

General Information

Symbol

Dmel\stai

Species

D. melanogaster

Name

stathmin

Annotation Symbol

CG31641

Feature Type

protein_coding_gene

FlyBase ID

FBgn0266521

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Summary

stathmin (stai) encodes a tubulin binding protein involved in axo-dendritic transport, gamete generation and synaptic growth at neuromuscular junction. [Date last reviewed: 2019-09-19] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

D-stathmin, rdtp

Key Links

Genomic Location

Cytogenetic map

23E-23E

Sequence location

2L:6,100,377..6,124,653 [+]

Recombination map

2-18

RefSeq locus

NT_033779 REGION:6100377..6124653

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables tubulin binding

inferred from direct assay

(Lachkar et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables tubulin binding

inferred from biological aspect of ancestor with PANTHER:PTN000802387

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in axo-dendritic transport

inferred from mutant phenotype

(Duncan et al., 2013)

involved_in border follicle cell migration

inferred from mutant phenotype

(Yang et al., 2012, Borghese et al., 2006)

involved_in germ cell migration

inferred from mutant phenotype

(Ozon et al., 2002)

involved_in nervous system development

inferred from mutant phenotype

(Ozon et al., 2002)

involved_in synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Graf et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in microtubule depolymerization

inferred from biological aspect of ancestor with PANTHER:PTN000802387

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in neuron projection development

inferred from biological aspect of ancestor with PANTHER:PTN000802387

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of microtubule polymerization or depolymerization

inferred from biological aspect of ancestor with PANTHER:PTN000802387

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in neuromuscular junction

inferred from mutant phenotype

(Graf et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000802387

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in neuron projection

inferred from biological aspect of ancestor with PANTHER:PTN000802387

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

stathmin (stai) encodes a tubulin binding protein involved in axo-dendritic transport, gamete generation and synaptic growth at neuromuscular junction. [Date last reviewed: 2019-09-19]

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\stai for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

stai-RA

FBtr0079198

NM_164684

2067

250

stai-RB

FBtr0079197

NM_164683

2977

302

stai-RC

FBtr0079196

NM_164682

1859

257

stai-RD

FBtr0304908

NM_001258983

2872

381

stai-RE

FBtr0333406

NM_001273193

2395

302

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

stai-PA

FBpp0078829

28.5

250

10.26

NP_723158

AAF52345

stai-PB

FBpp0078828

34.7

302

10.20

NP_723157

AAN10581

stai-PC

FBpp0078827

29.6

257

8.65

NP_723156

AAN10580

stai-PD

FBpp0293447

43.9

381

8.20

NP_001245912

AFH03586

stai-PE

FBpp0305598

34.7

302

10.20

NP_001260122

AGB92658

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

302 aa isoforms: stai-PB, stai-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\stai using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

organism | ubiquitous

Comment: isoform-specific expression

(Lachkar et al., 2010, Ozon et al., 2002)

embryonic stage 5 -- 17

germline cell

Comment: isoform-specific expression

(Lachkar et al., 2010)

embryonic stage 6 -- 17

primordial germ cell

(Ozon et al., 2002)

embryonic stage 12 -- 17

central nervous system

(Ozon et al., 2002)

embryonic/larval central nervous system

Comment: isoform-specific expression

(Lachkar et al., 2010)

embryonic stage 14 -- 17

peripheral nervous system

(Ozon et al., 2002)

chordotonal organ

(Ozon et al., 2002)

embryonic stage 15 -- 17

embryonic/larval peripheral nervous system

Comment: isoform-specific expression

(Lachkar et al., 2010)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

organism

(Ozon et al., 2002)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis

border follicle cell

(Borghese et al., 2006)

Additional Descriptive Data

stai transcripts originating from the upstream promoter are expressed in early embryos and then are restricted to germline cells. Transcripts originating from the first downstream promoter are expressed in the central and peripheral nervous systems.

(Lachkar et al., 2010)

stai is enriched in border follicle cells relative to follicle cells.

(Borghese et al., 2006)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

organism | ubiquitous

(Ozon et al., 2002)

embryonic stage 4 -- 17

primordial germ cell

(Ozon et al., 2002)

embryonic stage 12 -- 17

central nervous system

(Ozon et al., 2002)

embryonic stage 14 -- 17

peripheral nervous system

(Ozon et al., 2002)

third instar larval stage

motor neuron

• axon

(Graf et al., 2011)

embryonic/larval wrapping glial cell

(Graf et al., 2011)

embryonic/larval PNS perineurial glial cell

(Graf et al., 2011)

oogenesis

border follicle cell

(Borghese et al., 2006)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism

Comment: 0-24 hr AEL

(Ozon et al., 2002)

third instar larval stage

embryonic/larval brain

(Graf et al., 2011)

adult stage | female

ovary

(Lachkar et al., 2010)

Additional Descriptive Data

stai is enriched in migrating border follicle cells relative to follicle cells..

(Borghese et al., 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in neuromuscular junction

inferred from mutant phenotype

(Graf et al., 2011)

Expression Deduced from Reporters

Reporter: PBac{544.SVS-1}stai^CPTI002399

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

Reporter: PBac{681.P.FSVS-1}stai^CPTI001234

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

ellipsoid body | faint

(Knowles-Barley, 2011.8.24)

adult mushroom body | faint

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\stai in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\stai

View exonic expression by tissue for Dmel\stai

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB

33863/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0266521

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31641

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 36 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of stai

Transgenic constructs containing regulatory region of stai

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel6015

(Ryder, 2004.4.26)

Df(2L)stai^L27

(Borghese et al., 2006)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PU

stai^GD8550

lethal | recessive

stai^rdtp

lethal - all die before end of larval stage

stai^rdtp

partially lethal - majority die

stai^B200

partially lethal - majority die, with Scer\GAL4^29BD

stai^GS2209

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

stai^GD8550

viable, with Scer\GAL4^Mef2.PR

stai^GD8550

viable, with Scer\GAL4^pnr-MD237

stai^GD8550

viable, with Scer\GAL4^tin.CΔ4

stai^GD8550

viable (with Df(2L)stai^L27)

stai^KO

Sterility

Allele

female semi-sterile

stai^KO

fertile

stai^exC

male sterile

stai^KO

Other Phenotypes

Allele

abnormal locomotor behavior

stai^KO

abnormal neuroanatomy

stai^B200

abnormal neuroanatomy (with Df(2L)ED384)

stai^B200

abnormal neuroanatomy (with Df(2L)stai^L27)

stai^B200

abnormal neuroanatomy | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

abnormal neuroanatomy | third instar larval stage

stai^B200

bang sensitive | dominant

long lived, with Scer\GAL4^hs.PB

stai^GS2209

paralytic | posterior | recessive | third instar larval stage

stai^B200

paralytic | posterior | third instar larval stage

stai^rdtp

paralytic | posterior | third instar larval stage (with Df(2L)Exel6015)

stai^B200

paralytic | posterior | third instar larval stage (with stai^B200)

stai^rdtp

paralytic | posterior | third instar larval stage (with stai^rdtp)

stai^B200

short lived

stai^B200

wild-type, with Scer\GAL4^c355

stai^GS2209

wild-type, with Scer\GAL4^dpp.blk1

stai^GS2209

wild-type, with Scer\GAL4^hs.2sev

stai^GS2209

Phenotype manifest in

Allele

border follicle cell

stai^KO

border follicle cell, with Df(2L)stai^L27/stai^exC, Scer\GAL4^slbo.2.6

stai^{dsRNA.UAS.WIZ}

border follicle cell (with Df(2L)stai^L27), with Scer\GAL4^slbo.2.6, stai^{dsRNA.UAS.WIZ}

stai^exC

border follicle cell | somatic clone

stai^KO

bouton

stai^B200

bouton | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

larval segmental nerve | third instar larval stage

stai^B200

neuromuscular junction

stai^B200

neuromuscular junction (with Df(2L)ED384)

stai^B200

neuromuscular junction (with Df(2L)stai^L27)

stai^B200

neuromuscular junction | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

stai^{dsRNA.UAS.WIZ}

synapse

stai^B200

synapse (with Df(2L)ED384)

stai^B200

synapse (with Df(2L)stai^L27)

stai^B200

synapse | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\STMN3

8 of 15

Yes

Hsap\STMN4

8 of 15

Yes

Hsap\STMN2

7 of 15

Yes

Hsap\STMN1

6 of 15

Yes

Hsap\KCMF1

1 of 15

Hsap\MIR3917

1 of 15

Yes

Hsap\STMND1

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Stmn3

8 of 15

Yes

Mmus\Stmn4

8 of 15

Yes

Mmus\Stmn1

7 of 15

Yes

Mmus\Stmn2

7 of 15

Yes

Mmus\Kcmf1

1 of 15

Mmus\Stmnd1

1 of 15

Yes

Rattus norvegicus (Norway rat) (7)

Rnor\Stmn1

7 of 13

Yes

Rnor\Stmn2

5 of 13

Yes

Rnor\Stmn4

5 of 13

Yes

Rnor\Stmn3

4 of 13

Yes

Rnor\Cfap53

1 of 13

Rnor\Kcmf1

1 of 13

Rnor\LOC102554838

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (5)

Xtro\stmn4

8 of 12

Yes

Xtro\stmn2

6 of 12

Yes

Xtro\stmn3

6 of 12

Yes

Xtro\stmn1

4 of 12

Yes

Xtro\kcmf1

1 of 12

Danio rerio (Zebrafish) (9)

Drer\stmn4l

10 of 15

Yes

Drer\stmn3

9 of 15

Yes

Drer\stmn4

9 of 15

Yes

Drer\stmn1a

8 of 15

Yes

Drer\stmn1b

8 of 15

Yes

Drer\stmn2a

8 of 15

Yes

Drer\stmn2b

8 of 15

Yes

Drer\kcmf1

1 of 15

Drer\stmnd1

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\ZK652.6

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\AT4G01180

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190AOG )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16358

Drosophila persimilis

Dper\GL19068

Drosophila willistoni

Dwil\GK14732

Drosophila virilis

Dvir\GJ15867

Drosophila mojavensis

Dmoj\GI17318

Drosophila grimshawi

Dgri\GH10808

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509MG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017094

Glossina morsitans

Tsetse fly

Gmor\GMOY006609

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_13694

Mayetiola destructor

Hessian fly

Mdes\Mdes004942

Mayetiola destructor

Hessian fly

Mdes\Mdes014847

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012840

Anopheles darlingi

American malaria mosquito

Adar\ADAC008156

Anopheles gambiae

Malaria mosquito

Agam\AGAP009940

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ005489

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08ZR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006043

Danaus plexippus

Monarch butterfly

Dple\DPOGS201869-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL013433

Apis florea

Little honeybee

Aflo\2228502788

Apis mellifera

Western honey bee

Amel\GB45137

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP15038

Bombus terrestris

Buff-tailed bumblebee

Bter\15212375

Linepithema humile

Argentine ant

Lhum\LH19413

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00316e

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013295

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08310

Tribolium castaneum

Red flour beetle

Tcas\TC013090

Pediculus humanus

Human body louse

Phum\PHUM465870

Rhodnius prolixus

Kissing bug

Rpro\RPRC008569

Cimex lectularius

Bed bug

Clec\CLEC005556

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI064163

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_02496

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X08VP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR011744

Ixodes scapularis

Black-legged tick

Isca\ISCW003366

Stegodyphus mimosarum

African social velvet spider

Smim\KFM73471.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM65265.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_308960

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0DVM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_010483gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_2863

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_022118gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003733gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_1221

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hypp_2311

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (6)

Gene Symbol

Score

Source

Alignment

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

8 of 15

8 of 15

7 of 15

6 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

stai

Hsap\STMN1

(Duncan et al., 2013)

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

stai - CG11474

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

stai

enhanceable

Khc

(Duncan et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

stai

(Krupp et al., 2005)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266521

MIST (protein-protein) - An integrated Molecular Interaction Database

stai

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-18

Cytogenetic map

23E-23E

Sequence location

2L:6,100,377..6,124,653 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

23E-23E

Left limit from (method unavailable) (FBrf0126149) Right limit from (method unavailable) (FBrf0126149)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

23E-23E

(Haghnia et al., 2000)

Experimentally Determined Recombination Data

Location

2-18

(FlyBase, 2016)

2-19.6

(Comeron et al., 2012)

(Haghnia et al., 1999)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Bloomington

32541

stai^rdtp/CyO, P{sevRas1.V12}FK1

53925

y¹ v¹; P{TRiP.HMJ21270}attP40

65660

w¹¹¹⁸; PBac{IT.GAL4}stai^1304-G4

66195

w¹¹¹⁸; PBac{IT.GAL4}stai^2185-G4

77535

w¹¹¹⁸; PBac{IT.GAL4}stai^0225-G4

77554

w¹¹¹⁸; PBac{IT.GAL4}stai^0416-G4

43703

y¹ w^*; Mi{MIC}stai^MI07398

FlyORF

F001475

M{UAS-stai.ORF}ZH-86Fb

F000859

M{UAS-stai.ORF.3xHA}ZH-86Fb

Kyoto

123927

w¹¹¹⁸; P{RS3}stai^CB-6118-3

VDRC

v330086

P{VSH330086}attP40

v32370

w¹¹¹⁸; P{GD8550}v32370

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (142)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0266521

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33863

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: stathmin BEST:LD33989

(FlyBase, 1996-)

Source for database merge of

Source for merge of: stai rdtp

(Duncan et al., 2013)

Additional comments

Source for identity of stathmin BEST:LD33989 was sequence comparison ( date:001203 ).

(FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-)

Other Comments

stai is necessary to maintain the stability of the neuromuscular junction.

(Graf et al., 2011)

Loss of stai causes impaired neuromuscular junction growth and stability.

(Graf et al., 2011)

stai acts in the neuron to prevent neuromuscular junction retraction.

(Graf et al., 2011)

Expression is enriched in embryonic gonads.

(Shigenobu et al., 2006)

dsRNA interference (RNAi) inactivation of stai results in arrest of germ cell migration at stage 14 in embryos. Defects in nervous system development are also seen.

(Ozon et al., 2002)

Mutant larvae show progressive distal paralysis that causes them to flip their tails upward as they crawl. Axonal transport defects are seen.

(Haghnia et al., 1999)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 69 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33863

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0266521

DRscDB

33863/tissue=All

EMBL-EBI Single Cell Expression Atlas

FBgn0266521

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31641

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33863

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG31641

MARRVEL_MODEL

33863

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0266521

MIST (protein-protein) - An integrated Molecular Interaction Database

stai

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

BEST:LD33989

CG31641

(Meadows, 2017.1.11, Schertel et al., 2013, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Dietzl et al., 2007)

CG5981

(Hughes et al., 2008, Dallman et al., 2004, Seong et al., 2001, BDGP Project Members, 2000-, Goldberg, 2000.12.7, Goldstein and Gunawardena, 2000)

D-stat

(Chauvin et al., 2008)

LD33989

(Toba et al., 1999)

SCG10-like

(Dallman et al., 2004)

Stai

(Yildirim et al., 2019, Wang et al., 2018)

rdt

(Haghnia et al., 1999)

rdtp

(Goldstein, 2010.12.4)

stai

(Hope et al., 2020, Ramond et al., 2020, Kline et al., 2017, Clandinin and Owens, 2016-, Chauvin and Sobel, 2015, Gene Disruption Project members, 2015-, Tiebe et al., 2015, Liang et al., 2014, Zenger et al., 2014, Duncan et al., 2013, Schertel et al., 2013, Yang et al., 2012, Graf et al., 2011, Lachkar et al., 2010, Dietzl et al., 2007, Georlette et al., 2007, Shigenobu et al., 2006, Liu et al., 2005)

Name Synonyms

D-stathmin

(Chauvin et al., 2008, Ozon et al., 2002)

Stathmin

(Duncan et al., 2013, Yang et al., 2012)

redtape

(Haghnia et al., 1999)

stathmin

(Tao et al., 2016, Duncan et al., 2013, Graf et al., 2011, Lachkar et al., 2010, Borghese et al., 2009, Hoopfer et al., 2008, Borghese et al., 2006, Terry et al., 2006, Ozon, 1999.11.8)

Secondary FlyBase IDs

FBgn0026184
FBgn0051641
FBgn0026568
FBgn0031780

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (91)

Report Sections

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