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General Information
Symbol
Dmel\tau
Species
D. melanogaster
Name
tau
Annotation Symbol
CG45110
Feature Type
FlyBase ID
FBgn0266579
Gene Model Status
Stock Availability
Gene Summary
microtubule-associated protein - delivery of synaptic proteins - vesicular axonal transport - a target for PAR-1 in dendritic pruning - Dendrite severing - regulation of photoreceptor development and progressive neuronal degeneration (Interactive Fly, tau )
Contribute a Gene Snapshot for this gene.
Also Known As

dtau

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:27,639,886..27,656,996 [-]
Recombination map
3-94
RefSeq locus
NT_033777 REGION:27639886..27656996
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000161190
(assigned by GO_Central )
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000161190
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000161190
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
colocalizes_with cytoplasmic microtubule
inferred from direct assay
located_in dendrite
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000161190
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
-
Summaries
Summary (Interactive Fly)

microtubule-associated protein - delivery of synaptic proteins - vesicular axonal transport - a target for PAR-1 in dendritic pruning - Dendrite severing - regulation of photoreceptor development and progressive neuronal degeneration

Gene Model and Products
Number of Transcripts
14
Number of Unique Polypeptides
12

Please see the JBrowse view of Dmel\tau for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model includes transcripts encoding non-overlapping portions of the full CDS.

Gene model reviewed during 5.44

Gene model reviewed during 6.03

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0344741
2243
361
FBtr0344742
2425
361
FBtr0344743
2459
349
FBtr0344744
1343
93
FBtr0344745
1802
403
FBtr0344746
3754
717
FBtr0344747
1457
288
FBtr0344748
1643
350
FBtr0344749
2084
308
FBtr0344750
1781
278
FBtr0344751
1803
278
FBtr0344752
2261
367
FBtr0347394
3340
375
FBtr0479931
2369
324
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0311073
38.5
361
10.45
FBpp0311074
38.5
361
10.45
FBpp0311075
37.6
349
10.41
FBpp0311076
10.0
93
4.85
FBpp0311077
43.3
403
10.65
FBpp0311078
78.0
717
10.42
FBpp0311079
30.9
288
10.70
FBpp0311080
37.5
350
10.75
FBpp0311081
32.7
308
10.52
FBpp0311082
29.7
278
10.71
FBpp0311083
29.7
278
10.71
FBpp0311084
39.2
367
10.40
FBpp0312546
40.3
375
10.36
FBpp0428263
34.9
324
10.39
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

361 aa isoforms: tau-PA, tau-PB
278 aa isoforms: tau-PK, tau-PL
Additional Polypeptide Data and Comments
Reported size (kDa)

60 (kD observed)

Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tau using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Maternal tau proteinpersists in the embryo until stage 4. Expression is observed from stage 14 in the embryonic brain and ventral nerve cord. After stage 15, expression is seen in the cap cells of particular chordotonal organs. These include the dch3 cluster in the thoracic segments, the lch5 cluster and lch1 in segments A1-A7, and the lch3 clusters in A8 and A9. tau protein is expressed in larval eye discs, in photorecptor cells posterior to the morphogenetic furrow, as well as in the optic lobe, ventral nerve cord, and leg discs. In adults, tau protein is observed in the visual system. tau protein co-localizes with microtubules in several larval and adult tissues.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
colocalizes_with cytoplasmic microtubule
inferred from direct assay
located_in dendrite
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain

Comment: expression throughout adult brain

High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\tau in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of tau
Transgenic constructs containing regulatory region of tau
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Inferred from location ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
Yes
 
149  
6 of 15
No
Yes
5 of 15
No
Yes
1  
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
6 of 15
Yes
Yes
5 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (6)
4 of 13
Yes
Yes
4 of 13
Yes
Yes
4 of 13
Yes
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
5 of 12
Yes
Yes
3 of 12
No
Yes
3 of 12
No
Yes
Danio rerio (Zebrafish) (7)
6 of 15
Yes
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
3 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (2)
8 of 15
Yes
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190DD1 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509UL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02M7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0G74 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 7 )
Potential Models Based on Orthology ( 4 )
Modifiers Based on Experimental Evidence ( 5 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
RNA-RNA
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-94
Cytogenetic map
Sequence location
3R:27,639,886..27,656,996 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
98A13-98A14
Limits computationally determined from genome sequence between P{PZ}sda03884 and P{PZ}btzrL203
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (26)
Genomic Clones (29)
cDNA Clones (36)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
RNAi and Array Information
Linkouts
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Other Information
Relationship to Other Genes
Source for database identify of

Source for identity of: tau CG5606 CG12881

Source for database merge of

Source for merge of: tau BcDNA:RE16764

Source for merge of: tau CG31058 CG34294

Additional comments

Annotations CG31057, CG31058 and CG34294 merged as CG45110 in release 5.55 of the genome annotation. The CG34294 annotation overlapped the 3' end of some isoforms, but corresponded to a different ORF.

Source for identity of tau CG5606 CG12881 was sequence comparison ( date:011010 ).

Annotation CG5606 split into CG31057 (tau) and CG31058 in release 3 of the genome annotation. In addition, CG31057 contains sequences corresponding to release 3 annotation CG12881.

Source for merge of tau BcDNA:RE16764 was a shared cDNA ( date:030728 ).

Other Comments

New annotation (CG34294) in release 5.2 of the genome annotation.

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 82 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
Linkouts
DroID - A comprehensive database of gene and protein interactions.
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Synonyms and Secondary IDs (13)
Reported As
Symbol Synonym
BcDNA:RE16764
CG31058
Name Synonyms
Secondary FlyBase IDs
  • FBgn0051057
  • FBgn0039535
  • FBgn0063056
  • FBgn0051058
  • FBgn0039533
  • FBgn0063637
  • FBgn0085323
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (158)