microtubule-associated protein - delivery of synaptic proteins - vesicular axonal transport - a target for PAR-1 in dendritic pruning - Dendrite severing - regulation of photoreceptor development and progressive neuronal degeneration
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 5.44
Gene model reviewed during 6.03
Gene model reviewed during 6.32
60 (kD observed)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\tau using the Feature Mapper tool.
Maternal tau proteinpersists in the embryo until stage 4. Expression is observed from stage 14 in the embryonic brain and ventral nerve cord. After stage 15, expression is seen in the cap cells of particular chordotonal organs. These include the dch3 cluster in the thoracic segments, the lch5 cluster and lch1 in segments A1-A7, and the lch3 clusters in A8 and A9. tau protein is expressed in larval eye discs, in photorecptor cells posterior to the morphogenetic furrow, as well as in the optic lobe, ventral nerve cord, and leg discs. In adults, tau protein is observed in the visual system. tau protein co-localizes with microtubules in several larval and adult tissues.
GBrowse - Visual display of RNA-Seq signalsView Dmel\tau in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: tau CG5606 CG12881
Annotations CG31057, CG31058 and CG34294 merged as CG45110 in release 5.55 of the genome annotation. The CG34294 annotation overlapped the 3' end of some isoforms, but corresponded to a different ORF.
Source for identity of tau CG5606 CG12881 was sequence comparison ( date:011010 ).
Annotation CG5606 split into CG31057 (tau) and CG31058 in release 3 of the genome annotation. In addition, CG31057 contains sequences corresponding to release 3 annotation CG12881.
Source for merge of tau BcDNA:RE16764 was a shared cDNA ( date:030728 ).
New annotation (CG34294) in release 5.2 of the genome annotation.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.