FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Gene: Dmel\Cenp-C
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General Information
Symbol
Dmel\Cenp-C
Species
D. melanogaster
Name
Centromeric protein-C
Annotation Symbol
CG31258
Feature Type
protein_coding_gene
FlyBase ID
FBgn0266916
Gene Model Status
Current
Stock Availability
23 publicly available
Gene Summary
Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)85Aa, dCENP-C, CenpC, L1

Key Links
Genomic Location
Cytogenetic map
85A3-85A3
Sequence location
Recombination map
3-48
RefSeq locus
NT_033777 REGION:8564105..8569248
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables chromatin-protein adaptor activity
inferred from direct assay
(Chen et al., 2014)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in chromosome segregation
inferred from mutant phenotype
(Przewloka et al., 2007)
involved_in female meiosis chromosome segregation
inferred from mutant phenotype
(Unhavaithaya and Orr-Weaver, 2013)
involved_in kinetochore assembly
inferred from direct assay
(Chen et al., 2014)
inferred from mutant phenotype
(Lipinszki et al., 2015, Orr and Sunkel, 2011)
involved_in mitotic metaphase chromosome alignment
inferred from mutant phenotype
(Przewloka et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in chromosome, centromeric region
inferred from direct assay
(Lipinszki et al., 2015, Heeger et al., 2005)
located_in condensed chromosome, centromeric region
inferred from direct assay
(Schuh et al., 2007)
located_in kinetochore
inferred from direct assay
(Orr and Sunkel, 2011, Goshima et al., 2007, Schittenhelm et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Snapshot
    Centromeric protein-C (Cenp-C) encodes an essential centromere protein. It binds to the product of cid and provides a binding site for the Mis12 kinetochore protein complex, which is recruited to the centromere at the start of mitotic and meiotic M phases. It also binds the product of cal1, which is crucial for propagation of the epigenetic mark that specifies centromere identity during progression through the cell division cycle. [Date last reviewed: 2019-03-07]
    Summary (Interactive Fly)

    centromere protein required for normal attachment of kinetochores to the spindle

    Gene Model and Products
    Number of Transcripts
    2
    Number of Unique Polypeptides
    2

    Please see the JBrowse view of Dmel\Cenp-C for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VHP9)

    If you don't see a structure in the viewer, refresh your browser.
    Model Confidence:
    • Very high (pLDDT > 90)
    • Confident (90 > pLDDT > 70)
    • Low (70 > pLDDT > 50)
    • Very low (pLDDT < 50)

    AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

    Experimentally Determined Structures
    Crossreferences
    PDB - An information portal to biological macromolecular structures
    Comments on Gene Model

    Gene model reviewed during 5.49

    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    Cenp-C-RA
    FBtr0089973
    NM_169228
    4682
    1411
    Cenp-C-RB
    FBtr0339328
    NM_001300308
    4453
    1399
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    UniProt
    RefSeq ID
    GenBank
    Cenp-C-PA
    FBpp0088911
    157.7
    1411
    8.63
    Q9VHP9
    NP_731254
    AAF54252
    Cenp-C-PB
    FBpp0308429
    156.4
    1399
    8.72
    A0A0B4LGX0
    NP_001287237
    AHN57236
    Polypeptides with Identical Sequences

    None of the polypeptides share 100% sequence identity.

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    PDB - An information portal to biological macromolecular structures
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cenp-C using the Feature Mapper tool.

    External Data
    Crossreferences
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    -0.26

    Transcript Expression
    Polypeptide Expression
    immunolocalization
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    embryonic stage 4 -- 5
    cell

    Comment: Localization observed at interphase and during mitosis of embryonic cycle 14

    (Schittenhelm et al., 2007)
    Additional Descriptive Data
    Marker for
     
    chromosome, centromeric region
    (Schittenhelm et al., 2007)
    Subcellular Localization
    CV Term
    Evidence
    References
    located_in chromosome, centromeric region
    inferred from direct assay
    (Lipinszki et al., 2015, Heeger et al., 2005)
    located_in condensed chromosome, centromeric region
    inferred from direct assay
    (Schuh et al., 2007)
    located_in kinetochore
    inferred from direct assay
    (Orr and Sunkel, 2011, Goshima et al., 2007, Schittenhelm et al., 2007)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\Cenp-C in JBrowse
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 9 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 42 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of Cenp-C
    Transgenic constructs containing regulatory region of Cenp-C
    Aberrations (Deficiencies and Duplications) ( 22 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    lethal
    lethal, with Scer\GAL4insc-Mz1407
    lethal | recessive
    lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
    lethal - all die during embryonic stage (with Df(3R)p25)
    lethal - all die during embryonic stage | recessive
    lethal - all die during P-stage, with Scer\GAL4Mef2.PR
    partially lethal | male limited, with Scer\GAL4Bx-MS1096
    partially lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
    viable
    viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
    Sterility
    Allele
    female sterile
    female sterile (with Cenp-CIR35)
    female sterile (with Cenp-CZ3-4375)
    Other Phenotypes
    Allele
    abnormal meiotic cell cycle | semidominant
    abnormal mitotic cell cycle
    abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
    increased cell death (with Df(3R)p25)
    some die during embryonic stage (with Df(3R)p25)
    some die during embryonic stage | recessive
    some die during pupal stage, with Scer\GAL4pnr-MD237
    visible, with Scer\GAL4Bx-MS1096
    visible, with Scer\GAL4GMR.PF
    visible | female limited, with Scer\GAL4Bx-MS1096
    visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
    Phenotype manifest in
    Allele
    chromosome, centromeric region
    chromosome, centromeric region (with Cenp-CIR35)
    chromosome, centromeric region (with Cenp-CZ3-4375)
    eye, with Scer\GAL4GMR.PF
    ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
    larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
    male germline stem cell | adult stage, with Scer\GAL4C587
    male germline stem cell | adult stage, with Scer\GAL4VP16.nanos.UTR
    mitosis & nuclear chromosome
    mitotic anaphase & nuclear chromosome
    mitotic prometaphase
    mitotic telophase & nuclear chromosome
    oocyte
    oocyte (with Cenp-CIR35)
    oocyte (with Cenp-CZ3-4375)
    presumptive embryonic/larval central nervous system (with Df(3R)p25)
    testis | adult stage, with Scer\GAL4C587
    testis | adult stage, with Scer\GAL4VP16.bam
    testis | adult stage, with Scer\GAL4VP16.nanos.UTR
    wing, with Scer\GAL4Bx-MS1096
    wing | cold sensitive, with Scer\GAL4Bx-MS1096
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (1)
    Hsap\KRTCAP2
    1 of 14
    Yes
    No
    1  
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (0)
    Mus musculus (laboratory mouse) (1)
    Mmus\Krtcap2
    1 of 14
    Yes
    No
    Xenopus tropicalis (Western clawed frog) (0)
    Danio rerio (Zebrafish) (1)
    Drer\krtcap2
    1 of 14
    Yes
    No
    Caenorhabditis elegans (Nematode, roundworm) (1)
    Cele\set-2
    1 of 14
    Yes
    No
    Anopheles gambiae (African malaria mosquito) (1)
    Agam\AgaP_AGAP003126
    1 of 12
    Yes
    No
    Arabidopsis thaliana (thale-cress) (1)
    Atha\AT1G77350
    1 of 13
    Yes
    No
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    Schizosaccharomyces pombe (Fission yeast) (0)
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:Cenp-C. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Gene Symbol
    Score
    Source
    Compara
    Domainoid
    eggNOG
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Drosophila melanogaster (Fruit fly) (1)
    CG31460
    1 of 13
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Cenp-C
      cosedimentation, molecular weight, molecular sieving, molecular weight estimation by staining, x-ray crystallography, phenotype-based detection assay, inferred by author, fluorescence microscopy
      (Medina-Pritchard et al., 2020, Chik et al., 2019, Roure et al., 2019)
      Cenp-C - 14-3-3ε
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015, Przewloka et al., 2011)
      Cenp-C - 14-3-3ζ
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015, Przewloka et al., 2011)
      Cenp-C - Bub3
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2011)
      Cenp-C - Hmr
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
      (Thomae et al., 2013)
      Cenp-C - Hr78
      two hybrid array
      (Shokri et al., 2019)
      Cenp-C - Kmn1
      molecular sieving, cosedimentation, molecular weight estimation by staining, anti tag coimmunoprecipitation, peptide massfingerprinting, protein cross-linking with a bifunctional reagent, anti bait coimmunoprecipitation
      (Liu et al., 2016, Richter et al., 2016, Lipinszki et al., 2015, Przewloka et al., 2011)
      Cenp-C - Lhr
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting
      (Thomae et al., 2013)
      Cenp-C - Mis12
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, pull down, molecular sieving, protein cross-linking with a bifunctional reagent, mass spectrometry study of hydrogen/deuterium exchange, cosedimentation, molecular weight estimation by staining
      (Liu et al., 2016, Richter et al., 2016, Przewloka et al., 2011)
      Cenp-C - Mnt
      two hybrid array
      (Shokri et al., 2019)
      Cenp-C - Ndc80
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2011)
      Cenp-C - Nnf1a
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, protein cross-linking with a bifunctional reagent, molecular sieving, cosedimentation, molecular weight estimation by staining, pull down, mass spectrometry study of hydrogen/deuterium exchange
      (Liu et al., 2016, Richter et al., 2016, Przewloka et al., 2011)
      Cenp-C - Nnf1b
      molecular sieving, cosedimentation, molecular weight estimation by staining, protein cross-linking with a bifunctional reagent, peptide massfingerprinting
      (Liu et al., 2016)
      Cenp-C - Nuf2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2011)
      Cenp-C - PPP4R2r
      anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting, pull down, western blot
      (Lipinszki et al., 2015)
      Cenp-C - Pp2A-29B
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2011)
      Cenp-C - Pp4-19C
      anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot, pull down, western blot
      (Lipinszki et al., 2015)
      Cenp-C - Rel
      two hybrid array
      (Shokri et al., 2019)
      Cenp-C - Snap29
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2011)
      Cenp-C - Spc105R
      molecular sieving, cosedimentation, molecular weight estimation by staining, anti tag coimmunoprecipitation, peptide massfingerprinting
      (Liu et al., 2016, Lipinszki et al., 2015, Przewloka et al., 2011)
      Cenp-C - Spc25
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2011)
      Cenp-C - Ssrp
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015)
      Cenp-C - Top2
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015)
      Cenp-C - apt
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015)
      Cenp-C - baf
      anti bait coimmunoprecipitation, western blot, anti tag western blot
      (Torras-Llort et al., 2020)
      Cenp-C - ball
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015)
      Cenp-C - cal1
      x-ray crystallography, anti tag coimmunoprecipitation, western blot, two hybrid, phenotype-based detection assay, fluorescence microscopy, inferred by author, molecular sieving, molecular weight estimation by staining, cosedimentation, molecular weight, anti bait coimmunoprecipitation
      (Medina-Pritchard et al., 2020, Roure et al., 2019, Chen et al., 2015, Schittenhelm et al., 2010, Erhardt et al., 2008)
      Cenp-C - cid
      anti tag coimmunoprecipitation, western blot, phenotype-based detection assay, inferred by author, fluorescence microscopy, protein three hybrid, peptide massfingerprinting
      (Roure et al., 2019, Lipinszki et al., 2015, Schittenhelm et al., 2010, Erhardt et al., 2008)
      Cenp-C - crm
      two hybrid array
      (Shokri et al., 2019)
      Cenp-C - dre4
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015)
      Cenp-C - flfl
      anti tag coimmunoprecipitation, anti tag western blot, pull down, autoradiography, peptide massfingerprinting, western blot, molecular sieving, molecular weight estimation by staining, x-ray crystallography, peptide array
      (Lipinszki et al., 2015)
      Cenp-C - jigr1
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015)
      Cenp-C - ncd
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Przewloka et al., 2011)
      Cenp-C - phol
      two hybrid array
      (Shokri et al., 2019)
      Cenp-C - prod
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Lipinszki et al., 2015)
      Cenp-C - sage
      two hybrid array
      (Shokri et al., 2019)
      Cenp-C - sug
      two hybrid array
      (Shokri et al., 2019)
      RNA-protein
      Physical Interaction
      Assay
      References
      Cenp-C - satDNA
      anti tag coimmunoprecipitation, quantitative reverse transcription pcr
      (Rošić et al., 2014)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Cenp-C
      enhanceable
      cal1
      (Unhavaithaya and Orr-Weaver, 2013)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      cal1
      enhanceable
      Cenp-C
      (Unhavaithaya and Orr-Weaver, 2013)
      cid
      enhanceable
      Cenp-C
      (Heeger et al., 2005)
      pim
      enhanceable
      Cenp-C
      (Heeger et al., 2005)
      thr
      enhanceable
      Cenp-C
      (Heeger et al., 2005)
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-48
      Cytogenetic map
      85A3-85A3
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      85A3-85A3
      Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      85A3-85A3
      (Oh et al., 2003)
      Experimentally Determined Recombination Data
      Location

      3-48

      (FlyBase, 2016)

      3-45.4

      (Comeron et al., 2012)

      3-[48]

      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (23)
      Genomic Clones (18)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (15)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Fellmeth et al., 2023, Torras-Llort et al., 2020, Richter et al., 2016, Lipinszki et al., 2015)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
        Other Comments

        RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle, the formation of aberrantly long spindles and pole detachment when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

        (Goshima et al., 2007)

        New incorporation of Cenp-C protein into centromeres takes place during anaphase of the syncytial divisions of embryos. This incorporation is independent of DNA replication and of normal pulling forces generated by the mitotic spindle, but is strictly coupled to mitotic progression.

        (Schuh et al., 2007)

        RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

        (Boutros et al., 2004)

        1 allele of l(3)SH157 recovered in a P-insertion screen.

        (Oh et al., 2003)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: CG11745 CG11746

        (Whitfield, 2000.12.15)

        Source for merge of: l(3)85Aa CG31258

        (Heeger et al., 2005)

        Source for merge of: Cenp-C l(3)SH157

        (FlyBase, 1996-)
        Additional comments

        Annotation CG11745 split into CG31258 and CG31460 in release 3 of the genome annotation.

        (FlyBase Genome Annotators, 2002-2003)
        Nomenclature History
        Source for database identify of

        Source for identity of: Cenp-C l(3)85Aa CG31258

        (Heeger et al., 2005)
        Nomenclature comments
        Etymology
        Synonyms and Secondary IDs (19)
        Reported As
        Symbol Synonym
        CENP-C
        (Shapiro et al., 2025, Chabot et al., 2024, Kochendoerfer et al., 2023, Ranjan and Chen, 2022, Kochendoerfer et al., 2021, Lukacs et al., 2021, Carty and Dunleavy, 2020, Dattoli et al., 2020, Fellmeth and McKim, 2020, Palladino et al., 2020, Shatskikh et al., 2020, Torras-Llort et al., 2020, Chik et al., 2019, Bobkov et al., 2018, Collins et al., 2018, Liu et al., 2016, Chen et al., 2015, Kuhn, 2015, Lipinszki et al., 2015, Radford et al., 2015, Chen et al., 2014, Feijão et al., 2013, Ross et al., 2013, Venkei et al., 2012, Mellone et al., 2011, Mendiburo et al., 2011, Olszak et al., 2011, Orr and Sunkel, 2011, Przewloka et al., 2011, Podhraski et al., 2010, Torras-Llort et al., 2010, Martins et al., 2009, Erhardt et al., 2008, Wen et al., 2008, Zhang and Karpen, 2008, Goshima et al., 2007, Przewloka et al., 2007, Williams et al., 2007, Blower et al., 2006, Heun et al., 2006)
        CG11745
        (Boutros et al., 2004)
        CG11746
        (Whitfield, 2000.12.15)
        CG31258
        (Hosono et al., 2015, Lipinszki et al., 2015, Fukuoh et al., 2014, Schertel et al., 2013, Bridon et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Goshima et al., 2007, Heeger et al., 2005, Fouix et al., 2003)
        CLD1
        (Erhardt et al., 2008)
        Cenp-C
        (Choudhury et al., 2024, Collins et al., 2024, Fellmeth et al., 2023, Kabakci et al., 2022, Okuda et al., 2022, Slaidina et al., 2021, Fresán et al., 2020, Lehner, 2020.12.1, Shokri et al., 2019, Das et al., 2016, Liu et al., 2016, Ye et al., 2016, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Gonzalez et al., 2014, Bonke et al., 2013, Thomae et al., 2013, Althoff et al., 2012, Bridon et al., 2012, Raychaudhuri et al., 2012, Grimberg et al., 2011, Neumüller et al., 2011, Schittenhelm et al., 2010, Bucciarelli et al., 2009, Costello et al., 2009, Schittenhelm et al., 2009, Lehner et al., 2007, Pandey et al., 2007, Schittenhelm et al., 2007, Schuh et al., 2007, Schuh et al., 2007)
        Cenp-C1
        (Teixeira et al., 2018)
        CenpC
        (Derive et al., 2015, Torras-Llort et al., 2010)
        L1
        (Bender et al., 1987)
        cenp-C
        (Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya and Orr-Weaver, 2013, Unhavaithaya et al., 2013)
        dCENP-C
        (Kyriacou and Heun, 2023, Roure et al., 2019)
        dCenpC
        (Kochanova et al., 2020)
        l(2)SH3 157
        (Oh et al., 2002.3.26)
        l(3)85Aa
        (Christensen et al., 2007.3.22, Gresens and Cook, 2006.8.29, Heeger et al., 2005)
        l(3)SH157
        Name Synonyms
        Cenp-C
        (Costello et al., 2009)
        Centromeric protein-C
        centromeric protein C
        (Lipinszki et al., 2015)
        lethal (3) 85Aa
        lethal (3) SH157
        Secondary FlyBase IDs
        • FBgn0086697
        • FBgn0051258
        • FBgn0037598
        • FBgn0037597
        • FBgn0002310
        • FBgn0065118
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 35 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        PDB - An information portal to biological macromolecular structures
        Linkouts
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (141)