l(3)85Aa, CenpC, L1
Gene model reviewed during 5.49
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cenp-C using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Cenp-C in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Cenp-C l(3)85Aa CG31258
Annotation CG11745 split into CG31258 and CG31460 in release 3 of the genome annotation.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle, the formation of aberrantly long spindles and pole detachment when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
New incorporation of Cenp-C protein into centromeres takes place during anaphase of the syncytial divisions of embryos. This incorporation is independent of DNA replication and of normal pulling forces generated by the mitotic spindle, but is strictly coupled to mitotic progression.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.