Tep6, E(br)155, dTEPVI, TepVI
Gene model reviewed during 5.45
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mcr using the Feature Mapper tool.
Mcr expression is detected in plasmatocytes and in all imaginal discs in larvae. In adults it is observed in the proventriculus, in the crop epithelium and in the epidermis underlying the cuticle in the abodomen but only on the ventral side. Expression is also detected in the mesothoracic phragma, the structure found at the border between thorax and abdomen and to which flight muscles are attached posteriorly.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mcr in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mcr is required cell autonomously for the correct membrane localisation of several septate junction components and is required for epithelial barrier formation.
Mcr is required cell-autonomously for septate junction organisation in embryonic epithelia and larval wing imaginal discs and is required for paracellular barrier function.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. However, the dsRNA treatment does not affect phagocytosis of either Escherichia coli, Staphylococcus aureus or latex beads.