TnI, hdp, troponin I, heldup, TpnI
cytoskeletal protein - along with Tropomyosin regulates muscle contraction - required to maintain nuclear integrity and apico-basal polarity during early embryogenesis - required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.56
Binds to actin and tropomyosin.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wupA using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\wupA in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: wupA fliH
wupA transheterozygotes show transvection, evidenced by normal wing position in adults.
Mutation within a 4kb region of mostly non-coding sequences in wupA (the 'dominant lethal' domain of 16F) results in a dominant lethal phenotype due to the inactivation of the wupA, l(1)16Fe and l(1)16Fm genes. This 'dominant lethal' domain probably represents a long-range cis-regulatory region. In direction of increasing cytology: l(1)16Fo? l(1)16Fp? l(1)16Fq? mnb? l(1)16Fa? l(1)16Fb? l(1)16Fc? Sh? anon-16Fc? l(1)16Fh? anon-16Fd? scu? anon-16Fe? Taf8? anon-16Ff? wupA? l(1)16Fe? l(1)16Fm? l(1)16Fk? l(1)16Fn? ari-1? Frq1?
A splicing defect in the wupA gene causes abnormal development of flight muscles.
A sequence comparison and numerical analysis of the RRM-containing (RNA recognition motif) proteins suggests that functionally related RRM-containing proteins have significant sequence similarities in their RRMs.