FlyBase Gene Report: Dmel\S6k

General Information

Symbol

Dmel\S6k

Species

D. melanogaster

Name

Ribosomal protein S6 kinase

Annotation Symbol

CG10539

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283472

Gene Model Status

Current

Stock Availability

28 publicly available

Enzyme Name (EC)

Gene Summary

Ribosomal protein S6 kinase (S6k) encodes an important component of the target of rapamycin pathway. It is involved in the control of synapse development, autophagy and cell size. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

dS6K, S6 kinase, p70S6K, fs(3)07084, RPS6-p70-protein kinase

Key Links

Genomic Location

Cytogenetic map

64E8-64E11

Sequence location

3L:5,797,549..5,810,931 [-]

Recombination map

3-15

RefSeq locus

NT_037436 REGION:5797549..5810931

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (28 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Tak1; FB:FBgn0026323

(Shin et al., 2013)

enables ribosomal protein S6 kinase activity

inferred from mutant phenotype

(Kim et al., 2017)

inferred from direct assay

(Radimerski et al., 2002, Oldham et al., 2000, Watson et al., 1996)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR017441, InterPro:IPR017892

(InterPro Project Members, 2004-)

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441

(InterPro Project Members, 2004-)

enables protein kinase activity

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR008271

(InterPro Project Members, 2004-)

enables protein serine/threonine kinase activity

inferred from electronic annotation with InterPro:IPR000961, InterPro:IPR016238, InterPro:IPR017892

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN008614469

(GO Reference Genome Project, 2011-)

Biological Process (19 terms)

Terms Based on Experimental Evidence (18 terms)

CV Term

Evidence

References

involved_in cellular response to amino acid stimulus

inferred from direct assay

(Liu et al., 2024, Radimerski et al., 2002)

involved_in cellular response to insulin stimulus

inferred from direct assay

(Radimerski et al., 2002)

involved_in dendrite morphogenesis

inferred from mutant phenotype

(Koike-Kumagai et al., 2009)

involved_in determination of adult lifespan

inferred from mutant phenotype

(Kapahi et al., 2004)

involved_in female germ-line stem cell population maintenance

inferred from mutant phenotype

(Su et al., 2018)

involved_in insulin receptor signaling pathway

inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499

(Tandon and Sarkar, 2021)

inferred from mutant phenotype

(Zhang et al., 2011, Kockel et al., 2010, Wu et al., 2007)

inferred from direct assay

(Radimerski et al., 2002)

involved_in larval feeding behavior

inferred from mutant phenotype

(Wu et al., 2005)

involved_in lipid homeostasis

inferred from mutant phenotype

(Murillo-Maldonado et al., 2011)

involved_in multicellular organism growth

inferred from mutant phenotype

(Murillo-Maldonado et al., 2011)

involved_in positive regulation of axon guidance

inferred from genetic interaction with FLYBASE:Rheb; FB:FBgn0041191

(Dimitroff et al., 2012)

involved_in positive regulation of cell growth

inferred from mutant phenotype

(Goberdhan et al., 2005)

involved_in positive regulation of cell size

inferred from mutant phenotype

(Parisi et al., 2011, Cully et al., 2010, Sims et al., 2009, Saucedo et al., 2003, Montagne et al., 1999)

inferred from genetic interaction with FLYBASE:gig; FB:FBgn0005198

(Cully et al., 2010)

involved_in positive regulation of macroautophagy

inferred from mutant phenotype

(Pircs et al., 2012)

involved_in regulation of response to drug

inferred from mutant phenotype

(Dar et al., 2012)

involved_in response to oxidative stress

inferred from direct assay

(Cully et al., 2010)

involved_in synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Cheng et al., 2011)

involved_in TORC1 signaling

inferred from direct assay

(Kim et al., 2017)

involved_in vascular endothelial growth factor receptor signaling pathway

inferred from mutant phenotype

(Sopko et al., 2015)

inferred from direct assay

(Tran et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR016238

(InterPro Project Members, 2004-)

involved_in TORC1 signaling

inferred from biological aspect of ancestor with PANTHER:PTN000682103

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in presynaptic active zone

inferred from direct assay

(Cheng et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN008614612

(GO Reference Genome Project, 2011-)

is_active_in nucleoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000682103

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED AGC KINASES

Pathway (FlyBase)

INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS

PVR SIGNALING PATHWAY CORE COMPONENTS

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine kinase activity

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED AGC KINASES -: This group comprises AGC kinases that do not classify under other groups in FlyBase.

Pathway (FlyBase)

INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS -: The Insulin-like Receptor (IR) signaling pathway in Drosophila is initiated by the binding of an insulin-like peptides to the Insulin-like receptor (InR). (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989.)
PVR SIGNALING PATHWAY CORE COMPONENTS -: PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).

Summary (Interactive Fly)

signaling - regulates growth response - targets ribosomal protein S6 - a target of the TOR pathway - essential for Myc-dependent rDNA transcription

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\S6k for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q94533)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.43

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

S6k-RA

FBtr0077114

NM_079217

3486

490

S6k-RB

FBtr0333264

NM_001274521

4885

490

Additional Transcript Data and Comments

Reported size (kB)

5.0, 3.7, 2.8 (northern blot)

(Montagne et al., 1999)

5.0, 3.7 (northern blot)

(Stewart et al., 1996)

5.0, 3.0, 2.5, 2.3 (northern blot)

(Watson et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

S6k-PA

FBpp0076820

55.4

490

5.93

FBpp0305462

55.4

490

5.93

Q94533

NP_001261450

AGB94145

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

490 aa isoforms: S6k-PA, S6k-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

490 (aa)

(Montagne et al., 1999)

637 (aa); 73 (kD predicted)

(Stewart et al., 1996)

637 (aa); 76 (kD predicted)

(Watson et al., 1996)

Comments

Two peaks of S6 kinase activity were observed in

S2 cells, one of which is rapamycin sensitive. The cloned S6k was shown

to have identity with the rapamycin sensitive form.

(Watson et al., 1996)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\S6k using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

S6k_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-2.52

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Watson et al., 1996)

adult stage

(Stewart et al., 1996)

adult stage | female

(Montagne et al., 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

S6k protein is detected in extracts of S2 cells.

(Stewart et al., 1996)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

located_in nucleoplasm

inferred from high throughput direct assay

(Lye et al., 2014)

located_in presynaptic active zone

inferred from direct assay

(Cheng et al., 2011)

Expression Deduced from Reporters

Reporter: PBac{803.P.SVS-0}S6k^CPTI003751

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

Comment: expression throughout adult brain

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\S6k in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\S6k

View exonic expression by tissue for Dmel\S6k

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38654/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283472

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015806

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283472

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10539

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 11 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 35 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of S6k

Transgenic constructs containing regulatory region of S6k

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3L)64D-F

(Montagne et al., 1999)

Df(3L)Exel6107

(Ryder, 2004.4.26)

Df(3L)ZN47

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene partially disrupted in

Df(3)07084

(Buffin et al., 2007)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

S6k^l-1

lethal (with Df(3L)BSC438)

S6k^{MI11374-TG4.0}

lethal | recessive

lethal - all die before end of larval stage | recessive

S6k⁰⁷⁰⁸⁴

partially lethal

S6k⁰⁷⁰⁸⁴

partially lethal - majority die | recessive

S6k⁰⁷⁰⁸⁴

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

S6k^GD6646

viable, with Scer\GAL4^pnr-MD237

S6k^GD6646

viable, with Scer\GAL4^tin.CΔ4

S6k^GD6646

viable (with S6k⁰⁷⁰⁸⁴)

S6k^l-1

viable (with S6k^l-1)

S6k⁰⁷⁰⁸⁴

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

female semi-sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

female sterile

S6k⁰⁷⁰⁸⁴

female sterile | recessive

S6k⁰⁷⁰⁸⁴

Other Phenotypes

Allele

abnormal cell shape | oogenesis, with Scer\GAL4^C587

S6k^KQ.UAS

abnormal feeding behavior, with Scer\GAL4^Ilp2.PW

abnormal immune response | adult stage, with Scer\GAL4^NP0001

S6k^HMJ02231

abnormal memory | heat sensitive, with Scer\GAL4^hs.PU

S6k^UAS.cFa

abnormal neuroanatomy | P-stage, with Scer\GAL4^Tab2-201Y

S6k^STDE.UAS

abnormal neuroanatomy | somatic clone

S6k^l-1

abnormal neuroanatomy | third instar larval stage (with Df(3L)CH18)

S6k^l-1

abnormal neurophysiology | adult stage (with S6k⁰⁷⁰⁸⁴)

S6k^l-1

abnormal neurophysiology | adult stage (with S6k^l-1)

S6k⁰⁷⁰⁸⁴

abnormal neurophysiology | larval stage, with Scer\GAL4^G14

S6k^STDE.UAS

abnormal neurophysiology | larval stage (with Df(3L)BSC438)

S6k^l-1

abnormal neurophysiology | third instar larval stage

S6k^l-1

abnormal neurophysiology | third instar larval stage (with Df(3L)CH18)

S6k^l-1

abnormal size, with Scer\GAL4^nub-AC-62

abnormal size | adult stage, with Scer\GAL4^GMR.PF

S6k^UAS.cWa

abnormal size | adult stage, with Scer\GAL4^NP0001

abnormal size | adult stage | somatic clone

S6k^l-1

abnormal size | larval stage

S6k^l-1

chemical resistant, with Scer\GAL4^Act5C.PP

S6k^UAS.cWa

chemical resistant | adult stage, with Scer\GAL4^elav.PU

S6k^CA.UAS.cUa

decreased body size

decreased body size | adult stage (with S6k⁰⁷⁰⁸⁴)

S6k^l-1

decreased body size | adult stage (with S6k^l-1)

S6k⁰⁷⁰⁸⁴

decreased body size | nutrition conditional, with Scer\GAL4^ppl.PP

S6k^KQ.UAS

decreased cell number, with Scer\GAL4^nub-AC-62

decreased cell number | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

S6k^HMS04459

decreased cell number | oogenesis | progressive, with Scer\GAL4^C587

S6k^KQ.UAS

decreased cell size

decreased cell size | cell autonomous | somatic clone

S6k^unspecified

decreased cell size | somatic clone

S6k^l-1

decreased cell size | somatic clone, with Scer\GAL4^Act.PU

S6k^KQ.UAS

decreased size | larval stage (with Df(3L)BSC438)

S6k^l-1

increased body size | larval stage, with Scer\GAL4^da.G32

S6k^UAS.cMa

increased body size | pupal stage, with Scer\GAL4^Cg.PA

S6k^TE.UAS

increased cell growth rate, with Scer\GAL4^GMR.PF

S6k^UAS.cMa

increased cell number, with Scer\GAL4^ap-md544

S6k^UAS.cMa

increased cell size, with Scer\GAL4^AB1

increased cell size, with Scer\GAL4^nub-AC-62

S6k^TE.UAS

increased cell size | somatic clone, with Scer\GAL4^Act.PU

S6k^STDETE.UAS

long lived, with Scer\GAL4^da.G32

S6k^KQ.UAS

long lived, with Scer\GAL4^da.PU

S6k^KQ.UAS

long lived, with Scer\GAL4^elav.PU

S6k^HMJ02231

long lived, with Scer\GAL4^Lk6-DJ634

S6k^KQ.UAS

long lived, with Scer\GAL4^{Rab27-Gal4-KO}

S6k^KQ.UAS

long lived, with Scer\GAL4^VT014429

S6k^KQ.UAS

short lived, with Scer\GAL4^da.G32

S6k^STDETE.UAS

short lived | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

some die during larval stage | recessive

S6k⁰⁷⁰⁸⁴

visible

visible, with Scer\GAL4^ap-md52

S6k^UAS.cMa

visible, with Scer\GAL4^ap-md544

visible, with Scer\GAL4^pnr-MD237

S6k^GD6646

visible | adult stage, with Scer\GAL4^GMR.PF

S6k^UAS.cWa

visible | adult stage (with S6k⁰⁷⁰⁸⁴)

S6k^l-1

visible | adult stage (with S6k^l-1)

S6k⁰⁷⁰⁸⁴

visible | adult stage | somatic clone

S6k^l-1

visible | recessive | somatic clone

S6k^l-1

wild-type

S6k^αTub.PM

Phenotype manifest in

Allele

adult

S6k⁰⁷⁰⁸⁴

adult enterocyte, with Scer\GAL4^NP0001

S6k^HMJ02231

adult midgut, with Scer\GAL4^NP0001

adult mushroom body gamma-lobe | P-stage, with Scer\GAL4^Tab2-201Y

S6k^STDE.UAS

axon | P-stage, with Scer\GAL4^Tab2-201Y

S6k^STDE.UAS

dendrite | somatic clone

S6k^l-1

dendritic arborizing neuron | somatic clone

S6k^l-1

embryo | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

embryonic/larval fat body | larval stage, with Scer\GAL4^Cg.PA

S6k^STDETE.UAS

embryonic/larval fat body | third instar larval stage

S6k^l-1

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^G14

S6k^STDE.UAS

embryonic/larval neuromuscular junction | larval stage (with Df(3L)BSC438)

S6k^l-1

embryonic myoblast, with Scer\GAL4^kirre.PU

S6k^RNAi.UAS.cUa

escort cell, with Scer\GAL4^C587

S6k^KQ.UAS

eye, with Scer\GAL4^GMR.PF

eye | somatic clone

S6k^l-1

female germline cyst, with Scer\GAL4^C587

S6k^KQ.UAS

female germline stem cell | decreased number, with Scer\GAL4^{VP16.nanos.UTR}

S6k^HMS04459

female germline stem cell | progressive, with Scer\GAL4^C587

S6k^KQ.UAS

larval salivary gland & nucleus

S6k^l-1

larval somatic muscle cell, with Scer\GAL4^kirre.PU

S6k^RNAi.UAS.cUa

lipid droplet | adult stage, with Scer\GAL4^NP0001

mitotic cell cycle | somatic clone

S6k^l-1

muscle cell of A1-7 dorsal acute muscle 1, with Scer\GAL4^kirre.PU

S6k^RNAi.UAS.cUa

NMJ bouton | third instar larval stage (with Df(3L)CH18)

S6k^l-1

ommatidium

S6k^l-1

ommatidium, with Scer\GAL4^GMR.PF

S6k^UAS.cMa

ommatidium | somatic clone

oocyte

S6k⁰⁷⁰⁸⁴

presynaptic active zone | decreased number | larval stage (with Df(3L)BSC438)

S6k^l-1

salivary gland, with Scer\GAL4^AB1

segment border muscle cell, with Scer\GAL4^kirre.PU

S6k^RNAi.UAS.cUa

trichogen cell, with Scer\GAL4^pnr-MD237

S6k^GD6646

wing

S6k^l-1

wing, with Scer\GAL4^ap-md52

S6k^UAS.cMa

wing, with Scer\GAL4^ap-md544

wing, with Scer\GAL4^nub-AC-62

wing (with S6k⁰⁷⁰⁸⁴)

S6k^l-1

wing (with S6k^l-1)

S6k⁰⁷⁰⁸⁴

wing & cell | somatic clone

S6k^unspecified

wing blade, with Scer\GAL4^ap-md544

wing disc

S6k^l-1

wing disc | larval stage

S6k^l-1

wing hair, with Scer\GAL4^e16A

S6k^UAS.cUa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (90)

Hsap\RPS6KB1

14 of 14

Yes

Hsap\RPS6KB2

13 of 14

Yes

Hsap\C8orf44-SGK3

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Hsap\SGK2

3 of 14

Yes

Hsap\SGK3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (59)

Rnor\Rps6kb1

14 of 14

Yes

Rnor\Rps6kb2

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (56)

Mmus\Rps6kb1

14 of 14

Yes

Mmus\Rps6kb2

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Mmus\Sgk2

3 of 14

Yes

Mmus\Sgk3

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (55)

Xtro\rps6kb1

8 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\stk35

1 of 13

Yes

Xtro\stk39

1 of 13

Xtro\tapbp

1 of 13

Yes

Xtro\wee2

1 of 13

Xtro\wnt3a

1 of 13

Xtro\XB5729975

1 of 13

Danio rerio (Zebrafish) (74)

Drer\rps6kb1b

14 of 14

Yes

Drer\rps6kb1a

11 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\sgk2a

3 of 14

Yes

Drer\sgk3

3 of 14

Yes

Drer\si:ch211-195b13.1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-192d15.2

1 of 14

Drer\si:zfos-2326c3.2

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (47)

Cele\rsks-1

14 of 14

Yes

Cele\R04A9.7

7 of 14

Yes

Cele\akt-1

2 of 14

Cele\akt-2

2 of 14

Cele\F28C10.3

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (39)

Agam\AgaP_AGAP007333

12 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (72)

Atha\PK1

10 of 13

Yes

Atha\S6K2

10 of 13

Yes

Atha\AGC1.5

1 of 13

Atha\AGC1.7

1 of 13

Atha\AGC2-1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G36350

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT4G13000

1 of 13

Yes

Atha\AT4G14350

1 of 13

Atha\AT4G33080

1 of 13

Atha\AT5G03640

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\PHOT2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\UCNL

1 of 13

Yes

Atha\WAG1

1 of 13

Atha\WAG2

1 of 13

Atha\WEE1

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (25)

Scer\YPK1

5 of 13

Yes

Scer\YPK2

5 of 13

Yes

Scer\YPK3

5 of 13

Yes

Scer\SCH9

4 of 13

Scer\FPK1

2 of 13

Yes

Scer\KIN82

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (16)

Spom\psk1

8 of 12

Yes

Spom\gad8

3 of 12

Yes

Spom\sck1

3 of 12

Spom\sck2

3 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Spom\ppk21

1 of 12

Spom\ppk22

1 of 12

Yes

Spom\ppk33

1 of 12

Spom\ppk38

1 of 12

Spom\sid2

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:S6k. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (38)

S6kII

5 of 13

JIL-1

4 of 13

Akt

2 of 13

S6KL

2 of 13

aPKC

1 of 13

aurA

1 of 13

bsk

1 of 13

CaMKI

1 of 13

CG12069

1 of 13

CG32944

1 of 13

dop

1 of 13

for

1 of 13

gek

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mbt

1 of 13

msn

1 of 13

Myt1

1 of 13

Nak

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Pkn

1 of 13

Raf

1 of 13

Rok

1 of 13

sgg

1 of 13

sti

1 of 13

trc

1 of 13

Wee1

1 of 13

wts

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 3 )

Allele

Disease

Evidence

References

S6k⁰⁷⁰⁸⁴

model of type 2 diabetes mellitus

CEA with S6k^l-1

(Murillo-Maldonado et al., 2011)

model of glucose metabolism disease

CEA with S6k^l-1

(Álvarez-Rendón and Riesgo-Escovar, 2023, Álvarez-Rendón and Riesgo-Escovar, 2020)

S6k^l-1

model of type 2 diabetes mellitus

CEA with S6k⁰⁷⁰⁸⁴

(Murillo-Maldonado et al., 2011)

model of glucose metabolism disease

CEA with S6k⁰⁷⁰⁸⁴

(Álvarez-Rendón and Riesgo-Escovar, 2023, Álvarez-Rendón and Riesgo-Escovar, 2020)

S6k^CA.UAS.cUa

model of alcohol dependence

CEA

(Acevedo et al., 2015)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 10 )

Allele

Disease

Interaction

References

S6k⁰⁷⁰⁸⁴

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN8OS^CTG112.UAS

(Mutsuddi et al., 2004)

S6k^KQ.UAS

ameliorates amyotrophic lateral sclerosis

modeled by Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

ameliorates congenital muscular dystrophy due to LMNA mutation

modeled by LamC^G489V.UAS

(Chandran et al., 2019)

S6k^STDE.UAS

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

S6k^STDETE.UAS

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

exacerbates amyotrophic lateral sclerosis type 10

modeled by TBPH^UAS.cLa

(Cheng et al., 2015)

S6k^TE.UAS

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

modeled by Pink1^B9

(Liu and Lu, 2010)

S6k^l-1

ameliorates Parkinson's disease

modeled by Hsap\LRRK2^UAS.cVa

(Penney et al., 2016)

modeled by Lrrk^UAS.cIa

(Penney et al., 2016)

S6k^GD6646

ameliorates brain glioma

modeled by btl::Egfr^λ.UAS, Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}

(Read et al., 2009)

S6k^KK107986

ameliorates cancer

modeled by Pten^KK109278

(Parniewska and Stocker, 2020)

S6k^UAS.cUa

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Bakhoum et al., 2014)

exacerbates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

S6k^RNAi.UAS.cUa

ameliorates brain cancer

modeled by brat^RNAi.UAS.cUa

(Mukherjee et al., 2018)

ameliorates Parkinson's disease 6

modeled by Pink1^RNAi.UAS.cYa

(Liu and Lu, 2010)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPS6KB1; ribosomal protein S6 kinase B1

14 of 14

RIBOSOMAL PROTEIN S6 KINASE B1; RPS6KB1

RPS6KB2; ribosomal protein S6 kinase B2

13 of 14

608939

C8orf44-SGK3; C8orf44-SGK3 readthrough

3 of 14

RPS6KA1; ribosomal protein S6 kinase A1

3 of 14

601684

RPS6KA2; ribosomal protein S6 kinase A2

3 of 14

601685

RPS6KA3; ribosomal protein S6 kinase A3

3 of 14

RIBOSOMAL PROTEIN S6 KINASE A3; RPS6KA3

RPS6KA4; ribosomal protein S6 kinase A4

3 of 14

603606

RPS6KA5; ribosomal protein S6 kinase A5

3 of 14

603607

RPS6KA6; ribosomal protein S6 kinase A6

3 of 14

300303

SGK1; serum/glucocorticoid regulated kinase 1

3 of 14

602958

SGK2; serum/glucocorticoid regulated kinase 2

3 of 14

607589

SGK3; serum/glucocorticoid regulated kinase family member 3

3 of 14

607591

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

S6k - 14-3-3ζ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Act5C

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Aldh

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Arc42

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Arf1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - AsnRS

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - CCT1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - CCT4

pull down, western blot, anti bait coimmunoprecipitation

(Kim and Choi, 2019)

S6k - CCT5

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - CG1316

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - CG4972

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - CG5504

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Cdc37

anti tag coimmunoprecipitation, Identification by mass spectrometry, peptide massfingerprinting

(Vinayagam et al., 2016, Glatter et al., 2011)

S6k - Chc

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Chd64

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Dp1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Dref

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Droj2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Fib

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Gale

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Gtpbp1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Hel25E

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - His2B

enzymatic study, autoradiography

(Montagne et al., 2010)

S6k - Hsc70-3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Ipo9

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Kap-α3

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Kcmf1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Ldh

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Mcad

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Mcm7

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Mec2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Nfs1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Pcb

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Pef

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Pp1-87B

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Pyk

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - RPA1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Rab27

anti tag coimmunoprecipitation, western blot, proximity ligation assay, fluorescence microscopy

(Lien et al., 2020)

S6k - RpS5a

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - Scsα1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - ScsβA

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - SsRβ

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - UQCR-C2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - ana2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - bif

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - cathD

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - cpa

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - eEF1α1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - eIF4A

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - fax

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - galla-2

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - kuk

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - l(1)G0320

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - levy

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - lic

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - msn

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - mt:CoII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - raptor

anti tag coimmunoprecipitation, peptide massfingerprinting

(Glatter et al., 2011)

S6k - sqd

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - sqh

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - tws

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - wrd

anti tag coimmunoprecipitation, anti tag western blot

(Hahn et al., 2010)

S6k - αCOP

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - β'COP

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - βTub56D

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - βTub60D

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

S6k - βTub97EF

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

S6k

suppressible

Akt

(Radimerski et al., 2002)

S6k

enhanceable

bun

(Gluderer et al., 2008)

S6k

suppressible

bun

(Gluderer et al., 2008)

S6k

suppressible

eIF4E1

(Penney et al., 2012)

suppressible

(Gao et al., 2002)

suppressible

(Lv et al., 2012)

enhanceable

(Resnik-Docampo and de Celis, 2011)

S6k

suppressible

Hr3

(Montagne et al., 2010)

S6k|Tsc1

suppressible

mTor

(Radimerski et al., 2002)

S6k

suppressible

Pdk1

(Rintelen et al., 2001)

S6k

enhanceable

Pdk1

(Radimerski et al., 2002)

S6k

suppressible

raptor

(Lee and Chung, 2007)

enhanceable

(Xu et al., 2008)

suppressible

(Xu et al., 2008)

enhanceable

(Lee et al., 2010)

suppressible

(Mukherjee and Duttaroy, 2013)

S6k

suppressible

Trpm

(Georgiev et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Acc

suppressible

S6k

(Amartuvshin et al., 2025)

AMPKα

suppressible

S6k

(Onyenwoke et al., 2015)

suppressible

(Lee et al., 2007)

suppressible

(Wen et al., 2017)

suppressible

(Wong et al., 2013)

suppressible

(Kim et al., 2010)

suppressible

(Li et al., 2023)

suppressible

(Rabinovich et al., 2016)

Elp6

suppressible

S6k

(Bolukbasi et al., 2012)

foxo

enhanceable

S6k

(Goberdhan et al., 2005)

gig

suppressible

S6k

(Quan et al., 2013, Gao et al., 2002)

suppressible

(Li et al., 2010)

suppressible

(Penney et al., 2012)

hppy

enhanceable

S6k

(Resnik-Docampo and de Celis, 2011)

hppy

suppressible

S6k

(Resnik-Docampo and de Celis, 2011)

Hr51

suppressible

S6k

(Yaniv et al., 2012)

enhanceable

S6k

(Wang and Huang, 2009)

LamC

suppressible

S6k

(Chandran et al., 2019)

Lrrk

suppressible

S6k

(Penney et al., 2016)

mTor

suppressible

S6k

(Penney et al., 2012, Scott et al., 2004, Zhang et al., 2000)

mTor|Tsc1

suppressible

S6k

(Radimerski et al., 2002)

suppressible

(Lin et al., 2015)

suppressible

(Cheng et al., 2011, Rintelen et al., 2001)

pHCl-2

suppressible

S6k

(Redhai et al., 2020)

Pi3K92E|btl::Egfr

suppressible

S6k

(Read et al., 2009)

Pten

suppressible

S6k

(Montagne et al., 2010)

raptor

suppressible

S6k

(Lee and Chung, 2007)

Ras85D|dlg1

suppressible

S6k

(Willecke et al., 2011)

Rbf

suppressible

S6k

(Hsieh et al., 2010)

Rbf|gig

suppressible

S6k

(Hsieh et al., 2010, Li et al., 2010)

Rheb

suppressible

S6k

(Dimitroff et al., 2012, Saucedo et al., 2003, Stocker et al., 2003)

Rheb|mTor

suppressible

S6k

(Stocker et al., 2003)

suppressible

(Li et al., 2022)

suppressible

(Shin et al., 2013)

Tak1

enhanceable

S6k

(Shin et al., 2013)

Tcs5

suppressible

S6k

(Ibar et al., 2013)

enhanceable

(Hsu et al., 2007)

suppressible

(Das et al., 2014)

suppressible

(Radimerski et al., 2002)

Tsc1|gig

suppressible

S6k

(Montagne et al., 2010, Tapon et al., 2001)

Vap33

suppressible

S6k

(Deivasigamani et al., 2014)

wrd

suppressible

S6k

(Hahn et al., 2010)

External Data

Linkouts

MIST (genetic) - An integrated Molecular Interaction Database

38654

MIST (protein-protein) - An integrated Molecular Interaction Database

38654

Pathways

Signaling Pathways (FlyBase)

INSULIN-LIKE RECEPTOR SIGNALING PATHWAY CORE COMPONENTS
PVR SIGNALING PATHWAY CORE COMPONENTS

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-15

Cytogenetic map

64E8-64E11

Sequence location

3L:5,797,549..5,810,931 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

64E8-64E11

Limits computationally determined from genome sequence between P{PZ}Bre1⁰¹⁶⁴⁰ and P{PZ}vn¹⁰⁵⁶⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

65D1-65D6

(Watson, 1996.8.19)

64E8-64E12

(determined by in situ hybridisation)

(Spradling et al., 1999, Perrimon et al., 1996)

64F1-64F3

(Montagne et al., 1999)

65D-65D

(determined by in situ hybridisation)

(Watson et al., 1996)

64E8-64E12

(BDGP Project Members, 1994-1999)

64F-64F

(determined by in situ hybridisation)

(Kalderon and Rubin, 1988)

Experimentally Determined Recombination Data

Location

3-15

(FlyBase, 2016)

3-13.9

(Comeron et al., 2012)

3-[20]

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (28)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

6911

w¹¹¹⁸; P{UAS-S6k.KQ}2

6912

w¹¹¹⁸; P{UAS-S6k.TE}2

6913

w¹¹¹⁸; P{UAS-S6k.STDE}3

6910

w¹¹¹⁸; P{UAS-S6k.M}2/CyO

6914

w¹¹¹⁸; P{UAS-S6k.STDETE}2

51563

w^*; P{PTT-GC}S6k^CC01583

84183

y¹ v¹; M{WKO.P1-D3}ZH-86Fb

NIG-Fly

10539R-2

P{NIG.10539R}2

10539R-3

P{NIG.10539R}3

HMS02267

y¹ v¹; P{TRiP.HMS02267}attP2

VDRC

v104369

P{KK107986}VIE-260B

v18126

w¹¹¹⁸ P{GD6646}v18126

More stocks available...

Genomic Clones (30)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (143)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI18808

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283472

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Stewart et al., 1996)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S6k plays a negative role for autophagy in normal conditions. When starvation induces autophagy, S6k may act as a positive regulator of autophagy.

(Shin et al., 2013)

dsRNA made from templates generated with primers directed against this gene results in an immediate reduction in cell size. Silencing both eIF-4E and S6k together does not reduce mean cell diameter to the same extent as rapamycin treatment.

(Guertin et al., 2006)

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

dsRNA made from templates generated with primers directed against this gene used to treat S2 cells.

(Yang et al., 2006)

dsRNA made from templates generated with primers directed against this gene increases Akt1 phosphorylation in S2 cells.

(Yang et al., 2006)

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in the proportion of G1 phase cells is seen.

(Bettencourt-Dias et al., 2004)

Loss of S6k causes failure to induce autophagy under fed or starvation conditions or in reponse to loss of Tor. Activation of S6k does not affect autophagy induction in wild type, but increases the level of autophagy in Tor mutants.

(Scott et al., 2004)

Promotes starvation-induced autophagy in the fat body.

(Scott et al., 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R⁺ cells: increased or polarized (uneven) accumulation of F-actin.

(Kiger et al., 2003)

Pk61C is an upstream effector of S6k.

(Radimerski et al., 2002)

Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.

(McDonald and Rosbash, 2001)

The S6k gene product regulates cell size in a cell-autonomous manner without impinging on cell number.

(Montagne et al., 1999)

Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

(Harvie et al., 1998)

The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(w^hs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. S6k is required for germ cell viability or early oogenesis.

(Perrimon et al., 1996)

Isolated using a rat p70^s6k fragment as a probe.

(Stewart et al., 1996)

S6k has been cloned and sequenced.

(Stewart et al., 1996, Watson et al., 1996)

Isolated from a cDNA library using rat p70^S6k cDNA sequences as a probe, under low stringency conditions.

(Watson et al., 1996)

Isolated from a genomic library using a Pka-C1 probe.

(Kalderon and Rubin, 1988)

Pk64F may encode a protein kinase.

(Kalderon and Rubin, 1988)

Gene in D.melanogaster encoding product related (by sequence comparison) to the serine-threonine protein kinases of mammals. Isolated from Drosophila clones obtained with mammalian probes.

Relationship to Other Genes

Source for database merge of

Source for merge of: S6k Pk64F

(FlyBase, 1992-)

Additional comments

BLAST of sequence given in Fig 9 of FBrf0048100 together with cytological location indicates that 'Pk64F' from FBrf0048100 corresponds to 'S6k'.

(FlyBase, 1992-)

Nomenclature History

Source for database identify of

Source for identity of: S6k CG10539

(Gabrielian, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (57)

Reported As

Symbol Synonym

10539

(Ravi et al., 2009)

7-10

(Kalderon and Rubin, 1988)

7084

(Harvie et al., 1998)

CG10539

(Schertel et al., 2013, Glatter et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Chen et al., 2008, Buffin et al., 2007, Sarbassov et al., 2004, Morrison et al., 2000)

DS6K

(Radimerski et al., 2001, Coelho and Leevers, 2000, Montagne et al., 2000, Radimerski et al., 2000, Weinkove and Leevers, 2000, Leevers, 1999, Szuromi, 1999)

Dp70^s6k

(Montagne et al., 1997, Stewart et al., 1996)

Dp70S6k

(Stewart et al., 1997)

Dp70s6k

(Montagne et al., 1998, Stewart, 1996.8.11)

Pk64F

Pk?6

(Clémot et al., 2024, Kosakamoto et al., 2024, Nishida et al., 2021)

S6 K

(Lin et al., 2019)

S6K

(Álvarez-Rendón and Riesgo-Escovar, 2025, Amartuvshin et al., 2025, Chikamatsu et al., 2025, Frappaolo et al., 2025, Sun et al., 2025, Tahan Zadeh et al., 2025, Toshniwal et al., 2025, Bhattacharya et al., 2024, Chvilicek et al., 2024, Dark et al., 2024, Jang et al., 2024, Jeong, 2024, Meng et al., 2024, Zhang et al., 2024, Zhu et al., 2024, Feng et al., 2023, Kim et al., 2023, Lee et al., 2023, Li et al., 2023, Li et al., 2023, Sanal et al., 2023, Socha et al., 2023, Jarabo et al., 2022, Kakanj et al., 2022, Karam et al., 2022, Li et al., 2022, Miao et al., 2022, Noguchi et al., 2022, Regan et al., 2022, Weina et al., 2022, Zhao et al., 2022, Bonfini et al., 2021, Cai et al., 2021, Dapergola et al., 2021, Hou and Pei, 2021, Jacomin et al., 2021, Kim and O'Connor, 2021, Kim et al., 2021, Layalle et al., 2021, Lee et al., 2021, Liguori et al., 2021, Lu et al., 2021, Ma et al., 2021, Oliveira et al., 2021, Song et al., 2021, Strassburger et al., 2021, Ulgherait et al., 2021, Voo et al., 2021, Yang et al., 2021, Yue et al., 2021, Zhou et al., 2021, Arnés et al., 2020, Bjedov and Rallis, 2020, Cheng et al., 2020, Flatt, 2020, Frank et al., 2020, Lien et al., 2020, Luo et al., 2020, Ma et al., 2020, Parniewska and Stocker, 2020, Redhai et al., 2020, Sanaki et al., 2020, Sim et al., 2020, Ulgherait et al., 2020, Venugopal et al., 2020, Wang et al., 2020, Yuan et al., 2020, Jeong et al., 2019, Lee et al., 2019, Meltzer, 2019-, Meltzer et al., 2019, Schinaman et al., 2019, Şentürk et al., 2019, Sim et al., 2019, Ahmad et al., 2018, Ayala et al., 2018, Calap-Quintana et al., 2018, Das and Cagan, 2018, Inoue et al., 2018, Lee et al., 2018, Lee et al., 2018, Staats et al., 2018, Velentzas et al., 2018, Bolukbasi et al., 2017, Chang et al., 2017, Filer et al., 2017, Kapahi et al., 2017, Lee et al., 2017, Liu and Jin, 2017, Melani et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Park et al., 2017, Romero-Pozuelo et al., 2017, Strilbytska et al., 2017, Wen et al., 2017, Wu et al., 2017, Yun et al., 2017, Alfa and Kim, 2016, Allen et al., 2016, Cai et al., 2016, Garratt et al., 2016, Jun et al., 2016, Kakanj et al., 2016, Kwak et al., 2016, Rabinovich et al., 2016, Wei et al., 2016, Xin et al., 2016, Yaniv and Schuldiner, 2016, Zhang et al., 2016, Das and Dobens, 2015, Diop et al., 2015, Fischer et al., 2015, Gross et al., 2015, Jin et al., 2015, Kim and Lee, 2015, Lin et al., 2015, Mitchell et al., 2015, Nässel et al., 2015, Rojas-Benitez et al., 2015, Tiebe et al., 2015, Wong et al., 2015, Zhang et al., 2015, Zheng et al., 2015, Bakhoum et al., 2014, Benbahouche et al., 2014, Danielsen et al., 2014, Das et al., 2014, Deivasigamani et al., 2014, Homem et al., 2014, Lanet and Maurange, 2014, Lin et al., 2014, Liu et al., 2014, Metaxakis et al., 2014, Mulakkal et al., 2014, Sun et al., 2014, Yin et al., 2014, Andersen et al., 2013, Clark et al., 2013, Das et al., 2013, Erion and Sehgal, 2013, Fropf et al., 2013, Gupta et al., 2013, Hada et al., 2013, Hartman et al., 2013, Hur et al., 2013, Ibar et al., 2013, Itskov and Ribeiro, 2013, Koyama et al., 2013, Lin et al., 2013, Luo et al., 2013, Mukherjee and Duttaroy, 2013, Rajan and Perrimon, 2013, Tixier et al., 2013, Tixier et al., 2013, Tran et al., 2013, Wong et al., 2013, Bolukbasi et al., 2012, Dimitroff et al., 2012, Homem and Knoblich, 2012, Kapuria et al., 2012, Lee et al., 2012, Lv et al., 2012, Pallares-Cartes et al., 2012, Papatheodorou et al., 2012, Pircs et al., 2012, Sun et al., 2012, Taillebourg et al., 2012, van der Harst et al., 2012, Wang et al., 2012, Zitserman et al., 2012, Ambegaokar and Jackson, 2011, Boyd et al., 2011, Cheng et al., 2011, Kondylis et al., 2011, Lindquist et al., 2011, Murillo-Maldonado et al., 2011, Oldham, 2011, Read, 2011, Söderberg et al., 2011, Zacharogianni et al., 2011, Zhang et al., 2011, Birse et al., 2010, Bjedov et al., 2010, Cully et al., 2010, Fernández-Ayala et al., 2010, Hahn et al., 2010, Lee et al., 2010, Li et al., 2010, Liu and Lu, 2010, Ribeiro and Dickson, 2010, Sun et al., 2010, Chittaranjan et al., 2009, Koike-Kumagai et al., 2009, Nuzhdin et al., 2009, Ravi et al., 2009, Schleich and Teleman, 2009, Shen and Ganetzky, 2009, Chen et al., 2008, Choi et al., 2008, Howlett et al., 2008, Kim et al., 2008, Teleman et al., 2008, Xu et al., 2008, Ahrens et al., 2007, Dong et al., 2007, Grewal et al., 2007, Hietakangas and Cohen, 2007, Hoshizaki and Gibbs, 2007, Jovceva et al., 2007, Lee and Chung, 2007, Lee et al., 2007, Sandmann et al., 2007, Scott et al., 2007, Edgar, 2006, Friedman and Perrimon, 2006, Goraksha and Neufeld, 2006, Guertin et al., 2006, Ruvinsky, 2006, Shiojima and Walsh, 2006, Wu and Brown, 2006, Yang et al., 2006, Corradetti et al., 2005, Cygnar et al., 2005, Findlay et al., 2005, Goberdhan et al., 2005, Mikeladze-Dvali et al., 2005, Nelson et al., 2005, Scott et al., 2005, Sustar and Schubiger, 2005, Hay and Sonenberg, 2004, Pan et al., 2004, Reiling and Hafen, 2004, Scott et al., 2004, Scott et al., 2004, Gumienny and Padgett, 2003, Hafen and Stocker, 2003, Nijhout, 2003, Stocker et al., 2003, Stocker et al., 2003, Gao et al., 2002, Kozma and Thomas, 2002, Saucedo and Edgar, 2002, Potter and Xu, 2001, Radimerski et al., 2000)

S6K1

(Shin et al., 2013, Zitserman et al., 2012, Findlay et al., 2007)

S6k

(Backlund et al., 2025, Cao et al., 2025, Serebrovska et al., 2025, Simmons et al., 2025, Keirn et al., 2024, Lee and Min, 2024, Lottes et al., 2024, Meyer et al., 2024, Srivastav et al., 2024, Yun et al., 2024, Álvarez-Rendón and Riesgo-Escovar, 2023, Chen et al., 2023, Heigwer et al., 2023, Huang et al., 2023, Tuo et al., 2023, Chang et al., 2022, Deshpande et al., 2022, Huang et al., 2022, Liu et al., 2022, Pun et al., 2022, Thangadurai et al., 2022, Fabian et al., 2021, Lebo et al., 2021, Ostalé et al., 2021, Yang et al., 2021, Álvarez-Rendón and Riesgo-Escovar, 2020, Chapman et al., 2020, Cheng et al., 2020, Khan et al., 2020, Lee et al., 2020, Lin and Hsu, 2020, Luo et al., 2020, Polan et al., 2020, Texada et al., 2020, Vernizzi et al., 2020, Zhao et al., 2020, Banerjee et al., 2019, Chandran et al., 2019, Chatterjee et al., 2019, Evangelakou et al., 2019, Huang et al., 2019, Huichalaf et al., 2019, Kim and Choi, 2019, Krittika and Yadav, 2019, Li et al., 2019, Ramanathan et al., 2019, Tang et al., 2019, Bai et al., 2018, Chiku et al., 2018, Ignesti et al., 2018, Lee et al., 2018, Muñoz-Soriano et al., 2018, Nowak et al., 2018, Singh and Chowdhuri, 2018, Lin et al., 2017, Stobdan et al., 2017, Transgenic RNAi Project members, 2017-, Tsuyama et al., 2017, Yoon et al., 2017, Clandinin and Owens, 2016-, Gene Disruption Project members, 2016-, Kuleesha et al., 2016, Le et al., 2016, Penney et al., 2016, Vinayagam et al., 2016, Acevedo et al., 2015, Aradska et al., 2015, Calap-Quintana et al., 2015, Danilov et al., 2015, Francis and Ghabrial, 2015, Germain et al., 2015, Kim et al., 2015, Onyenwoke et al., 2015, Sopko et al., 2015, Morelli et al., 2014, Mulakkal et al., 2014, Sato-Miyata et al., 2014, Sopko et al., 2014, Villa-Cuesta et al., 2014, Kim et al., 2013, Kwon et al., 2013, Quan et al., 2013, Schertel et al., 2013, Soh et al., 2013, Sopko and Perrimon, 2013, Alvarez-Ponce et al., 2012, Dar et al., 2012, Eleftherianos and Castillo, 2012, Gurudatta et al., 2012, Penney et al., 2012, Pritchett and McCall, 2012, Tokusumi et al., 2012, Yaniv et al., 2012, Alic et al., 2011, Friedman et al., 2011, Glatter et al., 2011, Tang et al., 2011, Willecke et al., 2011, Cho et al., 2010, Kim et al., 2010, Kockel et al., 2010, Kong et al., 2010, Lee et al., 2010, Montagne et al., 2010, Sun et al., 2010, Zheng and Sehgal, 2010, Alvarez-Ponce et al., 2009, Shen and Ganetzky, 2009, Sims et al., 2009, Wang et al., 2009, Chen et al., 2008, Hou et al., 2008, McClure and Schubiger, 2008, Buszczak et al., 2007, Knox et al., 2007, Hennig et al., 2006, Khurana et al., 2006, Patel and Tamanoi, 2006, Stroschein-Stevenson et al., 2006, Stanyon et al., 2004)

d-S6K

(Gamberi et al., 2017)

dP70S6K

(Wu and Storey, 2016)

dS6K

(Dai et al., 2023, Frappaolo and Giansanti, 2023, Øvrebø et al., 2022, Zuko et al., 2021, Toshniwal et al., 2019, Zahoor et al., 2019, Álvarez-Rendón et al., 2018, Yan et al., 2015, Erion and Sehgal, 2013, Li and Guan, 2013, O'Farrell et al., 2013, Shin et al., 2013, Bar-Peled et al., 2012, Debat et al., 2011, Fenton and Gout, 2011, Kamakura, 2011, Murillo-Maldonado et al., 2011, Partridge et al., 2011, Resnik-Docampo and de Celis, 2011, Yang and Xu, 2011, Bryk et al., 2010, Georgiev et al., 2010, Montagne et al., 2010, Vargas et al., 2010, Chang and Neufeld, 2009, Read et al., 2009, Wang and Huang, 2009, Wessells et al., 2009, Gluderer et al., 2008, Kim et al., 2008, Sancak et al., 2008, Bielinski and Mumby, 2007, Gluderer et al., 2007, Lee et al., 2007, Parvy and Montagne, 2007, Wu et al., 2007, Inoki and Guan, 2006, Ruvinsky, 2006, Yang et al., 2006, Yang et al., 2006, Dekanty et al., 2005, Goraksha and Neufeld, 2005, Sarbassov et al., 2005, Wu et al., 2005, Jorgensen and Tyers, 2004, Kapahi et al., 2004, Sarbassov et al., 2004, Sarbassov et al., 2004, Barcelo and Stewart, 2003, Bennion et al., 2003, Manning and Cantley, 2003, Miron et al., 2003, Oldham and Hafen, 2003, Barcelo and Stewart, 2002, Barcelo and Stewart, 2002, Johnston and Gallant, 2002, Montagne et al., 2002, Potter et al., 2002, Radimerski et al., 2002, Radimerski et al., 2002, Radimerski et al., 2002, Gingras et al., 2001, Montagne et al., 2001, Rintelen et al., 2001, Oldham et al., 2000, Stocker and Hafen, 2000, Thomas, 2000, Montagne et al., 1999, Ridley, 1999, Roche, 1999)

dS6K1

(Katewa and Kapahi, 2011)

dS6k

(Kim et al., 2010, Hsu et al., 2007, Herranz et al., 2006, Wu et al., 2005, Kapahi et al., 2004, Colombani et al., 2003, Cho et al., 2001, Potter et al., 2001, Oldham et al., 2000, Edgar, 1999)

dp70^S6k

(Watson et al., 1996)

dp70s6k

(Stewart et al., 1998)

dps6k

(Montagne et al., 1999)

ds6k

(Xia et al., 2016, Parker and Struhl, 2015, Buffin et al., 2007, Hsu and Choi, 2007, Jacinto and Hall, 2003)

fs(3)07084

(Perrimon et al., 1996, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project, 1993.6.1)

l(3)07084

p-S6K

(Chambers et al., 2015)

p70 S6K

(Chittoor-Vinod et al., 2020, Parrish et al., 2009, Rhode et al., 2001)

p70/S6K

(Wu et al., 2005)

p70<up>S6 kinase</up>

(Edgar, 1999)

p70^S6K

(Lee et al., 2008)

p70^S6k

(Dearolf, 1998)

p70^S6kinase

(Lehner, 1999)

p70S6K

(Hwang et al., 2019, Brill et al., 2016, Xia et al., 2016, Chambers et al., 2015, Griciuc et al., 2014, Clark et al., 2013, Ravi et al., 2009, Stewart et al., 1998)

p70S6k

(Chatterjee et al., 2019)

p70s6K

(Spradling et al., 1999)

pS6K

(Yang et al., 2020)

s6k

(Yu et al., 2024, Gui et al., 2023, Li et al., 2023, Metaxakis et al., 2023, Jacobs et al., 2020, David-Morrison et al., 2016, Ghosh et al., 2015, Ghosh et al., 2014, Gordon et al., 2013, Hsieh et al., 2010, Li et al., 2010, Gilbert et al., 2009, Gilbert et al., 2009, Wang et al., 2009, McNeill et al., 2008, Buffin et al., 2007, Hall et al., 2007)

s6k11

(McDonald and Rosbash, 2001)

Name Synonyms

Protein kinase-like 64F

RPS6-p70-protein kinase

(Mulakkal et al., 2014, Itskov and Ribeiro, 2013, Ribeiro and Dickson, 2010, Watson et al., 1996)

Ribosomal protein S6 kinase

S6 Kinase

(Montagne et al., 2010, Howlett et al., 2008)

S6-kinase

(Patel and Tamanoi, 2006)

S6K kinase

(Griciuc et al., 2014)

S6kinase

(Potter et al., 2001)

dS6 kinase

(Marygold and Leevers, 2002)

p70 S6 Kinase

(Gross et al., 2015, Parrish et al., 2009)

p70 S6 kinase

(Parrish et al., 2009)

p70 S6 kinase 1

(Shin et al., 2013)

p70 ribosomal S6 kinase

(Nelson et al., 2005)

p70 s6 kinase

(Dionne et al., 2006)

p70S6 kinase

(Griciuc et al., 2014)

p70S6K kinase

(Griciuc et al., 2014)

ribosomal S6 protein kinase

(Lee et al., 2010)

ribosomal protein S6 kinase

(Koyama et al., 2013, Hall et al., 2007, Wu and Brown, 2006)

Secondary FlyBase IDs

FBgn0015806
FBgn0010455
FBgn0011551
FBgn0004460

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

PPI_InR-Tor_interaction_map

interactome

Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38654

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q94533

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q94533

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38654/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283472

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283472

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10539

MARRVEL_MODEL - MARRVEL (model organism gene)

38654

Linkouts

Cell Signaling Technology - Commercial vendor for primary antibodies and antibody conjugates.

9206
9209

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283472

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

S6k_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015806

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283472

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10539

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011817

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

38654

MIST (protein-protein) - An integrated Molecular Interaction Database

38654

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (648)

The following external sites may use different assemblies or annotations than FlyBase.

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