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FB2026_02
,
released June 18, 2026
Aph, Aph-1
Please see the JBrowse view of Dmel\Alp1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Alp1 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\Alp1 in JBrowse3-47
3-43.8
3-47.3
3-46.3 +/- 0.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Four forms of the enzyme are very similar in their properties (except pH optima and protein thermal stability).
Two forms of the enzyme are very similar in their properties (except pH optima).
An intimate relationship exists between larval and pupal Aph-1 with regards to developmental, electrophoretic and genetic properties.
Electrophoretic variation in the larval Aph-1 gene has been found. Inheritance of these enzyme variations is controlled by a pair of codominant alleles.
That the larval and pupal enzymes are differently modified products of the same locus is indicated by genetic inseparability and by concordance in the orders of mobilities of electrophoretic alleles (FBrf0019197).
Locus responsible for one of several different alkaline phosphatase species (APH1). APH1 becomes active in the larval cuticle and muscle during the third instar. Electrophoretic mobility of a pupal form of the enzyme, which differs from that found in the larva, also appears to be controlled by this locus (FBrf0019197).
Source for merge of: Alp1 CG5656
'Alp1' had been mapped by recombination to 3-46.3 (+/- 0.5) in FBrf0091310, and to between 'hid' and 'p' at 3-47.3 in FBrf0019197. FBrf0019197 also states this phosphatase "becomes active in the larval cuticle and muscle during the third instar" and it is often referred to as 'larval alkaline phosphatase'. Of the 13 annotated Dmel genes predicted to encoded Alkaline phosphatases, only one, CG5656, at cytogenetic position 78D (which corresponds to 3-47 according to the FlyBase cyto-genetic-seq correspondence file) fulfils these criteria.
Source for identity of: Alp1 Aph-1
The gene symbol "Aph-1" has been changed to "Alp1" in order to reduce confusion with the "aph-1" ("anterior pharynx defective 1') gene symbol, from which it differed only by case.
