FlyBase Gene Report: Dmel\Phm

General Information

Symbol

Dmel\Phm

Species

D. melanogaster

Name

Peptidylglycine-α-hydroxylating monooxygenase

Annotation Symbol

CG3832

Feature Type

protein_coding_gene

FlyBase ID

FBgn0283509

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

peptidylglycine monooxygenase (1.14.17.3)

Gene Summary

Peptidylglycine-α-hydroxylating monooxygenase (Phm) encodes a hydroxylating monooxygenase, dedicated to the regulated secretory pathway and critical for proper neuropeptide biosynthesis. It promotes the potency and stability of secreted neuropeptides via C-terminal amidation. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

dPHM

Key Links

Genomic Location

Cytogenetic map

60A16-60A16

Sequence location

2R:23,985,175..23,988,455 [-]

Recombination map

2-105

RefSeq locus

NT_033778 REGION:23985175..23988455

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables peptidylglycine monooxygenase activity

inferred from direct assay

(Kolhekar et al., 1997)

NOT enables peptidylamidoglycolate lyase activity

inferred from direct assay

(Kolhekar et al., 1997)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables catalytic activity

inferred from electronic annotation with InterPro:IPR000720, InterPro:IPR008977

(InterPro Project Members, 2004-)

enables copper ion binding

inferred from electronic annotation with InterPro:IPR000323, InterPro:IPR036939

(InterPro Project Members, 2004-)

enables monooxygenase activity

inferred from electronic annotation with InterPro:IPR000323, InterPro:IPR036939

(InterPro Project Members, 2004-)

enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

inferred from electronic annotation with InterPro:IPR000323, InterPro:IPR014783, InterPro:IPR014784, InterPro:IPR036939

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in insemination

inferred from high throughput expression pattern

(Findlay et al., 2008)

involved_in memory

inferred from mutant phenotype

(Iliadi et al., 2008)

involved_in regulation of imaginal disc-derived wing size

inferred from mutant phenotype

(Ray et al., 2015)

involved_in response to fungus

inferred from high throughput expression pattern

(Levy et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in peptide metabolic process

inferred from electronic annotation with InterPro:IPR000720

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in extracellular region

inferred from biological aspect of ancestor with PANTHER:PTN000840899

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR000720

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

MONOOXYGENASES, REDUCED ASCORBATE AS ONE DONOR

Protein Family (UniProt)

Belongs to the copper type II ascorbate-dependent monooxygenase family. (O01404)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

peptidylglycine monooxygenase activity

a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C- terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O (1.14.17.3)

RHEA 21452:

Summaries

Gene Snapshot

Gene Group (FlyBase)

MONOOXYGENASES, REDUCED ASCORBATE AS ONE DONOR -: Monooxygenases, reduced ascorbate as one donor include dehydrogenases that catalyze an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor.

Protein Function (UniProtKB)

Monooxygenase that catalyzes an essential reaction in C-terminal alpha-amidation of peptides. Produces an unstable peptidyl(2-hydroxyglycine) intermediate. C-terminal amidation of peptides is required for normal developmental transitions and for biosynthesis of secretory peptides throughout the life.

(UniProt, O01404)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

ll: lanceolate

Wings narrowed at tips and slightly divergent. Eyes slightly smaller than normal and bulging; head narrow. Waddington finds wing effect detectable in middle pupal stage. RK3.

ll2

ll2: lanceolate-2

Edith M. Wallace, unpublished.

Wings pointed and narrow. Eyes small and bulging. Head narrow. Wing shape first seen in early contraction stage of wing development (23-hr pupa at 25) (Waddington, 1939, Proc. Nat. Acad. Sci. USA 25: 303). More extreme and more useful than ll. RK2.

Summary (Interactive Fly)

an enzyme involved in producing amidated neuropeptides - amidated secretory peptides are required for signaling events that ensure progression through several critical developmental transitions

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Phm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O01404)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Phm-RA

FBtr0072203

NM_057877

1603

365

Phm-RB

FBtr0072202

NM_166644

1439

365

Additional Transcript Data and Comments

Reported size (kB)

1.7 (northern blot)

(Kolhekar et al., 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Phm-PA

FBpp0072112

40.6

365

6.04

FBpp0072111

40.6

365

6.04

O01404

NP_726394

AAF47128

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

365 aa isoforms: Phm-PA, Phm-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

365 (aa); 35 (kD observed)

(Kolhekar et al., 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Phm using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

l-LNv neuron

(Park et al., 2011)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 5

mesoderm anlage

(Markstein et al., 2004)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

embryonic/larval salivary gland body

(Fisher et al., 2012)

embryonic stage 16 -- 17

larval central nervous system

(Park et al., 2011)

third instar larval stage

larval ventral nerve cord | restricted

(Iliadi et al., 2008)

Additional Descriptive Data

Phm transcript is expressed at a moderate level in the CNS of late stage embryos. Phm transcript is also expressed in dimm-positive neurons in adults.

(Park et al., 2011)

Prominent Phm staining is observed in the larval CNS in the T1-T3 dorsal and ventral neurons and in lateral neurons. Co-expression with nemy is seen in many lateral and ventral nerve cord cells as well as in A8 pair cells.

(Iliadi et al., 2008)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval endocrine system

(Kolhekar et al., 1997)

larval central nervous system

(Kolhekar et al., 1997)

FMRFamide SE2 neuron

(Kolhekar et al., 1997)

larval digestive system

(Kolhekar et al., 1997)

first instar larval stage

apterous-expressing neuron of the lateral cluster of the thorax Ap4

(Allan et al., 2005)

apterous-expressing neuron of the lateral cluster of the thorax Ap1

(Allan et al., 2005)

neurosecretory neuron

(Allan et al., 2005)

prepupal stage P4(i)

peritracheal cell | subset

(O'Brien and Taghert, 1998)

pharate adult stage P14 -- adult stage

adult peritracheal PM cell | subset

(O'Brien and Taghert, 1998)

adult stage

adult brain | restricted

(Hewes et al., 2006)

neurosecretory neuron of adult brain | restricted

(Hewes et al., 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Phm is expressed in a series of lateral abdominal neurons, and in some insulin-like producing cells (IPCs).

(Hewes et al., 2006)

Co-localisation of Phm and ScerGAL4^dimm-929 is observed in most of the Phm-positive neurons of the central nervous system, corpus cardiacum, midgut cells, peritracheal cells and lateral Kolbchen lbd neurons. Weakly stained Phm-positive neurons do not express ScerGAL4^dimm-929.

(Hewes et al., 2003)

Phm protein is detected throughout all levels of the larval CNS as well as in other tissues, including the endocrine glands and the gut. Staining is observed in the cell bodies and in the neuropil of the brain. Staining is also prevalent in secretory cells of the ring gland, salivary gland, and in diverse cells in all levels of the midgut. In the CNS, several strongly staining cells were identified as neuroendocrine neurons. Many Phm-positive neurons were shown to be peptidergic cells.

(Kolhekar et al., 1997)

Marker for

neurosecretory neuron

(Allan et al., 2005)

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from high throughput direct assay

(Findlay et al., 2008)

Expression Deduced from Reporters

Reporter: P{Phm.272.eve-lacZ}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5

mesoderm anlage

(Markstein et al., 2004)

Reporter: P{Phm-GAL4.WT}

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage

larval central nervous system | restricted

(Park et al., 2008)

third instar larval stage

larval brain | restricted

(Park et al., 2008)

larval ventral nerve cord | restricted

(Park et al., 2008)

embryonic/larval mushroom body

(Park et al., 2008)

wandering third instar larval stage

larval brain | restricted

(Jansen et al., 2009)

larval ventral nerve cord | restricted

(Jansen et al., 2009)

adult stage

adult brain | restricted

(Jansen et al., 2009)

adult mushroom body

(Park et al., 2008)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Phm in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Phm

View exonic expression by tissue for Dmel\Phm

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0019948

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37823/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283509

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0019948

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283509

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3832

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Phm

Transgenic constructs containing regulatory region of Phm

Aberrations (Deficiencies and Duplications) ( 21 )

Inferred from experimentation ( 21 )

Gene not disrupted in

Gene duplicated in

Dp(2;3)P

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Phm^k07623

lethal | recessive

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Phm^GD506

Other Phenotypes

Allele

abnormal memory, with Scer\GAL4^Mef2.247

Phm^GD506

abnormal memory, with Scer\GAL4^NP0335

Phm^GD506

abnormal memory, with Scer\GAL4^OK66

Phm^GD506

abnormal neurophysiology | dominant | third instar larval stage

Phm^k07623

some die during embryonic stage | recessive

Phm^k07623

some die during larval stage | recessive

Phm^k07623

visible

Phenotype manifest in

Allele

adult head

embryonic/larval neuromuscular junction | third instar larval stage

Phm^k07623

eye

mouthpart | increased number

Phm^k07623

pupa, with Phm^A5.hs

Phm^P(29)

pupa, with Phm^P(29)

Phm^A5.hs

puparium cuticle, with Phm^A5.hs

Phm^P(29)

puparium cuticle, with Phm^P(29)

Phm^A5.hs

wing

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (4)

Hsap\PAM

4 of 14

Yes

Hsap\DBH

1 of 14

Hsap\MOXD1

1 of 14

Hsap\MOXD2P

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Pam

4 of 14

Yes

Rnor\Dbh

1 of 14

Rnor\Moxd1

1 of 14

Rnor\Moxd2

1 of 14

Mus musculus (laboratory mouse) (4)

Mmus\Pam

4 of 14

Yes

Mmus\Dbh

1 of 14

Mmus\Moxd1

1 of 14

Mmus\Moxd2

1 of 14

Xenopus tropicalis (Western clawed frog) (2)

Xtro\pam

2 of 13

Yes

Xtro\pspc1

1 of 13

Danio rerio (Zebrafish) (4)

Drer\pam

3 of 14

Yes

Drer\dbh

1 of 14

Drer\moxd1

1 of 14

Drer\moxd1l

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\pghm-1

13 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP007420

12 of 12

Yes

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Phm. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

5 of 13

4 of 13

1 of 13

1 of 13

Tbh

1 of 13

wech

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PAM; peptidylglycine alpha-amidating monooxygenase

4 of 14

170270

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

nej

enhanceable

Phm

(Anderson et al., 2005)

External Data

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

37823

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-105

Cytogenetic map

60A16-60A16

Sequence location

2R:23,985,175..23,988,455 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A16-60A16

Limits computationally determined from genome sequence between P{EP}Tal^EP489&P{EP}CG3065^EP316 and P{lacW}Phm^k07623&P{lacW}tsr^k05633

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60A12-60A16

(Kolhekar, 1997.6.3)

60A12-60B1

(Kolhekar, 1996.11.4)

60B1-60B2

(determined by in situ hybridisation)

(Spradling et al., 1999)

60B1-60B2

(Beaton, 1997.12.27)

60A12-60A16

(determined by in situ hybridisation)

(Kolhekar et al., 1997)

Experimentally Determined Recombination Data

Location

2-105

(FlyBase, 2016)

2-109.8

(Comeron et al., 2012)

2-106.7

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

333

Phm^ll-2

362

Snap29^pd-1 Phm^ll-1

12198

y¹ w^67c23; P{lacW}Phm^k07623/CyO

55392

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04080}attP40

Kyoto

111444

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{neoFRT}42D P{lacW}Phm^k07623 /CyO y⁺

NIG-Fly

HMJ23573

y¹ v¹; P{TRiP.HMJ23573}attP40/CyO

2RG-0250

y² VhaAC39-1^cho-1 v¹; P{U6-Phm.NIG.sgRNA}attP40/CyO

VDRC

v104028

P{KK112513}VIE-260B

v51058

w¹¹¹⁸; P{GD506}v51058

v52052

w¹¹¹⁸; P{GD506}v52052

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (121)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH12243

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0283509

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kolhekar et al., 1997)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Phm is required for peptide α-amidating activity throughout the life of Drosophila.

(Jiang et al., 2000)

Genetic combinations with mutants of nub cause additive phenotypes.

(Cifuentes and Garcia-Bellido, 1997)

Relationship to Other Genes

Source for database merge of

Source for merge of: Phm ll

(Ray et al., 2015)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Phm CG3832

(Wang, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG3832

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Levy et al., 2004, Kang et al., 2002)

PHM

(Luo et al., 2017, Knight et al., 2015, Chen et al., 2014, Hwang et al., 2014, Laneve et al., 2013, Jansen et al., 2009, Iliadi et al., 2008, Park et al., 2008, Shang et al., 2008, Gu et al., 2006, Park et al., 2005, Han et al., 2004, Park et al., 2004, Hewes et al., 2003, Suster et al., 2003, Taghert et al., 2001, Jiang et al., 2000)

dPHM

(Han et al., 2004, O'Brien and Taghert, 1998, Kolhekar, 1997.6.3, Kolhekar et al., 1997, Taghert et al., 1997, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4, Kolhekar, 1996.11.4)

lance-b

phm

(Liu et al., 2025, Li et al., 2024, Turingan et al., 2024, Floc'hlay et al., 2023)

Name Synonyms

Peptidyl gycine α hydroxylating monooxygenase

(Kang et al., 2002)

Peptidylglycine-alpha-hydroxylating monooxygenase

(Suster et al., 2003)

Peptidylglycine-α-hydroxylating monooxygenase

(Gauthier and Hewes, 2006, Kolhekar et al., 1997)

lanceolate

lanceolote

(Ray et al., 2015)

peptidylglycine α-hydroxylating monooxygenase

(Park et al., 2008)

peptidylglycine-α-hydroxylating monooxygenase

(Jansen et al., 2009)

Secondary FlyBase IDs

FBgn0019948
FBgn0002554

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37823

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O01404

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O01404

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

E2QCL8

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O01404

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0019948

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37823/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0283509

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0283509

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3832

MARRVEL_MODEL - MARRVEL (model organism gene)

37823

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0283509

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0019948

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0283509

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3832

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

37823

References (112)

The following external sites may use different assemblies or annotations than FlyBase.

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