Perlecan, Pcan, zw1, l(1)zw1, zw-1
extracellular matrix component - homolog of perlecan - regulates larval neuroblast division by modulating both FGF and Hedgehog signaling
Please see the JBrowse view of Dmel\trol for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 6.29
Gene model reviewed during 6.06
Gene model reviewed during 6.45
Gene model reviewed during 5.51
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.39
Gene model reviewed during 6.03
Gene model reviewed during 6.32
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\trol using the Feature Mapper tool.
Comment: two clusters of cells at inner side of brain hemispheres.
Comment: reference states Kc[[1]] cells
trol-protein is expressed in a subset of neurons in the embryonic ventral nerve cord, some of which co-express the motor neuron marker Scer\GAL4exex-Gal4. Strong staining is observed in abdominal apodemes and at branch points of the intersegmental nerve ISNb and the segmental nerve SNa. A fainter expression is detected in several regions of ventral and lateral hypodermal muscles with an accumulation along motor axon trajectories close to the ISNb pathway.
In stage 16 embryos, particular depositions of trol protein are observed in the basement membrane of cardiac cells, the dorsal vessel, muscle attachment sites of dorsal muscles, the central nervous system, CNS channels, and dorsal median cells of the CNS.
Comment: unstructured neuropil throughout adult brain
GBrowse - Visual display of RNA-Seq signals
View Dmel\trol in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: trol pcan
Source for merge of: trol l(1)G0023 l(1)G0271 l(1)G0374
Source for merge of: trol anon-WO0153538.72
Source for merge of: pcan EG:BACR25B3.11
Source for merge of: trol BcDNA:GM02481
Source for merge of: EG:BACR25B3.11 CG7981
Source for merge of: trol EG:BACR25B3.1 EG:BACR25B3.10
Source for merge of: EG:BACR25B3.2 CG12497
Source for merge of: trol MRE7
Source for merge of: trol l(1)G0021 l(1)G0181 l(1)G0412 l(1)G0019 l(1)G0211
MRE7 corresponds to a portion of the 3' UTR of a short isoform of trol.
Source for merge of EG:BACR25B3.2 CG12497 was sequence comparison ( date:000425 ).
"l(1)G0019" may affect "trol". "l(1)G0021" may affect "trol". "l(1)G0073" may affect "trol". "l(1)G0023" may affect "trol". "l(1)G0374" may affect "trol". "l(1)G0181" may affect "trol". "l(1)G0211" may affect "trol". "l(1)G0377" may affect "trol". "l(1)G0271" may affect "trol". "l(1)G0412" may affect "trol". "l(1)G0362" may affect "trol".
"l(1)G0021" may affect "trol".
"l(1)G0181" may affect "trol".
"l(1)G0412" may affect "trol".
"l(1)G0019" may affect "trol".
"l(1)G0211" may affect "trol".
"l(1)G0023" may affect "trol".
"l(1)G0271" may affect "trol".
"l(1)G0374" may affect "trol".
" EG:BACR25B3.2 " may correspond to "Scim4". Sequence analysis off ends of P{SUPor-P} in Scim insertion mutant places "Scim4" near/in " EG:BACR25B3.2 " and/or " EG:BACR25B3.3 ".
Source for merge of pcan EG:BACR25B3.11 was sequence comparison ( date:000228 ).
Source for merge of trol BcDNA:GM02481 was a shared cDNA ( date:030728 ).
Source for merge of trol anon-WO0153538.72 was sequence comparison ( date:051113 ).
Source for merge of EG:BACR25B3.11 CG7981 was sequence comparison ( date:000425 ).
trol does not have an essential role in apical-basal follicle cell polarity.
Loss of trol increases basement membrane tension in a Collagen IV-dependent manner.
trol gene product is required for the activation of proliferation in quiescent optic lobe and thoracic neuroblasts.
trol acts downstream of ana, it is possible that trol may function to inactivate or bypass ana repression to activate cell proliferation. trol is required specifically to regulate initiation of proliferation and may be part of a switch that controls the transition from quiescence to active proliferation.
Mutations in trol cause optic lobe defects.
Partial maternal insufficiency of trol does not cause embryonic lethality.
Tight alleles <up>trol9, trol12, trol23, trol33</up> are polyphasic, dying during L2, L3 and post-puparial stages; cell viable. Semilethal alleles <up>trol2 and trol6</up> die as pupae; escapers have rough eyes, shriveled or blistered wings and crippled metathoracic legs; phenotype of X0 more extreme than that of XY males. XY escapers fertile but females sterile <up>trol2/trol2 and trol2/trol6</up> or nearly so <up>trol6/trol6</up>. The latter females sterile in crosses to trol6 males, but produce heterozygous daughters when outcrossed (Shannon, Kaufman, Shen and Judd, 1975). In line freed of sgg4 (Robbins), trol14 survives as epidermal clones and as oogenic clones, which produce lethal zygotes (Garcia-Bellido and Robbins, 1983).