FB2026_03 , released September 17, 2026
Gene: Dmel\SRPK
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General Information
Symbol
Dmel\SRPK
Species
D. melanogaster
Name
SR Protein Kinase
Annotation Symbol
CG8174
Feature Type
protein_coding_gene
FlyBase ID
FBgn0286813
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Summary
SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. [Date last reviewed: 2019-08-01] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dSRPK1, mat(2)synPL63, fs(2)abc

Key Links
Genomic Location
Cytogenetic map
51F11-51F12
Sequence location
Recombination map
2-74
RefSeq locus
NT_033778 REGION:15380724..15387851
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein serine/threonine kinase activity
inferred from direct assay
(Allemand et al., 2001)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(InterPro Project Members, 2004-)
enables protein kinase activity
inferred from electronic annotation with InterPro:IPR008271
(InterPro Project Members, 2004-)
enables protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000622883
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in oocyte karyosome formation
inferred from mutant phenotype
(Loh et al., 2012)
involved_in spindle assembly involved in female meiosis
inferred from mutant phenotype
(Loh et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of mRNA processing
inferred from biological aspect of ancestor with PANTHER:PTN000622883
(GO Reference Genome Project, 2011-)
involved_in spliceosomal complex assembly
inferred from biological aspect of ancestor with PANTHER:PTN000622883
(GO Reference Genome Project, 2011-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000622884
(GO Reference Genome Project, 2011-)
located_in cytoplasm
inferred from sequence or structural similarity with UniProtKB:Q96SB4
(Gene Ontology Curators, 2002-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000622884
(GO Reference Genome Project, 2011-)
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:Q96SB4
(Gene Ontology Curators, 2002-)
Gene Group / Complex (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. [Date last reviewed: 2019-08-01]
Gene Group / Complex (FlyBase)
SERINE-ARGININE PROTEIN KINASES -
Serine-arginine protein kinases (SRPKs) are a group of serine kinases that phosphorylate proteins with serine-arginine dipeptide repeats, particularly targeting the SR family of splicing factors. SRPKs are constitutively active. They contain a well-conserved kinase domain that is bifurcated by a large non-conserved insert domain. (Adapted from PMID:21205204).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the JBrowse view of Dmel\SRPK for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A0A6M3Q7C8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.43

Stop-codon suppression (UAA) postulated; FBrf0216885.

Gene model reviewed during 5.44

Gene model reviewed during 5.50

Double stop-codon suppression (UAA, UGA) postulated; FBrf0243886.

Gene model reviewed during 6.32

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
SRPK-RA
FBtr0087383
NM_166093
3713
764
SRPK-RB
FBtr0087384
NM_137190
5116
764
SRPK-RC
FBtr0087385
NM_166094
4483
607
SRPK-RD
FBtr0330628
NM_001274064
3713
939
SRPK-RE
FBtr0479824
NM_001382195
5121
1009
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
SRPK-PA
FBpp0086515
85.1
764
9.44
Q0E965
NP_725458
AAF58140
SRPK-PB
FBpp0086516
85.1
764
9.44
Q0E965
NP_611034
AAM68537
SRPK-PC
FBpp0086517
68.1
607
8.99
A1ZA05
NP_725459
AAM68538
SRPK-PD
FBpp0303478
103.3
939
9.74
A0A0B4KF69
NP_001260993
AGB93525
SRPK-PE
FBpp0428157
111.9
1009
10.11
QJC18710
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

764 aa isoforms: SRPK-PA, SRPK-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SRPK using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.06

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
hindgut anlage
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval nervous system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\SRPK in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of SRPK
Transgenic constructs containing regulatory region of SRPK
Aberrations (Deficiencies and Duplications) ( 14 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4VP16.otu
lethal - all die during embryonic stage | maternal effect | recessive
lethal - all die during embryonic stage | non-rescuable maternal effect | recessive
partially lethal - majority die | recessive
viable
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with Df(2R)ED2426)
viable (with Df(2R)ED2436)
viable (with Df(2R)Exel9015)
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
female semi-sterile, with Scer\GAL4VP16.nanos.UTR, Scer\GAL4VP16.otu, Scer\GAL4nanos.PG
female semi-sterile | recessive
female sterile
female sterile (with Df(2R)ED2426)
female sterile (with Df(2R)ED2436)
female sterile (with Df(2R)Exel9015)
female sterile | recessive
male sterile
Other Phenotypes
Allele
decreased rate of feeding behavior | adult stage, with Scer\GAL4yolk
some die during embryonic stage, with Scer\GAL4VP16.otu
some die during embryonic stage | recessive
some die during embryonic stage | recessive | maternal effect | recessive
Phenotype manifest in
Allele
aster
centrosome
egg chorion (with SRPK2)
egg chorion (with SRPK4)
egg chorion | germline clone
embryo | embryonic stage 4
embryo | maternal effect, with Scer\GAL4VP16.mat.αTub67C
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
endochorion
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
karyosome (with Df(2R)ED2426)
karyosome (with Df(2R)ED2436)
karyosome (with Df(2R)Exel9015)
karyosome | germline clone
meiotic spindle (with Df(2R)ED2436)
nucleus | embryonic stage 4
oocyte | germline clone
primordial germ cell | maternal effect
spindle
yolk nucleus
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (19)
Hsap\SRPK1
11 of 14
Yes
Yes
Hsap\SRPK2
9 of 14
No
Yes
Hsap\SRPK3
9 of 14
No
Yes
1  
Hsap\ARAF
1 of 14
No
No
Hsap\CILK1
1 of 14
No
No
Hsap\CLK1
1 of 14
No
No
Hsap\CLK2
1 of 14
No
No
4  
Hsap\CLK3
1 of 14
No
No
1  
Hsap\CLK4
1 of 14
No
No
1  
Hsap\DYRK1B
1 of 14
No
No
Hsap\DYRK2
1 of 14
No
No
Hsap\DYRK3
1 of 14
No
No
1  
Hsap\DYRK4
1 of 14
No
No
1  
Hsap\MAPK1
1 of 14
No
No
Hsap\MAPK14
1 of 14
No
No
Hsap\MYLK
1 of 14
No
No
Hsap\STK10
1 of 14
No
No
Hsap\STK17A
1 of 14
No
No
Hsap\STK17B
1 of 14
No
No
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (16)
Rnor\Srpk1
10 of 14
Yes
Yes
Rnor\Srpk2
9 of 14
No
Yes
Rnor\Srpk3
8 of 14
No
Yes
Rnor\Araf
1 of 14
No
No
Rnor\Cilk1
1 of 14
No
No
Rnor\Clk1
1 of 14
No
No
Rnor\Clk2
1 of 14
No
No
Rnor\Clk3
1 of 14
No
No
Rnor\Dyrk1b
1 of 14
No
No
Rnor\Dyrk2
1 of 14
No
No
Rnor\Dyrk3
1 of 14
No
No
Rnor\Mapk1
1 of 14
No
No
Rnor\Mapk14
1 of 14
No
No
Rnor\Mylk
1 of 14
No
No
Rnor\Scamp3
1 of 14
No
No
Rnor\Zap70
1 of 14
No
No
Mus musculus (laboratory mouse) (18)
Mmus\Srpk1
11 of 14
Yes
Yes
Mmus\Srpk3
9 of 14
No
Yes
Mmus\Srpk2
8 of 14
No
Yes
Mmus\Araf
1 of 14
No
No
Mmus\Cdk3
1 of 14
No
No
Mmus\Cilk1
1 of 14
No
No
Mmus\Clk1
1 of 14
No
No
Mmus\Clk2
1 of 14
No
No
1  
Mmus\Clk3
1 of 14
No
No
Mmus\Clk4
1 of 14
No
No
Mmus\Dyrk1b
1 of 14
No
No
Mmus\Dyrk2
1 of 14
No
No
Mmus\Dyrk3
1 of 14
No
No
Mmus\Mapk1
1 of 14
No
No
Mmus\Mapk14
1 of 14
No
No
Mmus\Mylk
1 of 14
No
No
Mmus\Prpf4b
1 of 14
No
No
Mmus\Zap70
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\srpk1
9 of 13
Yes
Yes
Xtro\srpk2
7 of 13
No
Yes
Xtro\srpk3
6 of 13
No
Yes
Xtro\XB5772073
3 of 13
No
Yes
Xtro\gpr26
2 of 13
No
Yes
Xtro\cdk12
1 of 13
No
No
Xtro\clk1
1 of 13
No
No
Xtro\clk3
1 of 13
No
No
Xtro\dclk1
1 of 13
No
No
Xtro\dyrk1a.2
1 of 13
No
No
Xtro\dyrk2
1 of 13
No
No
Xtro\dyrk3
1 of 13
No
No
Xtro\LOC101732252
1 of 13
No
No
Xtro\man2b2
1 of 13
No
No
Xtro\mapk15
1 of 13
No
No
Xtro\ttn
1 of 13
No
No
Danio rerio (Zebrafish) (29)
Drer\srpk1a
11 of 14
Yes
Yes
Drer\srpk1b
11 of 14
Yes
Yes
Drer\srpk3
6 of 14
No
Yes
Drer\si:ch211-220i18.4
5 of 14
No
Yes
Drer\LOC110438375
3 of 14
No
Yes
Drer\cdk4
1 of 14
No
No
Drer\cdk15
1 of 14
No
No
Drer\cdk21
1 of 14
No
No
Drer\clk2a
1 of 14
No
No
Drer\clk2b
1 of 14
No
No
Drer\clk4a
1 of 14
No
No
Drer\clk4b
1 of 14
No
No
Drer\dyrk1ab
1 of 14
No
No
Drer\dyrk2
1 of 14
No
No
Drer\dyrk3
1 of 14
No
No
Drer\dyrk4
1 of 14
No
No
Drer\mak
1 of 14
No
No
Drer\mapk1
1 of 14
No
No
Drer\mapk14a
1 of 14
No
No
Drer\mapk14b
1 of 14
No
No
Drer\mknk1
1 of 14
No
No
Drer\mylkb
1 of 14
No
No
Drer\pak6b
1 of 14
No
No
Drer\prkd4
1 of 14
No
No
Drer\pskh1
1 of 14
No
No
Drer\si:dkey-151g10.3
1 of 14
No
No
Drer\srpk2
1 of 14
No
Yes
Drer\stk17al
1 of 14
No
No
Drer\stk17b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\spk-1
7 of 14
Yes
Yes
Cele\madd-3
2 of 14
No
No
Cele\C16A11.10
1 of 14
No
No
Cele\C36B7.2
1 of 14
No
No
Cele\C49C3.10
1 of 14
No
No
Cele\dyf-5
1 of 14
No
No
Cele\F32D8.1
1 of 14
No
No
Cele\lit-1
1 of 14
No
No
Cele\mbk-2
1 of 14
No
No
Cele\R03D7.5
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (9)
Agam\AgaP_AGAP005322
10 of 12
Yes
Yes
Agam\AgaP_AGAP000847
1 of 12
No
No
Agam\AgaP_AGAP002119
1 of 12
No
No
Agam\AgaP_AGAP003040
1 of 12
No
No
Agam\AgaP_AGAP005729
1 of 12
No
No
Agam\AgaP_AGAP007847
1 of 12
No
No
Agam\AgaP_AGAP008241
1 of 12
No
No
Agam\AgaP_AGAP008863
1 of 12
No
No
Agam\AgaP_AGAP013457
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (38)
Atha\SRPK4
11 of 13
Yes
Yes
Atha\AT3G44850
10 of 13
No
Yes
Atha\AT5G22840
10 of 13
No
Yes
Atha\AT2G17530
9 of 13
No
Yes
Atha\AT4G35500
9 of 13
No
Yes
Atha\AME3
1 of 13
No
No
Atha\AT1G13350
1 of 13
No
No
Atha\AT1G18390
1 of 13
No
No
Atha\AT1G61550
1 of 13
No
Yes
Atha\AT1G66930
1 of 13
No
Yes
Atha\AT1G73450
1 of 13
No
No
Atha\AT1G73460
1 of 13
No
No
Atha\AT2G25760
1 of 13
No
No
Atha\AT2G40120
1 of 13
No
No
Atha\AT2G41930
1 of 13
No
Yes
Atha\AT3G17750
1 of 13
No
No
Atha\AT3G25840
1 of 13
No
No
Atha\AT3G53640
1 of 13
No
No
Atha\AT4G03175
1 of 13
No
No
Atha\AT4G10010
1 of 13
No
No
Atha\AT5G38260
1 of 13
No
No
Atha\AT5G39030
1 of 13
No
Yes
Atha\ATMPK13
1 of 13
No
No
Atha\ATSK12
1 of 13
No
No
Atha\CDKB1;2
1 of 13
No
No
Atha\CDKB2;1
1 of 13
No
No
Atha\CPK17
1 of 13
No
No
Atha\CPK25
1 of 13
No
No
Atha\FC1
1 of 13
No
No
Atha\FC2
1 of 13
No
No
Atha\MEK1
1 of 13
No
No
Atha\MEKK1
1 of 13
No
No
Atha\MHK
1 of 13
No
No
Atha\MPK1
1 of 13
No
No
Atha\MPK2
1 of 13
No
No
Atha\MPK6
1 of 13
No
No
Atha\RKF2
1 of 13
No
No
Atha\YAK1
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\SKY1
8 of 13
Yes
Yes
Scer\DUN1
1 of 13
No
No
Scer\FPK1
1 of 13
No
No
Scer\KNS1
1 of 13
No
No
Scer\KSS1
1 of 13
No
No
Scer\SLT2
1 of 13
No
No
Scer\YAK1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (10)
Spom\dsk1
9 of 12
Yes
Yes
Spom\byr1
1 of 12
No
No
Spom\lkh1
1 of 12
No
No
Spom\pck1
1 of 12
No
No
Spom\pef1
1 of 12
No
No
Spom\pom1
1 of 12
No
No
Spom\pom2
1 of 12
No
No
Spom\ppk15
1 of 12
No
No
Spom\prp4
1 of 12
No
No
Spom\srb10
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:SRPK. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (18)
CG8565
8 of 13
Srpk79D
7 of 13
bsk
1 of 13
CG42366
1 of 13
Doa
1 of 13
Dyrk2
1 of 13
Dyrk3
1 of 13
Erk7
1 of 13
KP78a
1 of 13
KP78b
1 of 13
Lk6
1 of 13
mnb
1 of 13
nmo
1 of 13
p38a
1 of 13
p38b
1 of 13
p38c
1 of 13
Pdk1
1 of 13
rl
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Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SRPK1; SRSF protein kinase 1
    11 of 14
    601939
        SRPK2; SRSF protein kinase 2
        9 of 14
        602980
            SRPK3; SRSF protein kinase 3
            9 of 14
            301002
               
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              Interaction Browsers
              View in FlyBase Interactions Browser   View in MIST tool (external link)
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              SRPK - Nrd1
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Yoon et al., 2017)
              Summary of Genetic Interactions
              Interaction Browsers
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              External Data
              Linkouts
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              FlyBase
              External Links
              External Data
              Linkouts
              Class of Gene
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              2R
              Recombination map
              2-74
              Cytogenetic map
              51F11-51F12
              Sequence location
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              51F11-51F12
              Limits computationally determined from genome sequence between P{lacW}dupk03308 and P{lacW}Vha36k07207
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              The fs(2)abc complementation group maps to the genomic interval 2R:15375176..15386324 , release 6 genome (left limit from complementation mapping against Df(2R)Exel9015, right limit from complementation mapping against Df(2R)Exel9015).
              (Kahsai and Cook, 2018)
              52A1-52A2
              (Allemand, 2000.8.29)
              Experimentally Determined Recombination Data
              Location

              2-74

              (FlyBase, 2016)

              2-78.2

              (Comeron et al., 2012)

              2-72

              (Schupbach and Wieschaus, 1989)

              2-[73]

              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (18)
              Genomic Clones (30)
              cDNA Clones (82)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                    Other Comments

                    4 alleles of SRPK have been isolated in a screen for mutants with defects in dorsoventral patterning of the eggshell.

                    (Barbosa et al., 2007)

                    Mutant embryos show defects occurring during syncytial blastoderm formation: a narrow halo of clear cytoplasm appears at egg periphery.

                    (Schupbach and Wieschaus, 1989)
                    Relationship to Other Genes
                    Source for database merge of

                    Source for merge of: SRPK BcDNA:SD03158

                    (BDGP Project Members, 2000-)

                    Source for merge of: SRPK CG8174

                    (FlyBase, 1996-)

                    Source for merge of: SRPK fs(2)abc

                    (Kahsai and Cook, 2018)
                    Additional comments

                    Source for merge of SRPK CG8174 was sequence comparison ( date:000225 ).

                    (FlyBase, 1996-)
                    Nomenclature History
                    Source for database identify of
                    Nomenclature comments
                    Etymology

                    The gene is named "cuaba", after a brand of Cuban cigars, due to the mutant eggshell phenotype.

                    (Barbosa et al., 2007)
                    Synonyms and Secondary IDs (15)
                    Reported As
                    Symbol Synonym
                    BcDNA:SD03158
                    CG8174
                    (National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Aerts et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Barbosa et al., 2007, Molnar et al., 2006, Brody et al., 2002, Allemand et al., 2001, Mount and Salz, 2000)
                    SRPK
                    (Garrido et al., 2025, Menzies et al., 2024, Miao et al., 2024, Mercier et al., 2023, Chang et al., 2022, DePew and Mosca, 2021, Malik et al., 2021, Parniewska and Stocker, 2020, FlyBase Genome Annotators, 2019-, Hughes et al., 2018, Kahsai and Cook, 2018, Lee et al., 2018, Transgenic RNAi Project members, 2017-, Yoon et al., 2017, Gene Disruption Project members, 2015-, Kwong et al., 2015, Ashwal-Fluss et al., 2014, Luck et al., 2014, Saccone et al., 2014, Sopko et al., 2014, Bonke et al., 2013, Handler et al., 2013, Handler et al., 2013, Schertel et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Jungreis, 2011.11.18, Aerts et al., 2010, Gan et al., 2010, Mudiganti et al., 2010, Grieder et al., 2007, Molnar et al., 2006)
                    abc
                    (Vessey et al., 1991)
                    dSRPK
                    (Mattox et al., 1999)
                    dSRPK1
                    (Lee et al., 2004, Allemand et al., 2001)
                    fs(2)abc
                    (Kahsai and Cook, 2018)
                    mat(2)syn-F
                    mat(2)synPL63
                    (Schupbach and Wieschaus, 1989)
                    srpk
                    (Loh et al., 2012, Smibert et al., 2012, Barbosa et al., 2007)
                    srpk79D
                    (Saccone et al., 2014)
                    syn-PL63
                    (Tadros et al., 2003)
                    Name Synonyms
                    SR Protein Kinase
                    SRPK
                    cuaba
                    (Barbosa et al., 2007)
                    female sterile abnormal chromatin
                    Secondary FlyBase IDs
                    • FBgn0026370
                    • FBgn0034015
                    • FBgn0064783
                    • FBgn0002678
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    Study result (0)
                    Result
                    Result Type
                    Title
                    External Crossreferences and Linkouts ( 42 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    MARRVEL_MODEL - MARRVEL (model organism gene)
                    Linkouts
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    References (90)