FlyBase Gene Report: Dmel\SRPK

General Information

Symbol

Dmel\SRPK

Species

D. melanogaster

Name

SR Protein Kinase

Annotation Symbol

CG8174

Feature Type

protein_coding_gene

FlyBase ID

FBgn0286813

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Snapshot

SR Protein Kinase (SRPK) encodes a protein involved in spindle microtubule assembly and karyosome formation in oocytes. [Date last reviewed: 2019-08-01]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

fs(2)abc, dSRPK1, mat(2)synPL63

Key Links

Genomic Location

Cytogenetic map

51F11-51F12

Sequence location

2R:15,380,724..15,387,851 [+]

Recombination map

2-74

RefSeq locus

NT_033778 REGION:15380724..15387851

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein serine/threonine kinase activity

inferred from direct assay

(Allemand et al., 2001)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables MAP kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in oocyte karyosome formation

inferred from mutant phenotype

(Loh et al., 2012)

involved_in peptidyl-serine phosphorylation

inferred from direct assay

(Allemand et al., 2001)

involved_in spindle assembly involved in female meiosis

inferred from mutant phenotype

(Loh et al., 2012)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of gene expression

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of mRNA processing

inferred from biological aspect of ancestor with PANTHER:PTN000622883

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in spliceosomal complex assembly

inferred from biological aspect of ancestor with PANTHER:PTN000622883

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with HGNC:11305

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from sequence or structural similarity with HGNC:11305

(FlyBase Curators, 2008--)

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

SERINE-ARGININE PROTEIN KINASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

SERINE-ARGININE PROTEIN KINASES -: Serine-arginine protein kinases (SRPKs) are a group of serine kinases that phosphorylate proteins with serine-arginine dipeptide repeats, particularly targeting the SR family of splicing factors. SRPKs are constitutively active. They contain a well-conserved kinase domain that is bifurcated by a large non-conserved insert domain. (Adapted from PMID:21205204).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\SRPK for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.43

Stop-codon suppression (UAA) postulated; FBrf0216885.

Gene model reviewed during 5.44

Gene model reviewed during 5.50

Double stop-codon suppression (UAA, UGA) postulated; FBrf0243886.

Gene model reviewed during 6.32

Sequence Ontology: Class of Gene

gene

gene_with_stop_codon_read_through

(FlyBase Genome Annotators, 2019-, Jungreis, 2011.11.18)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

SRPK-RA

FBtr0087383

NM_166093

3713

764

SRPK-RB

FBtr0087384

NM_137190

5116

764

SRPK-RC

FBtr0087385

NM_166094

4483

607

SRPK-RD

FBtr0330628

NM_001274064

3713

939

SRPK-RE

FBtr0479824

NM_001382195

5121

1009

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

SRPK-PA

FBpp0086515

85.1

764

9.44

NP_725458

AAF58140

SRPK-PB

FBpp0086516

85.1

764

9.44

NP_611034

AAM68537

SRPK-PC

FBpp0086517

68.1

607

8.99

NP_725459

AAM68538

SRPK-PD

FBpp0303478

103.3

939

9.74

NP_001260993

AGB93525

SRPK-PE

FBpp0428157

111.9

1009

10.11

QJC18710

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

764 aa isoforms: SRPK-PA, SRPK-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\SRPK using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

hindgut anlage

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium