icon, A69, inappropriate contacts
Ig repeat transmembrane protein with fibronectin type III domain - a receptor involved in muscle cell fusion
Please see the JBrowse view of Dmel\hbs for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.56
Gene model reviewed during 5.50
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hbs using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
hbs transcript is first expressed in a narrow band along the dorsal surface of stage 5 embryos, extending 2/3 of the length of the embryo. This band broadens laterally while decreasing in length until confined to the dorsal furrow. By stage 8, hbs is still expressed in the dorsal furrow, as well as ventrally in mesectodermal cells. At stage 10, hbs is expressed in the visceral mesoderm in lateral clusters of cells that resolve into patches by stage 11. By late stage 11, hbs is expressed in somatic and visceral mesoderm. By stage 12, hbs is present in fusion competent myoblasts, but not in muscle founder cells. Somatic mesoderm expression stops by stage 14; as mesoderm expression decreases, epidermal expression begins. Epidermal expression at stage 12 is observed at segment boundaries and in lateral patches; by stage 14, this expression is confined to muscle attachment sites. Stage 14 expression is also observed in pericardial cells. In the CNS,hbs is expressed in a set of ventral midline cells posterior to the developing posterior commissures at stage 12; by stage 14, expression is restricted to 2-3 cells below the posterior commissures, and absent in these cells by stage 15. hbs transcript is expressed in a subset of exit glial cells from stages 12-15. Third instar larval expression is observed in cells posterior to the morphogenetic furrow of the eye disc, and in cell clusters in the morphogenetic furrow. Expression in the wing disc is observed along both sides of the presumptive wing margin, and at presumptive wing veins L3 and L4. hbs is expressed in concentric circles in the leg discs. hbs is expressed in the larval optic lobes.
hbs protein expression is upregulated in third larval instar eye discs in the morphogenetic furrow and in clusters as they emerge from the morphogenetic furrow. There is also a low level of expression in all cells. By rows 2-4, hbs protein was enriched around ommatidial preclusters and in all developing photoreceptors (including R3/R4). Expression is maintained at later stages of eye development. The data suggest that hbs protein is enriched apically at plasma membranes near junctions and is also present in early and recycling endosomes.
Expression of the hbs protein was detected in stage 15 embryonic Malpighian tubule stellate cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\hbs in JBrowse2-73
2-77.3
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
ChEST reveals this is a target of Mef2.
Mutants exhibit a phenotype in which the A/P cone cell contact is improperly maintained through the end of pattern formation.
hbs appears to function as a dose dependant regulator of myoblast fusion.
Identification: Mutation that disrupts the expression pattern of opsins in the eye.
Source for merge of: hbs A69
Source for merge of: hbs CG7449
Source for merge of: hbs icon
The free myoblasts of the hbs mutant phenotype represent rebelliousness, insolence, and transgression of rules (in this case in the mesodermal "society"), the three qualities that the minor Greek Goddess "hibris" represents.
