FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: high-fat diet, obesity
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General Information
Name
high-fat diet, obesity
FlyBase ID
FBhh0000495
Disease Ontology Term
Parent Disease
OMIM
Overview

Flies fed a high-fat diet develop some of the phenotypes associated with obesity; observation of elevated triglycerides is frequently used as an indication of similarity to obesity. Decreased resistance to various sources of stress has been observed in flies fed a high-fat diet, including reduced cold tolerance; cardiomyopathy is also observed (see FBhh0000483). Genes that ameliorate or otherwise modify effects of a high-fat diet have been identified.

In the view of some researchers, the fly adult stage is more appropriate for models of diet-induced obesity than the larval stage. During larval stages, fat body function is primarily directed to organismal growth and lipid storage; in the adult, there is a shift in fat body function to energy homeostasis. The adult fat body is subject to diet-induced lipid overload, unlike the larval fat body, making the adult fly a better model for studies of diet-induced obesity (FBrf0200903).

Offspring (fed a normal diet) of mothers fed a high-fat diet exhibit a shortened lifespan, elevated molecular markers of ROS stress, and other metabolic dysfunctions (see FBhh0001547).

[updated Feb. 2024 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-fat diet, obesity
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    diabesity
    HFD, obesity
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
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          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
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          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
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          Publicly Available Stocks
          References (77)