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General Information
high-fat diet, obesity
FlyBase ID
Disease Ontology Term
Parent Disease

Flies fed a high-fat diet develop some of the phenotypes associated with obesity; observation of elevated triglycerides is frequently used as an indication of similarity to obesity. Decreased resistance to various sources of stress has been observed in flies fed a high-fat diet, including reduced cold tolerance; cardiomyopathy is also observed (see FBhh0000483). Genes that ameliorate or otherwise modify effects of a high-fat diet have been identified.

In the view of some researchers, the fly adult stage is more appropriate for models of diet-induced obesity than the larval stage. During larval stages, fat body function is primarily directed to organismal growth and lipid storage; in the adult, there is a shift in fat body function to energy homeostasis. The adult fat body is subject to diet-induced lipid overload, unlike the larval fat body, making the adult fly a better model for studies of diet-induced obesity (FBrf0200903).

Offspring (fed a normal diet) of mothers fed a high-fat diet exhibit a shortened lifespan, elevated molecular markers of ROS stress, and other metabolic dysfunctions.

[updated Jul. 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-fat diet, obesity
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    HFD, obesity
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
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          Bloomington Stock Center Disease Page
          Selected mammalian transgenes
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          Selected Drosophila transgenes
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          RNAi constructs available
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          Selected Drosophila classical alleles
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          References (44)