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General Information
infection by prokaryotic pathogens
FlyBase ID
Disease Ontology Term
Parent Disease

This is a report collecting publications that describe Drosophila models of infection by prokaryotic pathogens that can infect humans. There are detailed reports available for Drosophila models of infection by specific prokaryotes, see the 'Related Diseases' section below.

There are two prevalent methods to study infection using Drosophila: direct infection and transgenic expression of pathogenic proteins. For a review of fly models using transgenic expression of pathogenic proteins see Harnish et al., 2021 (FBrf02488558).

This report does not cover interactions of non-pathogenic bacteria with Drosophila, such as Wolbachia or commensal bacteria that compose the Drosophila microbiome, nor the mechanics of the innate immune system response in general, rather than in response to a bacterial pathogen.

[updated May 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: infection by prokaryotic pathogens
OMIM report
Symptoms and phenotype
Cellular phenotype and pathology
Molecular information

In Drosophila, microbial challenge leads to the rapid and robust production of a battery of antimicrobial peptides (AMPs), a defense initiated by the fly's innate immune system. Several families of AMPs have been described in Drosophila, with antifungal and antibacterial (both anti-Gram-negative or anti-Gram-positive) activities. Some of these AMPs appear to be unique to insects, e.g., Diptericin, while others have homologs in mammals, e.g., Defensins, Cecropins and Drosomycin. (Adapted from Silverman et al. 2009 and references therein, FBrf0215549. See FlyBase Gene Group FBgg0001101 for information on specific AMPs.)

External links
    Disease synonyms
    bacterial infection
    bacterial pathogen
    prokaryotic infection
    prokaryotic pathogen
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Selected mammalian transgenes
          Publicly Available Stocks
          Selected Drosophila transgenes
          Publicly Available Stocks
          RNAi constructs available
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele class
          Publicly Available Stocks
          References (119)