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General Information
infection by prokaryotic pathogens
FlyBase ID
Disease Ontology Term
Parent Disease

This is a report collecting publications that describe Drosophila models of infection by prokaryotic pathogens that can infect humans. There are detailed reports available for Drosophila models of infection by specific prokaryotes, see the 'Related Diseases' section below.

This report does not cover interactions of non-pathogenic bacteria with Drosophila, such as Wolbachia or commensal bacteria that compose the Drosophila microbiome, nor the mechanics of the innate immune system response in general, rather than in response to a bacterial pathogen.

[updated January 2020 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: infection by prokaryotic pathogens
OMIM report
Symptoms and phenotype
Cellular phenotype and pathology
Molecular information

In Drosophila, microbial challenge leads to the rapid and robust production of a battery of antimicrobial peptides (AMPs), a defense initiated by the fly's innate immune system. Several families of AMPs have been described in Drosophila, with antifungal and antibacterial (both anti-Gram-negative or anti-Gram-positive) activities. Some of these AMPs appear to be unique to insects, e.g., Diptericin, while others have homologs in mammals, e.g., Defensins, Cecropins and Drosomycin. (Adapted from Silverman et al. 2009 and references therein, FBrf0215549. See FlyBase Gene Group FBgg0001101 for information on specific AMPs.)

External links
    Disease synonyms
    prokaryotic pathogen
    prokaryotic infection
    bacterial pathogen
    bacterial infection
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Synthetic Gene(s) Used (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Selected mammalian transgenes
        Publicly Available Stocks
        Selected Drosophila transgenes
        Publicly Available Stocks
        RNAi constructs available
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele class
        Publicly Available Stocks
        References (88)