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General Information
Name
seizure sensitive/resistant (postulated), PRKG1-related
FlyBase ID
FBhh0001135
Disease Ontology Term
Parent Disease
OMIM
Overview

Using a larval electroconvulsive seizure recovery assay, it was determined that alleles of the Drosophila gene for exhibit shorter (in the case of higher activity variants) or prolonged (in the case of a null mutation) recovery times. Dmel\for is a member of the protein kinase G family and is orthologous to the human gene PRKG1. Pharmaceuticals known to affect the activity of PRKG1 have been assessed in this system.

The human PRKG1 gene has been transfected into S2 cells, but as not been introduced into flies.

Animals homozygous for amorphic alleles of Dmel\for typically die during the pupal stage. Naturally-occurring for variants with higher levels of activity affect feeding, locomotion, learning and memory, stress, and social behavior phenotypes. A small number of genetic and physical interactions have been described for for; see below and in the for gene report.

[updated Nov. 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: seizure sensitive/resistant (postulated), PRKG1-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information

PRKG1 is a member of the protein kinase G family, serine/threonine kinases activated by cGMP, and acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth; numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium. [Gene Cards, PRKG1; 2019.11.05]

External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
    Human gene (HGNC)
    D. melanogaster ortholog (based on DIOPT)
    Comments on ortholog(s)

    One to one: 1 human to 1 Drosophila (reciprocal best hits); multiple related genes in both species.

    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (1)
      Gene Snapshot
      foraging (for) encodes a serine/threonine kinase and a member of the protein kinase G family. For roles include feeding, locomotion, metabolism, development, olfactory habituation, learning and memory, stress, social behavior, as well as Malpighian tubule, heart, muscle and synaptic function. [Date last reviewed: 2019-03-07]
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      High-scoring ortholog of human PRKG1 (reciprocal best hit for PRKG1; multiple related genes in both species). Dmel\for shares 60% identity and 75% similarity with PRKG1.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (1 groups)
        protein-protein
        Interacting group
        Assay
        References
        anti tag coimmunoprecipitation, anti tag western blot, western blot
        Alleles Reported to Model Human Disease (Disease Ontology) (3 alleles)
        Models Based on Experimental Evidence ( 3 )
        Allele
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Selected mammalian transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        gamma ray
        natural population
        amorphic allele - genetic evidence
        cre recombinase
        References (3)