Open Close
General Information
Name
cancer, epithelial, ING1-related
FlyBase ID
FBhh0001289
Disease Ontology Term
Parent Disease
OMIM
Overview

This report is based upon experiments in Drosophila designed to identify genes involved in later stages of cancer development, including cellular acquisition of invasive behavior. The Drosophila gene CG7379 was identified in this screen. Dmel\CG7379 encodes a component of a Sin3-type histone deacetylase complex; it has been shown to physically interact with Dmel\p53. A limited numbers of genetic reagents have been generated for CG7379 including RNAi-targeting constructs and an allele caused by insertional mutagenesis.

There are two genes orthologous to Dmel\CG7379 in human, ING1 and ING2. ING1 has been previously identified as a tumor suppressor gene and is implicated in several forms of squamous cell carcinoma. Neither genes has been introduced into flies. Using a breast cancer cell line, the effect of knockdown of ING1 was assessed; a significant increase in both invasion and migration was observed. The ING2 gene was not tested in this assay.

[updated Nov. 2020 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cancer, epithelial, ING1-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information

ING1 encodes a nuclear protein that physically interacts with the tumor suppressor protein TP53; it cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. ING1 is implicated as a tumor suppressor gene. [Gene Cards, ING1; 2020.11.28]

External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
    Human gene (HGNC)
    D. melanogaster ortholog (based on DIOPT)
    Comments on ortholog(s)

    Many to one: 2 human genes to 1 Drosophila gene.

    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (1)
      Cellular component (GO)
      Gene Groups / Pathways
        Comments on ortholog(s)

        Moderate- to high-scoring ortholog of human ING1 and ING2 (1 Drosophila to 2 human). Dmel\CG7379 shares 26-28% identity and 40-41% similarity with the human genes.

        Orthologs and Alignments from DRSC
        DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
        Synthetic Gene(s) Used (0)
        Summary of Physical Interactions (3 groups)
        protein-protein
        Interacting group
        Assay
        References
        pull down, autoradiography
        experimental knowledge based
        anti tag coimmunoprecipitation, peptide massfingerprinting
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Selected mammalian transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (3)