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Citation
Basler, K., Siegrist, P., Hafen, E. (1989). The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.  EMBO J. 8(8): 2381--2386.
FlyBase ID
FBrf0049618
Publication Type
Research paper
Abstract

The sevenless gene controls the fate of a single photoreceptor cell type in the developing eye of Drosophila. Its RNA and protein accumulate transiently in a subpopulation of cells in the developing eye imaginal disc. We have used P-element transformation with different minigenes and marker gene constructs to identify cis-acting regulatory regions required for the complex sevenless expression pattern. Our results indicate that the upstream region of the sevenless gene is devoid of any detectable regulatory elements and that sequences located 3' to the transcription start site are sufficient to promote the sevenless expression pattern. These gene-internal sequences function in both orientations on heterologous promoters, also when placed at the 3' end of a lacZ reporter gene.

PubMed ID
PubMed Central ID
PMC401176 (PMC) (EuropePMC)
DOI
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Alleles (15)
    Genes (5)
    Molecular Constructs (13)
    Sequence Features (2)
    Experimental Tools (1)
    Transgenic Constructs (16)