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Bourgouin, C., Lundgren, S.E., Thomas, J.B. (1992). Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles.  Neuron 9(): 549--561.
FlyBase ID
FBrf0057363
Publication Type
Research paper
Abstract

The recently discovered LIM motif is found in a set of homeodomain-containing proteins thought to mediate the generation of particular cell types. Of the four LIM domain family members described to date, mec-3 and lin-11 determine cell lineages in C. elegans. Isl-1 and Xlim-1 may play similar roles in vertebrates. We have identified a Drosophila member of this class, the product of the apterous (ap) gene. During embryogenesis, ap is expressed in a small subset of fusing mesodermal precursors that give rise to 6 muscles in each abdominal hemisegment and in 5 neurons within each corresponding CNS hemisegment. Lack of ap function results in loss of ap-expressing muscles, while misexpression of ap using a heterologous promoter produces ectopic muscles.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Aberrations (2)
    Alleles (11)
    Balancers (2)
    Genes (7)
    Molecular Constructs (3)
    Molecular Segments (5)
    Insertions (4)
    Experimental Tools (1)
    Transgenic Constructs (3)