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Citation
O'Dell, K.M.C. (1993). The effect of the inactive mutation on longevity, sex, rhythm and resistance to p-Cresol in Drosophila melanogaster.  Heredity 70(4): 393--399.
FlyBase ID
FBrf0058651
Publication Type
Research paper
Abstract

Flies carrying the inactive (iav) mutation exhibit low locomotor activity and poor mating success, both of which are associated with a deficiency in the putative neurotransmitter, octopamine. Several other aspects of the iav mutant phenotype are described here. Male and female iav mutants show a small reduction in longevity but it is not clear whether this is a consequence of the iav mutation or their inactive phenotype. Young iav males show extended attractiveness to older courting males, which supports the notion that the iav gene has a role in post-eclosional maturation. The eclosion rhythm of iav mutants is normal, discounting the possibility of a role for octopamine in the maintenance of circadian rhythm. Flies carrying the iav mutation are highly susceptible to the octopamine analogue p-Cresol. Other phenotypically inactive flies show wild type levels of p-Cresol resistance. This is attributed to the deficiency of octopamine in iav mutants because low octopamine levels may be unable to out-compete the toxic effect of p-Cresol. Some inferences on the possible mode of action of the iav gene product are discussed.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Heredity
    Title
    Heredity
    Publication Year
    1947-
    ISBN/ISSN
    0018-067X
    Data From Reference
    Alleles (7)
    Genes (6)