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Citation
Hill, K.K., Bedian, V., Juang, J.L., Hoffmann, F.M. (1995). Genetic interactions between the Drosophila Abelson, Abl, tyrosine kinase and failed axon connections (Fax), a novel protein in axon bundles.  Genetics 141(2): 595--606.
FlyBase ID
FBrf0084025
Publication Type
Research paper
Abstract

Mutations in the failed axon connections (fax) gene have been identified as dominant genetic enhancers of the Abl mutant phenotype. These mutations in fax all result in defective or absent protein product. In a genetic background with wild-type Abl function, the fax loss-of-function alleles are homozygous viable, demonstrating that fax is not an essential gene unless the animal is also mutant for Abl. The fax gene encodes a novel 47-kD protein expressed in a developmental pattern similar to that of Abl in the embryonic mesoderm and axons of the central nervous system. The conditional, extragenic noncomplementation between fax and another Abl modifier gene, disabled, reveal that the two proteins are likely to function together in a process downstream or parallel to the Abl protein tyrosine kinase.

PubMed ID
PubMed Central ID
PMC1206759 (PMC) (EuropePMC)
DOI
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genetics
    Title
    Genetics
    Publication Year
    1916-
    ISBN/ISSN
    0016-6731
    Data From Reference
    Aberrations (6)
    Alleles (16)
    Genes (10)
    Insertions (1)
    Transgenic Constructs (2)