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Citation
Fambrough, D., Pan, D., Rubin, G.M., Goodman, C.S. (1996). The cell surface metalloprotease/disintegrin Kuzbanian is required for axonal extension in Drosophila.  Proc. Natl. Acad. Sci. U.S.A. 93(23): 13233--13238.
FlyBase ID
FBrf0090545
Publication Type
Research paper
Abstract

It has long been suspected that proteolytic activity associated with advancing growth cones may be required for axon extension. We have isolated mutations in the kuzbanian (kuz) gene, which is expressed in the nervous system and encodes a putative zinc metalloprotease with a disintegrin domain. Drosophila embryos with loss-of-function mutations in kuz have dramatic defects in the development of central nervous system axon pathways, with many axons stalling and failing to extend through the nerve cord. This phenotype is rescued by panneural expression of kuz mRNA in the embryo. These results show that the Kuz metalloprotease is required for axon extension, suggesting a requirement for proteolytic activity at the growth cone surface.

PubMed ID
PubMed Central ID
PMC24076 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Aberrations (1)
    Alleles (4)
    Genes (6)
    Insertions (1)
    Experimental Tools (1)
    Transgenic Constructs (1)