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Citation
Wolfgang, W.J., Roberts, I.J., Quan, F., O'Kane, C., Forte, M. (1996). Activation of protein kinase A-independent pathways by Gs alpha in Drosophila.  Proc. Natl. Acad. Sci. U.S.A. 93(25): 14542--14547.
FlyBase ID
FBrf0090863
Publication Type
Research paper
Abstract

One of the best-described transmembrane signal transduction mechanisms is based on receptor activation of the alpha subunit of the heterotrimeric G protein Gs, leading to stimulation of adenylyl cyclase and the production of cAMP. Intracellular cAMP is then thought to mediate its effects largely, if not entirely, by activation of protein kinase A and the subsequent phosphorylation of substrates which in turn control diverse cellular phenomena. In this report we demonstrate, by two different methods, that reduction or elimination of protein kinase A activity had no effect on phenotypes generated by activation of Gs alpha pathways in Drosophila wing epithelial cells. These genetic studies show that the Gs alpha pathway mediates its primary effects by a novel pathway in differentiating, wing epithelial cells. This novel pathway may in part be responsible for some of the complex, cell-specific responses observed following activation of this pathway in different cell types.

PubMed ID
PubMed Central ID
PMC26169 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (13)
    Genes (10)
    Insertions (3)
    Experimental Tools (3)
    Transgenic Constructs (6)
    Transcripts (1)