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Citation
Harrison, D.A., McCoon, P.E., Binari, R., Gilman, M., Perrimon, N. (1998). Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.  Genes Dev. 12(20): 3252--3263.
FlyBase ID
FBrf0105239
Publication Type
Research paper
Abstract

In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of activating the pathway have been described. We have characterized the unpaired (upd) gene, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway. We propose that Upd is a ligand that relies on JAK signaling to stimulate transcription of pair-rule genes in a segmentally restricted manner in the early Drosophila embryo.

PubMed ID
PubMed Central ID
PMC317220 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Aberrations (7)
    Alleles (14)
    Genes (12)
    Cell Lines (1)
    Transgenic Constructs (1)